DK658688A - 1-aryl-3-quinolin- og 1-aryl-3-isoquinolin-carboxamider, deres fremstilling og anvendelse som laegemidler - Google Patents

1-aryl-3-quinolin- og 1-aryl-3-isoquinolin-carboxamider, deres fremstilling og anvendelse som laegemidler

Info

Publication number
DK658688A
DK658688A DK658688A DK658688A DK658688A DK 658688 A DK658688 A DK 658688A DK 658688 A DK658688 A DK 658688A DK 658688 A DK658688 A DK 658688A DK 658688 A DK658688 A DK 658688A
Authority
DK
Denmark
Prior art keywords
aryl
quinoline
preparation
medicinal products
isoquinoline carboxamides
Prior art date
Application number
DK658688A
Other languages
Danish (da)
English (en)
Other versions
DK658688D0 (da
Inventor
Edward J Glamkowski
Russell Richard Lee Hamer
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of DK658688D0 publication Critical patent/DK658688D0/da
Publication of DK658688A publication Critical patent/DK658688A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
DK658688A 1987-11-27 1988-11-25 1-aryl-3-quinolin- og 1-aryl-3-isoquinolin-carboxamider, deres fremstilling og anvendelse som laegemidler DK658688A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/125,971 US4786644A (en) 1987-11-27 1987-11-27 1-aryl-3-quinolinecarboxamide

Publications (2)

Publication Number Publication Date
DK658688D0 DK658688D0 (da) 1988-11-25
DK658688A true DK658688A (da) 1989-05-28

Family

ID=22422331

Family Applications (1)

Application Number Title Priority Date Filing Date
DK658688A DK658688A (da) 1987-11-27 1988-11-25 1-aryl-3-quinolin- og 1-aryl-3-isoquinolin-carboxamider, deres fremstilling og anvendelse som laegemidler

Country Status (5)

