DK375188A - Fremgangsmaade til fremstilling af et biologisk aktivt kompleks og det fremstillede kompleks - Google Patents

Fremgangsmaade til fremstilling af et biologisk aktivt kompleks og det fremstillede kompleks

Info

Publication number
DK375188A
DK375188A DK375188A DK375188A DK375188A DK 375188 A DK375188 A DK 375188A DK 375188 A DK375188 A DK 375188A DK 375188 A DK375188 A DK 375188A DK 375188 A DK375188 A DK 375188A
Authority
DK
Denmark
Prior art keywords
complex
molecule
inactivation
procedure
preparation
Prior art date
Application number
DK375188A
Other languages
English (en)
Other versions
DK375188D0 (da
Inventor
Ezekiel Y Shami
Aser Rothstein
Mohabir Ramjeesingh
Original Assignee
Hybrisens Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybrisens Ltd filed Critical Hybrisens Ltd
Publication of DK375188D0 publication Critical patent/DK375188D0/da
Publication of DK375188A publication Critical patent/DK375188A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/82Asparaginase (3.5.1.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6815Enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6871Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK375188A 1987-07-07 1988-07-06 Fremgangsmaade til fremstilling af et biologisk aktivt kompleks og det fremstillede kompleks DK375188A (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7186187A 1987-07-07 1987-07-07
US18253088A 1988-04-18 1988-04-18
US20574888A 1988-06-21 1988-06-21

Publications (2)

Publication Number Publication Date
DK375188D0 DK375188D0 (da) 1988-07-06
DK375188A true DK375188A (da) 1989-01-08

Family

ID=27371979

Family Applications (1)

Application Number Title Priority Date Filing Date
DK375188A DK375188A (da) 1987-07-07 1988-07-06 Fremgangsmaade til fremstilling af et biologisk aktivt kompleks og det fremstillede kompleks

Country Status (7)

Country Link
EP (1) EP0298654B1 (da)
JP (1) JPH01138461A (da)
AT (1) ATE106250T1 (da)
AU (1) AU1865288A (da)
DE (1) DE3889783T2 (da)
DK (1) DK375188A (da)
ES (1) ES2056108T3 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686579A (en) * 1988-06-21 1997-11-11 Hybrisens, Ltd. Use of antibody/antigen interactions to protect biologically active proteins and peptides
JPH03133378A (ja) * 1989-07-19 1991-06-06 Modrovich Ivan E 被験体を安定化させて液体中でのその生物学的活性を保存する方法
ATE193600T1 (de) * 1990-11-20 2000-06-15 Dade Behring Marburg Gmbh Verfahren zur stabilisierung von enzym-konjugaten
AU6953696A (en) * 1996-08-16 1998-03-06 Procter & Gamble Company, The Detergent compositions comprising antibody controlled amylolytic activity
WO1998007820A1 (en) * 1996-08-16 1998-02-26 The Procter & Gamble Company Detergent compositions comprising antibody controlled enzymatic activity
AU6849696A (en) * 1996-08-16 1998-03-06 Procter & Gamble Company, The Detergent compositions comprising antibody controlled proteolytic activity
AU6953796A (en) * 1996-08-16 1998-03-06 Procter & Gamble Company, The Detergent compositions comprising antibody controlled cellulolytic activity
AU6777296A (en) * 1996-08-16 1998-03-06 Procter & Gamble Company, The Detergent compositions comprising antibody controlled lipolytic activity
WO1998007816A1 (en) * 1996-08-16 1998-02-26 The Procter & Gamble Company Detergent compositions comprising oxido-reductase antibody
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
WO2005094881A1 (ja) * 2004-03-30 2005-10-13 Takeda Pharmaceutical Company Limited 抗体医薬
RU2401842C2 (ru) * 2004-10-08 2010-10-20 Домантис Лимитед Антагонисты и способы их применения
CA2637707A1 (en) 2006-02-02 2007-08-09 Rinat Neuroscience Corporation Methods for treating obesity by administering a trkb antagonist

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2148299B (en) * 1983-09-01 1988-01-06 Hybritech Inc Antibody compositions of therapeutic agents having an extended serum half-life
EP0231649B1 (en) * 1985-12-28 1990-11-22 Nippon Hypox Laboratories Incorporated Albumin complex
DE3621828A1 (de) * 1986-06-28 1988-01-14 Biotest Pharma Gmbh Stabilisierung eines fuer therapeutische zwecke, insbesondere beim menschen, bestimmten interleukin-2-praeparates sowie dieses praeparat enthaltende stabilisierte waessrige loesung oder feststoff
US4704692A (en) * 1986-09-02 1987-11-03 Ladner Robert C Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides

Also Published As

Publication number Publication date
EP0298654A2 (en) 1989-01-11
AU1865288A (en) 1989-01-12
ATE106250T1 (de) 1994-06-15
DK375188D0 (da) 1988-07-06
DE3889783D1 (de) 1994-07-07
ES2056108T3 (es) 1994-10-01
EP0298654B1 (en) 1994-06-01
EP0298654A3 (en) 1990-02-07
DE3889783T2 (de) 1994-09-08
JPH01138461A (ja) 1989-05-31

Similar Documents

Publication Publication Date Title
DK375188D0 (da) Fremgangsmaade til fremstilling af et biologisk aktivt kompleks og det fremstillede kompleks
DE68903558D1 (de) Verfahren zur inaktivierung von viren.
DK0454898T3 (da) Glycosaminoglycan-modificeret protein, fremgangsmåde til fremstilling af proteinet, farmaceutiske præparater indeholdende proteinet samt anvendelse af proteinet
PT87083A (pt) Vascular-antikoaquilierende proteine dna die diese kodieren verfahren zu deren herstellung sowie deren verwendung
AU2891489A (en) Enzymatic process for the preparation of optically active cyanohydrins
ATE175211T1 (de) Neues, biologisch aktives, vom frosch stammendes peptid (frosch-cnp)
EP0188262A3 (en) Process for the isolation of chicken egg white cystatine, antiviral agents containing it and its use as viral protease inhibitor
YU88092A (sh) Enzimatski postupak za enantioselektivno pripremanje optički aktivnih cijanhidrina
DK0409521T3 (da) Forbedret enzymatisk oxidation af Ceph C til glutaryl-7-aminocephalosporansyre
NZ191225A (en) Hydrolysing sugar or protein with an immobilised enzyme apparatus therefor
DE58905691D1 (de) Verfahren zur Herstellung von L-alpha-Aminosäuren.
DK164916C (da) Fremgangsmaade til rensning eller berigelse af biologisk aktive proteiner og hertil egnet middel
ATE3981T1 (de) Verfahren zur gewinnung von alpha-2-sbglykoprotein.
DK710588A (da) Enzym samt fremgangsmaade til enzymatisk hydrolyse af alfa-aminoadipinyl-monoaminoforbindelser
DK0457035T3 (da) Fremgangsmåde til inaktivering af den biologiske aktivitet af DNA
DE3871519D1 (de) Verfahren zur inaktivierung rekombinanter dna.
SE8600987D0 (sv) Forfarande for framstellning av ett protein- koncentrat ur helblod
FI913907A0 (fi) t-PA-liuotus
ATE139118T1 (de) Ribozymenhemmer
DK621688A (da) Ethylerede avermectiner og praeparater indeholdende disse til behandling og forhindring af parasitinfektioner hos mennesker og dyr
JPS57186491A (en) Cultivation of fibroblast using fibronectin
DE3882654D1 (de) Enzymhemmer und methode zu dessen herstellung.
ATE105570T1 (de) Modifizierte menschliche anti-rh(d)-antikoerper.
RU93008907A (ru) Способ получения иммобилизованных ферментов
DE59304167D1 (de) Mikrobiologisches Verfahren zur Herstellung von 5-Hydroxy-2-pyrazincarbonsäure

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment