DK417289D0 - Beta-carboliner og deres bio-isosteriske benzofuran- og benzothiophenanaloge - Google Patents
Beta-carboliner og deres bio-isosteriske benzofuran- og benzothiophenanalogeInfo
- Publication number
- DK417289D0 DK417289D0 DK417289A DK417289A DK417289D0 DK 417289 D0 DK417289 D0 DK 417289D0 DK 417289 A DK417289 A DK 417289A DK 417289 A DK417289 A DK 417289A DK 417289 D0 DK417289 D0 DK 417289D0
- Authority
- DK
- Denmark
- Prior art keywords
- benzothiophenanalogue
- isosteric
- benzofuran
- bio
- beta carbolines
- Prior art date
Links
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 title 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D515/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8802123 | 1988-08-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK417289D0 true DK417289D0 (da) | 1989-08-24 |
| DK417289A DK417289A (da) | 1990-03-01 |
Family
ID=19852815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK417289A DK417289A (da) | 1988-08-29 | 1989-08-24 | Beta-carboliner og deres bio-isosteriske benzofuran- og benzothiophenanaloge |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5095020A (da) |
| EP (1) | EP0357122A3 (da) |
| JP (1) | JPH02111772A (da) |
| AU (1) | AU625068B2 (da) |
| CA (1) | CA1337200C (da) |
| DK (1) | DK417289A (da) |
| IL (1) | IL91452A (da) |
| NZ (1) | NZ230431A (da) |
| ZA (1) | ZA896473B (da) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3855147D1 (de) * | 1987-07-20 | 1996-05-02 | Duphar Int Res | 8,9-Anellierte 1,2,3,4-Tetrahydro-beta-carbolin-Derivate |
| EP0347980A1 (en) * | 1988-06-20 | 1989-12-27 | Duphar International Research B.V | 8,9-Annelated beta-carbolines and 8,9-anelated-3,4-dihydro-beta-carbolines |
| EP0380155A1 (en) * | 1989-01-19 | 1990-08-01 | Duphar International Research B.V | 8,9-Annelated-1,2,3,4-tetrahydro-beta-carboline derivatives |
| US5622960A (en) * | 1992-04-14 | 1997-04-22 | The United States Of America As Represented By The Department Of Health And Human Services | Topoisomerase II inhibitors and therapeutic uses therefor |
| GB9401090D0 (en) * | 1994-01-21 | 1994-03-16 | Glaxo Lab Sa | Chemical compounds |
| US6143746A (en) * | 1994-01-21 | 2000-11-07 | Icos Corporation | Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use |
| GB9514465D0 (en) * | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
| GB9514473D0 (en) | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
| GB9514464D0 (en) * | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Medicaments |
| WO1997043287A1 (en) | 1996-05-10 | 1997-11-20 | Icos Corporation | Carboline derivatives |
| DE19744257B4 (de) * | 1997-10-07 | 2004-04-15 | Zentaris Gmbh | Beta-Carboline und deren Verwendung zur Behandlung von malignen und anderen, auf pathologischen Zellproliferationen beruhenden Erkrankungen |
| ATE332903T1 (de) * | 2000-10-03 | 2006-08-15 | Lilly Icos Llc | Kondensierte pyridoindolderivate |
| TWI329111B (en) | 2002-05-24 | 2010-08-21 | X Ceptor Therapeutics Inc | Azepinoindole and pyridoindole derivatives as pharmaceutical agents |
| WO2004113300A1 (ja) * | 2003-06-23 | 2004-12-29 | Ono Pharmaceutical Co., Ltd. | 新規三環性複素環化合物 |
| CA2554150A1 (en) | 2004-01-23 | 2005-08-04 | Chiron Corporation | Tetrahydrocarboline compounds as anticancer agents |
| US7767689B2 (en) * | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
| US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
| PL1737461T3 (pl) * | 2004-03-15 | 2013-05-31 | Ptc Therapeutics Inc | Pochodne karbolinowe użyteczne w hamowaniu angiogenezy |
| US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
| AU2005273867B2 (en) | 2004-08-18 | 2010-12-23 | 4Sc Ag | Benzothienopyridines for use as inhibitors of Eg5 kinesin |
| WO2006068164A1 (ja) * | 2004-12-22 | 2006-06-29 | Ono Pharmaceutical Co., Ltd. | 三環式化合物およびその用途 |
| WO2006079645A1 (en) * | 2005-01-27 | 2006-08-03 | Nycomed Gmbh | Novel indolopyridines , benzofuranopyridines and benzothienopyridines |
| JP2008528551A (ja) * | 2005-01-28 | 2008-07-31 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | インドロピリジン、ベンゾフラノピリジン及びベンゾチエノピリジン |
