DK638389A - Transformerende vaekstfaktor-beta2 og forstadier derfor, fremgangsmaade til deres fremstilling, nucleotidsekvens som koder derfor samt eukaryotiske celler og cellelinier indeholdende denne - Google Patents

Transformerende vaekstfaktor-beta2 og forstadier derfor, fremgangsmaade til deres fremstilling, nucleotidsekvens som koder derfor samt eukaryotiske celler og cellelinier indeholdende denne Download PDF

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Publication number
DK638389A
DK638389A DK638389A DK638389A DK638389A DK 638389 A DK638389 A DK 638389A DK 638389 A DK638389 A DK 638389A DK 638389 A DK638389 A DK 638389A DK 638389 A DK638389 A DK 638389A
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Prior art keywords
echariotic
beta2
precautions
codes
procedures
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DK638389A
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English (en)
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DK638389D0 (da
Inventor
Anthony F Purchio
Linda Madisen
Nancy Webb
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Oncogen
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Publication of DK638389D0 publication Critical patent/DK638389D0/da
Publication of DK638389A publication Critical patent/DK638389A/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK638389A 1988-12-16 1989-12-15 Transformerende vaekstfaktor-beta2 og forstadier derfor, fremgangsmaade til deres fremstilling, nucleotidsekvens som koder derfor samt eukaryotiske celler og cellelinier indeholdende denne DK638389A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28514088A 1988-12-16 1988-12-16
US07/446,020 US5221620A (en) 1987-10-06 1989-12-05 Cloning and expression of transforming growth factor β2

Publications (2)

Publication Number Publication Date
DK638389D0 DK638389D0 (da) 1989-12-15
DK638389A true DK638389A (da) 1990-06-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DK638389A DK638389A (da) 1988-12-16 1989-12-15 Transformerende vaekstfaktor-beta2 og forstadier derfor, fremgangsmaade til deres fremstilling, nucleotidsekvens som koder derfor samt eukaryotiske celler og cellelinier indeholdende denne

Country Status (8)

Country Link
US (1) US5221620A (da)
EP (2) EP0376785A3 (da)
CN (1) CN1045992A (da)
AU (1) AU640115B2 (da)
DK (1) DK638389A (da)
FI (1) FI896001A0 (da)
IL (1) IL92737A0 (da)
NZ (1) NZ231803A (da)

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JPH05503003A (ja) * 1989-11-22 1993-05-27 ジェネンテク，インコーポレイテッド 潜在性関与ペプチドおよびその使用
US5168050A (en) * 1990-05-24 1992-12-01 Genentech, Inc. Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
AU2738392A (en) * 1991-11-11 1993-05-13 Ciba-Geigy Ag Novel hybrid transforming growth factors
IT1259042B (it) * 1992-01-27 1996-03-11 Mini Ricerca Scient Tecnolog Preparazione di vettori di espressione per la sintesi del polipeptide chiamato fattore osteogenetico op-1 in cellule eucariotiche di spodoptera frugiperda via infezione con baculovirus ricombinante
DK0625989T3 (da) * 1992-02-12 2000-06-26 Bioph Biotech Entw Pharm Gmbh DNA-sekvenser kodende for hidtil ukendte vækst-/differentieringsfaktorer
US6395494B1 (en) * 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6306421B1 (en) 1992-09-25 2001-10-23 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5770609A (en) * 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5595722A (en) * 1993-01-28 1997-01-21 Neorx Corporation Method for identifying an agent which increases TGF-beta levels
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
DE69429617T2 (de) * 1993-04-30 2002-08-22 Biognostik Ges Antisense-oligonukleotide zur behandlung des immunsuppressiven effektes des transformierenden wachstumsfaktor-beta1(tgf-beta1)
US6197789B1 (en) 1995-06-07 2001-03-06 Neorx Corporation Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
JPH08510451A (ja) * 1993-05-13 1996-11-05 ネオルックス コーポレイション 異常増殖性平滑筋細胞に関連した病因の予防及び治療
US6521227B1 (en) 1999-11-18 2003-02-18 Peter L. Hudson Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides
US5994102A (en) * 1994-12-15 1999-11-30 Human Genome Sciences, Inc. Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides
EP0856579A1 (en) * 1997-01-31 1998-08-05 BIOGNOSTIK GESELLSCHAFT FÜR BIOMOLEKULARE DIAGNOSTIK mbH An antisense oligonucleotide preparation method
WO1998046588A2 (en) * 1997-04-11 1998-10-22 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
EP1117805A2 (en) 1998-10-07 2001-07-25 STRYKER CORPORATION (a Michigan corporation) Modified tgf-beta superfamily proteins
US6756215B1 (en) * 2000-10-20 2004-06-29 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Functionalized TGF-β fusion proteins
US7575751B2 (en) 2004-04-27 2009-08-18 Research Development Foundation Activin-A mutants
CN100389120C (zh) * 2005-04-12 2008-05-21 中国人民解放军第三军医大学野战外科研究所 封闭TGF－β1的反义寡核苷酸及其在制备治疗纤维化相关疾病药物中的用途
WO2010144696A1 (en) 2009-06-11 2010-12-16 Burnham Institute For Medical Research Directed differentiation of stem cells
US9758786B2 (en) 2016-02-09 2017-09-12 Autotelic, Llc Compositions and methods for treating pancreatic cancer

