DK4172170T3 - Fluorescerende cytosinanaloger og anvendelse deraf i transskription og translation - Google Patents
Fluorescerende cytosinanaloger og anvendelse deraf i transskription og translation Download PDFInfo
- Publication number
- DK4172170T3 DK4172170T3 DK21734353.2T DK21734353T DK4172170T3 DK 4172170 T3 DK4172170 T3 DK 4172170T3 DK 21734353 T DK21734353 T DK 21734353T DK 4172170 T3 DK4172170 T3 DK 4172170T3
- Authority
- DK
- Denmark
- Prior art keywords
- transcription
- translation
- cytosine analogues
- fluorescent
- fluorescent cytosine
- Prior art date
Links
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical class NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 title 1
- 238000013518 transcription Methods 0.000 title 1
- 230000035897 transcription Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/10—Nucleotidyl transfering
- C12Q2521/119—RNA polymerase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/101—Modifications characterised by incorporating non-naturally occurring nucleotides, e.g. inosine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/117—Modifications characterised by incorporating modified base
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Saccharide Compounds (AREA)
- Electroluminescent Light Sources (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2009705.1A GB2600372A (en) | 2020-06-25 | 2020-06-25 | Fluorescent Cytosine analogues and their application in transcription and translation |
| PCT/EP2021/067342 WO2021260107A1 (en) | 2020-06-25 | 2021-06-24 | Fluorescent cytosine analogues and their application in transcription and translation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK4172170T3 true DK4172170T3 (da) | 2024-12-02 |
Family
ID=71949604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK21734353.2T DK4172170T3 (da) | 2020-06-25 | 2021-06-24 | Fluorescerende cytosinanaloger og anvendelse deraf i transskription og translation |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230219995A1 (https=) |
| EP (1) | EP4172170B1 (https=) |
| JP (1) | JP2023533484A (https=) |
| DK (1) | DK4172170T3 (https=) |
| ES (1) | ES2995470T3 (https=) |
| GB (1) | GB2600372A (https=) |
| IL (1) | IL299302A (https=) |
| WO (1) | WO2021260107A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025091026A1 (en) * | 2023-10-27 | 2025-05-01 | University Of Connecticut | Therapeutic compositions containing g-clamp pna and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6028183A (en) * | 1997-11-07 | 2000-02-22 | Gilead Sciences, Inc. | Pyrimidine derivatives and oligonucleotides containing same |
| US20030158403A1 (en) * | 2001-07-03 | 2003-08-21 | Isis Pharmaceuticals, Inc. | Nuclease resistant chimeric oligonucleotides |
| WO2005020885A2 (en) * | 2003-05-21 | 2005-03-10 | Isis Pharmaceuticals, Inc. | Compositions and methods for the treatment of severe acute respiratory syndrome (sars) |
| US20110130440A1 (en) * | 2008-03-26 | 2011-06-02 | Alnylam Pharmaceuticals, Inc. | Non-natural ribonucleotides, and methods of use thereof |
| WO2011034895A1 (en) * | 2009-09-15 | 2011-03-24 | Regents Of The University Of Colorado | Compositions, methods and uses for nucleotide analogues |
| US11447519B2 (en) * | 2016-11-10 | 2022-09-20 | San Diego State University Research Foundation | Compounds for fluorescence sensing of duplex formation |
-
2020
- 2020-06-25 GB GB2009705.1A patent/GB2600372A/en not_active Withdrawn
-
2021
- 2021-06-24 EP EP21734353.2A patent/EP4172170B1/en active Active
- 2021-06-24 WO PCT/EP2021/067342 patent/WO2021260107A1/en not_active Ceased
- 2021-06-24 US US18/001,805 patent/US20230219995A1/en active Pending
- 2021-06-24 ES ES21734353T patent/ES2995470T3/es active Active
- 2021-06-24 JP JP2022580419A patent/JP2023533484A/ja active Pending
- 2021-06-24 IL IL299302A patent/IL299302A/en unknown
- 2021-06-24 DK DK21734353.2T patent/DK4172170T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| GB2600372A (en) | 2022-05-04 |
| WO2021260107A1 (en) | 2021-12-30 |
| EP4172170B1 (en) | 2024-09-25 |
| JP2023533484A (ja) | 2023-08-03 |
| IL299302A (en) | 2023-02-01 |
| EP4172170A1 (en) | 2023-05-03 |
| US20230219995A1 (en) | 2023-07-13 |
| GB202009705D0 (en) | 2020-08-12 |
| ES2995470T3 (en) | 2025-02-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK4161935T3 (da) | Brm-målrettende forbindelser og tilhørende anvendelsesmetoder | |
| DK4355749T3 (da) | Tricykliske parp1-hæmmere og deres anvendelse | |
| EP4240436A4 (en) | SCAFFOLDING AND TISSUE CONSTRUCTIONS | |
| DK3668972T3 (da) | Konstruerede dnase-enzymer og anvendelse i terapi | |
| IL312076A (en) | Methionine adenosyltransferase 2a (mat2a) inhibitors and uses thereof | |
| DK3990028T3 (da) | Micellære nanopartikler og anvendelse deraf | |
| IL311790A (en) | Natural killer cells and methods of use thereof | |
| PL4271967T3 (pl) | Głowica sondy i zastosowanie głowicy sondy | |
| SI4426434T1 (sl) | Inverzni agonisti PPARG in njihova uporaba | |
| IL312555A (en) | Treatment of cancer with nk cells and multispecific engagers | |
| PL4249191T3 (pl) | Zespół buforowy i manipulator | |
| DK3710485T3 (da) | Anti-sez6-antistof-lægemiddelkonjugater og anvendelsesfremgangsmåder | |
| IT201900020274A1 (it) | Punta per chirurgia e metodo di realizzazione | |
| KR102832050B9 (ko) | 콜라겐 및 이의 용도 | |
| EP4084697A4 (en) | ORTHOPEDIC CLAMPS AND RELATED INSTRUMENTS | |
| EP4126903A4 (en) | CYCLOPHILIN INHIBITORS AND THEIR USES | |
| EP4208095C0 (en) | FLEXIBLE AND DRY ELECTRODE | |
| DK4172170T3 (da) | Fluorescerende cytosinanaloger og anvendelse deraf i transskription og translation | |
| EP4536239A4 (en) | GPCR INHIBITORS AND THEIR USES | |
| EP4504190A4 (en) | OXADIAZOLE HDAC6 INHIBITORS AND THEIR USES | |
| DK4255563T3 (da) | 5´-o-phenylacetyluridin og terapeutisk anvendelse | |
| IL312994A (en) | Low emissivity materials and associate methods | |
| IL311782A (en) | Transposases and uses thereof | |
| EP4365253A4 (en) | THICKENER AND ADHESIVE COMPOSITION | |
| EP4468789A4 (en) | MEASURING METHODS AND APPARATUS |