DK449588A - 4-oxo-1,4-dihydroquinolin-2-carboxylsyrederivat, dets anvendelse og fremstilling - Google Patents

4-oxo-1,4-dihydroquinolin-2-carboxylsyrederivat, dets anvendelse og fremstilling

Info

Publication number
DK449588A
DK449588A DK449588A DK449588A DK449588A DK 449588 A DK449588 A DK 449588A DK 449588 A DK449588 A DK 449588A DK 449588 A DK449588 A DK 449588A DK 449588 A DK449588 A DK 449588A
Authority
DK
Denmark
Prior art keywords
oxo
dihydroquinoline
compounds
vivo
preparation
Prior art date
Application number
DK449588A
Other languages
Danish (da)
English (en)
Other versions
DK449588D0 (da
Inventor
Paul Leeson
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of DK449588D0 publication Critical patent/DK449588D0/da
Publication of DK449588A publication Critical patent/DK449588A/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK449588A 1987-08-12 1988-08-11 4-oxo-1,4-dihydroquinolin-2-carboxylsyrederivat, dets anvendelse og fremstilling DK449588A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878719102A GB8719102D0 (en) 1987-08-12 1987-08-12 Therapeutic agents

Publications (2)

Publication Number Publication Date
DK449588D0 DK449588D0 (da) 1988-08-11
DK449588A true DK449588A (da) 1989-04-06

Family

ID=10622209

Family Applications (1)

Application Number Title Priority Date Filing Date
DK449588A DK449588A (da) 1987-08-12 1988-08-11 4-oxo-1,4-dihydroquinolin-2-carboxylsyrederivat, dets anvendelse og fremstilling

Country Status (7)

Country Link
EP (1) EP0303387B1 (de)
JP (1) JPS6466167A (de)
AT (1) ATE88344T1 (de)
CA (1) CA1330660C (de)
DE (1) DE3880396T2 (de)
DK (1) DK449588A (de)
GB (1) GB8719102D0 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231102A (en) * 1989-03-08 1993-07-27 Merck Sharp & Dohme, Ltd. Tetrahydroquinoline derivatives useful for neurodegenerative disorders
IL93610A0 (en) * 1989-03-08 1990-12-23 Merck Sharp & Dohme Tetrahydroquinoline derivatives,their preparation and pharmaceutical compositions containing them
US5026700A (en) * 1989-05-16 1991-06-25 Merrell Dow Pharmaceuticals Certain quinolines and thienopyridines as excitatory amino acid antagonists
IT1232352B (it) * 1989-08-11 1992-01-28 Moroni Flavio Firenze Derivati dell'acido chinurenico ad attivita' sul sistema nervoso centrale, loro preparazione e relative composizioni farmaceutiche
EP0459561B1 (de) * 1990-05-31 1995-09-20 MERCK SHARP & DOHME LTD. Dioxo-tetrahydrochinolinderivate
GB9022785D0 (en) * 1990-10-19 1990-12-05 Merck Sharp & Dohme Therapeutic agents
GB9026389D0 (en) * 1990-12-05 1991-01-23 Merck Sharp & Dohme Therapeutic agents
EP0573562B1 (de) * 1991-02-27 1996-04-24 Merrell Pharmaceuticals Inc. Dihydrochinolin NMDA Antagonisten
US5606063A (en) * 1991-02-27 1997-02-25 Merrell Pharmaceuticals Inc. NMDA antagonists
GB9109007D0 (en) * 1991-04-26 1991-06-12 Merck Sharp & Dohme Therapeutic method
GB9125485D0 (en) * 1991-11-29 1992-01-29 Merck Sharp & Dohme Therapeutic agents
DK0731792T3 (da) * 1993-11-29 1999-09-13 Merrell Pharma Inc Heterocycliske benzensulfonyliminderivater som inhibitorer af IL-1-virkning
PT731791E (pt) * 1993-11-29 2000-11-30 Merrell Pharma Inc Novos derivados de benzeno-sulfonil-imina como inibidores da accao da il-1.
US5817496A (en) * 1994-07-07 1998-10-06 Pharmacia & Upjohn S.P.A. Recombinant kat enzyme from rat
FR2733233B1 (fr) * 1995-04-20 1997-05-30 Roussel Uclaf Nouveaux derives de quinoleine, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
US6025369A (en) * 1996-05-03 2000-02-15 The Board Of Regents Of The University Nebraska N-methyl-D-aspartate (NMDA) receptor blockers for the prevention of atherosclerosis
CA2608476A1 (en) * 2005-06-28 2007-01-04 Bausch & Lomb Incorporated Preparations comprising arylazine substituted with a carbonylic moiety to increase the activity of gelatinase a in ocular cells
HU230366B1 (hu) 2010-06-29 2016-03-29 Szegedi Tudományegyetem Kinurénsavamid származékok alkalmazása Huntington-kór kezelésére
JP2019508400A (ja) 2016-02-09 2019-03-28 ファーマケア，インク． キノリノンリシルオキシダーゼ様２阻害剤とその使用
HUP1600179A2 (hu) 2016-03-04 2017-09-28 Univ Szegedi Új típusú C-3 szubsztituált kinurénsavszármazékok hatékonyabb neuroprotektív aktivitással
EP3427729A1 (de) 2017-07-13 2019-01-16 Paris Sciences et Lettres - Quartier Latin Probenecid zur behandlung von epileptischen erkrankungen, störungen oder zuständen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1207771A (en) * 1968-03-18 1970-10-07 Warner Lambert Pharmaceutical Anti-virally active quinoline derivatives
GB1334705A (en) * 1970-06-19 1973-10-24 Ici Ltd Pharmaceutical compositions containing kynurenic acid derivatives
US4156726A (en) * 1974-12-07 1979-05-29 Fisons Limited 4-Oxo-2-carboxyl quinoline derivatives used as antiallergic compounds

Also Published As

Publication number Publication date
DK449588D0 (da) 1988-08-11
DE3880396D1 (de) 1993-05-27
JPS6466167A (en) 1989-03-13
EP0303387B1 (de) 1993-04-21
EP0303387A1 (de) 1989-02-15
DE3880396T2 (de) 1993-10-21
ATE88344T1 (de) 1993-05-15
GB8719102D0 (en) 1987-09-16
CA1330660C (en) 1994-07-12

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment