DK37388A - Steroid-5-alfa-reduktaseinhibitorer - Google Patents

Steroid-5-alfa-reduktaseinhibitorer

Info

Publication number
DK37388A
DK37388A DK037388A DK37388A DK37388A DK 37388 A DK37388 A DK 37388A DK 037388 A DK037388 A DK 037388A DK 37388 A DK37388 A DK 37388A DK 37388 A DK37388 A DK 37388A
Authority
DK
Denmark
Prior art keywords
alpha
steroid
reductase inhibitors
double bond
reductase
Prior art date
Application number
DK037388A
Other languages
Danish (da)
English (en)
Other versions
DK37388D0 (da
Inventor
Dennis Alan Holt
Mark Alan Levy
Brian Walter Metcalf
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of DK37388D0 publication Critical patent/DK37388D0/da
Publication of DK37388A publication Critical patent/DK37388A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J31/00Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J3/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J73/00Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/16Benz[e]indenes; Hydrogenated benz[e]indenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
DK037388A 1987-01-28 1988-01-26 Steroid-5-alfa-reduktaseinhibitorer DK37388A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/007,539 US4888336A (en) 1987-01-28 1987-01-28 Steroid 5-alpha-reductase inhibitors

Publications (2)

Publication Number Publication Date
DK37388D0 DK37388D0 (da) 1988-01-26
DK37388A true DK37388A (da) 1988-07-29

Family

ID=21726780

Family Applications (4)

Application Number Title Priority Date Filing Date
DK037388D DK168525B1 (da) 1987-01-28 1988-01-26 17-substituerede 4-aza-5-alfa-androsten-3-on-derivater samt farmaceutisk middel med indhold deraf
DK037388A DK37388A (da) 1987-01-28 1988-01-26 Steroid-5-alfa-reduktaseinhibitorer
DK196691A DK169438B1 (da) 1987-01-28 1991-12-05 Fremgangsmåde til fremstilling af 17 substituerede 4-aza-5alfa-androsten-3-on-derivater samt mellemprodukter til anvendelse ved fremgangsmåden
DK073594A DK169840B1 (da) 1987-01-28 1994-06-21 Fremgangsmåde til fremstilling af 17-substituerede 4-aza-5,7-androstadien-3-on-derivater

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK037388D DK168525B1 (da) 1987-01-28 1988-01-26 17-substituerede 4-aza-5-alfa-androsten-3-on-derivater samt farmaceutisk middel med indhold deraf

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK196691A DK169438B1 (da) 1987-01-28 1991-12-05 Fremgangsmåde til fremstilling af 17 substituerede 4-aza-5alfa-androsten-3-on-derivater samt mellemprodukter til anvendelse ved fremgangsmåden
DK073594A DK169840B1 (da) 1987-01-28 1994-06-21 Fremgangsmåde til fremstilling af 17-substituerede 4-aza-5,7-androstadien-3-on-derivater

Country Status (13)

Country Link
US (1) US4888336A (fr)
EP (1) EP0277002B1 (fr)
JP (1) JPS63192800A (fr)
AT (1) ATE77388T1 (fr)
AU (1) AU608560B2 (fr)
CA (1) CA1325006C (fr)
DE (1) DE3871965T2 (fr)
DK (4) DK168525B1 (fr)
ES (1) ES2042725T3 (fr)
GR (1) GR3005284T3 (fr)
IE (1) IE61594B1 (fr)
PT (1) PT86652B (fr)
ZA (1) ZA88549B (fr)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138063A (en) * 1984-02-27 1992-08-11 Merck & Co., Inc. 17β-methoxycarbonyl-4-aza-androsten-1-en-3-ones
US5571817A (en) * 1984-02-27 1996-11-05 Merck & Co., Inc. Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones]
US4814324A (en) * 1987-03-06 1989-03-21 Merck & Co., Inc. Sterol inhibitors of testosterone 5α-reductase
US5372996A (en) * 1989-03-10 1994-12-13 Endorecherche, Inc. Method of treatment of androgen-related diseases
US5595985A (en) * 1989-03-10 1997-01-21 Endorecherche Inc. Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia
US5405978A (en) * 1989-05-30 1995-04-11 The Upjohn Company Oxidative preparation of 3,5-secoandrost-5-one-3,17 β-dioic acid
DK0943328T3 (da) * 1989-07-07 2004-10-18 Endorech Inc Kombinationsterapi til profylakse og/eller behandling af godartet prostatahyperplasi
ES2189784T3 (es) * 1989-07-07 2003-07-16 Endorech Inc Procedimiento para el tratamiento de enfermedades relacionadas con adrogenos.
DE69032648T2 (de) * 1989-07-07 1999-04-08 Endorecherche Inc., Ste-Foy, Quebec Androgenderivate zur Hemming der Aktivität der Sexualsteroide
US5162332A (en) * 1990-06-20 1992-11-10 Merck & Co., Inc. Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors
US5151430A (en) * 1990-06-20 1992-09-29 Merck & Co., Inc. Specific 17β-thiobenzoyl-4-aza-5α-androst-1-en-3-ones as antiandrogen agents
US5061802A (en) * 1990-06-20 1991-10-29 Merck & Co. Inc. 17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents
US5098908A (en) * 1990-06-20 1992-03-24 Merck & Co., Inc. 17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors
US5091380A (en) * 1990-06-28 1992-02-25 Merck & Co., Inc. N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors
IL101243A (en) * 1991-03-20 1999-12-22 Merck & Co Inc Pharmaceutical preparations for the treatment of benign prostatic hyperplasia containing steroid history
US5250539A (en) * 1991-08-21 1993-10-05 Eli Lilly And Company Hexahydrobenzo[f]quinolinones
US5304562A (en) * 1991-10-09 1994-04-19 Ciba-Geigy Corporation 17β-substituted Aza-androstane derivatives
CA2084799C (fr) * 1991-12-17 2003-01-28 Glenn J. Gormley Methode de prevention du carcinome prostatique a l'aide de 17 beta-n-monosubstitue-carbamyl-4-aza-5 alpha-androst-1 -en-3-ones
EP0547687A1 (fr) * 1991-12-18 1993-06-23 Merck & Co. Inc. 17-bêta-substitués adamantyle/norbornanyle-4-aza-5-alpha-androsta-1-en-3-ones et androsta-3-ones
US5543406A (en) * 1991-12-20 1996-08-06 Glaxo Wellcome, Inc. Inhibitors of 5-α-testosterone reductase
DE69329856D1 (de) * 1992-05-20 2001-02-15 Merck & Co Inc Ester derivate von 4-aza-steroiden
US5237064A (en) * 1992-05-20 1993-08-17 Merck & Co., Inc. Process for producing 7β-substituted-aza-5αandrostan-3-ones
EP0646007B1 (fr) * 1992-05-20 1997-08-13 Merck & Co. Inc. NOUVELLES 4-AZA-5$g(a)-ANDROSTAN-ONES SUBSTITUEES EN POSITION 17$g(b), SATUREES ET DELTA-17 ET DELTA-20 OLEFINIQUES ET SATUREES UTILISEES COMME INHIBITEURS DE 5$g(a)-REDUCTASE
US5710275A (en) * 1992-05-20 1998-01-20 Merck & Co., Inc. 7β-substituted-4-aza-5α-androstan-3-ones as 5α-reductase inhibitors
WO1993023039A1 (fr) * 1992-05-20 1993-11-25 Merck & Co., Inc. 4-aza-5a-androstan ones substituees utilisees en tant qu'inhibitors de la 5a-reductase
AU675225B2 (en) * 1992-05-20 1997-01-30 Merck & Co., Inc. 17-amino substituted 4-azasteroid 5alpha-reductase inhibitors
