DK581278A - Fremgangsmaade til fremstilling af aminderivater - Google Patents

Fremgangsmaade til fremstilling af aminderivater

Info

Publication number
DK581278A
DK581278A DK581278A DK581278A DK581278A DK 581278 A DK581278 A DK 581278A DK 581278 A DK581278 A DK 581278A DK 581278 A DK581278 A DK 581278A DK 581278 A DK581278 A DK 581278A
Authority
DK
Denmark
Prior art keywords
procedure
preparation
amin
derivatives
amin derivatives
Prior art date
Application number
DK581278A
Other languages
Danish (da)
English (en)
Inventor
M Martin-Smith
B J Price
J Bradshaw
J W Clitherow
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DK581278A publication Critical patent/DK581278A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK581278A 1977-12-23 1978-12-22 Fremgangsmaade til fremstilling af aminderivater DK581278A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB5371677 1977-12-23
GB7844778 1978-11-16

Publications (1)

Publication Number Publication Date
DK581278A true DK581278A (da) 1979-08-09

Family

ID=26267325

Family Applications (1)

Application Number Title Priority Date Filing Date
DK581278A DK581278A (da) 1977-12-23 1978-12-22 Fremgangsmaade til fremstilling af aminderivater

Country Status (11)

Country Link
US (3) US4233302A (es)
EP (1) EP0002930B1 (es)
JP (1) JPS54109963A (es)
AU (1) AU525927B2 (es)
DE (1) DE2862355D1 (es)
DK (1) DK581278A (es)
ES (1) ES476305A1 (es)
FI (1) FI783917A (es)
IE (1) IE47701B1 (es)
IT (1) IT1109339B (es)
NZ (1) NZ189253A (es)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4309435A (en) * 1978-10-16 1982-01-05 Imperial Chemical Industries Ltd. Antisecretory guanidine derivatives and pharmaceutical compositions containing them
JPS568352A (en) * 1979-07-03 1981-01-28 Shionogi & Co Ltd Aminoalkylvenzene derivative
DE3067564D1 (en) * 1979-10-22 1984-05-24 Glaxo Group Ltd 1,2,4-triazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
EP0027744B1 (en) * 1979-10-23 1984-03-14 Glaxo Group Limited Thiophene derivatives, processes for the production thereof and pharmaceutical compositions containing them
US4238487A (en) * 1979-10-31 1980-12-09 Merck & Co., Inc. Aminoalkyl benzofuran derivatives
YU53681A (en) * 1980-03-08 1983-12-31 Smith Kline French Lab Process for obtaining 5-dimethylamino-methyl-2-furane methanol
IL63968A (en) * 1980-10-01 1985-10-31 Glaxo Group Ltd Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
JPS57102852A (en) * 1980-12-19 1982-06-26 Shionogi & Co Ltd Dicarboxylic acid diamide
US4374378A (en) * 1981-01-28 1983-02-15 The United States Of America As Represented By The United States National Aeronautics And Space Administration Scanning seismic intrusion detection method and apparatus
EP0057981A3 (en) 1981-02-09 1982-08-25 Beecham Group Plc Aromatic compounds, processes for their preparation and their use
US4503051A (en) * 1981-05-18 1985-03-05 Bristol-Myers Company Substituted 3-cyclobutene-1,2-diones, pharmaceutical compositions thereof and methods of use
US4526973A (en) * 1981-05-18 1985-07-02 Bristol-Myers Company Chemical compounds
US4539316A (en) * 1981-05-18 1985-09-03 Bristol-Myers Company Pyridine derivatives of 1,2-diaminocyclobutene-3,4-diones
US4607105A (en) * 1981-05-18 1986-08-19 Bristol-Myers Company 3-cyclobutene-1,2-dione intermediates
US4546188A (en) * 1981-05-18 1985-10-08 Bristol-Myers Company Substituted 1,2-diaminocyclobutene-3,4-diones
US4522943A (en) * 1981-05-18 1985-06-11 Bristol-Myers Company Chemical compounds
US4597902A (en) * 1981-05-20 1986-07-01 A. H. Robins Company, Incorporated N-(arylthioalkyl)-N'-(aminoalkyl)ureas
US4724235A (en) * 1981-05-20 1988-02-09 A. H. Robins Company, Incorporated N-(arylthioalkyl)-N'-(aminoalkyl)ureas useful in the treatment of arrhythmia
US4443375A (en) * 1981-06-03 1984-04-17 Smith Kline & French Laboratories Limited Tetrahydroimidazo(3,4-c)-1,3-diazocine intermediates for production of guanidines
US4375435A (en) * 1981-06-03 1983-03-01 Smith Kline & French Laboratories Limited 3-,4-Dihydroimidazo (3,4-c)-1,3-pyrimidines and 4,5-dihydroimidazo (3,4-c)-1,3-diazepines
IT1168163B (it) * 1981-08-18 1987-05-20 Ausonia Farma Srl Composto ad attivita' antiulcera, procedimento per la sua preparazione e composizioni farmaceutiche relative
WO1983002113A1 (en) * 1981-12-17 1983-06-23 Yuki, Hiroshi Propenylamine derivatives and drug containing same
US4478821A (en) * 1982-01-26 1984-10-23 The Gillette Company Inhibition of body odor
DE3213509A1 (de) * 1982-04-10 1983-10-20 Basf Ag, 6700 Ludwigshafen N-substituierte imidazol-derivate, ihre herstellung, diese enthaltende arzneimittel und ihre verwendung
IT1190793B (it) * 1982-04-27 1988-02-24 Magis Farmaceutici Composti attivi nel trattamento dell'ulcera e sintomi allergici della pelle
DE3238867A1 (de) * 1982-10-20 1984-04-26 Ludwig Heumann & Co GmbH, 8500 Nürnberg Heterocyclische verbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
CA1254212A (en) * 1982-11-12 1989-05-16 Shiro Hirai Amine derivatives, salts thereof, process for preparing the same and an anti-ulcer agent containing the same
JPS5988458A (ja) * 1982-11-12 1984-05-22 Toyama Chem Co Ltd アミン誘導体およびその塩
DE3343884A1 (de) * 1982-12-08 1984-06-14 Degussa Ag, 6000 Frankfurt Neue ethendiamin- und guanidin-derivate
NL8303965A (nl) * 1982-12-08 1984-07-02 Degussa Nieuwe etheendiamine- en guanidine-derivaten; werkwijze voor het bereiden daarvan; geneesmiddelen die ze bevatten; werkwijze voor het bereiden van dergelijke geneesmiddelen; toepassing van de verbindingen voor het bereiden van geneesmiddelen en in de geneeskunde.
ES8407016A1 (es) * 1983-03-30 1984-08-16 Ferrer Int Procedimiento de obtencion de nuevas n-ciano-formamidinas.
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
IT1196133B (it) * 1984-06-06 1988-11-10 Ausonia Farma Srl Derivati furanici con attivita' antiulcera
IT1178026B (it) * 1984-10-05 1987-09-03 Medosan Ind Biochimi Derivati del 2-amino-tiazolo
HU196979B (en) * 1985-01-11 1989-02-28 Gyogyszerkutato Intezet Process for producing basic thioether and salt
US4663333A (en) * 1985-02-04 1987-05-05 G. D. Searle & Co. Acylaminoalkylpyridines ad use in treatment of inflammation and allergy reactions
AU581324B2 (en) * 1985-07-05 1989-02-16 Smith Kline & French Laboratories Limited Substituted 6-phenyl-4,5-dihydro pyradazin-3-ones
US4897485A (en) * 1987-03-18 1990-01-30 Ciba-Geigy Corporation Insecticidal pyrid-3-yl-2,3-diaza-butadien-1-yl-disulfies
DE3784698D1 (de) * 1987-04-06 1993-04-15 Heumann Pharma Gmbh & Co Verfahren zur herstellung von nitroethenderivaten.
ES2161212T3 (es) * 1987-08-01 2001-12-01 Takeda Chemical Industries Ltd Aminas alfa-insaturadas, su produccion y uso.
JPH0639466B2 (ja) * 1987-08-03 1994-05-25 杏林製薬株式会社 ウレア誘導体
US4918086A (en) * 1987-08-07 1990-04-17 Ciba-Geigy Corporation 1-nitro-2,2-diaminoethylene derivatives
JPH01131172A (ja) * 1987-08-28 1989-05-24 Toyama Chem Co Ltd アミン誘導体およびその塩、それらの製造法、並びにそれらを含有する抗潰瘍剤
GB2209163B (en) * 1987-08-28 1991-04-24 Toyama Chemical Co Ltd Amine derivative and its salt, process for producing the same, and anti-ulcer agent containing the same
US4988828A (en) * 1987-11-27 1991-01-29 Fujirebio Kabushiki Kaisha Phenoxypropyl derivatives
US4950789A (en) * 1989-01-25 1990-08-21 The Dow Chemical Company Aromatic polyalkyleneoxy polyamines containing amioncarbonyl or aminothiocarbonyl moieties and a compatible mixture of high and low molecular weight polyols made therefrom
GB9009437D0 (en) * 1990-04-26 1990-06-20 Glaxo Group Ltd Chemical compounds
USRE37303E1 (en) * 1992-01-10 2001-07-31 Institut National Del La Sante Et De La Recherche Medicale Imidazole compounds and their therapeutic applications
FR2686084B1 (fr) * 1992-01-10 1995-12-22 Bioprojet Soc Civ Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
WO1993023360A1 (fr) * 1992-05-12 1993-11-25 Zeria Pharmaceutical Co., Ltd. Nouveaux sels d'ammonium quaternaires et utilisation de ces sels comme medicament
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
US4046907A (en) * 1973-05-17 1977-09-06 Smith Kline & French Laboratories Limited Imidazole alkylaminoethylene compounds
US4002759A (en) * 1973-05-17 1977-01-11 Smith Kline & French Laboratories Limited Pyridylbutylamino ethylene compounds
US4024260A (en) * 1973-05-17 1977-05-17 Smith Kline & French Laboratories Limited Ethylene derivatives
GB1431589A (en) 1973-07-13 1976-04-07 Smith Kline French Lab Ureas, thioureas and guanidines n,n-disubstituted by heterocyclo- alkylene and/or heterocycloalkylenethioalkylene groups
US4025527A (en) * 1973-07-13 1977-05-24 Smith Kline & French Laboratories Limited Certain thiazoles and oxazoles
GB1565205A (en) * 1975-07-31 1980-04-16 Smith Kline French Lab Heterocyclic sulphoxides
US4013769A (en) * 1974-05-09 1977-03-22 Smith Kline & French Laboratories Limited Pyridyl-alkylaminoethylene compounds
GB1497260A (en) * 1974-06-28 1978-01-05 Smith Kline French Lab Guanidine derivatives
US4093729A (en) * 1974-06-28 1978-06-06 Smith Kline & French Laboratories Limited N-Oxy and N-amino guanidines
GB1565647A (en) 1975-07-31 1980-04-23 Smith Kline French Lab Pharmacologically active compounds 4-substituted-imidazole-5-methanols
GB1564502A (en) * 1975-07-31 1980-04-10 Smith Kline French Lab Guanidines thioureas and 1,1-diamino-2-nitroethylene derivatives
US4080459A (en) * 1975-11-05 1978-03-21 Smith Kline & French Laboratories Limited Pyridyl-alkylaminoethylene compounds
US4067984A (en) * 1975-11-05 1978-01-10 Smith Kline & French Laboratories Limited Pyridylbutylamino ethylene compounds
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
GB1601459A (en) * 1977-05-17 1981-10-28 Allen & Hanburys Ltd Aminoalkyl thiophene derivatives
IE46886B1 (en) * 1977-05-17 1983-10-19 Allen & Hanburys Ltd Aminoalkyl-benzene derivatives
US4203909A (en) * 1978-09-26 1980-05-20 Bristol-Myers Company Furan compounds

Also Published As

Publication number Publication date
IE782542L (en) 1979-06-23
ES476305A1 (es) 1980-05-16
NZ189253A (en) 1981-07-13
JPS54109963A (en) 1979-08-29
EP0002930A1 (en) 1979-07-11
JPH0220639B2 (es) 1990-05-10
US4304780A (en) 1981-12-08
US4233302A (en) 1980-11-11
AU4273578A (en) 1979-06-28
IT1109339B (it) 1985-12-16
US4279911A (en) 1981-07-21
DE2862355D1 (en) 1984-01-19
AU525927B2 (en) 1982-12-09
IE47701B1 (en) 1984-05-30
FI783917A (fi) 1979-06-24
EP0002930B1 (en) 1983-12-14
IT7852447A0 (it) 1978-12-22

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Legal Events

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