DK3656875T3 - Ikke-invasiv prænatal diagnostik - Google Patents

Ikke-invasiv prænatal diagnostik Download PDF

Info

Publication number
DK3656875T3
DK3656875T3 DK19202922.1T DK19202922T DK3656875T3 DK 3656875 T3 DK3656875 T3 DK 3656875T3 DK 19202922 T DK19202922 T DK 19202922T DK 3656875 T3 DK3656875 T3 DK 3656875T3
Authority
DK
Denmark
Prior art keywords
prenatal diagnosis
invasive prenatal
invasive
diagnosis
prenatal
Prior art date
Application number
DK19202922.1T
Other languages
English (en)
Inventor
Anupama Srinivasan
Darya I Chudova
Richard P Rava
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Application granted granted Critical
Publication of DK3656875T3 publication Critical patent/DK3656875T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/10Ploidy or copy number detection
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10Sequence alignment; Homology search
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/20Sequence assembly
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20Supervised data analysis
DK19202922.1T 2014-07-18 2015-07-17 Ikke-invasiv prænatal diagnostik DK3656875T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462026548P 2014-07-18 2014-07-18
EP15745053.7A EP3169803B1 (en) 2014-07-18 2015-07-17 Non-invasive prenatal diagnosis of fetal genetic condition using cellular dna and cell free dna

Publications (1)

Publication Number Publication Date
DK3656875T3 true DK3656875T3 (da) 2021-12-13

Family

ID=53765569

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19202922.1T DK3656875T3 (da) 2014-07-18 2015-07-17 Ikke-invasiv prænatal diagnostik

Country Status (6)

Country Link
US (7) US10119167B2 (da)
EP (3) EP3169803B1 (da)
AU (1) AU2015289414B2 (da)
CA (1) CA2955367C (da)
DK (1) DK3656875T3 (da)
WO (1) WO2016011414A1 (da)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
EP2572003A4 (en) 2010-05-18 2016-01-13 Natera Inc METHOD FOR NONINVASIVE PRANATAL PLOIDIE ASSIGNMENT
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
CN103608466B (zh) 2010-12-22 2020-09-18 纳特拉公司 非侵入性产前亲子鉴定方法
US20150065358A1 (en) * 2011-03-30 2015-03-05 Verinata Health, Inc. Method for verifying bioassay samples
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP2931919B1 (en) 2012-12-14 2019-02-20 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2014124338A1 (en) 2013-02-08 2014-08-14 10X Technologies, Inc. Polynucleotide barcode generation
US10395758B2 (en) 2013-08-30 2019-08-27 10X Genomics, Inc. Sequencing methods
US9824068B2 (en) 2013-12-16 2017-11-21 10X Genomics, Inc. Methods and apparatus for sorting data
CN106460070B (zh) 2014-04-21 2021-10-08 纳特拉公司 检测染色体片段中的突变和倍性
MX2016016713A (es) 2014-06-26 2017-05-23 10X Genomics Inc Procesos y sistemas para el montaje de secuencias de acido nucleico.
MX2016016902A (es) 2014-06-26 2017-03-27 10X Genomics Inc Metodos para analizar acidos nucleicos de celulas individuales o poblaciones de celulas.
US10119167B2 (en) 2014-07-18 2018-11-06 Illumina, Inc. Non-invasive prenatal diagnosis of fetal genetic condition using cellular DNA and cell free DNA
WO2016114970A1 (en) 2015-01-12 2016-07-21 10X Genomics, Inc. Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
KR20170106979A (ko) 2015-01-13 2017-09-22 10엑스 제노믹스, 인크. 구조 변이 및 위상 조정 정보를 시각화하기 위한 시스템 및 방법
AU2016219480B2 (en) 2015-02-09 2021-11-11 10X Genomics, Inc. Systems and methods for determining structural variation and phasing using variant call data
WO2016137973A1 (en) 2015-02-24 2016-09-01 10X Genomics Inc Partition processing methods and systems
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
US10395759B2 (en) 2015-05-18 2019-08-27 Regeneron Pharmaceuticals, Inc. Methods and systems for copy number variant detection
TW202300654A (zh) * 2015-09-22 2023-01-01 香港中文大學 藉由母體血漿dna之淺深度測序以準確定量胎兒dna含量
US11081208B2 (en) 2016-02-11 2021-08-03 10X Genomics, Inc. Systems, methods, and media for de novo assembly of whole genome sequence data
NZ745249A (en) * 2016-02-12 2021-07-30 Regeneron Pharma Methods and systems for detection of abnormal karyotypes
US20190085406A1 (en) * 2016-04-14 2019-03-21 Guardant Health, Inc. Methods for early detection of cancer
WO2017193044A1 (en) * 2016-05-06 2017-11-09 Counsyl, Inc. Noninvasive prenatal diagnostic
CN107663536B (zh) * 2016-07-27 2020-03-17 上海奥根诊断技术有限公司 一种cfDNA中超低频突变的检测方法
EP3510174A4 (en) * 2016-09-07 2020-02-19 Baylor College of Medicine CLINICAL APPLICATION OF ACELLULAR DNA ANALYSIS TECHNOLOGIES TO NON-INVASIVE PRENATAL DIAGNOSIS AND OTHER LIQUID BIOPSIES
US11485996B2 (en) 2016-10-04 2022-11-01 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
US10982351B2 (en) 2016-12-23 2021-04-20 Grail, Inc. Methods for high efficiency library preparation using double-stranded adapters
CN117512066A (zh) 2017-01-30 2024-02-06 10X基因组学有限公司 用于基于微滴的单细胞条形编码的方法和系统
WO2018156418A1 (en) 2017-02-21 2018-08-30 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
WO2018183918A1 (en) 2017-03-30 2018-10-04 Grail, Inc. Enhanced ligation in sequencing library preparation
US11118222B2 (en) 2017-03-31 2021-09-14 Grail, Inc. Higher target capture efficiency using probe extension
DK3385394T3 (da) 2017-04-07 2022-03-07 Inguran Llc Fremgangsmåder til genomisk vurdering hos husdyr
US11342047B2 (en) * 2017-04-21 2022-05-24 Illumina, Inc. Using cell-free DNA fragment size to detect tumor-associated variant
CN116064732A (zh) 2017-05-26 2023-05-05 10X基因组学有限公司 转座酶可接近性染色质的单细胞分析
US10844372B2 (en) 2017-05-26 2020-11-24 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
GB2564848A (en) * 2017-07-18 2019-01-30 Congenica Ltd Prenatal screening and diagnostic system and method
CN107217310A (zh) * 2017-08-01 2017-09-29 安诺优达基因科技(北京)有限公司 一种用于染色体异常检测的文库构建方法及试剂盒
CN109486923B (zh) * 2017-09-11 2022-02-18 广州永诺生物科技有限公司 多重扩增子测序用引物系统、其应用以及测序文库的构建方法
CN111051523B (zh) 2017-11-15 2024-03-19 10X基因组学有限公司 功能化凝胶珠
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
WO2019024341A1 (zh) * 2017-11-27 2019-02-07 深圳华大生命科学研究院 一种体液游离dna的文库构建方法及其应用
CN112262218A (zh) 2018-04-06 2021-01-22 10X基因组学有限公司 用于单细胞处理中的质量控制的系统和方法
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
CN113056563A (zh) * 2018-09-03 2021-06-29 拉莫特特拉维夫大学有限公司 识别血液中基因异常的方法及系统
CA3111813A1 (en) * 2018-09-07 2020-03-12 Illumina, Inc. A method to determine if a circulating fetal cell isolated from a pregnant mother is from either the current or a historical pregnancy
EP3899030A2 (en) * 2018-12-17 2021-10-27 Natera, Inc. Methods for analysis of circulating cells
AU2019403269A1 (en) 2018-12-18 2021-06-17 Grail, Llc Methods for detecting disease using analysis of RNA
CN110322963B (zh) * 2019-07-04 2024-01-30 成都新基因格生物科技有限公司 一种新生儿遗传代谢病检测分析方法、装置及系统
CN116323978A (zh) * 2020-10-20 2023-06-23 深圳华大基因股份有限公司 确定孕妇的孕期状态的方法
CN113073135B (zh) * 2021-03-30 2024-02-23 人和未来生物科技(长沙)有限公司 一种检测耳聋基因的参考品及其制备方法与应用
CN113684246A (zh) * 2021-08-06 2021-11-23 南方科技大学 高灵敏度、无需扩增的核酸检测方法及其应用
WO2023129936A1 (en) * 2021-12-29 2023-07-06 AiOnco, Inc. System and method for text-based biological information processing with analysis refinement
WO2023135487A2 (en) 2022-01-17 2023-07-20 Stephen Little Method for analyzing blood stored for later analysis of cell free dna
CN116179533A (zh) * 2022-09-05 2023-05-30 卡秋(江苏)生物科技有限公司 一种核酸提取纯化试剂盒及使用方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629147A (en) * 1992-07-17 1997-05-13 Aprogenex, Inc. Enriching and identifying fetal cells in maternal blood for in situ hybridization
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US8372584B2 (en) * 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
CA2668818C (en) 2006-10-10 2018-06-26 Xenomics, Inc. Compositions, methods and kits for isolating nucleic acids from body fluids using anion exchange media
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
CA2701726A1 (en) 2007-10-04 2009-04-09 Halcyon Molecular Sequencing nucleic acid polymers with electron microscopy
EP2229441B1 (en) 2007-12-12 2014-10-01 The Board of Trustees of The Leland Stanford Junior University Method and apparatus for magnetic separation of cells
US11634747B2 (en) 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
US8304187B2 (en) 2009-02-18 2012-11-06 Streck, Inc. Preservation of cell-free RNA in blood samples
US20130196862A1 (en) * 2009-07-17 2013-08-01 Natera, Inc. Informatics Enhanced Analysis of Fetal Samples Subject to Maternal Contamination
US10017812B2 (en) * 2010-05-18 2018-07-10 Natera, Inc. Methods for non-invasive prenatal ploidy calling
HRP20230134T1 (hr) * 2009-11-05 2023-03-31 The Chinese University Of Hong Kong Analiza genoma fetusa iz biološkog uzorka majke
EP2513341B1 (en) * 2010-01-19 2017-04-12 Verinata Health, Inc Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
US20110312503A1 (en) * 2010-01-23 2011-12-22 Artemis Health, Inc. Methods of fetal abnormality detection
EP2572003A4 (en) * 2010-05-18 2016-01-13 Natera Inc METHOD FOR NONINVASIVE PRANATAL PLOIDIE ASSIGNMENT
US11322224B2 (en) * 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
CN102409046B (zh) * 2010-09-21 2013-09-18 深圳华大基因科技服务有限公司 小分子rna标签
CN103608466B (zh) * 2010-12-22 2020-09-18 纳特拉公司 非侵入性产前亲子鉴定方法
CA2822439A1 (en) * 2010-12-23 2012-06-28 Sequenom, Inc. Fetal genetic variation detection
US20130122492A1 (en) * 2011-11-14 2013-05-16 Kellbenx Inc. Detection, isolation and analysis of rare cells in biological fluids
WO2013150503A1 (en) * 2012-04-06 2013-10-10 The Chinese University Of Hong Kong Noninvasive prenatal diagnosis of fetal trisomy by allelic ratio analysis using targeted massively parallel sequencing
US20130316347A1 (en) 2012-05-24 2013-11-28 Rarecells Sas Process for multi-analyses of rare cells extracted or isolated from biological samples through filtration
US20140093873A1 (en) 2012-07-13 2014-04-03 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US20140100126A1 (en) * 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
US9512422B2 (en) 2013-02-26 2016-12-06 Illumina, Inc. Gel patterned surfaces
US9193998B2 (en) 2013-03-15 2015-11-24 Illumina, Inc. Super resolution imaging
US10119167B2 (en) 2014-07-18 2018-11-06 Illumina, Inc. Non-invasive prenatal diagnosis of fetal genetic condition using cellular DNA and cell free DNA

Also Published As

Publication number Publication date
US20210032696A1 (en) 2021-02-04
WO2016011414A1 (en) 2016-01-21
US20180237852A1 (en) 2018-08-23
EP3656875A1 (en) 2020-05-27
US10119167B2 (en) 2018-11-06
US10837055B2 (en) 2020-11-17
US20190062832A1 (en) 2019-02-28
US9982295B2 (en) 2018-05-29
EP3169803B1 (en) 2019-11-20
US20160186253A1 (en) 2016-06-30
US20210108265A1 (en) 2021-04-15
CA2955367C (en) 2021-11-30
US10781485B2 (en) 2020-09-22
AU2015289414B2 (en) 2021-07-08
AU2015289414A1 (en) 2017-02-02
EP3940703A1 (en) 2022-01-19
CA2955367A1 (en) 2016-01-21
EP3656875B1 (en) 2021-09-22
US11519031B2 (en) 2022-12-06
US20160017412A1 (en) 2016-01-21
US11629378B2 (en) 2023-04-18
EP3169803A1 (en) 2017-05-24
US20230332225A1 (en) 2023-10-19

Similar Documents

Publication Publication Date Title
DK3656875T3 (da) Ikke-invasiv prænatal diagnostik
DE112015002825A5 (de) Nicht-invasive Stoffanalyse
FIC20240010I1 (fi) Sipaglukosidaasi alfa
DE112015001474A5 (de) Doppelkupplung
DK3094728T3 (da) Kiralt design
DK3175132T3 (da) Befæstelseselementer
MA55696A (fr) Combinaisons
DK3386954T3 (da) Dimere kontrastmidler
DE112015001577A5 (de) Doppelkupplung
DE112015001664A5 (de) Betätigungsaktuator
DE112015003929A5 (de) Doppelkupplung
FR3025617B1 (fr) Architecture bi-voies
DK3166473T3 (da) Oftalmoskoper
DK3154689T3 (da) Komplekser
SG10201404895XA (en) Diagnosis
DK3348191T3 (da) Kapnometer
DK3190964T3 (da) Spirometer
DK3154945T3 (da) Komplekser
FI20145972A (fi) Potkurisekoitin
DE102014000623A8 (de) Halbhohlnietelement
FI20145971A (fi) Potkurisekoitin
FI20145146A (fi) Laitteisto ketjukäyttöön
DK3412700T3 (da) Forbindelser
FI11194U1 (fi) Mittausjärjestely
DE112015003601A5 (de) Antriebsstrang