DK3649257T3 - Berigelse af målrettede genomiske regioner til multiplekset parallel analyse - Google Patents

Berigelse af målrettede genomiske regioner til multiplekset parallel analyse Download PDF

Info

Publication number
DK3649257T3
DK3649257T3 DK18745508.4T DK18745508T DK3649257T3 DK 3649257 T3 DK3649257 T3 DK 3649257T3 DK 18745508 T DK18745508 T DK 18745508T DK 3649257 T3 DK3649257 T3 DK 3649257T3
Authority
DK
Denmark
Prior art keywords
enrichment
genomic regions
parallel analysis
targeted genomic
multiplex parallel
Prior art date
Application number
DK18745508.4T
Other languages
English (en)
Inventor
George Koumbaris
Marios Ioannides
Elena KYPRI
Acilleas Achilleos
Petros MINA
Kyriakos Tsangaras
Philippos Patsalis
Original Assignee
Nipd Genetics Public Company Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nipd Genetics Public Company Ltd filed Critical Nipd Genetics Public Company Ltd
Application granted granted Critical
Publication of DK3649257T3 publication Critical patent/DK3649257T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G06F17/18—Complex mathematical operations for evaluating statistical data, e.g. average values, frequency distributions, probability functions, regression analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/185—Modifications characterised by incorporating bases where the precise position of the bases in the nucleic acid string is important
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/204—Modifications characterised by specific length of the oligonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122—Massive parallel sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/159—Reduction of complexity, e.g. amplification of subsets, removing duplicated genomic regions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Theoretical Computer Science (AREA)
  • Data Mining & Analysis (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Pure & Applied Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Mathematical Physics (AREA)
  • Computational Mathematics (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Informatics (AREA)
  • Algebra (AREA)
  • Databases & Information Systems (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Probability & Statistics with Applications (AREA)
DK18745508.4T 2017-07-07 2018-07-06 Berigelse af målrettede genomiske regioner til multiplekset parallel analyse DK3649257T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762529667P 2017-07-07 2017-07-07
PCT/EP2018/068402 WO2019008148A1 (en) 2017-07-07 2018-07-06 ENRICHMENT OF TARGETED GENOMIC REGIONS FOR MULTIPLEXED PARALLEL ANALYSIS

Publications (1)

Publication Number Publication Date
DK3649257T3 true DK3649257T3 (da) 2022-07-04

Family

ID=63012984

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18745508.4T DK3649257T3 (da) 2017-07-07 2018-07-06 Berigelse af målrettede genomiske regioner til multiplekset parallel analyse

Country Status (11)

Country Link
US (1) US20200157602A1 (da)
EP (1) EP3649257B1 (da)
AU (1) AU2018296568A1 (da)
CA (1) CA3068198A1 (da)
CY (1) CY1125226T1 (da)
DK (1) DK3649257T3 (da)
ES (1) ES2920280T3 (da)
PL (1) PL3649257T3 (da)
PT (1) PT3649257T (da)
WO (1) WO2019008148A1 (da)
ZA (1) ZA201908614B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3649259T3 (da) 2017-07-07 2022-08-15 Nipd Genetics Public Company Ltd Target-beriget multiplekset parallel analyse til vurdering af risiko for genetiske tilstande
AU2018298437A1 (en) 2017-07-07 2020-01-16 Medicover Public Co Ltd Target-enriched multiplexed parallel analysis for assessment of fetal DNA samples
CN113621692B (zh) * 2021-10-12 2022-02-22 北京求臻医疗器械有限公司 人类fgfr1基因拷贝数变异核酸标准物质及其制备方法、及试剂盒