EP0641204B1 (fr) * 1992-05-20 2000-08-16 Merck & Co. Inc. 17-ethers et thioethers de 4-aza-steroides
CA2135167A1 (fr) * 1992-05-20 1993-11-25 Donald W. Graham Nouveaux derives 17-ester, amide, et cetone de 3-oxo-4-azasteroides, utilises comme inhibiteurs de la 5a-reductase
RU94046044A (ru) * 1992-05-20 1996-10-10 Мерк Энд Ко. Новые 7 бета -замещенные 4-аза- 5 альфа -холестан-оны в качестве ингибиторов 5 альфа -редуктазы, фармацевтическая композиция на их основе, способ ее получения
ATE195129T1 (de) * 1992-05-20 2000-08-15 Merck & Co Inc 4-azasteroide als 5-alpha-reduktase
WO1993023053A1 (fr) * 1992-05-21 1993-11-25 Endorecherche Inc. INHIBITEURS D'ACTIVITE DE LA TESTOSTERONE 5α-REDUCTASE
GB9210880D0 (en) * 1992-05-21 1992-07-08 Smithkline Beecham Corp Compounds
AU680818B2 (en) * 1992-05-21 1997-08-14 Endorecherche Inc. Improved antiandrogens
GB9213901D0 (en) * 1992-06-30 1992-08-12 Smithkline Beecham Corp Compounds
US5302589A (en) * 1992-08-07 1994-04-12 Glaxo, Inc. Heterocyclic inhibitors of 5-α-testosterone reductase
US5324734A (en) * 1992-09-15 1994-06-28 Merck & Co., Inc. Oxidization metabolites of 5-α-23-methyl-4-aza-21-nor-chol-1-ene-3, 20-dione
HU212459B (en) * 1992-10-02 1996-06-28 Richter Gedeon Vegyeszet Process for producing new 17-beta-substituted 4-aza-androstane-derivatives and pharmaceutical compositions containing them
US5278159A (en) * 1992-10-06 1994-01-11 Merck & Co., Inc. Aryl ester derivatives of 3-oxo-4-aza-androstane 17-β-carboxylates as 5-α-reductase inhibitors
US5359071A (en) * 1993-03-12 1994-10-25 Merck & Co., Inc. 15-substituted 4-azasteroids
AU6413594A (en) * 1993-03-24 1994-10-11 Merck & Co., Inc. Substituted 3-phenanthridinone derivatives as 5alpha-reductase inhibitors
JP3325026B2 (ja) * 1993-06-28 2002-09-17 メルク エンド カンパニー インコーポレーテッド 4−アザ−プレグナン5α−レダクターゼアイソザイム1阻害剤
TW408127B (en) * 1993-09-17 2000-10-11 Glaxo Inc Androstenones
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5817818A (en) * 1994-09-16 1998-10-06 Glaxo Wellcome Inc. Androstenones
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5595996A (en) * 1994-10-25 1997-01-21 Merck & Co., Inc. 7-substituted 4-aza cholanic acid derivatives and their use
US6365597B1 (en) * 1996-02-14 2002-04-02 Aventis Pharmaceuticals Inc. 4-aza steroids
US5998427A (en) * 1998-05-14 1999-12-07 Glaxo Wellcome Inc. Androstenones
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
JP2009508494A (ja) 2005-09-16 2009-03-05 ラプトール ファーマシューティカル インコーポレイテッド Crを含むタンパク質に対して特異的な受容体−結合タンパク質(rap)変異体を含む組成物およびその使用
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑-磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2897202A (en) * 1956-03-19 1959-07-28 Monsanto Chemicals 3-keto-4-aza-delta5-steroids and method of preparing same
KR830000085B1 (ko) * 1978-04-13 1983-02-08 제임스 에프. 너우톤 5α-환원효소 억제제로서 유용한 4-아자-17-치환-5α-안드로스탄-3-온류의 제조방법
US4191759A (en) * 1978-04-13 1980-03-04 Merck & Co., Inc. N-substituted-17β-carbamoylandrost-4-en-3-one 5α reductase inhibitors
AU527030B2 (en) * 1978-04-13 1983-02-10 Merck & Co., Inc. 4-aza-17-substituted-5a-androstan-3-ones
US4377584A (en) * 1978-04-13 1983-03-22 Merck & Co., Inc. 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
US4220775A (en) * 1979-03-15 1980-09-02 Merck & Co., Inc. Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors
US4317817A (en) * 1979-08-27 1982-03-02 Richardson-Merrell Inc. Novel steroid 5α-reductase inhibitors
US4760071A (en) * 1984-02-27 1988-07-26 Merck & Co., Inc. 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
NZ211145A (en) * 1984-02-27 1988-10-28 Merck & Co Inc 4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
GB8505862D0 (en) * 1985-03-07 1985-04-11 Erba Farmitalia Steroidic 5alpha-reductase inhibitors

