DK83092D0 - Fremgangsmaade til udvinding af thrombin - Google Patents

Fremgangsmaade til udvinding af thrombin

Info

Publication number
DK83092D0
DK83092D0 DK92830A DK83092A DK83092D0 DK 83092 D0 DK83092 D0 DK 83092D0 DK 92830 A DK92830 A DK 92830A DK 83092 A DK83092 A DK 83092A DK 83092 D0 DK83092 D0 DK 83092D0
Authority
DK
Denmark
Prior art keywords
thrombin
procedure
extraction
animal
relates
Prior art date
Application number
DK92830A
Other languages
Danish (da)
English (en)
Inventor
Ulla Weis-Fogh
Original Assignee
Unes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unes As filed Critical Unes As
Priority to DK92830A priority Critical patent/DK83092D0/da
Publication of DK83092D0 publication Critical patent/DK83092D0/da
Priority to AU43501/93A priority patent/AU675650B2/en
Priority to CA 2367124 priority patent/CA2367124C/en
Priority to CA 2367024 priority patent/CA2367024C/en
Priority to NZ328945A priority patent/NZ328945A/xx
Priority to NZ253294A priority patent/NZ253294A/xx
Priority to CA 2367105 priority patent/CA2367105C/en
Priority to DE69333286T priority patent/DE69333286T2/de
Priority to PCT/GB1993/001323 priority patent/WO1994000566A1/en
Priority to CA 2263800 priority patent/CA2263800C/en
Priority to EP93913420A priority patent/EP0654078B1/en
Priority to CA002131316A priority patent/CA2131316C/en
Priority to JP6502157A priority patent/JPH07508275A/ja
Priority to NZ299131A priority patent/NZ299131A/en
Priority to DK93913420T priority patent/DK0654078T3/da
Priority to AT93913420T priority patent/ATE253631T1/de
Priority to FI946004A priority patent/FI946004A/fi
Priority to NO944997A priority patent/NO944997L/no
Priority to US08/749,717 priority patent/US5795571A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6429Thrombin (3.4.21.5)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10Polypeptides; Proteins
    • A61L24/106Fibrin; Fibrinogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21005Thrombin (3.4.21.5)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70Enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK92830A 1992-06-24 1992-06-24 Fremgangsmaade til udvinding af thrombin DK83092D0 (da)

Priority Applications (19)

Application Number Priority Date Filing Date Title
DK92830A DK83092D0 (da) 1992-06-24 1992-06-24 Fremgangsmaade til udvinding af thrombin
AT93913420T ATE253631T1 (de) 1992-06-24 1993-06-24 Eine thrombin-blutfraktion zur verwendung in einem medizinischen verfahren
PCT/GB1993/001323 WO1994000566A1 (en) 1992-06-24 1993-06-24 A thrombin blood fraction for use in a medical procedure
EP93913420A EP0654078B1 (en) 1992-06-24 1993-06-24 A thrombin blood fraction for use in a medical procedure
CA 2367024 CA2367024C (en) 1992-06-24 1993-06-24 A thrombin blood fraction for use in a medical procedure
NZ328945A NZ328945A (en) 1992-06-24 1993-06-24 Preparation of thrombin blood fraction from whole blood or plasma by contacting with a surface capable of activating factors xi and xii
NZ253294A NZ253294A (en) 1992-06-24 1993-06-24 Extraction of prothrombin from blood
CA 2367105 CA2367105C (en) 1992-06-24 1993-06-24 A thrombin blood fraction for use in a medical procedure
DE69333286T DE69333286T2 (de) 1992-06-24 1993-06-24 Eine thrombin-blutfraktion zur verwendung in einem medizinischen verfahren
AU43501/93A AU675650B2 (en) 1992-06-24 1993-06-24 A thrombin blood fraction for use in a medical procedure
CA 2263800 CA2263800C (en) 1992-06-24 1993-06-24 A thrombin blood fraction for use in a medical procedure
CA 2367124 CA2367124C (en) 1992-06-24 1993-06-24 A thrombin blood fraction for use in a medical procedure
CA002131316A CA2131316C (en) 1992-06-24 1993-06-24 A thrombin blood fraction for use in a medical procedure
JP6502157A JPH07508275A (ja) 1992-06-24 1993-06-24 医療処置で用いるトロンビン血液分画
NZ299131A NZ299131A (en) 1992-06-24 1993-06-24 Use of thrombin blood fraction in keratinocyte cell culture growth and activation of platelets
DK93913420T DK0654078T3 (da) 1992-06-24 1993-06-24 Thrombinblodfraktion til anvendelse i en medicinsk procedure
FI946004A FI946004A (fi) 1992-06-24 1994-12-21 Lääketieteellisessä toimenpiteessä käytettävä trombiiniverifraktio
NO944997A NO944997L (no) 1992-06-24 1994-12-23 Trombin-blodfraksjon for anvendelse ved en medisinsk fremgangsmåte
US08/749,717 US5795571A (en) 1992-06-24 1996-11-15 Composition containing autologous thrombin blood fraction for use in a medical procedure

