DK3738957T3 - Fremgangsmåde til acetylering af cannabinoider - Google Patents

Fremgangsmåde til acetylering af cannabinoider Download PDF

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Publication number
DK3738957T3
DK3738957T3 DK20158964.5T DK20158964T DK3738957T3 DK 3738957 T3 DK3738957 T3 DK 3738957T3 DK 20158964 T DK20158964 T DK 20158964T DK 3738957 T3 DK3738957 T3 DK 3738957T3
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DK
Denmark
Prior art keywords
cannabinoids
acetylation
procedure
Prior art date
Application number
DK20158964.5T
Other languages
English (en)
Inventor
Ryan Delmoral Ko
Brock Hughes
Krupal Devendra Pal
Ivan Jason Casselman
Original Assignee
Nextleaf Solutions Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nextleaf Solutions Ltd filed Critical Nextleaf Solutions Ltd
Application granted granted Critical
Publication of DK3738957T3 publication Critical patent/DK3738957T3/da

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D3/00Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/14Fractional distillation or use of a fractionation or rectification column
    • B01D3/143Fractional distillation or use of a fractionation or rectification column by two or more of a fractionation, separation or rectification step
    • B01D3/148Fractional distillation or use of a fractionation or rectification column by two or more of a fractionation, separation or rectification step in combination with at least one evaporator
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/80Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82Xanthenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/80Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82Xanthenes
    • C07D311/84Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/86Oxygen atoms, e.g. xanthones
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D1/00Evaporating
    • B01D1/22Evaporating by bringing a thin layer of the liquid into contact with a heated surface
    • B01D1/222In rotating vessels; vessels with movable parts
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/04Solvent extraction of solutions which are liquid
    • B01D11/0492Applications, solvents used
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D3/00Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/10Vacuum distillation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D3/00Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/14Fractional distillation or use of a fractionation or rectification column
    • B01D3/143Fractional distillation or use of a fractionation or rectification column by two or more of a fractionation, separation or rectification step
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D3/00Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/34Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
    • B01D3/343Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances the substance being a gas
    • B01D3/346Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances the substance being a gas the gas being used for removing vapours, e.g. transport gas
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D5/00Condensation of vapours; Recovering volatile solvents by condensation
    • B01D5/0057Condensation of vapours; Recovering volatile solvents by condensation in combination with other processes
    • B01D5/006Condensation of vapours; Recovering volatile solvents by condensation in combination with other processes with evaporation or distillation
    • B01D5/0063Reflux condensation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pyrane Compounds (AREA)
DK20158964.5T 2019-05-17 2020-02-24 Fremgangsmåde til acetylering af cannabinoider DK3738957T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16/415,782 US10569189B1 (en) 2019-05-17 2019-05-17 Method for acetylation of cannabinoids

Publications (1)

Publication Number Publication Date
DK3738957T3 true DK3738957T3 (da) 2021-09-20

Family

ID=69590667

Family Applications (1)

Application Number Title Priority Date Filing Date
DK20158964.5T DK3738957T3 (da) 2019-05-17 2020-02-24 Fremgangsmåde til acetylering af cannabinoider

Country Status (8)

Country Link
US (4) US10569189B1 (da)
EP (1) EP3738957B1 (da)
KR (1) KR102271508B1 (da)
AU (1) AU2020200438B1 (da)
CA (2) CA3067195C (da)
DK (1) DK3738957T3 (da)
MA (1) MA51491A (da)
WO (1) WO2020232526A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10569189B1 (en) * 2019-05-17 2020-02-25 NextLeaf Solutions Ltd. Method for acetylation of cannabinoids
US10954209B1 (en) * 2019-09-15 2021-03-23 NextLeaf Solutions Ltd. Acetylation of cannabinoids using sulfuric acid catalyst
EP4186886A1 (en) * 2021-11-30 2023-05-31 Tresco Labs GmbH Process for the synthesis and purification of cannabinoic acids and acylated derivatives thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008383A (en) * 1998-10-26 1999-12-28 University Of Mississippi Method of preparing delta-9-tetrahydrocannabinol esters
DE602005011844D1 (de) * 2004-11-02 2009-01-29 Pfizer Sulfonylbenzimidazolderivate
KR100680023B1 (ko) * 2004-12-06 2007-02-07 한국전자통신연구원 생체신호를 이용한 착용형 휴대폰 입력 장치 및 그 제어방법
EP1928853A4 (en) * 2005-09-29 2011-02-16 Amr Technology Inc PROCESS FOR THE PRODUCTION OF DELTA-9-TETRAHYDROCANNABINOL
US10406453B2 (en) * 2017-09-29 2019-09-10 NextLeaf Solutions Ltd. Cannabinoid extraction process using brine
US10569189B1 (en) * 2019-05-17 2020-02-25 NextLeaf Solutions Ltd. Method for acetylation of cannabinoids

Also Published As

Publication number Publication date
US10569189B1 (en) 2020-02-25
US11097204B2 (en) 2021-08-24
KR102271508B1 (ko) 2021-07-02
US20210379507A1 (en) 2021-12-09
CA3081302C (en) 2021-01-12
US10792584B1 (en) 2020-10-06
CA3081302A1 (en) 2020-03-26
WO2020232526A1 (en) 2020-11-26
EP3738957A1 (en) 2020-11-18
NZ761029A (en) 2020-11-27
EP3738957B1 (en) 2021-08-04
MA51491A (fr) 2021-03-24
KR20200135299A (ko) 2020-12-02
CA3067195C (en) 2020-07-14
CA3067195A1 (en) 2020-03-26
AU2020200438B1 (en) 2020-06-25
US20200398183A1 (en) 2020-12-24

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