Also Published As

Publication number Publication date
US4888336A (en) 1989-12-19
PT86652B (pt) 1992-02-28
DE3871965D1 (de) 1992-07-23
IE61594B1 (en) 1994-11-16
DK169438B1 (da) 1994-10-31
IE880189L (en) 1988-07-28
ATE77388T1 (de) 1992-07-15
DK196691D0 (da) 1991-12-05
PT86652A (pt) 1988-02-01
EP0277002B1 (fr) 1992-06-17
EP0277002A2 (fr) 1988-08-03
DE3871965T2 (de) 1993-01-14
EP0277002A3 (en) 1988-10-26
AU1077888A (en) 1988-08-04
GR3005284T3 (fr) 1993-05-24
DK196691A (da) 1991-12-05
AU608560B2 (en) 1991-04-11
ZA88549B (en) 1988-07-27
DK37388D0 (da) 1988-01-26
CA1325006C (fr) 1993-12-07
DK169840B1 (da) 1995-03-13
DK73594A (da) 1994-06-21
DK168525B1 (da) 1994-04-11
JPS63192800A (ja) 1988-08-10
ES2042725T3 (es) 1993-12-16

Similar Documents

Publication Publication Date Title
PT86652A (pt) Steroid 5-alpha-reductase inhibitors
GEP19981274B (en) Urinary follicle stimulating hormone, pharmaceutical composition, component of pharmaceutical composition
ZA899671B (en) Phosphinic acid substituted steroids as inhibitors of steroid 5-alpha-reductase
GR1001503B (el) Μέ?οδος δια την παρασκευή φαρμακευτικών ενώσεων αι οποίαι περιέχουν ως δραστική ουσία καρβονικά οξέα τα οποία περιέχουν ?είον κα?ώς και η χρησιμοποίησις αυτών δια την καταπολέμησιν των ρετροιών.
MY103352A (en) Piperazinyl-heterocyclic compounds
IL87885A (en) Pharmaceutical compositions having antiprogestational and anti-estrogenic activities for the treatment of hormone- dependent tumors
MY103518A (en) Steroid 5- -reductase inhibitors
EP0293751A3 (en) Taurohyodeoxycholic acid for the therapy of calculosis of the biliary tract and of biliary dyspepsia
NZ239022A (en) Piperidyl ethers and thioethers; preparatory processes and pharmaceutical compositions
ZA899670B (en) Phosphonic acid substituted steroids as steroid 5-alpha-reductase inhibitors
DE3686022D1 (de) Monosaccharide enthaltende zusammensetzung zum heilen von wunden.
ZA886097B (en) Pharmaceutical composition for the treatment of psoriasis
SE8405588D0 (sv) New compounds
NZ223293A (en) Beta-alkyl melatonins and pharmaceutical compositions
EP0266993A3 (en) Method and therapeutic compositions for the treatment of bleeding disorders
EP0378824A3 (en) Use of omega-3-fatty acids as anticachexia agents
DK99987D0 (da) Oestrogenpraeparater
EP0256805A3 (fr) Compositions pharmaceutiques pour le traitement de maladies des systèmes vasculaires occlus
ES8504774A1 (es) Procedimiento para preparar derivados de 2-piperacinil-quinazolina
CA1268468C (fr) Analogues des prostaglandines avec groupement thiabicycloheptane substitue
NZ228023A (en) 24(r)-scymnol; preparatory processes and pharmaceutical compositions
IL86731A (en) Pharmaceutical compositions containing estradien-3-one derivatives and androst-2-ene-carbonitrile derivatives
JO1519B1 (en) New compounds (new benzimidazole derivatives are effective as ulcers)
CS330884A2 (en) Zpusob vyroby 2-alkythio-1-aminoalkyl-5-oxo-2-pyrrolin-3-karbonitrilu

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed