DK3548652T3 - Fremgangsmåder til proteinanalyse - Google Patents
Fremgangsmåder til proteinanalyse Download PDFInfo
- Publication number
- DK3548652T3 DK3548652T3 DK17877076.4T DK17877076T DK3548652T3 DK 3548652 T3 DK3548652 T3 DK 3548652T3 DK 17877076 T DK17877076 T DK 17877076T DK 3548652 T3 DK3548652 T3 DK 3548652T3
- Authority
- DK
- Denmark
- Prior art keywords
- methods
- protein analysis
- protein
- analysis
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662429063P | 2016-12-01 | 2016-12-01 | |
| US201762500455P | 2017-05-02 | 2017-05-02 | |
| PCT/US2017/064322 WO2018102759A1 (en) | 2016-12-01 | 2017-12-01 | Methods of assaying proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3548652T3 true DK3548652T3 (da) | 2024-07-08 |
Family
ID=62242782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17877076.4T DK3548652T3 (da) | 2016-12-01 | 2017-12-01 | Fremgangsmåder til proteinanalyse |
Country Status (6)
| Country | Link |
|---|---|
| US (13) | US10473654B1 (https=) |
| EP (3) | EP3548652B1 (https=) |
| JP (3) | JP2020514746A (https=) |
| CN (1) | CN110249082B (https=) |
| DK (1) | DK3548652T3 (https=) |
| WO (1) | WO2018102759A1 (https=) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| CA2839702C (en) | 2011-06-23 | 2021-04-20 | Board Of Regents, The University Of Texas System | Identifying peptides at the single molecule level |
| US11435358B2 (en) | 2011-06-23 | 2022-09-06 | Board Of Regents, The University Of Texas System | Single molecule peptide sequencing |
| CA3208970A1 (en) | 2014-09-15 | 2016-05-06 | Board Of Regents, The University Of Texas System | Improved single molecule peptide sequencing |
| EP3548652B1 (en) | 2016-12-01 | 2024-04-03 | Nautilus Subsidiary, Inc. | Methods of assaying proteins |
| CN111566261B (zh) | 2017-08-18 | 2025-03-25 | 诺迪勒思附属公司 | 选择结合试剂的方法 |
| US11721412B2 (en) | 2017-10-23 | 2023-08-08 | Nautilus Subsidiary, Inc. | Methods for identifying a protein in a sample of unknown proteins |
| WO2019083856A1 (en) * | 2017-10-23 | 2019-05-02 | Ignite Biosciences, Inc. | METHODS AND SYSTEMS FOR PROTEIN IDENTIFICATION |
| JP7390027B2 (ja) | 2017-10-31 | 2023-12-01 | エンコディア， インコーポレイテッド | 核酸エンコーディングおよび／または標識を使用する解析のためのキット |
| KR20250152680A (ko) | 2017-12-29 | 2025-10-23 | 노틸러스 서브시디어리, 인크. | 단백질 식별을 위한 디코딩 접근법 |
| EP3775196A4 (en) | 2018-04-04 | 2021-12-22 | Nautilus Biotechnology, Inc. | METHOD FOR GENERATING NANOARRAYS AND MICROARRAYS |
| CA3110800A1 (en) | 2018-07-12 | 2020-01-16 | Board Of Regents, The University Of Texas System | Molecular neighborhood detection by oligonucleotides |
| CN112805416B (zh) | 2018-08-23 | 2024-03-01 | 普诺森公司 | 用于检测和分析自由硫醇的系统和方法 |
| CA3117476A1 (en) | 2018-10-05 | 2020-04-09 | Board Of Regents, The University Of Texas System | Solid-phase n-terminal peptide capture and release |
| KR20260016611A (ko) | 2018-11-07 | 2026-02-03 | 시어 인코퍼레이티드 | 단백질 코로나 분석을 위한 조성물, 방법 및 시스템 및 그것들의 용도 |
| US11993865B2 (en) | 2018-11-20 | 2024-05-28 | Nautilus Subsidiary, Inc. | Selection of affinity reagents |
| JP7518852B2 (ja) | 2019-03-26 | 2024-07-18 | シアー， インコーポレイテッド | 生物流体からのタンパク質コロナ分析のための組成物、方法およびシステム、ならびにそれらの使用 |
| CA3135206A1 (en) | 2019-04-29 | 2020-11-05 | Pierre Indermuhle | Methods and systems for integrated on-chip single-molecule detection |
| WO2021087402A1 (en) | 2019-10-30 | 2021-05-06 | Nautilus Biotechnology, Inc. | Flow cell systems and methods |
