DK449588A - 4-oxo-1,4-dihydroquinolin-2-carboxylsyrederivat, dets anvendelse og fremstilling - Google Patents
4-oxo-1,4-dihydroquinolin-2-carboxylsyrederivat, dets anvendelse og fremstillingInfo
- Publication number
- DK449588A DK449588A DK449588A DK449588A DK449588A DK 449588 A DK449588 A DK 449588A DK 449588 A DK449588 A DK 449588A DK 449588 A DK449588 A DK 449588A DK 449588 A DK449588 A DK 449588A
- Authority
- DK
- Denmark
- Prior art keywords
- oxo
- dihydroquinoline
- compounds
- vivo
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB878719102A GB8719102D0 (en) | 1987-08-12 | 1987-08-12 | Therapeutic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DK449588D0 DK449588D0 (da) | 1988-08-11 |
DK449588A true DK449588A (da) | 1989-04-06 |
Family
ID=10622209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK449588A DK449588A (da) | 1987-08-12 | 1988-08-11 | 4-oxo-1,4-dihydroquinolin-2-carboxylsyrederivat, dets anvendelse og fremstilling |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0303387B1 (da) |
JP (1) | JPS6466167A (da) |
AT (1) | ATE88344T1 (da) |
CA (1) | CA1330660C (da) |
DE (1) | DE3880396T2 (da) |
DK (1) | DK449588A (da) |
GB (1) | GB8719102D0 (da) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5231102A (en) * | 1989-03-08 | 1993-07-27 | Merck Sharp & Dohme, Ltd. | Tetrahydroquinoline derivatives useful for neurodegenerative disorders |
EP0386839B1 (en) * | 1989-03-08 | 1997-01-15 | Merck Sharp & Dohme Ltd. | Tetrahydroquinoline derivatives useful for neurodegenerative disorders |
US5026700A (en) * | 1989-05-16 | 1991-06-25 | Merrell Dow Pharmaceuticals | Certain quinolines and thienopyridines as excitatory amino acid antagonists |
IT1232352B (it) * | 1989-08-11 | 1992-01-28 | Moroni Flavio Firenze | Derivati dell'acido chinurenico ad attivita' sul sistema nervoso centrale, loro preparazione e relative composizioni farmaceutiche |
ATE128136T1 (de) * | 1990-05-31 | 1995-10-15 | Merck Sharp & Dohme | Dioxo-tetrahydrochinolinderivate. |
GB9022785D0 (en) * | 1990-10-19 | 1990-12-05 | Merck Sharp & Dohme | Therapeutic agents |
GB9026389D0 (en) * | 1990-12-05 | 1991-01-23 | Merck Sharp & Dohme | Therapeutic agents |
US5606063A (en) * | 1991-02-27 | 1997-02-25 | Merrell Pharmaceuticals Inc. | NMDA antagonists |
CA2104297C (en) * | 1991-02-27 | 2003-05-27 | Boyd Lynn Harrison | 4-sulfanimide-quinoline nmda antagonists |
GB9109007D0 (en) * | 1991-04-26 | 1991-06-12 | Merck Sharp & Dohme | Therapeutic method |
GB9125485D0 (en) * | 1991-11-29 | 1992-01-29 | Merck Sharp & Dohme | Therapeutic agents |
KR100351884B1 (ko) * | 1993-11-29 | 2002-12-31 | 메렐 파마슈티칼스 인크. | Il-1작용억제제로서의헤테로시클릭벤젠술포닐이민유도체 |
PT731791E (pt) * | 1993-11-29 | 2000-11-30 | Merrell Pharma Inc | Novos derivados de benzeno-sulfonil-imina como inibidores da accao da il-1. |
US5817496A (en) * | 1994-07-07 | 1998-10-06 | Pharmacia & Upjohn S.P.A. | Recombinant kat enzyme from rat |
FR2733233B1 (fr) * | 1995-04-20 | 1997-05-30 | Roussel Uclaf | Nouveaux derives de quinoleine, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
US6025369A (en) * | 1996-05-03 | 2000-02-15 | The Board Of Regents Of The University Nebraska | N-methyl-D-aspartate (NMDA) receptor blockers for the prevention of atherosclerosis |
CA2608476A1 (en) * | 2005-06-28 | 2007-01-04 | Bausch & Lomb Incorporated | Preparations comprising arylazine substituted with a carbonylic moiety to increase the activity of gelatinase a in ocular cells |
HU230366B1 (hu) | 2010-06-29 | 2016-03-29 | Szegedi Tudományegyetem | Kinurénsavamid származékok alkalmazása Huntington-kór kezelésére |
EP3414229B1 (en) | 2016-02-09 | 2021-06-16 | Pharmakea, Inc. | Quinolinone lysyl oxidase-like 2 inhibitors and uses thereof |
HUP1600179A2 (hu) | 2016-03-04 | 2017-09-28 | Univ Szegedi | Új típusú C-3 szubsztituált kinurénsavszármazékok hatékonyabb neuroprotektív aktivitással |
EP3427729A1 (en) | 2017-07-13 | 2019-01-16 | Paris Sciences et Lettres - Quartier Latin | Probenecid for use in treating epileptic diseases, disorders or conditions |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1207771A (en) * | 1968-03-18 | 1970-10-07 | Warner Lambert Pharmaceutical | Anti-virally active quinoline derivatives |
GB1334705A (en) * | 1970-06-19 | 1973-10-24 | Ici Ltd | Pharmaceutical compositions containing kynurenic acid derivatives |
US4156726A (en) * | 1974-12-07 | 1979-05-29 | Fisons Limited | 4-Oxo-2-carboxyl quinoline derivatives used as antiallergic compounds |
-
1987
- 1987-08-12 GB GB878719102A patent/GB8719102D0/en active Pending
-
1988
- 1988-08-02 AT AT88307142T patent/ATE88344T1/de not_active IP Right Cessation
- 1988-08-02 DE DE88307142T patent/DE3880396T2/de not_active Expired - Fee Related
- 1988-08-02 EP EP88307142A patent/EP0303387B1/en not_active Expired - Lifetime
- 1988-08-09 CA CA000574224A patent/CA1330660C/en not_active Expired - Fee Related
- 1988-08-11 DK DK449588A patent/DK449588A/da not_active Application Discontinuation
- 1988-08-12 JP JP63200262A patent/JPS6466167A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ATE88344T1 (de) | 1993-05-15 |
JPS6466167A (en) | 1989-03-13 |
EP0303387A1 (en) | 1989-02-15 |
GB8719102D0 (en) | 1987-09-16 |
DE3880396D1 (de) | 1993-05-27 |
DE3880396T2 (de) | 1993-10-21 |
CA1330660C (en) | 1994-07-12 |
DK449588D0 (da) | 1988-08-11 |
EP0303387B1 (en) | 1993-04-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment |