DK537684A - Mevinolinlignende forbindelse, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende en saadan forbindelse - Google Patents

Mevinolinlignende forbindelse, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende en saadan forbindelse Download PDF

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Publication number
DK537684A
DK537684A DK537684A DK537684A DK537684A DK 537684 A DK537684 A DK 537684A DK 537684 A DK537684 A DK 537684A DK 537684 A DK537684 A DK 537684A DK 537684 A DK537684 A DK 537684A
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DK
Denmark
Prior art keywords
chem
hydrogen
mevinol
preparing
procedure
Prior art date
Application number
DK537684A
Other languages
English (en)
Other versions
DK171498B1 (da
DK537684D0 (da
Inventor
William F Hoffman
Ta Jyh Lee
Gerald E Stokker
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK537684D0 publication Critical patent/DK537684D0/da
Publication of DK537684A publication Critical patent/DK537684A/da
Application granted granted Critical
Publication of DK171498B1 publication Critical patent/DK171498B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/08—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms
    • C07C205/09—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK537684A 1983-11-14 1984-11-13 Mevinolinlignende forbindelser, fremgangsmåde til fremstilling deraf og farmaceutiske præparater indeholdene sådanne forbindelser DK171498B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55070783A 1983-11-14 1983-11-14
US55070783 1983-11-14

Publications (3)

Publication Number Publication Date
DK537684D0 DK537684D0 (da) 1984-11-13
DK537684A true DK537684A (da) 1985-05-15
DK171498B1 DK171498B1 (da) 1996-12-02

Family

ID=24198285

Family Applications (1)

Application Number Title Priority Date Filing Date
DK537684A DK171498B1 (da) 1983-11-14 1984-11-13 Mevinolinlignende forbindelser, fremgangsmåde til fremstilling deraf og farmaceutiske præparater indeholdene sådanne forbindelser

Country Status (8)

Country Link
EP (1) EP0142146B1 (da)
JP (1) JPS60123445A (da)
AT (1) ATE36845T1 (da)
CA (1) CA1327360C (da)
DE (1) DE3473755D1 (da)
DK (1) DK171498B1 (da)
ES (1) ES8603372A1 (da)
IE (1) IE57872B1 (da)

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US5208258A (en) * 1985-10-11 1993-05-04 The Regents Of The University Of California Antihypercholesterolemic compounds and synthesis thereof
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US4897490A (en) * 1987-02-25 1990-01-30 Bristol-Meyers Company Antihypercholesterolemic tetrazole compounds
US5091378A (en) * 1987-05-22 1992-02-25 E. R. Squibb & Sons, Inc. Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method
US4904646A (en) * 1987-05-22 1990-02-27 E. R. Squibb & Sons, Inc. Phosphorus-containing HMG-COA reductase inhibitors
US5506219A (en) * 1988-08-29 1996-04-09 E. R. Squibb & Sons, Inc. Pyridine anchors for HMG-CoA reductase inhibitors
US5166364A (en) * 1989-02-27 1992-11-24 E. R. Squibb & Sons, Inc. Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same
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US4970221A (en) * 1989-07-28 1990-11-13 E. R. Squibb & Sons, Inc. 3,5-dihydroxypentanoic acid derivatives useful as antihypercholesterolemic agents and method for preparing same
US5189180A (en) * 1989-09-28 1993-02-23 E. R. Squibb & Sons, Inc. Seco-mevinic acid derivatives useful as antihypercholesterolemic agents and new intermediates
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Also Published As

Publication number Publication date
DE3473755D1 (en) 1988-10-06
DK171498B1 (da) 1996-12-02
EP0142146B1 (en) 1988-08-31
IE842908L (en) 1985-05-14
CA1327360C (en) 1994-03-01
EP0142146A3 (en) 1985-08-07
IE57872B1 (en) 1993-05-05
JPS60123445A (ja) 1985-07-02
ES537582A0 (es) 1985-12-16
DK537684D0 (da) 1984-11-13
ATE36845T1 (de) 1988-09-15
EP0142146A2 (en) 1985-05-22
ES8603372A1 (es) 1985-12-16

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