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK92830A DK83092D0 (da) 1992-06-24 1992-06-24 Fremgangsmaade til udvinding af thrombin

Publications (1)

Publication Number Publication Date
DK83092D0 true DK83092D0 (da) 1992-06-24

Family

ID=8098037

Family Applications (2)

Application Number Title Priority Date Filing Date
DK92830A DK83092D0 (da) 1992-06-24 1992-06-24 Fremgangsmaade til udvinding af thrombin
DK93913420T DK0654078T3 (da) 1992-06-24 1993-06-24 Thrombinblodfraktion til anvendelse i en medicinsk procedure

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK93913420T DK0654078T3 (da) 1992-06-24 1993-06-24 Thrombinblodfraktion til anvendelse i en medicinsk procedure

Country Status (12)

Country Link
US (1) US5795571A (fi)
EP (1) EP0654078B1 (fi)
JP (1) JPH07508275A (fi)
AT (1) ATE253631T1 (fi)
AU (1) AU675650B2 (fi)
CA (1) CA2131316C (fi)
DE (1) DE69333286T2 (fi)
DK (2) DK83092D0 (fi)
FI (1) FI946004A (fi)
NO (1) NO944997L (fi)
NZ (2) NZ299131A (fi)
WO (1) WO1994000566A1 (fi)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585007A (en) * 1994-12-07 1996-12-17 Plasmaseal Corporation Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant
US5643192A (en) * 1995-04-06 1997-07-01 Hamilton Civic Hospitals Research Development, Inc. Autologous fibrin glue and methods for its preparation and use
WO2000062828A1 (en) * 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
DE29723807U1 (de) * 1996-04-30 1999-11-04 Medtronic, Inc., Minneapolis, Minn. Autologe Fibrin-Blutstillungsmittel
US7745106B2 (en) * 1997-06-24 2010-06-29 Cascade Medical Enterprises, Llc Methods and devices for separating liquid components
US6979307B2 (en) 1997-06-24 2005-12-27 Cascade Medical Enterprises Llc Systems and methods for preparing autologous fibrin glue
US6478808B2 (en) 1997-12-17 2002-11-12 Closys Corporation Clotting cascade initiating apparatus and methods of use and methods of closing wounds
US6159232A (en) 1997-12-16 2000-12-12 Closys Corporation Clotting cascade initiating apparatus and methods of use and methods of closing wounds
US6274090B1 (en) * 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
US7276235B2 (en) 1998-11-18 2007-10-02 Zlb Behring Gmbh Tissue glue with improved antiadhesive properties
US6447774B1 (en) 1998-11-18 2002-09-10 Aventis Behring Gmbh Stabilized protein preparations for a tissue adhesive
AU764347B2 (en) 1998-12-02 2003-08-14 Vivolution A/S Spray delivery of cells
US20030069601A1 (en) * 1998-12-15 2003-04-10 Closys Corporation Clotting cascade initiating apparatus and methods of use
AU5311700A (en) 1999-06-01 2000-12-28 Closys Corporation Clotting cascade initiating apparatus and methods of use
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
US6942880B1 (en) * 2001-04-09 2005-09-13 Medtronic, Inc. Autologous platelet gel having beneficial geometric shapes and methods of making the same
JP4289886B2 (ja) * 2001-05-09 2009-07-01 バイオインターラクションズ リミテッド 創傷閉鎖システム及び方法
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US7992725B2 (en) 2002-05-03 2011-08-09 Biomet Biologics, Llc Buoy suspension fractionation system
US7832566B2 (en) 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
WO2003099412A1 (en) 2002-05-24 2003-12-04 Biomet Manufacturing Corp. Apparatus and method for separating and concentrating fluids containing multiple components
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US20060278588A1 (en) 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
EP2338442B1 (en) 2003-12-11 2013-01-30 Isto Technologies Inc. Particulate cartilage system
US7837708B2 (en) * 2004-04-22 2010-11-23 Arthrex, Inc. Accelerated healing with intraoperative combination of suture and autogenous blood components