| WO2021146219A1 (en) | 2020-01-13 | 2021-07-22 | Becton, Dickinson And Company | Cell capture using du-containing oligonucleotides |
| US20210246492A1 (en) * | 2020-02-12 | 2021-08-12 | Becton, Dickinson And Company | Intracellular abseq |
| CN111289425B (zh) * | 2020-03-12 | 2021-03-30 | 中国计量科学研究院 | 基于荧光标记流式单分子计数的蛋白质含量计量基准方法 |
| GB202004469D0 (en) | 2020-03-27 | 2020-05-13 | Olink Proteomics Ab | Controls for proximity detection assays |
| WO2021252800A1 (en) | 2020-06-11 | 2021-12-16 | Nautilus Biotechnology, Inc. | Methods and systems for computational decoding of biological, chemical, and physical entities |
| KR102576033B1 (ko) * | 2020-07-17 | 2023-09-11 | 주식회사 아론티어 | 3d-컨벌루션 뉴럴 네트워크의 앙상블을 이용한 단백질-리간드 결합 친화도 예측 방법 및 이를 위한 시스템 |
| IL300826A (en) | 2020-08-25 | 2023-04-01 | Seer Inc | Compositions and methods for testing proteins and nucleic acids |
| US11880345B2 (en) * | 2020-09-14 | 2024-01-23 | Tata Consultancy Services Limited | Method and system for generating annotations and field-names for relational schema |
| AU2021378290B2 (en) | 2020-11-11 | 2025-10-30 | Nautilus Subsidiary, Inc. | Affinity reagents having enhanced binding and detection characteristics |
| EP4281774B1 (en) | 2021-01-20 | 2025-11-26 | Nautilus Subsidiary, Inc. | Biomolecule quantitation |
| WO2022159663A1 (en) | 2021-01-21 | 2022-07-28 | Nautilus Biotechnology, Inc. | Systems and methods for biomolecule preparation |
| IL305336B2 (en) * | 2021-03-11 | 2025-09-01 | Nautilus Subsidiary Inc | Systems and methods for preserving biomolecules |
| US20220412998A1 (en) | 2021-06-24 | 2022-12-29 | Nautilus Biotechnology, Inc. | Methods and systems for assay refinement |
| CA3227872A1 (en) | 2021-09-09 | 2023-03-16 | James Henry JOLY | Characterization and localization of protein modifications |
| AU2022352593B2 (en) * | 2021-09-22 | 2026-03-26 | Nautilus Subsidiary, Inc. | Methods and systems for determining polypeptide interactions |
| EP4416731A1 (en) | 2021-10-11 | 2024-08-21 | Nautilus Subsidiary, Inc. | Highly multiplexable analysis of proteins and proteomes |
| WO2023081728A1 (en) | 2021-11-03 | 2023-05-11 | Nautilus Biotechnology, Inc. | Systems and methods for surface structuring |
| US12474346B2 (en) | 2021-11-05 | 2025-11-18 | Encodia, Inc. | Methods and kits for multicycle encoding assay |
| AU2022402132A1 (en) | 2021-11-30 | 2024-05-30 | Nautilus Subsidiary, Inc. | Particle-based isolation of proteins and other analytes |
| US20250067765A1 (en) | 2021-12-22 | 2025-02-27 | Nautilus Subsidiary, Inc. | Systems and methods for carrying out highly multiplexed bioanalyses |
| CN114388060B (zh) * | 2022-01-13 | 2023-06-20 | 西湖大学 | 基于圆形控制器的蛋白球形截面生成方法 |
| CN114388058A (zh) * | 2022-01-13 | 2022-04-22 | 西湖大学 | 基于九轴imu的蛋白任意截面生成方法 |
| US12092578B2 (en) | 2022-03-29 | 2024-09-17 | Nautilus Subsidiary, Inc. | Integrated arrays for single-analyte processes |
| EP4515026A1 (en) | 2022-04-25 | 2025-03-05 | Nautilus Subsidiary, Inc. | Systems and methods for assessing and improving the quality of multiplex molecular assays |
| US20250376716A1 (en) | 2022-06-21 | 2025-12-11 | Nautilus Subsidiary, Inc. | Method for detecting analytes at sites of optically non-resolvable distances |
| NL2032916B1 (en) | 2022-08-31 | 2024-03-15 | Univ Delft Tech | Single-molecule aptamer FRET for protein identification and structural analysis |
| WO2024058967A1 (en) | 2022-09-13 | 2024-03-21 | Nautilus Subsidiary, Inc. | Systems and methods of validating new affinity reagents |
