DK472684A - Enkephalinaseinhibitorer - Google Patents

Enkephalinaseinhibitorer Download PDF

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Publication number
DK472684A
DK472684A DK472684A DK472684A DK472684A DK 472684 A DK472684 A DK 472684A DK 472684 A DK472684 A DK 472684A DK 472684 A DK472684 A DK 472684A DK 472684 A DK472684 A DK 472684A
Authority
DK
Denmark
Prior art keywords
enkephalinase inhibitors
enkephalinase
inhibitors
Prior art date
Application number
DK472684A
Other languages
English (en)
Other versions
DK472684D0 (da
DK169759B1 (da
Inventor
Norma G Delaney
Eric M Gordon
Miguel A Ondetti
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of DK472684D0 publication Critical patent/DK472684D0/da
Publication of DK472684A publication Critical patent/DK472684A/da
Application granted granted Critical
Publication of DK169759B1 publication Critical patent/DK169759B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK472684A 1983-10-03 1984-10-02 Mercaptoalkanoyl- eller acetylmercaptoalkanoylforbindelser samt deres farmaceutisk acceptable salte DK169759B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53873183A 1983-10-03 1983-10-03
US53873183 1983-10-03
US64122184A 1984-08-16 1984-08-16
US64122184 1984-08-16

Publications (3)

Publication Number Publication Date
DK472684D0 DK472684D0 (da) 1984-10-02
DK472684A true DK472684A (da) 1985-04-04
DK169759B1 DK169759B1 (da) 1995-02-20

Family

ID=27065907

Family Applications (1)

Application Number Title Priority Date Filing Date
DK472684A DK169759B1 (da) 1983-10-03 1984-10-02 Mercaptoalkanoyl- eller acetylmercaptoalkanoylforbindelser samt deres farmaceutisk acceptable salte

Country Status (7)

Country Link
EP (1) EP0136883B1 (da)
AU (1) AU578909B2 (da)
CA (1) CA1273019C (da)
DE (1) DE3467754D1 (da)
DK (1) DK169759B1 (da)
FI (1) FI80258C (da)
IE (1) IE57986B1 (da)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0161769B1 (en) * 1984-04-02 1987-10-28 E.R. Squibb & Sons, Inc. Enkephalinase inhibitors
US4604417A (en) * 1984-12-10 1986-08-05 The Goodyear Tire & Rubber Company Polymerizable thioester synergists
FI870474A7 (fi) * 1986-02-07 1987-08-08 Ciba Geigy Ag Med svavelhaltiga grupper substituerade 5-amino-4-hydroxivalerylderivat.
EP0254032A3 (en) * 1986-06-20 1990-09-05 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
US4929641B1 (en) * 1988-05-11 1994-08-30 Schering Corp Mercapto-acylamino acid antihypertensives
US4801609B1 (en) * 1987-03-27 1993-11-09 Mercapto-acylamino acid antihypertensives
CA1322073C (en) * 1986-12-24 1993-09-07 Roger E. Markwell Thiol-carboxylic acid derivatives
US5262436A (en) * 1987-03-27 1993-11-16 Schering Corporation Acylamino acid antihypertensives in the treatment of congestive heart failure
CA1337400C (en) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibitors of neutral endopeptidase
IL88535A0 (en) * 1987-12-04 1989-06-30 Dana Farber Cancer Inst Inc Common acute lymphoblastic leukemia antigen
DE3804793A1 (de) * 1988-02-16 1989-08-24 Hoechst Ag Renin-hemmende aminosaeurederivate
US5202340A (en) * 1988-05-06 1993-04-13 Ono Pharmaceutical Co., Ltd. Amino acid derivatives
CA1330613C (en) * 1988-05-06 1994-07-05 Masanori Kawamura Amino acid derivatives
US4879309A (en) * 1988-09-27 1989-11-07 Schering Corporation Mercapto-acylamino acids as antihypertensives
ZA902661B (en) * 1989-04-10 1991-01-30 Schering Corp Mercapto-acyl amino acids
FR2652087B1 (fr) * 1989-09-15 1993-10-15 Bioprojet Ste Civile Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques.
ES2069893T3 (es) * 1990-05-17 1995-05-16 Schering Corp Derivados de disulfuros de mercaptoacilaminoacidos.
US5252601A (en) * 1991-05-03 1993-10-12 Merrell Dow Pharmaceuticals Inc. 2-mercaptomethylene-tetrahydronaphthalene and indane-2-carboxamide derivatives as enkephalinase inhibitors
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
FR2682952B1 (fr) * 1991-10-25 1993-12-03 Institut Nal Sante Recherc Medic Nouveaux n-(mercaptoacyl) amino-acides, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2707638B1 (fr) * 1993-07-16 1995-08-18 Bioprojet Soc Civ Nouveaux dérivés d'amino-acides, leurs procédés de préparation et leur application thérapeutique.
IT1266571B1 (it) * 1993-07-30 1997-01-09 Zambon Spa Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari
FR2744446B1 (fr) * 1996-02-05 1998-04-17 Bioprojet Soc Civ Procede de synthese asymetrique des derives s-acyles de l'acide 2-mercaptomethyl 3-phenyl propanoique, application a la synthese de derives n-(mercaptoacyl) amino-acides
SE9901573D0 (sv) 1999-05-03 1999-05-03 Astra Ab New compounds
US7045653B2 (en) 2002-12-23 2006-05-16 Pfizer, Inc. Pharmaceuticals
WO2005028419A2 (en) 2003-09-18 2005-03-31 Takasago International Corporation Asymmetric reductive amination of keto acid derivatives for producing amino acid derivatives
JP2012526810A (ja) 2009-05-13 2012-11-01 イントラ−セルラー・セラピーズ・インコーポレイテッド 有機化合物
MX2011012628A (es) 2009-05-28 2011-12-14 Novartis Ag Derivados amino-propionicos sustituidos como inhibidores de neprilisina.
ES2582395T3 (es) 2009-05-28 2016-09-12 Novartis Ag Derivados aminobutíricos sustituidos como inhibidores de neprilisina
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
JP6295277B2 (ja) 2013-02-14 2018-03-14 ノバルティス アーゲー Ｎｅｐ（中性エンドペプチダーゼ）阻害剤としての置換ビスフェニルブタン酸ホスホン酸誘導体
WO2014126972A1 (en) 2013-02-14 2014-08-21 Novartis Ag Substituted bisphenyl butanoic acid derivatives as nep inhibitors with improved in vivo efficacy
EP2956141A4 (en) 2013-02-17 2016-10-26 Intra Cellular Therapies Inc NEW USES
US10131671B2 (en) 2014-08-07 2018-11-20 Intra-Cellular Therapies, Inc. Organic compounds
US10682354B2 (en) 2016-03-28 2020-06-16 Intra-Cellular Therapies, Inc. Compositions and methods
US11839614B2 (en) 2018-01-31 2023-12-12 Intra-Cellular Therapies, Inc. Methods for treating or mitigating cardiotoxicity characterized by inhibition of adenosine A2 signaling and/or adenosine A2 receptor expression

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235885A (en) * 1979-06-25 1980-11-25 E. R. Squibb & Sons, Inc. Inhibitors of mammalian collagenase

Also Published As

Publication number Publication date
FI843894A0 (fi) 1984-10-03
EP0136883A3 (en) 1985-07-17
DE3467754D1 (de) 1988-01-07
AU3377884A (en) 1985-04-18
CA1273019A (en) 1990-08-21
CA1273019C (en) 1990-08-21
AU578909B2 (en) 1988-11-10
IE842493L (en) 1985-04-03
FI843894L (fi) 1985-04-04
EP0136883A2 (en) 1985-04-10
IE57986B1 (en) 1993-06-02
FI80258B (fi) 1990-01-31
EP0136883B1 (en) 1987-11-25
FI80258C (fi) 1990-05-10
DK472684D0 (da) 1984-10-02
DK169759B1 (da) 1995-02-20

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed