DK450187D0 - Fremgangsmaade til fremstilling af proteiner - Google Patents

Fremgangsmaade til fremstilling af proteiner

Info

Publication number
DK450187D0
DK450187D0 DK450187A DK450187A DK450187D0 DK 450187 D0 DK450187 D0 DK 450187D0 DK 450187 A DK450187 A DK 450187A DK 450187 A DK450187 A DK 450187A DK 450187 D0 DK450187 D0 DK 450187D0
Authority
DK
Denmark
Prior art keywords
production
amino acid
aprotinin
proteins
procedure
Prior art date
Application number
DK450187A
Other languages
Danish (da)
English (en)
Inventor
Kjeld Norris
Fanny Norris
Soeren Erik Bjoern
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Priority to DK450187A priority Critical patent/DK450187D0/da
Publication of DK450187D0 publication Critical patent/DK450187D0/da
Priority to DE3852105T priority patent/DE3852105T2/de
Priority to JP63507339A priority patent/JP2806958B2/ja
Priority to PCT/DK1988/000138 priority patent/WO1989001968A1/en
Priority to EP88907646A priority patent/EP0375718B1/de
Priority to AT88907646T priority patent/ATE113986T1/de
Priority to NO900920A priority patent/NO177967C/no
Priority to FI900991A priority patent/FI104428B/fi
Priority to DK051990A priority patent/DK171239B1/da
Priority to US08/084,718 priority patent/US5591603A/en
Priority to US08/443,977 priority patent/US5621074A/en
Priority to US08/443,976 priority patent/US5618915A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
DK450187A 1987-08-28 1987-08-28 Fremgangsmaade til fremstilling af proteiner DK450187D0 (da)

Priority Applications (12)

Application Number Priority Date Filing Date Title
DK450187A DK450187D0 (da) 1987-08-28 1987-08-28 Fremgangsmaade til fremstilling af proteiner
AT88907646T ATE113986T1 (de) 1987-08-28 1988-08-26 Verfahren zur herstellung von aprotinin und aprotinin-homologen in hefe.
EP88907646A EP0375718B1 (de) 1987-08-28 1988-08-26 Verfahren zur herstellung von aprotinin und aprotinin-homologen in hefe
JP63507339A JP2806958B2 (ja) 1987-08-28 1988-08-26 アプロチニン相同体及び酵母におけるアプロチニン及びアプロチニン相同体の生成方法
PCT/DK1988/000138 WO1989001968A1 (en) 1987-08-28 1988-08-26 Aprotinin homologues and process for the production of aprotinin and aprotinin homologues in yeast
DE3852105T DE3852105T2 (de) 1987-08-28 1988-08-26 Verfahren zur herstellung von aprotinin und aprotinin-homologen in hefe.
NO900920A NO177967C (no) 1987-08-28 1990-02-27 Fremgangsmåte ved fremstilling av aprotinin og aprotinin homologer i gjær, og en gjærstamme som anvendes i fremgangsmåten
FI900991A FI104428B (fi) 1987-08-28 1990-02-27 Menetelmä aprotiniinin ja aprotiniinihomologien tuottamiseksi hiivassa
DK051990A DK171239B1 (da) 1987-08-28 1990-02-28 Fremgangsmåde til fremstilling af aprotinin eller homologer deraf, vektor der er i stand til at replicere i gær samt gærstamme
US08/084,718 US5591603A (en) 1987-08-28 1993-06-23 Process for preparing aprotinin and aprotinin analogs in yeast cells
US08/443,977 US5621074A (en) 1987-08-28 1995-05-18 Aprotinin analogs
US08/443,976 US5618915A (en) 1987-08-28 1995-05-18 Aprotinin analogs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK450187A DK450187D0 (da) 1987-08-28 1987-08-28 Fremgangsmaade til fremstilling af proteiner

Publications (1)

Publication Number Publication Date
DK450187D0 true DK450187D0 (da) 1987-08-28

Family

ID=8134111

Family Applications (1)

Application Number Title Priority Date Filing Date
DK450187A DK450187D0 (da) 1987-08-28 1987-08-28 Fremgangsmaade til fremstilling af proteiner

Country Status (8)

Country Link
EP (1) EP0375718B1 (de)
JP (1) JP2806958B2 (de)
AT (1) ATE113986T1 (de)
DE (1) DE3852105T2 (de)
DK (1) DK450187D0 (de)
FI (1) FI104428B (de)
NO (1) NO177967C (de)
WO (1) WO1989001968A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591603A (en) * 1987-08-28 1997-01-07 Novo Nordisk A/S Process for preparing aprotinin and aprotinin analogs in yeast cells
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
DK105489D0 (da) * 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
US7413537B2 (en) 1989-09-01 2008-08-19 Dyax Corp. Directed evolution of disulfide-bonded micro-proteins
DE3930522A1 (de) * 1989-09-13 1991-03-21 Bayer Ag Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben
US5258302A (en) * 1990-07-03 1993-11-02 The Salk Institute Biotechnology/Industrial Associates, Inc. DNA for expression of aprotinin in methylotrophic yeast cells
IL99585A0 (en) * 1990-10-01 1992-08-18 Novo Nordisk As Aprotinin analogues,their production and pharmaceutical compositions containing them
ATE439435T1 (de) 1991-03-01 2009-08-15 Dyax Corp Chimäres protein mit mikroprotein mit zwei oder mehr disulfidbindungen und ausgestaltungen davon
DE4417353A1 (de) * 1994-05-18 1996-01-25 Bayer Ag Verfahren zur Herstellung von rekombinantem Aprotinin und rekombinanten Aprotinin Varianten mit der natürlichen N-terminlaen Sequenz

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
US5219569A (en) * 1985-04-22 1993-06-15 Genentech, Inc. Protease resistant urokinase
DE3930522A1 (de) * 1989-09-13 1991-03-21 Bayer Ag Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben

Also Published As

Publication number Publication date
NO177967B (no) 1995-09-18
ATE113986T1 (de) 1994-11-15
NO900920L (no) 1990-04-25
WO1989001968A1 (en) 1989-03-09
NO177967C (no) 1995-12-27
EP0375718B1 (de) 1994-11-09
DE3852105T2 (de) 1995-03-23
DE3852105D1 (de) 1994-12-15
FI900991A0 (fi) 1990-02-27
JP2806958B2 (ja) 1998-09-30
JPH03502519A (ja) 1991-06-13
FI104428B (fi) 2000-01-31
EP0375718A1 (de) 1990-07-04
NO900920D0 (no) 1990-02-27

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