| WO2024059655A1 (en) | 2022-09-15 | 2024-03-21 | Nautilus Subsidiary, Inc. | Characterizing accessibility of macromolecule structures |
| WO2024072614A1 (en) | 2022-09-27 | 2024-04-04 | Nautilus Subsidiary, Inc. | Polypeptide capture, in situ fragmentation and identification |
| WO2024073599A1 (en) | 2022-09-29 | 2024-04-04 | Nautilus Subsidiary, Inc. | Preparation of array surfaces for single-analyte processes |
| WO2024107857A1 (en) | 2022-11-15 | 2024-05-23 | Nautilus Subsidiary, Inc. | Standard polypeptides |
| US20240192202A1 (en) | 2022-12-09 | 2024-06-13 | Nautilus Subsidiary, Inc. | Fluidic media for single-analtye arrays |
| US20240201182A1 (en) | 2022-12-15 | 2024-06-20 | Nautilus Subsidiary, Inc. | Inhibition of photon phenomena on single molecule arrays |
| WO2024151373A1 (en) | 2023-01-12 | 2024-07-18 | Nautilus Subsidiary, Inc. | Characterization of glycans and glycoconjugates |
| EP4666071A2 (en) | 2023-02-13 | 2025-12-24 | Nautilus Subsidiary, Inc. | Affinity reagents having artificial polymer scaffolds |
| US20240301469A1 (en) | 2023-02-24 | 2024-09-12 | Nautilus Subsidiary, Inc. | Modifying, separating and detecting proteoforms |
| WO2024206122A1 (en) | 2023-03-24 | 2024-10-03 | Nautilus Subsidiary, Inc. | Improved transfer of nanoparticles to array surfaces |
| US20240353416A1 (en) | 2023-04-13 | 2024-10-24 | Nautilus Subsidiary, Inc. | Artificial proteins for displaying epitopes |
| WO2024243237A1 (en) | 2023-05-24 | 2024-11-28 | Nautilus Subsidiary, Inc. | Systems and methods for machine vision |
| AU2024305445A1 (en) | 2023-06-14 | 2026-01-08 | Nautilus Subsidiary, Inc. | Making and using structured nucleic acid particles |
| WO2024263696A1 (en) | 2023-06-21 | 2024-12-26 | Nautilus Subsidiary, Inc. | Compositions and methods for improving affinity reagent avidity |
| NL2035603B1 (en) | 2023-08-14 | 2025-02-25 | Univ Delft Tech | Proximity labelling and FRET-based protein fingerprinting |
| US20250066841A1 (en) | 2023-08-24 | 2025-02-27 | Nautilus Subsidiary, Inc. | Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions |
| US20250189519A1 (en) | 2023-12-11 | 2025-06-12 | Nautilus Subsidiary, Inc. | Methods and compositions of particle-based arrays |
| US20250205706A1 (en) | 2023-12-20 | 2025-06-26 | Nautilus Subsidiary, Inc. | Fluidic devices for single-analyte assays |
| US20250298016A1 (en) | 2024-03-22 | 2025-09-25 | Nautilus Subsidiary, Inc. | Plasmonic particle systems for single-analyte assays |
| US20250305034A1 (en) | 2024-04-01 | 2025-10-02 | Nautilus Subsidiary, Inc. | Nanostructures for modulation of analyte conformation |
| WO2025212417A1 (en) | 2024-04-01 | 2025-10-09 | Nautilus Subsidiary, Inc. | Single molecule-resolved characterization of affinity reagent kinetics and thermodynamics |
| WO2025240266A1 (en) | 2024-05-14 | 2025-11-20 | Nautilus Subsidiary, Inc. | Time-dependent profiling of binding interactions |
| WO2025255117A1 (en) | 2024-06-06 | 2025-12-11 | Nautilus Subsidiary, Inc. | Analyte characterization by differential binding of binding reagents |
| US20260049981A1 (en) | 2024-06-27 | 2026-02-19 | Nautilus Subsidiary, Inc. | Enrichment of particle reagents for array-based assays |
| US20260029416A1 (en) | 2024-07-26 | 2026-01-29 | Nautilus Subsidiary, Inc. | Systems, methods and compositions for analysis of proteoforms |
| WO2026072625A1 (en) | 2024-09-27 | 2026-04-02 | Nautilus Subsidiary, Inc. | Single analyte characterization under equilibrium binding conditions |
| US20260110691A1 (en) | 2024-10-17 | 2026-04-23 | Nautilus Subsidiary, Inc. | Analyte characterization via iterative analysis |
Family Cites Families (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1017524A (en) | 1911-05-01 | 1912-02-13 | Robert George Ferguson | Flush-tank. |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5635602A (en) | 1993-08-13 | 1997-06-03 | The Regents Of The University Of California | Design and synthesis of bispecific DNA-antibody conjugates |
| US6682886B1 (en) | 1994-04-28 | 2004-01-27 | Gilead Sciences, Inc. | Bivalent binding molecules of 7 transmembrane G protein-coupled receptors |
| SE9601676D0 (sv) | 1996-04-30 | 1996-04-30 | Ulf Landegren | Improved probing of specific mucleic acids |
| US6762056B1 (en) | 1997-11-12 | 2004-07-13 | Protiveris, Inc. | Rapid method for determining potential binding sites of a protein |
| US20070166741A1 (en) | 1998-12-14 | 2007-07-19 | Somalogic, Incorporated | Multiplexed analyses of test samples |
| US20060057573A1 (en) * | 2002-02-15 | 2006-03-16 | Somalogic, Inc | Methods and reagents for detecting target binding by nucleic acid ligands |
| US6489608B1 (en) | 1999-04-06 | 2002-12-03 | Micromass Limited | Method of determining peptide sequences by mass spectrometry |
| WO2000073787A1 (en) | 1999-05-27 | 2000-12-07 | Rockefeller University | An expert system for protein identification using mass spectrometric information combined with database searching |
| CA2393658A1 (en) | 1999-12-23 | 2001-06-28 | Illumina, Inc. | Decoding of array sensors with microspheres |
| US7306904B2 (en) | 2000-02-18 | 2007-12-11 | Olink Ab | Methods and kits for proximity probing |
| GB0022978D0 (en) * | 2000-09-19 | 2000-11-01 | Oxford Glycosciences Uk Ltd | Detection of peptides |
| WO2002071067A1 (en) * | 2001-03-07 | 2002-09-12 | Bio-Rad Laboratories, Inc. | Assay system for simultaneous detection and measurement of multiple modified cellular proteins |
| AU2001245011B2 (en) | 2001-03-10 | 2007-09-20 | Kent Ridge Digital Labs | System and method for systematic prediction of ligand/receptor activity |
| WO2002086081A2 (en) * | 2001-04-20 | 2002-10-31 | Carnegie Mellon University | Methods and systems for identifying proteins |
| US6720595B2 (en) | 2001-08-06 | 2004-04-13 | International Business Machines Corporation | Three-dimensional island pixel photo-sensor |
| JP2005509444A (ja) | 2001-11-23 | 2005-04-14 | シモン・フレデリックソン | 多価近接プローブにより近接プロービングするための方法およびキット |
| WO2003046144A2 (en) | 2001-11-26 | 2003-06-05 | Molecular Reflections, Inc. | Microscale immobilization of molecules using a hydrogel and methods of use thereof |
| US20040067599A1 (en) * | 2001-12-14 | 2004-04-08 | Katz Joseph L. | Separation identification and quantitation of protein mixtures |
| WO2003083441A2 (en) | 2002-03-29 | 2003-10-09 | Buck Institute | Identification of apoptotic peptides and methods of use thereof |
| US6998241B2 (en) | 2002-09-11 | 2006-02-14 | Kimberly-Clark Worldwide, Inc. | Antibody pair screening methods |
| CA2502246A1 (en) * | 2002-10-15 | 2004-04-29 | Abmetrix, Inc. | Sets of digital antibodies directed against short epitopes, and methods using same |
| CN101410530B (zh) | 2003-04-18 | 2013-03-27 | 贝克顿·迪金森公司 | 免疫-扩增 |
| US20040265938A1 (en) | 2003-06-25 | 2004-12-30 | Jose Remacle | Method for the determination of cell activation |
| JP3788513B2 (ja) * | 2003-09-11 | 2006-06-21 | セイコーエプソン株式会社 | 固相基板上への分子の固定化方法およびそれを用いるバイオセンサの製造方法 |
| US7593817B2 (en) | 2003-12-16 | 2009-09-22 | Thermo Finnigan Llc | Calculating confidence levels for peptide and protein identification |
| US20050148100A1 (en) * | 2003-12-30 | 2005-07-07 | Intel Corporation | Methods and devices for using Raman-active probe constructs to assay biological samples |
| US20060160234A1 (en) * | 2005-01-18 | 2006-07-20 | Viorica Lopez-Avila | Methods for assessing polypeptide array quality |
| EP1866326A4 (en) | 2005-03-17 | 2010-06-16 | Primex Clinical Lab Inc | IMMUNOGENES FOR VACCINES AGAINST ANTIGENVARIABLE PATHOGENES AND DISEASES |
| EP1880206B1 (en) | 2005-05-09 | 2012-11-14 | Affymetrix, Inc. | Multiplex capture of nucleic acids |
| EP1907410B1 (en) | 2005-06-10 | 2012-07-04 | Saint Louis University | Methods for the selection of aptamers |
| US7842793B2 (en) | 2005-06-14 | 2010-11-30 | The California Institute Of Technology | Methods of making nucleic acid nanostructures |
| EP3257949A1 (en) * | 2005-06-15 | 2017-12-20 | Complete Genomics Inc. | Nucleic acid analysis by random mixtures of non-overlapping fragments |
| JP4724816B2 (ja) * | 2005-09-06 | 2011-07-13 | シャープ株式会社 | タンパク質の測定方法 |
| US7955837B2 (en) | 2005-10-29 | 2011-06-07 | Bayer Technology Services Gmbh | Process for determining one or more analytes in samples of biological origin having complex composition, and use thereof |
| WO2007120208A2 (en) | 2005-11-14 | 2007-10-25 | President And Fellows Of Harvard College | Nanogrid rolling circle dna sequencing |
| US20070218503A1 (en) | 2006-02-13 | 2007-09-20 | Mitra Robi D | Methods of polypeptide identification, and compositions therefor |
| US7692783B2 (en) | 2006-02-13 | 2010-04-06 | Pacific Biosciences Of California | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
| US8492098B2 (en) | 2006-02-21 | 2013-07-23 | The Trustees Of Tufts College | Methods and arrays for target analyte detection and determination of reaction components that affect a reaction |
| GB0605584D0 (en) | 2006-03-20 | 2006-04-26 | Olink Ab | Method for analyte detection using proximity probes |
| WO2007117444A2 (en) | 2006-03-31 | 2007-10-18 | Yinghe Hu | Protein detection by aptamers |
| CN100500865C (zh) | 2006-04-21 | 2009-06-17 | 华东师范大学 | 一种通过同时识别多个表位来检测CatD蛋白的方法 |
| US7855054B2 (en) | 2007-01-16 | 2010-12-21 | Somalogic, Inc. | Multiplexed analyses of test samples |
| US7947447B2 (en) | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US8975026B2 (en) | 2007-01-16 | 2015-03-10 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US20110136099A1 (en) | 2007-01-16 | 2011-06-09 | Somalogic, Inc. | Multiplexed Analyses of Test Samples |
| US7964356B2 (en) | 2007-01-16 | 2011-06-21 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| CA2687292C (en) | 2007-04-10 | 2017-07-04 | Nanostring Technologies, Inc. | Methods and computer systems for identifying target-specific sequences for use in nanoreporters |
| US8404830B2 (en) | 2007-07-17 | 2013-03-26 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| AU2009234373B2 (en) | 2008-04-09 | 2015-09-24 | Cornell University | Coferons and methods of making and using them |
| US9102520B2 (en) | 2008-08-13 | 2015-08-11 | California Institute Of Technology | Nanocomposite structures and related methods and systems |
