DK3784662T3 - Forbindelser med en tubulin-polymerisationshæmmende aktivitet og immunomodulatoriske egenskaber - Google Patents
Forbindelser med en tubulin-polymerisationshæmmende aktivitet og immunomodulatoriske egenskaber Download PDFInfo
- Publication number
- DK3784662T3 DK3784662T3 DK19733845.2T DK19733845T DK3784662T3 DK 3784662 T3 DK3784662 T3 DK 3784662T3 DK 19733845 T DK19733845 T DK 19733845T DK 3784662 T3 DK3784662 T3 DK 3784662T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- inhibitory activity
- tubulin polymerization
- immunomodulatory properties
- polymerization inhibitory
- Prior art date
Links
- MQLACMBJVPINKE-UHFFFAOYSA-N 10-[(3-hydroxy-4-methoxyphenyl)methylidene]anthracen-9-one Chemical compound C1=C(O)C(OC)=CC=C1C=C1C2=CC=CC=C2C(=O)C2=CC=CC=C21 MQLACMBJVPINKE-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000002519 immonomodulatory effect Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1853709A FR3080620B1 (fr) | 2018-04-27 | 2018-04-27 | Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices |
| PCT/FR2019/050982 WO2019207257A1 (fr) | 2018-04-27 | 2019-04-26 | Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3784662T3 true DK3784662T3 (da) | 2022-12-19 |
Family
ID=63036097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19733845.2T DK3784662T3 (da) | 2018-04-27 | 2019-04-26 | Forbindelser med en tubulin-polymerisationshæmmende aktivitet og immunomodulatoriske egenskaber |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11634405B2 (enExample) |
| EP (1) | EP3784662B1 (enExample) |
| JP (1) | JP7408894B2 (enExample) |
| AU (1) | AU2019259112B2 (enExample) |
| CA (1) | CA3097622A1 (enExample) |
| DK (1) | DK3784662T3 (enExample) |
| ES (1) | ES2932370T3 (enExample) |
| FR (1) | FR3080620B1 (enExample) |
| WO (1) | WO2019207257A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116143693B (zh) * | 2020-06-24 | 2026-04-10 | 中国药科大学 | 一种具有抗肿瘤活性的2-甲基喹啉类衍生物及其合成方法和用途 |
| CN115417860B (zh) * | 2020-08-03 | 2023-10-20 | 中国药科大学 | 一种具有抗肿瘤活性的喹唑啉类衍生物及其合成方法和用途 |
| CN113173915B (zh) * | 2021-03-29 | 2022-12-09 | 中南大学湘雅医院 | 抗皮肤肿瘤化合物及其应用 |
| CN113620874B (zh) * | 2021-08-10 | 2024-02-06 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2-三氟甲基-4-氨基-喹啉衍生物及其用途 |
| CN114436975B (zh) * | 2022-01-26 | 2023-10-31 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2-三氟甲基-4-氨基喹唑啉类化合物及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9323290D0 (en) * | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
| GB9514265D0 (en) * | 1995-07-13 | 1995-09-13 | Wellcome Found | Hetrocyclic compounds |
| PT1154774E (pt) * | 1999-02-10 | 2005-10-31 | Astrazeneca Ab | Derivados de quinazolina como inibidores de angiogenese |
| BR0111377A (pt) * | 2000-06-06 | 2003-06-03 | Pfizer Prod Inc | Derivados de tiofeno úteis como agentes anticancerìgenos |
| GB0126433D0 (en) * | 2001-11-03 | 2002-01-02 | Astrazeneca Ab | Compounds |
| AU2004289303A1 (en) * | 2003-11-10 | 2005-05-26 | Synta Pharmaceuticals, Corp. | Fused heterocyclic compounds |
| AU2004309166B2 (en) * | 2003-12-23 | 2008-02-21 | Pfizer Inc. | Novel quinoline derivatives |
| WO2006074187A2 (en) * | 2005-01-03 | 2006-07-13 | Myriad Genetics, Inc. | Method of treating brain cancer |
| GB0508717D0 (en) * | 2005-04-29 | 2005-06-08 | Astrazeneca Ab | Chemical compounds |
| JP2009508917A (ja) * | 2005-09-20 | 2009-03-05 | アストラゼネカ アクチボラグ | 抗癌剤としてのキナゾリン誘導体 |
| FR2914640B1 (fr) | 2007-04-04 | 2012-11-16 | Centre Nat Rech Scient | Iso ca-4 et analogues : puissants cytotoxiques, inhibiteurs de polymerisation de la tubuline |
-
2018
- 2018-04-27 FR FR1853709A patent/FR3080620B1/fr active Active
-
2019
- 2019-04-26 US US17/050,772 patent/US11634405B2/en active Active
- 2019-04-26 ES ES19733845T patent/ES2932370T3/es active Active
- 2019-04-26 DK DK19733845.2T patent/DK3784662T3/da active
- 2019-04-26 AU AU2019259112A patent/AU2019259112B2/en active Active
- 2019-04-26 EP EP19733845.2A patent/EP3784662B1/fr active Active
- 2019-04-26 JP JP2020559423A patent/JP7408894B2/ja active Active
- 2019-04-26 CA CA3097622A patent/CA3097622A1/fr active Pending
- 2019-04-26 WO PCT/FR2019/050982 patent/WO2019207257A1/fr not_active Ceased
-
2023
- 2023-03-06 US US18/117,847 patent/US12371417B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| FR3080620A1 (fr) | 2019-11-01 |
| FR3080620B1 (fr) | 2021-11-12 |
| CA3097622A1 (fr) | 2019-10-31 |
| WO2019207257A8 (fr) | 2019-11-21 |
| US20230203005A1 (en) | 2023-06-29 |
| ES2932370T3 (es) | 2023-01-18 |
| EP3784662A1 (fr) | 2021-03-03 |
| AU2019259112A1 (en) | 2020-11-26 |
| EP3784662B1 (fr) | 2022-11-09 |
| WO2019207257A1 (fr) | 2019-10-31 |
| AU2019259112B2 (en) | 2024-02-08 |
| US11634405B2 (en) | 2023-04-25 |
| JP2021522244A (ja) | 2021-08-30 |
| US12371417B2 (en) | 2025-07-29 |
| US20210230140A1 (en) | 2021-07-29 |
| JP7408894B2 (ja) | 2024-01-09 |
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