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2429408T5 (es) 2006-02-02 2020-01-16 Univ Leland Stanford Junior Examen genético fetal no invasivo mediante análisis digital
US20080194414A1 (en) * 2006-04-24 2008-08-14 Albert Thomas J Enrichment and sequence analysis of genomic regions
WO2008027548A2 (en) * 2006-09-01 2008-03-06 Dana-Farber Cancer Institute, Inc. Microarray-based global chromatin structure mapping
EP3378951B1 (en) 2008-09-20 2020-05-13 The Board of Trustees of the Leland Stanford Junior University Noninvasive diagnosis of aneuploidy by sequencing
US20110039304A1 (en) * 2009-08-12 2011-02-17 President And Fellows Of Harvard College Methods to Generate Oligonucleotide Pools and Enrich Target Nucleic Acid Sequences
US20110160076A1 (en) * 2009-12-31 2011-06-30 Ventana Medical Systems, Inc. Methods for producing uniquely specific nucleic acid probes
US20120270739A1 (en) 2010-01-19 2012-10-25 Verinata Health, Inc. Method for sample analysis of aneuploidies in maternal samples
EP2366031B1 (en) 2010-01-19 2015-01-21 Verinata Health, Inc Sequencing methods in prenatal diagnoses
US20130123120A1 (en) * 2010-05-18 2013-05-16 Natera, Inc. Highly Multiplex PCR Methods and Compositions
EP3760731A1 (en) * 2011-02-09 2021-01-06 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20150203907A1 (en) * 2014-01-17 2015-07-23 Florida State University Research Foundation Genome capture and sequencing to determine genome-wide copy number variation
GB201414451D0 (en) * 2014-08-14 2014-10-01 Oxford Gene Technology Operations Ltd Hybridisation column for nucleic acid enrichment
WO2016040446A1 (en) * 2014-09-10 2016-03-17 Good Start Genetics, Inc. Methods for selectively suppressing non-target sequences
ES2790533T3 (es) 2015-05-22 2020-10-28 Nipd Genetics Public Company Ltd Análisis paralelo múltiplex de regiones genómicas blanco para análisis prenatales no invasivos

Also Published As

Publication number Publication date
PT3649257T (pt) 2022-05-19
US20200157602A1 (en) 2020-05-21
ES2920280T3 (es) 2022-08-02
PL3649257T3 (pl) 2022-07-18
EP3649257B1 (en) 2022-03-30
WO2019008148A9 (en) 2019-05-16
WO2019008148A1 (en) 2019-01-10
EP3649257A1 (en) 2020-05-13
ZA201908614B (en) 2022-07-27
CA3068198A1 (en) 2019-01-10
AU2018296568A1 (en) 2020-01-16
CY1125226T1 (el) 2024-09-20

Similar Documents

Publication Publication Date Title
DK3512959T3 (da) Fremgangsmåder til udførelse af multipleks PCR
DK3896171T3 (da) Fremgangsmåde for behandling af polynukleotider til analyse af individuelle celler
DK3445850T3 (da) Fremgangsmåder til tilvejebringelse af enkeltstrenget rna
DK3325664T3 (da) Analyse af fragmenteringsmønstre for cellefrit DNA
DK3901281T3 (da) Rumligt adskilt, multipleks nukleinsyreanalyse af biologiske prøver
DK3882357T3 (da) Fremgangsmåder og sammensætninger til analyse af nukleinsyrer
MA42847A (fr) Analyse de micro-moment
DK3110975T3 (da) Fremgangsmåder til analyse af somatiske mobile elementer og anvendelser deraf
DK3332034T3 (da) Systemer og fremgangsmåder til genomisk analyse
DK3194612T3 (da) Fremgangsmåder til kvantitativ genetisk analyse af cellefrit dna
DK2972353T3 (da) Forbedrede fremgangsmåder til udførelse af multipleksanalyser
DK3221457T3 (da) Fremgangsmåder og sammensætninger til targeteret genomisk modifikation ved anvendelse af parrede førings-rnaer
DK3256604T3 (da) Fremgangsmåder og sammensætninger til analyse af cellebestanddele
DK3374525T3 (da) Højeffektiv konstruktion af dna-biblioteker
DK3792378T3 (da) Fremgangsmåder og anordninger til analyse af partikler
DK3207373T3 (da) Fremgangsmåde til analyse af indholdet af dråber og tilhørende indretning
DK3666902T3 (da) Multiplex parallelanalyse af målrettede genomiske regioner til ikke-invasiv prænatal testning
DK3356386T3 (da) Fremgangsmåde til behandling af melanocortin-4 receptorbane-associerede lidelser
DK3822365T3 (da) Platform til opdagelse og analyse af terapeutiske midler
DK3455625T3 (da) Fremgangsmåder til forudsigelse af anvendeligheden af neo-antigener til immunterapi
DK3472338T3 (da) Midler og fremgangsmåder til at modifikation af flere alleler
DK3538891T3 (da) Sammensætninger og fremgangsmåder til samtidig genomisk, transkriptomisk og proteomisk analyse af enkeltceller
DK3366832T3 (da) Indretning til identifikation af stoftype
DK3515393T3 (da) Anordning til udførelse af vibrationstræning
DK3529262T3 (da) Fremgangsmåder til fremme af t-cellerespons