DK51087A - Antihypercholesterolaemiske forbindelser - Google Patents
Antihypercholesterolaemiske forbindelserInfo
- Publication number
- DK51087A DK51087A DK051087A DK51087A DK51087A DK 51087 A DK51087 A DK 51087A DK 051087 A DK051087 A DK 051087A DK 51087 A DK51087 A DK 51087A DK 51087 A DK51087 A DK 51087A
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- antihypercholesterolaemic
- methylglutaryl
- hmg
- coenzyme
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/824,900 US4772626A (en) | 1986-01-31 | 1986-01-31 | Antihypercholesterolemic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DK51087D0 DK51087D0 (da) | 1987-01-30 |
DK51087A true DK51087A (da) | 1987-08-01 |
Family
ID=25242603
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK051087A DK51087A (da) | 1986-01-31 | 1987-01-30 | Antihypercholesterolaemiske forbindelser |
Country Status (7)
Country | Link |
---|---|
US (1) | US4772626A (ja) |
EP (1) | EP0232997B1 (ja) |
JP (1) | JPS62190144A (ja) |
AT (1) | ATE56715T1 (ja) |
DE (1) | DE3764967D1 (ja) |
DK (1) | DK51087A (ja) |
ES (1) | ES2029829T3 (ja) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4855321A (en) * | 1986-01-31 | 1989-08-08 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
WO1989004821A1 (en) * | 1987-11-25 | 1989-06-01 | Pfizer Inc. | N-(biphenylmethyl)-3-hydroxyglutaramic acid and derivatives as hypocholesterolemic agents |
US4939143A (en) * | 1987-12-21 | 1990-07-03 | Rorer Pharmaceutical Corporation | Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors |
US4863957A (en) * | 1987-12-21 | 1989-09-05 | Rorer Pharmaceutical Corporation | Novel HMG-CoA reductase inhibitors |
US5001144A (en) * | 1987-12-21 | 1991-03-19 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors |
US4900754A (en) * | 1987-12-21 | 1990-02-13 | Rorer Pharmaceutical Corp. | HMG-COA reductase inhibitors |
US5001128A (en) * | 1987-12-21 | 1991-03-19 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | HMG-COA reductase inhibitors |
US4904691A (en) * | 1987-12-21 | 1990-02-27 | Rorer Pharmaceutical Corporation | Novel HMG-CoA reductase inhibitors |
US4876280A (en) * | 1988-03-10 | 1989-10-24 | Sandoz Pharm. Corp. | Arylcyclohexane and arylcyclohexene analogs of mevalonolactone derivatives and their use |
DE3818570A1 (de) * | 1988-06-01 | 1989-12-21 | Boehringer Mannheim Gmbh | Neue 6-substituierte-4-hydroxy-tetrahydro-pyran -2-on-derivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen |
US4916239A (en) * | 1988-07-19 | 1990-04-10 | Merck & Co., Inc. | Process for the lactonization of mevinic acids and analogs thereof |
NZ230121A (en) * | 1988-08-29 | 1993-08-26 | Squibb & Sons Inc | Pyridine and quinoline terminal groups for hmg-coenzyme a reductase inhibitors and pharmaceutical compositions for lowering blood serum cholesterol levels |
US5506219A (en) * | 1988-08-29 | 1996-04-09 | E. R. Squibb & Sons, Inc. | Pyridine anchors for HMG-CoA reductase inhibitors |
DE3909378A1 (de) * | 1989-03-22 | 1990-09-27 | Bayer Ag | Substituierte biphenyle |
FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
DE69122284T2 (de) * | 1990-03-07 | 1997-02-06 | Fujirebio Kk | 4-Hydroxytetrahydropyran-2-on Derivate nützlich als cholesterin- und lipidsenkende Agenzien |
WO1991013616A1 (en) * | 1990-03-08 | 1991-09-19 | Rorer International (Overseas) Inc. | NOVEL HMG-CoA REDUCTASE INHIBITORS |
US5089523A (en) * | 1990-05-11 | 1992-02-18 | E. R. Squibb & Sons, Inc. | Fluorinated derivatives of mevinic acids |
CN101678336B (zh) * | 2007-05-29 | 2012-12-19 | 赢创德固赛有限责任公司 | 活化的碱金属催化剂 |
CN111225672B (zh) | 2017-10-16 | 2023-09-29 | 清华大学 | 甲羟戊酸通路抑制剂及其药物组合物 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4567289A (en) * | 1979-08-17 | 1986-01-28 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
US4459422A (en) * | 1979-08-17 | 1984-07-10 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
US4375475A (en) * | 1979-08-17 | 1983-03-01 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
-
1986
- 1986-01-31 US US06/824,900 patent/US4772626A/en not_active Expired - Lifetime
-
1987
- 1987-01-22 DE DE8787300544T patent/DE3764967D1/de not_active Expired - Fee Related
- 1987-01-22 AT AT87300544T patent/ATE56715T1/de not_active IP Right Cessation
- 1987-01-22 EP EP87300544A patent/EP0232997B1/en not_active Expired - Lifetime
- 1987-01-22 ES ES198787300544T patent/ES2029829T3/es not_active Expired - Lifetime
- 1987-01-30 JP JP62020338A patent/JPS62190144A/ja active Pending
- 1987-01-30 DK DK051087A patent/DK51087A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DK51087D0 (da) | 1987-01-30 |
DE3764967D1 (de) | 1990-10-25 |
EP0232997A1 (en) | 1987-08-19 |
ES2029829T3 (es) | 1992-10-01 |
ATE56715T1 (de) | 1990-10-15 |
EP0232997B1 (en) | 1990-09-19 |
US4772626A (en) | 1988-09-20 |
JPS62190144A (ja) | 1987-08-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment |