DK504580A - Fremgangsmaade til fremstilling af benzodiazepinderivater eller farmaceutisk acceptable syreadditionssalte deraf samt ved fremgangsmaaden anvendelige mellemprodukter - Google Patents
Fremgangsmaade til fremstilling af benzodiazepinderivater eller farmaceutisk acceptable syreadditionssalte deraf samt ved fremgangsmaaden anvendelige mellemprodukterInfo
- Publication number
- DK504580A DK504580A DK504580A DK504580A DK504580A DK 504580 A DK504580 A DK 504580A DK 504580 A DK504580 A DK 504580A DK 504580 A DK504580 A DK 504580A DK 504580 A DK504580 A DK 504580A
- Authority
- DK
- Denmark
- Prior art keywords
- procedure
- preparation
- acid addition
- addition salts
- acceptable acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH103880 | 1980-02-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK504580A true DK504580A (da) | 1981-08-09 |
Family
ID=4201002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK504580A DK504580A (da) | 1980-02-08 | 1980-11-27 | Fremgangsmaade til fremstilling af benzodiazepinderivater eller farmaceutisk acceptable syreadditionssalte deraf samt ved fremgangsmaaden anvendelige mellemprodukter |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4374773A (fr) |
| EP (1) | EP0033974B1 (fr) |
| JP (1) | JPS56113786A (fr) |
| AU (1) | AU545357B2 (fr) |
| CA (1) | CA1152066A (fr) |
| DE (1) | DE3160987D1 (fr) |
| DK (1) | DK504580A (fr) |
| ZA (1) | ZA81695B (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3610848A1 (de) * | 1986-04-01 | 1987-10-15 | Boehringer Ingelheim Kg | Neue 1,4-diazepine |
| ES2654423T3 (es) | 2009-11-05 | 2018-02-13 | Glaxosmithkline Llc | Inhibidor de bromodominio de benzodiacepina |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| US9249161B2 (en) | 2010-12-02 | 2016-02-02 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| WO2012105876A1 (fr) | 2011-02-03 | 2012-08-09 | Husqvarna Ab | Scie à murs ou planchers |
| CA2832996C (fr) | 2011-04-26 | 2019-05-07 | Merck Sharp & Dohme Corp. | Composes triazoles tricycliques et leur utilisation comme inhibiteurs d'aldosterone synthase |
| EP2705039B1 (fr) | 2011-05-04 | 2017-07-26 | Constellation Pharmaceuticals, Inc. | Inhibiteurs de bromodomaines et leurs utilisations |
| EP2721031B1 (fr) | 2011-06-17 | 2016-01-20 | Constellation Pharmaceuticals, Inc. | Inhibiteurs à bromodomaine et leurs utilisations |
| WO2013184878A1 (fr) | 2012-06-06 | 2013-12-12 | Constellation Pharmaceuticals, Inc. | Inhibiteurs de bromo-domaine de benzo [b] isoxazoloazépines et applications associées |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| DK3157928T3 (da) | 2014-06-20 | 2019-05-20 | Constellation Pharmaceuticals Inc | Krystallinske former af 2-((4s)-6-(4-chlorphenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamid |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2252103A1 (en) * | 1973-11-28 | 1975-06-20 | Hoffmann La Roche | Hydroxamino-substd. oxazolobenzodiazepines - sedatives, muscle relaxants and anti-convulsants |
| US4251443A (en) * | 1979-08-02 | 1981-02-17 | Hoffmann-La Roche Inc. | Benzodiazepine derivatives |
-
1980
- 1980-11-18 CA CA000364874A patent/CA1152066A/fr not_active Expired
- 1980-11-27 DK DK504580A patent/DK504580A/da not_active Application Discontinuation
-
1981
- 1981-01-16 US US06/225,747 patent/US4374773A/en not_active Expired - Fee Related
- 1981-01-21 JP JP656981A patent/JPS56113786A/ja active Pending
- 1981-02-02 ZA ZA00810695A patent/ZA81695B/xx unknown
- 1981-02-02 AU AU66818/81A patent/AU545357B2/en not_active Ceased
- 1981-02-09 EP EP81100907A patent/EP0033974B1/fr not_active Expired
- 1981-02-09 DE DE8181100907T patent/DE3160987D1/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE3160987D1 (en) | 1983-11-03 |
| EP0033974A1 (fr) | 1981-08-19 |
| EP0033974B1 (fr) | 1983-09-28 |
| US4374773A (en) | 1983-02-22 |
| ZA81695B (en) | 1982-03-31 |
| AU6681881A (en) | 1981-09-24 |
| AU545357B2 (en) | 1985-07-11 |
| JPS56113786A (en) | 1981-09-07 |
| CA1152066A (fr) | 1983-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment | ||
| AHB | Application shelved due to non-payment |