DK464478A - Fremgangsmaade til fremstilling af 3-substituerede 6-(1'hydroxyethyl)-m-oxo-1-azabicyclo(3,2,0)hept-2-en-2-carboxylsyrer eller derivater deraf - Google Patents
Fremgangsmaade til fremstilling af 3-substituerede 6-(1'hydroxyethyl)-m-oxo-1-azabicyclo(3,2,0)hept-2-en-2-carboxylsyrer eller derivater derafInfo
- Publication number
- DK464478A DK464478A DK464478A DK464478A DK464478A DK 464478 A DK464478 A DK 464478A DK 464478 A DK464478 A DK 464478A DK 464478 A DK464478 A DK 464478A DK 464478 A DK464478 A DK 464478A
- Authority
- DK
- Denmark
- Prior art keywords
- azabicyclo
- hept
- oxo
- hydroxyethyl
- derivatives
- Prior art date
Links
- FYZUENZXIZCLAZ-UHFFFAOYSA-N 2-methylhept-2-enoic acid Chemical class CCCCC=C(C)C(O)=O FYZUENZXIZCLAZ-UHFFFAOYSA-N 0.000 title 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical compound C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/26—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
- C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84337577A | 1977-10-19 | 1977-10-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK464478A true DK464478A (da) | 1979-04-20 |
Family
ID=25289786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK464478A DK464478A (da) | 1977-10-19 | 1978-10-18 | Fremgangsmaade til fremstilling af 3-substituerede 6-(1'hydroxyethyl)-m-oxo-1-azabicyclo(3,2,0)hept-2-en-2-carboxylsyrer eller derivater deraf |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0001627B1 (ja) |
| JP (1) | JPS5466696A (ja) |
| AU (1) | AU4061378A (ja) |
| DE (1) | DE2862395D1 (ja) |
| DK (1) | DK464478A (ja) |
| ES (1) | ES474289A1 (ja) |
| IT (1) | IT1110867B (ja) |
| ZA (1) | ZA785857B (ja) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU531084B2 (en) * | 1977-10-19 | 1983-08-11 | Merck & Co., Inc. | Azetidine derivatives |
| EP0008888B1 (en) * | 1978-08-23 | 1983-09-21 | Beecham Group Plc | Beta-lactam antibacterial compounds, their preparation and pharmaceutical compositions containing them |
| DE2961882D1 (en) * | 1978-08-25 | 1982-03-04 | Beecham Group Plc | Beta-lactam anti-bacterials, compositions containing them and a process for their preparation |
| EP0011173B1 (en) * | 1978-11-01 | 1983-05-11 | Sanraku-Ocean Co., Ltd. | Process for producing antibiotic beta-lactam compounds |
| EP0017992A1 (en) * | 1979-04-19 | 1980-10-29 | Merck & Co. Inc. | 2-Substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing them, antibiotic pharmaceutical compositions containing same and process for preparing intermediates |
| US4376774A (en) * | 1979-05-29 | 1983-03-15 | Merck & Co., Inc. | Antibiotic N-heterocyclyl thienamycin |
| JPS565457A (en) * | 1979-06-27 | 1981-01-20 | Dai Ichi Seiyaku Co Ltd | Thienamycin intermediate |
| EP0024832B1 (en) * | 1979-08-10 | 1985-03-13 | Beecham Group Plc | Beta-lactam antibiotics, their preparation, pharmaceutical compositions containing them and their preparation |
| ATE10838T1 (de) * | 1980-02-28 | 1985-01-15 | Fujisawa Pharmaceutical Co., Ltd. | 4-substituierte 2-oxoazetidin-verbindungen, verfahren zu deren herstellung und ihre verwendung zur antibiotika-herstellung. |
| US4309346A (en) * | 1980-03-27 | 1982-01-05 | Merck & Co., Inc. | Process for the preparation of 1-carbapenems and intermediates via trithioorthoacetates |
| PT73791B (en) * | 1980-10-17 | 1983-10-14 | Merck & Co Inc | Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids |
| GB2089340B (en) * | 1980-10-25 | 1984-09-19 | Beecham Group Ltd | -lactam antibiotics their preparation and their use |
