DK3585776T3 - 5-(pyrimidin-4-yl)-2-(pyrrolidin-1-yl)nicotinonitril-forbindelser som ikke, tbk1 og/eller sik2 kinaseinhibitorer - Google Patents

5-(pyrimidin-4-yl)-2-(pyrrolidin-1-yl)nicotinonitril-forbindelser som ikke, tbk1 og/eller sik2 kinaseinhibitorer Download PDF

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Publication number
DK3585776T3
DK3585776T3 DK18708187.2T DK18708187T DK3585776T3 DK 3585776 T3 DK3585776 T3 DK 3585776T3 DK 18708187 T DK18708187 T DK 18708187T DK 3585776 T3 DK3585776 T3 DK 3585776T3
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DK
Denmark
Prior art keywords
nicotinonitril
chinase
sik2
tbk1
pyrrolidin
Prior art date
Application number
DK18708187.2T
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English (en)
Inventor
Gary Karl Newton
Mark Richard Stewart
Original Assignee
Domainex Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of DK3585776T3 publication Critical patent/DK3585776T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK18708187.2T 2017-02-23 2018-02-23 5-(pyrimidin-4-yl)-2-(pyrrolidin-1-yl)nicotinonitril-forbindelser som ikke, tbk1 og/eller sik2 kinaseinhibitorer DK3585776T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1702947.1A GB201702947D0 (en) 2017-02-23 2017-02-23 Novel compounds
PCT/GB2018/050475 WO2018154315A1 (en) 2017-02-23 2018-02-23 5-(pyrimidin-4-yl)-2-(pyrrolidin-1-yl)nicotinonitrile compounds as ikke, tbk1 and/or sik2 kinases inhibitors

Publications (1)

Publication Number Publication Date
DK3585776T3 true DK3585776T3 (da) 2021-05-25

Family

ID=58544208

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18708187.2T DK3585776T3 (da) 2017-02-23 2018-02-23 5-(pyrimidin-4-yl)-2-(pyrrolidin-1-yl)nicotinonitril-forbindelser som ikke, tbk1 og/eller sik2 kinaseinhibitorer

Country Status (9)

Country Link
US (1) US11058686B2 (da)
EP (1) EP3585776B1 (da)
JP (1) JP7136793B2 (da)
AU (1) AU2018224359B2 (da)
CA (1) CA3054343A1 (da)
DK (1) DK3585776T3 (da)
ES (1) ES2879821T3 (da)
GB (1) GB201702947D0 (da)
WO (1) WO2018154315A1 (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115073425B (zh) * 2021-03-16 2023-11-14 中国科学院上海药物研究所 一类作为tbk1抑制剂的化合物、包含其的药物组合物及其用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012262A1 (en) 2003-07-30 2005-02-10 Cyclacel Limited 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors
US20080187575A1 (en) 2004-08-27 2008-08-07 Bert Klebl Pyrimidine Derivatives
PT2200436E (pt) 2007-09-04 2015-04-29 Scripps Research Inst Pirimidinilaminas substituídas como inibidoras da proteína quinase
MX2010008926A (es) 2008-02-15 2011-02-23 Rigel Pharmaceuticals Inc Compuestos de pirimidin-2-amina y su uso como inhibidores de jak cinasas.
US20100056524A1 (en) * 2008-04-02 2010-03-04 Mciver Edward Giles Compound
PA8852901A1 (es) * 2008-12-22 2010-07-27 Lilly Co Eli Inhibidores de proteina cinasa
MX2012004313A (es) 2009-10-12 2012-07-20 Myrexis Inc Compuestos de amino-pirimidina como inhibidores de cinasa 1 de union a tank (tbk1) y/o i-kappa-b-cinasa epsilon (ikk epsilon).
GB201012105D0 (en) * 2010-07-19 2010-09-01 Domainex Ltd Novel pyrimidine compounds
DE102011008352A1 (de) 2011-01-12 2012-07-12 Merck Patent Gmbh 5-([1,2,3]Triazol-4-yl)-7H-pyrrolo-[2,3-d]pyrimidinderivate
DE102011009961A1 (de) 2011-02-01 2012-08-02 Merck Patent Gmbh 7-Azaindolderivate
CN103732067A (zh) 2011-04-12 2014-04-16 美国阿尔茨海默病研究所公司 化合物，组合物及它们的治疗用途
LT2714677T (lt) 2011-05-23 2018-12-10 Merck Patent Gmbh Piridino ir pirazino dariniai
GB201114051D0 (en) 2011-08-15 2011-09-28 Domainex Ltd Compounds and their uses
DE102011112978A1 (de) 2011-09-09 2013-03-14 Merck Patent Gmbh Benzonitrilderivate
DE102011119127A1 (de) 2011-11-22 2013-05-23 Merck Patent Gmbh 3-Cyanaryl-1H-pyrrolo[2.3-b]pyridin-Derivate
CA2863985C (en) 2012-02-09 2020-08-11 Merck Patent Gmbh Furo [3,2-b] - and thieno [3,2-b] pyridine derivatives as tbk1 and ikk inhibitors
GB201303109D0 (en) * 2013-02-21 2013-04-10 Domainex Ltd Novel pyrimidine compounds

Also Published As

Publication number Publication date
EP3585776B1 (en) 2021-02-17
CA3054343A1 (en) 2018-08-30
EP3585776A1 (en) 2020-01-01
US20200030326A1 (en) 2020-01-30
AU2018224359B2 (en) 2022-03-31
ES2879821T3 (es) 2021-11-23
US11058686B2 (en) 2021-07-13
GB201702947D0 (en) 2017-04-12
JP7136793B2 (ja) 2022-09-13
WO2018154315A1 (en) 2018-08-30
JP2020508341A (ja) 2020-03-19
AU2018224359A1 (en) 2019-10-17

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