US8124075B2 (en) * 2004-07-16 2012-02-28 Spinal Restoration, Inc. Enhanced biological autologous tissue adhesive composition and methods of preparation and use
US8206448B2 (en) 2004-10-29 2012-06-26 Spinal Restoration, Inc. Injection of fibrin sealant using reconstituted components in spinal applications
US7597687B2 (en) * 2004-10-29 2009-10-06 Spinal Restoration, Inc. Injection of fibrin sealant including an anesthetic in spinal applications
US20110213464A1 (en) * 2004-10-29 2011-09-01 Whitlock Steven I Injection of fibrin sealant in the absence of corticosteroids in spinal applications
US7866485B2 (en) 2005-02-07 2011-01-11 Hanuman, Llc Apparatus and method for preparing platelet rich plasma and concentrates thereof
EP2910258B1 (en) 2005-02-07 2018-08-01 Hanuman LLC Platelet rich plasma concentrate apparatus
US7708152B2 (en) 2005-02-07 2010-05-04 Hanuman Llc Method and apparatus for preparing platelet rich plasma and concentrates thereof
PL1848473T3 (pl) * 2005-02-07 2013-11-29 Hanuman Llc Urządzenie - koncentrator osocza
US7694828B2 (en) 2005-04-27 2010-04-13 Biomet Manufacturing Corp. Method and apparatus for producing autologous clotting components
US8480757B2 (en) 2005-08-26 2013-07-09 Zimmer, Inc. Implants and methods for repair, replacement and treatment of disease
US8277837B2 (en) 2006-01-11 2012-10-02 Entegrion, Inc. Hemostatic textile
WO2007127834A2 (en) 2006-04-26 2007-11-08 Medtronic, Inc. Compositions and methods of preparation thereof
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
EP2146794B1 (en) 2007-04-12 2016-10-19 Biomet Biologics, LLC Buoy suspension fractionation system
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
WO2008128075A1 (en) 2007-04-12 2008-10-23 Isto Technologies, Inc. Compositions and methods for tissue repair
EP2567692B1 (en) 2008-02-27 2016-04-06 Biomet Biologics, LLC Use of a device for obtaining interleukin-1 receptor antagonist rich solutions
EP2254991B1 (en) * 2008-02-29 2018-08-22 Biomet Manufacturing, LLC A system and process for separating a material
US8012077B2 (en) 2008-05-23 2011-09-06 Biomet Biologics, Llc Blood separating device
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
US9011800B2 (en) 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
US10231721B2 (en) 2010-06-24 2019-03-19 St. Croix Surgical Systems, Llc Failsafe percutaneous wound barrier
US20130096479A1 (en) * 2011-10-18 2013-04-18 St. Teresa Medical, Inc. Method of forming hemostatic products
US20130202675A1 (en) 2012-02-03 2013-08-08 Dynasil Biomedical Corporation Systems and methods for the fabrication of tissue patches
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US9550028B2 (en) 2014-05-06 2017-01-24 Biomet Biologics, LLC. Single step desiccating bead-in-syringe concentrating device
US9713810B2 (en) 2015-03-30 2017-07-25 Biomet Biologics, Llc Cell washing plunger using centrifugal force
US9757721B2 (en) 2015-05-11 2017-09-12 Biomet Biologics, Llc Cell washing plunger using centrifugal force
US9540548B1 (en) 2015-08-07 2017-01-10 Xcede Technologies, Inc. Adhesive compositions and related methods
CA2994959A1 (en) 2015-08-07 2017-02-16 Xcede Technologies, Inc. Adhesive compositions and related methods
US9833538B2 (en) 2015-08-07 2017-12-05 Xcede Technologies, Inc. Adhesive compositions and related methods
AU2016351557A1 (en) 2015-11-12 2018-05-31 St. Teresa Medical, Inc. A method of sealing a durotomy
CA3078625C (en) 2017-10-09 2023-01-17 Terumo Bct Biotechnologies, Llc Lyophilization container and method of using same
US10953128B2 (en) 2017-11-02 2021-03-23 St. Teresa Medical, Inc. Fibrin sealant products
WO2020185916A1 (en) 2019-03-14 2020-09-17 Terumo Bct Biotechnologies, Llc Lyophilization container fill fixture, system and method of use