| KR101415354B1 (ko) | 2006-02-22 | 2014-07-04 | 4에스체 악티엔게젤샤프트 | Ｅｇ5 키네신 조절제로서의 인돌로피리딘 |
| FR2914924A1 (fr) * | 2007-04-13 | 2008-10-17 | Fourtillan Snc | Derives de 4,5,11,11a-tetrahydro-1h,6h-oxazolo[3',4': 1,6] pyrido[3,4-b]indol-3-one et leur utilisation en therapeutique. |
| JP2012528181A (ja) | 2009-05-27 | 2012-11-12 | ピーティーシー セラピューティクス，インコーポレーテッド | 置換テトラヒドロβ−カルボリンの製造方法 |
| WO2010138652A1 (en) | 2009-05-27 | 2010-12-02 | Ptc Therapeutics, Inc. | Methods for treating kaposi sarcoma |
| MX348817B (es) | 2009-05-27 | 2017-06-30 | Ptc Therapeutics Inc | Metodos para tratar cancer y estados no neoplasicos. |
| US8703726B2 (en) | 2009-05-27 | 2014-04-22 | Ptc Therapeutics, Inc. | Methods for treating prostate conditions |
| US9168247B2 (en) | 2010-06-25 | 2015-10-27 | Facultes Universitaires Notre Dame De La Paix | Beta carboline derivatives useful in the treatment of proliferative disorders |
| JP5649170B2 (ja) * | 2010-11-26 | 2015-01-07 | 国立大学法人 千葉大学 | テトラヒドロ−β−カルボリン誘導体及びその製造方法 |
| CN103450199B (zh) * | 2012-06-01 | 2015-09-09 | 首都医科大学 | 茶氨酸修饰的咔啉酰氨基酸苄酯、其制备、抗肿瘤活性和应用 |
| KR20200035292A (ko) | 2017-08-01 | 2020-04-02 | 피티씨 테라퓨틱스, 인크. | 혈액 암 치료에 사용하기 위한 dhodh 억제제 |
| US10947253B2 (en) | 2019-08-05 | 2021-03-16 | Ankh Life Sciences Limited | Fused polycyclic dimers |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES273769A1 (es) * | 1961-01-18 | 1962-06-01 | Geigy Ag J R | Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico |
| FR1310971A (fr) * | 1962-01-17 | 1962-11-30 | Geigy Ag J R | Nouveaux dérivés de la beta-carboline et leur préparation |
| FR1310970A (fr) * | 1962-01-17 | 1962-11-30 | Geigy Ag J R | Nouveaux dérivés de la beta-carboline à substituants basiques et leur préparation |
| US3644384A (en) * | 1969-06-09 | 1972-02-22 | Sterling Drug Inc | Certain 2-(alpha-haloacetyl) - 1 2 3 4-tetrahydro - 9h - pyrido(3 4-b)indole-3-carboxylates and derivatives |
| US4336260A (en) * | 1977-12-08 | 1982-06-22 | The Dow Chemical Company | Method and compositions using 1-aryl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid for treating depression |
| PH25651A (en) * | 1986-05-21 | 1991-08-21 | Duphar Int Res | New di, tetrahydroisoquinoline derivatives |
| WO1988000826A1 (en) * | 1986-08-05 | 1988-02-11 | Harbor Branch Oceanographic Institution, Inc. | Antitumor compositions and their methods of use |
| DE3855147D1 (de) * | 1987-07-20 | 1996-05-02 | Duphar Int Res | 8,9-Anellierte 1,2,3,4-Tetrahydro-beta-carbolin-Derivate |
| DK686688A (da) * | 1987-12-14 | 1989-06-15 | Duphar Int Res | 8,9-annelerede beta-carboliner, deres fremstilling og laegemidler indeholdende forbindelserne |
| EP0347980A1 (en) * | 1988-06-20 | 1989-12-27 | Duphar International Research B.V | 8,9-Annelated beta-carbolines and 8,9-anelated-3,4-dihydro-beta-carbolines |
| US4962163A (en) * | 1989-01-17 | 1990-10-09 | The Dow Chemical Company | Vinyl ester resins containing mesogenic/rigid rodlike moieties |
-
1989
- 1989-08-11 EP EP19890202089 patent/EP0357122A3/en not_active Ceased
- 1989-08-24 ZA ZA896473A patent/ZA896473B/xx unknown
- 1989-08-24 US US07/397,859 patent/US5095020A/en not_active Expired - Fee Related
- 1989-08-24 CA CA000609208A patent/CA1337200C/en not_active Expired - Fee Related
- 1989-08-24 DK DK417289A patent/DK417289A/da unknown
- 1989-08-25 NZ NZ230431A patent/NZ230431A/en unknown
- 1989-08-28 AU AU40830/89A patent/AU625068B2/en not_active Ceased
- 1989-08-28 IL IL9145289A patent/IL91452A/en not_active IP Right Cessation
- 1989-08-29 JP JP1220479A patent/JPH02111772A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA1337200C (en) | 1995-10-03 |
| EP0357122A2 (en) | 1990-03-07 |
| DK417289A (da) | 1990-03-01 |
| IL91452A0 (en) | 1990-04-29 |
| JPH02111772A (ja) | 1990-04-24 |
| IL91452A (en) | 1994-05-30 |
| NZ230431A (en) | 1992-03-26 |
| AU625068B2 (en) | 1992-07-02 |
| ZA896473B (en) | 1990-09-26 |
| US5095020A (en) | 1992-03-10 |
| EP0357122A3 (en) | 1991-10-23 |
| AU4083089A (en) | 1990-05-10 |
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