Country Link
US (1) US4786644A (fr)
EP (1) EP0317991A3 (fr)
JP (1) JPH02138260A (fr)
DK (1) DK658688A (fr)
PT (1) PT89094B (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0172004B1 (fr) * 1984-08-15 1990-03-21 The Boots Company PLC Quinolinones, procédé pour leur préparation et compositions pharmaceutiques les contenant
US4959363A (en) * 1989-06-23 1990-09-25 Sterling Drug Inc. Quinolonecarboxamide compounds, their preparation and use as antivirals.
DE69209576T4 (de) * 1991-05-10 1997-01-30 Takeda Chemical Industries Ltd Pyridinderivate, deren Herstellung und Anwendung
US5514678A (en) * 1992-03-26 1996-05-07 E. I. Du Pont De Nemours And Company Arthropodicidal 1,2,4-triazinyl amides
EP0841927B1 (fr) * 1995-08-02 2004-01-28 Darwin Discovery Limited Quinolones et leur utilisation therapeutique
EP0841929B1 (fr) * 1995-08-02 2003-05-07 Darwin Discovery Limited Quinolones et leur utilisation therapeutique
US5945431A (en) * 1996-03-15 1999-08-31 Biochem Therapeutics Incorporated Cytomegalovirus inhibiting compounds
GB9605437D0 (en) * 1996-03-15 1996-05-15 Iaf Biochem Int Cytomegalovirus inhibiting compounds
DE69831506T2 (de) * 1997-12-22 2006-06-29 Pharmacia & Upjohn Co. Llc, Kalamazoo 4-hydroxychinolin-3-carboxamide und hydrazide als antivirale wirkstoffe
US6248736B1 (en) * 1999-01-08 2001-06-19 Pharmacia & Upjohn Company 4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents
CN101125138A (zh) * 2000-12-18 2008-02-20 株式会社医药分子设计研究所 炎症性细胞因子产生游离抑制剂
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
DE10222895A1 (de) * 2002-05-23 2003-12-11 Bosch Gmbh Robert Hochdruckspeicher für Kraftstoffeinspritzsysteme mit integriertem Druckregelventil
EP1510207A4 (fr) * 2002-06-05 2008-12-31 Inst Med Molecular Design Inc Medicaments therapeutiques destines au diabete
TW200407112A (en) * 2002-06-05 2004-05-16 Inst Med Molecular Design Inc Immunity-related protein kinase inhibitors
AU2003242127A1 (en) * 2002-06-05 2003-12-22 Institute Of Medicinal Molecular Design, Inc. Inhibitors against the activation of ap-1 and nfat
WO2003103656A1 (fr) * 2002-06-06 2003-12-18 株式会社医薬分子設計研究所 Derives hydroxyaryle o-substitues
CN1658872B (zh) * 2002-06-06 2010-09-22 株式会社医药分子设计研究所 抗过敏药
EP1535609A4 (fr) * 2002-06-10 2009-01-07 Inst Med Molecular Design Inc Inhibiteur de l'activation de nf-kb
EA010835B1 (ru) * 2002-06-10 2008-12-30 Инститьют Оф Медисинал Молекьюлар Дизайн. Инк. Лекарственное средство для лечения рака
AU2003242124A1 (en) * 2002-06-11 2003-12-22 Institute Of Medicinal Molecular Design, Inc. Medicament for treatment of neurodegenerative diseases
US7959161B2 (en) * 2002-11-12 2011-06-14 Nok Corporation Rubber-like elastic part
EP1603883B1 (fr) 2003-02-03 2012-03-28 Janssen Pharmaceutica NV Amides derives quinoliniques modulant le recepteur vr1 vanilloide
RU2556984C2 (ru) * 2004-06-24 2015-07-20 Вертекс Фармасьютикалз Инкорпорейтед Модуляторы транспортеров атф-связывающей кассеты
NZ587551A (en) 2004-06-24 2012-01-12 Vertex Pharma 5-Amino-phenol derivatives such as 5-amino-2,4-di-tert-butyl-phenol
SI2502911T1 (sl) * 2004-06-24 2017-07-31 Vertex Pharmaceuticals Incorporated Modulatorji transporterjev ATP vezavne kasete
US8354427B2 (en) * 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
CN101374849A (zh) * 2005-12-24 2009-02-25 沃泰克斯药物股份有限公司 作为abc转运蛋白调控剂的喹啉-4-酮衍生物
SI3219705T1 (sl) 2005-12-28 2020-08-31 Vertex Pharmaceuticals Incorporated Farmacevtski sestavki amorfne oblike N-(2,4-bis(1,1-dimetiletil)-5- hidroksifenil)-1,4-dihidro-4-oksokinolin-3-karboksamid
RU2543714C2 (ru) 2009-03-20 2015-03-10 Вертекс Фармасьютикалз Инкорпорейтед Способ получения модуляторов регулятора трансмембранной проводимости кистозного фиброза
NZ604176A (en) * 2010-07-09 2014-10-31 Active Biotech Ab Method for manufacturing of quinoline-3-carboxamides
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
BR112014021090B1 (pt) 2012-02-27 2023-01-24 Vertex Pharmaceuticals Incorporated Composição farmacêutica e uso de n-[2,4-bis(1,1-dimetiletil)-5-hidróxifenil]-1,4-di-hidro-4-oxoquinolina3-carboxamida na preparação da mesma
DK2888010T3 (da) * 2012-08-22 2021-06-28 Univ Cornell Fremgangsmåder til at hæmme fascin
JP6691869B2 (ja) 2014-02-20 2020-05-13 コーネル ユニヴァーシティー ファシンを阻害するための化合物及び方法
RU2749213C2 (ru) 2014-10-07 2021-06-07 Вертекс Фармасьютикалз Инкорпорейтед Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2324304A2 (fr) * 1975-09-22 1977-04-15 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
IE52670B1 (en) * 1981-03-03 1988-01-20 Leo Ab Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
HU190796B (en) * 1981-06-12 1986-11-28 Roussel Uclaf,Fr Process for producing n-dihydrothiazolyl-3-quinoline-carboxamide derivatives
FR2537140B1 (fr) * 1982-12-07 1986-07-18 Roussel Uclaf Nouveaux derives de la 4-hydroxy-3-quinoleine carboxamide, leur sels, procede de preparation, application a titre de medicaments, et compositions les renfermant
EP0172004B1 (fr) * 1984-08-15 1990-03-21 The Boots Company PLC Quinolinones, procédé pour leur préparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
PT89094A (pt) 1988-12-01
DK658688D0 (da) 1988-11-25
PT89094B (pt) 1993-03-31
EP0317991A2 (fr) 1989-05-31
US4786644A (en) 1988-11-22
JPH02138260A (ja) 1990-05-28
EP0317991A3 (fr) 1990-11-07

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Legal Events

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