DK627389A - PROTEINS AND DERIVATIVES THEREOF - Google Patents

PROTEINS AND DERIVATIVES THEREOF Download PDF

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Publication number
DK627389A
DK627389A DK627389A DK627389A DK627389A DK 627389 A DK627389 A DK 627389A DK 627389 A DK627389 A DK 627389A DK 627389 A DK627389 A DK 627389A DK 627389 A DK627389 A DK 627389A
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DK
Denmark
Prior art keywords
domain
thrombin
approx
ability
amino acids
Prior art date
Application number
DK627389A
Other languages
Danish (da)
Other versions
DK162169B (en
DK627389D0 (en
DK162169C (en
Inventor
Bjoern Andersen Nexoe
Esper Boel
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from DK299087A external-priority patent/DK299087D0/en
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Priority to DK627389A priority Critical patent/DK162169C/en
Publication of DK627389D0 publication Critical patent/DK627389D0/en
Publication of DK627389A publication Critical patent/DK627389A/en
Publication of DK162169B publication Critical patent/DK162169B/en
Application granted granted Critical
Publication of DK162169C publication Critical patent/DK162169C/en

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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention comprises a group of compounds which possess thrombomodulin activity defined by a high degree of affinity binding to thrombin and the ability to provide a complex between such a compound and thrombin having the ability to activate protein C, and which comprise, from the C-terminal moiety of the molecule, two or more of the following structural elements: a) a short cytoplasmic domain of approx. 56 amino acids, b) a transmembrane region of approx. 24 amino acids, c) a region which is rich in serine, threonine and proline residues, d) a domain which comprises at least two EGF domains, and e) a N-terminal domain, where one or more of the elements a), b) and/or c) can be omitted or replaced with affinity-imparting units or units which increase the solubility in physiological solutions, or physiologically compatible derivatives thereof. In a preferred embodiment, four EGF domains are coupled N- terminally to the signal peptide from human tissue-type plasminogen activator with the aid of an adapter sequence. The proteins can be used for treating and/or preventing thrombic episodes.
DK627389A 1987-06-12 1989-12-12 RECOMBINATE PROTEINS WITH THROMBOMODULIN ACTIVITY, DNA CONSTRUCTIONS CODING THEREOF, VECTORS, CELLS AND PROCEDURES FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING THE PROTEINES AND THE PROTEINES CONTAINING THE PROTEINES AND THE PROTEINES CONTAINING THE PROTEINES AND THE PROTEINES CONTAINING THE PROTEINS, AND THE DK162169C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK627389A DK162169C (en) 1987-06-12 1989-12-12 RECOMBINATE PROTEINS WITH THROMBOMODULIN ACTIVITY, DNA CONSTRUCTIONS CODING THEREOF, VECTORS, CELLS AND PROCEDURES FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING THE PROTEINES AND THE PROTEINES CONTAINING THE PROTEINES AND THE PROTEINES CONTAINING THE PROTEINES AND THE PROTEINES CONTAINING THE PROTEINS, AND THE

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DK299087A DK299087D0 (en) 1987-06-12 1987-06-12 PROTEINS AND DERIVATIVES THEREOF
DK299087 1987-06-12
PCT/DK1988/000089 WO1988009811A1 (en) 1987-06-12 1988-06-09 Proteins and derivatives thereof
DK8800089 1988-06-09
DK627389 1989-12-12
DK627389A DK162169C (en) 1987-06-12 1989-12-12 RECOMBINATE PROTEINS WITH THROMBOMODULIN ACTIVITY, DNA CONSTRUCTIONS CODING THEREOF, VECTORS, CELLS AND PROCEDURES FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING THE PROTEINES AND THE PROTEINES CONTAINING THE PROTEINES AND THE PROTEINES CONTAINING THE PROTEINES AND THE PROTEINES CONTAINING THE PROTEINS, AND THE

Publications (4)

Publication Number Publication Date
DK627389D0 DK627389D0 (en) 1989-12-12
DK627389A true DK627389A (en) 1990-02-12
DK162169B DK162169B (en) 1991-09-23
DK162169C DK162169C (en) 1992-03-16

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Family Applications (1)

Application Number Title Priority Date Filing Date
DK627389A DK162169C (en) 1987-06-12 1989-12-12 RECOMBINATE PROTEINS WITH THROMBOMODULIN ACTIVITY, DNA CONSTRUCTIONS CODING THEREOF, VECTORS, CELLS AND PROCEDURES FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING THE PROTEINES AND THE PROTEINES CONTAINING THE PROTEINES AND THE PROTEINES CONTAINING THE PROTEINES AND THE PROTEINES CONTAINING THE PROTEINS, AND THE

Country Status (1)

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DK (1) DK162169C (en)

Also Published As

Publication number Publication date
DK162169B (en) 1991-09-23
DK627389D0 (en) 1989-12-12
DK162169C (en) 1992-03-16

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