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH259254A (de) * 1945-12-28 1949-01-15 Szent Gyorgyi Albert Dr Verfahren zur Herstellung von Thrombin aus Blut.
US4265233A (en) * 1978-04-12 1981-05-05 Unitika Ltd. Material for wound healing
AT359653B (de) * 1979-02-15 1980-11-25 Immuno Ag Verfahren zur herstellung eines gewebekleb- stoffes
US4374830A (en) * 1979-10-04 1983-02-22 Research Corp. Platelet aggregating material from equine arterial tissue
US4363319A (en) * 1980-06-30 1982-12-14 Applied Medical Devices, Inc. Ready-to-use bandage incorporating a coagulant composition and method of preparing same
US4627879A (en) * 1984-09-07 1986-12-09 The Trustees Of Columbia University In The City Of New York Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma
US5165938A (en) * 1984-11-29 1992-11-24 Regents Of The University Of Minnesota Wound healing agents derived from platelets
US4696812A (en) * 1985-10-28 1987-09-29 Warner-Lambert Company Thrombin preparations
US4714457A (en) * 1986-09-15 1987-12-22 Robert Alterbaum Method and apparatus for use in preparation of fibrinogen from a patient's blood
DK475386D0 (da) * 1986-10-03 1986-10-03 Weis Fogh Ulla Sivertsen Fremgangsmaade og apparat til fremstilling af biologiske stoffer
US5352664A (en) * 1986-10-31 1994-10-04 Board Of Regents, The University Of Texas System Thrombin derived polypeptides; compositions and methods for use
US4965203A (en) * 1987-01-28 1990-10-23 Warner-Lambert Company Purified thrombin preparations
JPS63243032A (ja) * 1987-03-27 1988-10-07 Green Cross Corp:The トロンビンの加熱処理方法
JPS6440433A (en) * 1987-08-05 1989-02-10 Green Cross Corp Aqueous liquid composition of thrombin
US4752466A (en) * 1987-08-31 1988-06-21 Johnson & Johnson Products, Inc. Thrombin aerosol
DE3734923C1 (de) * 1987-10-15 1989-01-26 Biotest Pharma Gmbh Verfahren zur Herstellung einer sterilen Plasmaproteinloesung,die Fibrinogen und den Gerinnungsfaktor XIII enthaelt
US5290552A (en) * 1988-05-02 1994-03-01 Matrix Pharmaceutical, Inc./Project Hear Surgical adhesive material
FR2639958B1 (fr) * 1988-12-06 1992-08-21 Lille Transfusion Sanguine Support biologique pour cultures cellulaires constitue de proteines plasmatiques coagulees par la thrombine, son utilisation pour la culture des keratinocytes, leur recuperation et leur transport a des fins d'utilisation therapeutique
DE3843126C3 (de) * 1988-12-22 1994-10-06 Octapharma Ag Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates
US5219328A (en) * 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
US5318524A (en) * 1990-01-03 1994-06-07 Cryolife, Inc. Fibrin sealant delivery kit
US5185001A (en) * 1990-01-18 1993-02-09 The Research Foundation Of State University Of New York Method of preparing autologous plasma fibrin and application apparatus therefor
IE73210B1 (en) * 1990-01-24 1997-05-07 Warner Lambert Co Process for the production of thrombin and high purity thrombin preparation thereby obtained
ATE177781T1 (de) * 1990-02-20 1999-04-15 Baxter Int Gereinigtes, virusfreies menschliches thrombin
US5089415A (en) * 1990-09-17 1992-02-18 International Technidyne Corp. Method for clotting heparized blood by the addition of protamine, thrombin and snake venom
AU642987B2 (en) * 1991-03-25 1993-11-04 Warner-Lambert Company Ultra-pure thrombin preparation
DE69122376D1 (de) * 1991-03-28 1996-10-31 Warner Lambert Co Hochreine Thrombinzubereitung
FR2679251B1 (fr) * 1991-07-18 1993-11-12 Nord Assoc Essor Transfusion San Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.
EP0534178B1 (en) * 1991-09-27 2001-04-18 Omrix Biopharmaceuticals S.A. Improved tissue glue prepared by using cryoprecipitate
AT396937B (de) * 1992-04-06 1993-12-27 Immuno Ag Verfahren zur aktivierung von blutgerinnungsfaktoren
US5443959A (en) * 1992-09-09 1995-08-22 Tokuyama Corporation Method of assaying fibrinogen, dry reagent therefor, and process for the preparation thereof
US5506127A (en) * 1994-09-21 1996-04-09 Proba; Zbigniew Therapeutic grade thrombin produced by chromatography
US5510102A (en) * 1995-01-23 1996-04-23 The Regents Of The University Of California Plasma and polymer containing surgical hemostatic adhesives

Also Published As

Publication number Publication date
US5795571A (en) 1998-08-18
WO1994000566A1 (en) 1994-01-06
FI946004A0 (fi) 1994-12-21
CA2131316C (en) 2002-03-19
ATE253631T1 (de) 2003-11-15
CA2131316A1 (en) 1994-01-06
DK0654078T3 (da) 2004-01-26
NO944997D0 (no) 1994-12-23
NZ253294A (en) 1999-05-28
NZ299131A (en) 2001-07-27
DE69333286T2 (de) 2004-08-19
AU4350193A (en) 1994-01-24
FI946004A (fi) 1994-12-21
JPH07508275A (ja) 1995-09-14
EP0654078A1 (en) 1995-05-24
AU675650B2 (en) 1997-02-13
EP0654078B1 (en) 2003-11-05
DE69333286D1 (de) 2003-12-11
NO944997L (no) 1994-12-23

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