DK3697794T3 - Faste former af 3-(5-fluorbenzofuran-3-yl)-4-(5-methyl-5h-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dion - Google Patents

Faste former af 3-(5-fluorbenzofuran-3-yl)-4-(5-methyl-5h-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dion

Info

Publication number
DK3697794T3
DK3697794T3 DK18797367.2T DK18797367T DK3697794T3 DK 3697794 T3 DK3697794 T3 DK 3697794T3 DK 18797367 T DK18797367 T DK 18797367T DK 3697794 T3 DK3697794 T3 DK 3697794T3
Authority
DK
Denmark
Prior art keywords
fluorbenzofuran
dioxolo
dion
indol
pyrrole
Prior art date
Application number
DK18797367.2T
Other languages
Danish (da)
English (en)
Inventor
Yamin Zhang
Original Assignee
Actuate Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actuate Therapeutics Inc filed Critical Actuate Therapeutics Inc
Application granted granted Critical
Publication of DK3697794T3 publication Critical patent/DK3697794T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/056Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK18797367.2T 2017-10-16 2018-10-16 Faste former af 3-(5-fluorbenzofuran-3-yl)-4-(5-methyl-5h-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dion DK3697794T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762572603P 2017-10-16 2017-10-16
PCT/US2018/056083 WO2019079299A1 (en) 2017-10-16 2018-10-16 SOLID FORMS OF 3- (5-FLUOROBENZOFURAN-3-YL) -4- (5-METHYL-5H- [1,3] DIOXOLO [4,5-F] INDOL-7-YL) PYRROLE-2,5-DIONE

Publications (1)

Publication Number Publication Date
DK3697794T3 true DK3697794T3 (da) 2026-02-02

Family

ID=64110166

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18797367.2T DK3697794T3 (da) 2017-10-16 2018-10-16 Faste former af 3-(5-fluorbenzofuran-3-yl)-4-(5-methyl-5h-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dion

Country Status (16)

Country Link
US (3) US11407759B2 (https=)
EP (1) EP3697794B1 (https=)
JP (2) JP7776258B2 (https=)
KR (1) KR102891811B1 (https=)
CN (1) CN111315748B (https=)
AU (1) AU2018352384B2 (https=)
CA (1) CA3074037A1 (https=)
DK (1) DK3697794T3 (https=)
ES (1) ES3064009T3 (https=)
FI (1) FI3697794T3 (https=)
IL (1) IL273920B2 (https=)
MX (1) MX2020003431A (https=)
PL (1) PL3697794T3 (https=)
PT (1) PT3697794T (https=)
WO (1) WO2019079299A1 (https=)
ZA (1) ZA202002740B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3697794T3 (pl) * 2017-10-16 2026-04-07 Actuate Therapeutics Inc. Stałe postacie 3-(5-fluorobenzofuran-3-ylo)-4-(5-metylo-5h-[1,3]dioksolo[4,5-f]indol-7-ilo)pirolo-2,5-dionu
WO2019222483A1 (en) * 2018-05-17 2019-11-21 Board Of Regents, The University Of Texas System Treatment of idiopathic pulmonary fibrosis with glycogen synthase kinase 3 form beta inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2673368C (en) 2006-12-19 2014-10-28 The Board Of Trustees Of The University Of Illinois 3-benzofuranyl-4-indolyl maleimides as potent gsk3 inhibitors for neurogenerative disorders
EP3665176B1 (en) * 2017-08-11 2024-01-24 Actuate Therapeutics Inc. Solid forms of 3-(5-fluorobenzofuran-3-yl)-4-(5-methyl-5h[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione
PL3697794T3 (pl) * 2017-10-16 2026-04-07 Actuate Therapeutics Inc. Stałe postacie 3-(5-fluorobenzofuran-3-ylo)-4-(5-metylo-5h-[1,3]dioksolo[4,5-f]indol-7-ilo)pirolo-2,5-dionu

Also Published As

Publication number Publication date
JP2020536944A (ja) 2020-12-17
EP3697794B1 (en) 2025-12-24
IL273920A (en) 2020-05-31
MX2020003431A (es) 2020-07-29
PT3697794T (pt) 2026-03-04
PL3697794T3 (pl) 2026-04-07
IL273920B2 (en) 2025-07-01
US12116374B2 (en) 2024-10-15
ZA202002740B (en) 2025-12-17
JP2024001040A (ja) 2024-01-09
CN111315748B (zh) 2023-06-27
US20200239489A1 (en) 2020-07-30
US11407759B2 (en) 2022-08-09
ES3064009T3 (en) 2026-04-22
AU2018352384A1 (en) 2020-05-21
WO2019079299A1 (en) 2019-04-25
KR20200100615A (ko) 2020-08-26
EP3697794A1 (en) 2020-08-26
US20250115615A1 (en) 2025-04-10
CN111315748A (zh) 2020-06-19
IL273920B1 (en) 2025-03-01
CA3074037A1 (en) 2019-04-25
KR102891811B1 (ko) 2025-11-28
AU2018352384B2 (en) 2023-12-21
JP7776258B2 (ja) 2025-11-26
US20220348591A1 (en) 2022-11-03
BR112020007538A2 (pt) 2020-09-24
FI3697794T3 (fi) 2026-02-10

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