FR2252103A1 - Hydroxamino-substd. oxazolobenzodiazepines - sedatives, muscle relaxants and anti-convulsants - Google Patents

Hydroxamino-substd. oxazolobenzodiazepines - sedatives, muscle relaxants and anti-convulsants

Info

Publication number
FR2252103A1
FR2252103A1 FR7438731A FR7438731A FR2252103A1 FR 2252103 A1 FR2252103 A1 FR 2252103A1 FR 7438731 A FR7438731 A FR 7438731A FR 7438731 A FR7438731 A FR 7438731A FR 2252103 A1 FR2252103 A1 FR 2252103A1
Authority
FR
France
Prior art keywords
lower alkyl
convulsants
sedatives
muscle relaxants
oxazolobenzodiazepines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7438731A
Other languages
French (fr)
Other versions
FR2252103B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/419,582 external-priority patent/US3989681A/en
Priority claimed from US420118A external-priority patent/US3865815A/en
Priority claimed from US420119A external-priority patent/US3868362A/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2252103A1 publication Critical patent/FR2252103A1/en
Application granted granted Critical
Publication of FR2252103B1 publication Critical patent/FR2252103B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/16—Making multilayered or multicoloured articles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

The dizepines are of formula (I) (where R1 is H, lower alkyl, 4-10C cycloalkyl-lower alkyl, lower alkoxy-lower alkyl, hydroxy-lower alkyl or di-loweralkylamino-lower alkyl; R2 and R3 are H or lower alkyl and R4 is H or halogen) and their addn. salts are by selective redn. of the corresp. nitro cpd. (I) are sedatives, muscle relaxants and anti-convulsants, the daily dosage being 2-200 mg.
FR7438731A 1973-11-28 1974-11-26 Hydroxamino-substd. oxazolobenzodiazepines - sedatives, muscle relaxants and anti-convulsants Granted FR2252103A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41956373A 1973-11-28 1973-11-28
US05/419,582 US3989681A (en) 1973-11-28 1973-11-28 7-Azoxy substituted-1,4-benzodiazepin-2-ones
US420118A US3865815A (en) 1973-11-29 1973-11-29 7-Hydroxyamino-1,4-benzodiazepines
US420119A US3868362A (en) 1973-11-29 1973-11-29 Oxazolobenzodiazepines

Publications (2)

Publication Number Publication Date
FR2252103A1 true FR2252103A1 (en) 1975-06-20
FR2252103B1 FR2252103B1 (en) 1977-11-10

Family

ID=27503678

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7438731A Granted FR2252103A1 (en) 1973-11-28 1974-11-26 Hydroxamino-substd. oxazolobenzodiazepines - sedatives, muscle relaxants and anti-convulsants

Country Status (3)

Country Link
JP (1) JPS5084590A (en)
DE (1) DE2456311A1 (en)
FR (1) FR2252103A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0008421A2 (en) * 1978-08-11 1980-03-05 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Benzodiazepine derivatives, process for their preparation and pharmaceutical compositions containing them
FR2442239A1 (en) * 1978-11-27 1980-06-20 Shionogi & Co PROCESS FOR THE PREPARATION OF 4, L-BENZOXAZEPINES AND THEIR THIA ANALOG, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR THE TREATMENT OF MENTAL DISORDERS

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA794014B (en) * 1978-08-11 1980-05-28 Hoffmann La Roche Benzodiazepine derivatives
CA1152066A (en) * 1980-02-08 1983-08-16 Hoffmann-La Roche Limited Benzodiazepine derivatives
CA1145333A (en) * 1980-02-08 1983-04-26 Quirico Branca Benzodiazepine derivatives
DE3610848A1 (en) * 1986-04-01 1987-10-15 Boehringer Ingelheim Kg NEW 1,4-DIAZEPINE

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0008421A2 (en) * 1978-08-11 1980-03-05 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Benzodiazepine derivatives, process for their preparation and pharmaceutical compositions containing them
EP0008421A3 (en) * 1978-08-11 1980-05-28 F.Hoffmann-La Roche & Co. Aktiengesellschaft Benzodiazepine derivatives, their application, process and intermediates for their preparation and pharmaceutical compositions containing them
FR2442239A1 (en) * 1978-11-27 1980-06-20 Shionogi & Co PROCESS FOR THE PREPARATION OF 4, L-BENZOXAZEPINES AND THEIR THIA ANALOG, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR THE TREATMENT OF MENTAL DISORDERS

Also Published As

Publication number Publication date
FR2252103B1 (en) 1977-11-10
DE2456311A1 (en) 1975-06-05
JPS5084590A (en) 1975-07-08

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Legal Events

Date Code Title Description
ST Notification of lapse