| JPS57103057A (en) * | 1980-12-19 | 1982-06-26 | Meito Sangyo Kk | Automatic measuring method for hdl-cholesterol and its precipitant |
| US4552873A (en) * | 1981-08-19 | 1985-11-12 | Sankyo Company Limited | Carbapenem compounds, and compositions containing them |
| JPS5865291A (ja) * | 1981-10-14 | 1983-04-18 | Sankyo Co Ltd | カルバペネム−３−カルボン酸誘導体およびその製法 |
| EP0079167A1 (en) * | 1981-11-09 | 1983-05-18 | Beecham Group Plc | A carbapenem compound, preparation and use |
| US4683301A (en) * | 1982-04-08 | 1987-07-28 | Bristol-Myers Company | Carbapenem antibiotics |
| US4710568A (en) * | 1982-04-09 | 1987-12-01 | Bristol-Myers Company | Carbapenem antibiotics |
| US4642341A (en) * | 1982-04-09 | 1987-02-10 | Bristol-Myers Company | Carbapenem antibiotics |
| US4493839A (en) * | 1982-05-24 | 1985-01-15 | Merck & Co., Inc. | 1-Carbapenem-3-carboxylic esters as anti-inflammatory agents |
| US4536335A (en) * | 1982-06-18 | 1985-08-20 | Bristol-Myers Company | Carbapenem antibiotics |
| US4640799A (en) * | 1982-06-18 | 1987-02-03 | Bristol-Myers Company | Carbapenem antibiotics |
| US4665170A (en) * | 1982-06-18 | 1987-05-12 | Bristol-Myers Company | Carbapenem antibiotics |
| US4746736A (en) * | 1982-09-28 | 1988-05-24 | Bristol-Myers Company | Carbapenem antibiotics |
| US4732977A (en) * | 1982-09-28 | 1988-03-22 | Bristol Myers Company | Carbapenem antibiotics |
| US4665169A (en) * | 1985-09-11 | 1987-05-12 | Bristol-Myers Company | Carbapenem antibiotics |
| RU2532906C2 (ru) * | 2009-06-26 | 2014-11-20 | Ихара Кемикал Индастри Ко., Лтд. | Способ получения соединений, являющихся производными кетомалоновой кислоты, или их гидратов |
| EP3109227B1 (en) * | 2014-02-17 | 2020-04-08 | Kumiai Chemical Industry Co., Ltd. | Method for continuously producing ketomalonic acid compound using flow reactor |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3950357A (en) * | 1974-11-25 | 1976-04-13 | Merck & Co., Inc. | Antibiotics |
| DE2652676A1 (de) * | 1975-11-21 | 1977-06-02 | Merck & Co Inc | N-alkylierte derivate von thienamycin, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| JPS5283992A (en) * | 1976-01-01 | 1977-07-13 | Beecham Group Ltd | Novel antibiotic |
| DK488077A (da) * | 1976-11-19 | 1978-05-20 | Merck & Co Inc | Fremgangsmaade til fremstilling af 3-(2-aminoethylthio)-6(-1-hydroxyethyl)-7-oxo-1-azabicyclo (3.2.0) hept-2-en-2-carboxylsyre |
| GB1593524A (en) * | 1976-11-19 | 1981-07-15 | Merck & Co Inc | 1-carba-2-penem-3-carboxylic acids |
| AU531084B2 (en) * | 1977-10-19 | 1983-08-11 | Merck & Co., Inc. | Azetidine derivatives |
-
1978
- 1978-10-11 AU AU40613/78A patent/AU4061378A/en not_active Abandoned
- 1978-10-16 DE DE7878101156T patent/DE2862395D1/de not_active Expired
- 1978-10-16 EP EP78101156A patent/EP0001627B1/en not_active Expired
- 1978-10-17 ES ES474289A patent/ES474289A1/es not_active Expired
- 1978-10-18 IT IT51566/78A patent/IT1110867B/it active
- 1978-10-18 ZA ZA785857A patent/ZA785857B/xx unknown
- 1978-10-18 DK DK464478A patent/DK464478A/da unknown
- 1978-10-19 JP JP12792678A patent/JPS5466696A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| EP0001627A1 (en) | 1979-05-02 |
| DE2862395D1 (en) | 1984-05-10 |
| ES474289A1 (es) | 1979-11-01 |
| IT1110867B (it) | 1986-01-06 |
| AU4061378A (en) | 1980-04-17 |
| IT7851566A0 (it) | 1978-10-18 |
| JPS5466696A (en) | 1979-05-29 |
| EP0001627B1 (en) | 1984-04-04 |
| ZA785857B (en) | 1980-06-25 |
| JPH0438753B2 (ja) | 1992-06-25 |
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