DOP2010000251A - Paramyxovirus eficaz como antitumoral - Google Patents
Paramyxovirus eficaz como antitumoralInfo
- Publication number
- DOP2010000251A DOP2010000251A DO2010000251A DO2010000251A DOP2010000251A DO P2010000251 A DOP2010000251 A DO P2010000251A DO 2010000251 A DO2010000251 A DO 2010000251A DO 2010000251 A DO2010000251 A DO 2010000251A DO P2010000251 A DOP2010000251 A DO P2010000251A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- virus
- paramyxovirus
- kill
- antitumoral
- effective
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describen paramyxovirus del grupo APMV3, APMV4, APMV5, APMV6, APMV7, APMV8, APMV9, virus Mapuera y virus Fer-de-Lance, los cuales pueden ser usados para la producción de un medicamento para eI tratamiento de tumores. El virus tiene una selectividad para matar células tumorales humanas pero no para matar células diferenciadas normales humanas o en proliferación normal humanas con la misma dosis. Por medio de ingeniería genética, el virus se puede modificar de modo tal que se agreguen o reemplacen uno o más genes por los genes homólogos de un paramyxovirus relacionado. Por ese método, la actividad antitumoral del virus quimérico resultante se potencia en comparación con el virus parental.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08075121 | 2008-02-14 | ||
| US2965008P | 2008-02-19 | 2008-02-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2010000251A true DOP2010000251A (es) | 2010-08-31 |
Family
ID=40955326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2010000251A DOP2010000251A (es) | 2008-02-14 | 2010-08-13 | Paramyxovirus eficaz como antitumoral |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20090208495A1 (es) |
| EP (1) | EP2252307A2 (es) |
| JP (1) | JP2011512344A (es) |
| KR (1) | KR20100122482A (es) |
| CN (1) | CN101945660A (es) |
| AU (1) | AU2009214066A1 (es) |
| BR (1) | BRPI0908365A2 (es) |
| CA (1) | CA2715136A1 (es) |
| CO (1) | CO6290694A2 (es) |
| CR (1) | CR11631A (es) |
| DO (1) | DOP2010000251A (es) |
| EA (1) | EA201001266A1 (es) |
| EC (1) | ECSP10010401A (es) |
| IL (1) | IL206860A0 (es) |
| MX (1) | MX2010008942A (es) |
| WO (1) | WO2009101149A2 (es) |
| ZA (1) | ZA201006561B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8486418B2 (en) * | 2009-08-21 | 2013-07-16 | Merial Limited | Recombinant avian paramyxovirus vaccine and method for making and using thereof |
| GB0915515D0 (en) * | 2009-09-04 | 2009-10-07 | Ucl Business Plc | Treatment of vasculoproliferative conditions |
| US20130084264A1 (en) | 2010-06-10 | 2013-04-04 | Carla Christina Schrier | Anti-tumor composition |
| CN108130345A (zh) | 2012-01-24 | 2018-06-08 | 乔治亚大学研究基金公司 | 基于副流感病毒5的疫苗 |
| LT3508209T (lt) * | 2013-09-03 | 2022-06-10 | Medimmune Limited | Kompozicijos, kurių būdingasis požymis yra susilpnintas niukaslio ligos virusas, ir naudojimo būdai, skirti neoplazijos gydymui |
| US20200297787A1 (en) * | 2018-07-13 | 2020-09-24 | Icahn School Of Medicine At Mount Sinai | Apmv and uses thereof for the treatment of cancer |
| CN115089591B (zh) * | 2022-05-21 | 2024-04-12 | 复旦大学 | 布立尼布在制备抑制肠道病毒71型嗜神经性病毒药物中的应用 |
| CN116970650B (zh) * | 2023-09-22 | 2023-12-08 | 深圳华大生命科学研究院 | 一种包膜蛋白组合、含其的靶向病毒载体及制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1477964A (zh) * | 1999-04-15 | 2004-02-25 | 应用病毒治疗肿瘤 | |
| EP1217891B1 (en) * | 1999-09-24 | 2009-12-16 | Mayo Foundation For Medical Education And Research | Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family |
| EA013615B1 (ru) * | 2004-11-12 | 2010-06-30 | Байер Шеринг Фарма Акциенгезельшафт | Рекомбинантный онколитический парамиксовирус и его применение |
-
2009
- 2009-02-10 US US12/368,330 patent/US20090208495A1/en not_active Abandoned
- 2009-02-12 KR KR1020107017980A patent/KR20100122482A/ko not_active Application Discontinuation
- 2009-02-12 EA EA201001266A patent/EA201001266A1/ru unknown
- 2009-02-12 AU AU2009214066A patent/AU2009214066A1/en not_active Abandoned
- 2009-02-12 JP JP2010546341A patent/JP2011512344A/ja active Pending
- 2009-02-12 WO PCT/EP2009/051659 patent/WO2009101149A2/en active Application Filing
- 2009-02-12 EP EP09709608A patent/EP2252307A2/en not_active Withdrawn
- 2009-02-12 BR BRPI0908365-0A patent/BRPI0908365A2/pt not_active IP Right Cessation
- 2009-02-12 CA CA2715136A patent/CA2715136A1/en not_active Abandoned
- 2009-02-12 MX MX2010008942A patent/MX2010008942A/es not_active Application Discontinuation
- 2009-02-12 CN CN2009801051826A patent/CN101945660A/zh active Pending
-
2010
- 2010-07-07 IL IL206860A patent/IL206860A0/en unknown
- 2010-08-12 EC EC2010010401A patent/ECSP10010401A/es unknown
- 2010-08-13 DO DO2010000251A patent/DOP2010000251A/es unknown
- 2010-08-13 CR CR11631A patent/CR11631A/es not_active Application Discontinuation
- 2010-08-13 CO CO10100021A patent/CO6290694A2/es not_active Application Discontinuation
- 2010-09-13 ZA ZA2010/06561A patent/ZA201006561B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009101149A2 (en) | 2009-08-20 |
| WO2009101149A3 (en) | 2009-11-05 |
| CN101945660A (zh) | 2011-01-12 |
| CA2715136A1 (en) | 2009-08-20 |
| EA201001266A1 (ru) | 2011-04-29 |
| ECSP10010401A (es) | 2010-09-30 |
| EP2252307A2 (en) | 2010-11-24 |
| BRPI0908365A2 (pt) | 2015-08-11 |
| AU2009214066A1 (en) | 2009-08-20 |
| MX2010008942A (es) | 2010-09-07 |
| US20090208495A1 (en) | 2009-08-20 |
| CR11631A (es) | 2010-10-05 |
| JP2011512344A (ja) | 2011-04-21 |
| ZA201006561B (en) | 2012-02-29 |
| IL206860A0 (en) | 2010-12-30 |
| KR20100122482A (ko) | 2010-11-22 |
| CO6290694A2 (es) | 2011-06-20 |
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