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) * 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4338397A (en) * 1980-04-11 1982-07-06 President And Fellows Of Harvard College Mature protein synthesis
US4546082A (en) * 1982-06-17 1985-10-08 Regents Of The Univ. Of California E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins
EP0105014B1 (en) * 1982-09-24 1992-05-20 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Repair of tissue in animals
CA1230591A (en) * 1983-06-03 1987-12-22 Charles A. Frolik PURIFIED TRANSFORMING GROWTH FACTOR-.beta. DERIVED FROM HUMAN PLATELETS AND PLACENTAS
EP0155433A1 (en) * 1984-03-23 1985-09-25 Adriano Fontana Immunosuppressant factor
CA1341401C (en) * 1984-03-23 2002-11-26 Adriano Fontana Immunosuppressant factor derived from human glioblastoma cells
US4708948A (en) * 1984-04-20 1987-11-24 The United States Of America As Represented By The Department Of Health And Human Services Substantially purified tumor growth inhibitory factor
ATE128715T1 (de) * 1984-07-16 1995-10-15 Celtrix Pharma Polypeptide induzierende faktoren in knochen und knorpel.
IL78197A (en) * 1985-03-22 1991-07-18 Genentech Inc Nucleic acid encoding tgf-beta and its uses
PT86144B (pt) * 1986-11-17 1990-08-31 Sandoz Sa Processo para a preparacao de uma proteina tendo actividade semelhante a factor g-tsf humano e de composicoes farmaceuticas que o contem
AU1539188A (en) * 1987-05-04 1988-11-10 Bristol-Myers Squibb Company TGF-B2 and novel compositions having anti-neoplastic activity
EP0293785A3 (en) * 1987-05-29 1990-05-02 Oncogen Limited Partnership Cloning and expression of simian transforming growth factor-ss1
IL87877A0 (en) * 1987-10-06 1989-03-31 Oncogen Cloning and expression of transforming growth factor beta2
AU630075B2 (en) * 1987-10-06 1992-10-22 Bristol-Myers Squibb Company Cloning and expression of transforming growth factor 2b

Also Published As

Publication number Publication date
US5221620A (en) 1993-06-22
EP0376785A2 (en) 1990-07-04
DK638389D0 (da) 1989-12-15
IL92737A0 (en) 1990-09-17
EP0676474A1 (en) 1995-10-11
AU4683589A (en) 1991-06-21
CN1045992A (zh) 1990-10-10
EP0376785A3 (en) 1992-01-02
NZ231803A (en) 1992-10-28
FI896001A0 (fi) 1989-12-14
AU640115B2 (en) 1993-08-19

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