| US8222047B2 (en) | 2008-09-23 | 2012-07-17 | Quanterix Corporation | Ultra-sensitive detection of molecules on single molecule arrays |
| WO2010065531A1 (en) * | 2008-12-01 | 2010-06-10 | Robi David Mitra | Single molecule protein screening |
| WO2010111674A2 (en) | 2009-03-27 | 2010-09-30 | Life Technologies Corporation | Methods and apparatus for single molecule sequencing using energy transfer detection |
| US9532956B2 (en) | 2009-04-18 | 2017-01-03 | Massachusetts Institute Of Technology | PH sensitive biodegradable polymeric particles for drug delivery |
| EP2524054A2 (en) | 2010-01-14 | 2012-11-21 | Haplomics, Inc. | Predicting and reducing alloimmunogenicity of protein therapeutics |
| US8236574B2 (en) | 2010-03-01 | 2012-08-07 | Quanterix Corporation | Ultra-sensitive detection of molecules or particles using beads or other capture objects |
| US8415171B2 (en) | 2010-03-01 | 2013-04-09 | Quanterix Corporation | Methods and systems for extending dynamic range in assays for the detection of molecules or particles |
| US9678068B2 (en) | 2010-03-01 | 2017-06-13 | Quanterix Corporation | Ultra-sensitive detection of molecules using dual detection methods |
| JP5901610B2 (ja) | 2010-04-12 | 2016-04-13 | ソマロジック・インコーポレーテッド | ５位修飾ピリミジンとその使用 |
| US8774494B2 (en) * | 2010-04-30 | 2014-07-08 | Complete Genomics, Inc. | Method and system for accurate alignment and registration of array for DNA sequencing |
| US9523680B2 (en) | 2010-06-30 | 2016-12-20 | Ambergen, Inc. | Global Proteomic screening of random bead arrays using mass spectrometry imaging |
| CN102618940A (zh) | 2011-01-31 | 2012-08-01 | 艾比玛特生物医药（上海）有限公司 | 抗体制备方法及所得抗体和抗体库 |
| GB201101621D0 (en) | 2011-01-31 | 2011-03-16 | Olink Ab | Method and product |
| US20130053541A1 (en) | 2011-03-11 | 2013-02-28 | Lynntech, Inc. | Methods for discovering molecules that bind to proteins |
| CA2839702C (en) | 2011-06-23 | 2021-04-20 | Board Of Regents, The University Of Texas System | Identifying peptides at the single molecule level |
| JP6587934B2 (ja) | 2012-03-28 | 2019-10-09 | ソマロジック・インコーポレーテッド | Ｐｄｇｆおよびｖｅｇｆ結合アプタマー、および、ｐｄｇｆおよびｖｅｇｆが介在する病気の治療へのそれらの使用 |
| NL2009191C2 (en) | 2012-07-16 | 2014-01-20 | Univ Delft Tech | Single molecule protein sequencing. |
| AU2013344340B2 (en) | 2012-11-19 | 2019-09-19 | Pacific Biosciences Of California, Inc. | Digital analysis of molecular analytes using single molecule detection |
| US10829816B2 (en) | 2012-11-19 | 2020-11-10 | Apton Biosystems, Inc. | Methods of analyte detection |
| JP2016521134A (ja) * | 2013-05-16 | 2016-07-21 | バセトラ メディカル テクノロジー カンパニー リミテッド | 母体血から捕捉する胎児細胞を使用する胎児診断 |
| US9368187B2 (en) * | 2013-07-11 | 2016-06-14 | Qualcomm Incorporated | Insertion-override counter to support multiple memory refresh rates |
| KR102348283B1 (ko) | 2013-09-24 | 2022-01-10 | 소마로직, 인크. | 멀티앱타머 표적 검출 |
| KR102290214B1 (ko) | 2013-11-21 | 2021-08-18 | 소마로직, 인크. | 시티딘-5-카르복스아미드 변형된 뉴클레오티드 조성물 및 그와 관련된 방법들 |
| EP3087083B1 (en) | 2013-12-27 | 2019-10-16 | F.Hoffmann-La Roche Ag | Systemic discovery, maturation and extension of peptide binders to proteins |
| CA3208970A1 (en) | 2014-09-15 | 2016-05-06 | Board Of Regents, The University Of Texas System | Improved single molecule peptide sequencing |
| EP3009520B1 (en) | 2014-10-14 | 2018-12-12 | Karlsruher Institut für Technologie | Site-specific immobilization of DNA origami structures on solid substrates |
| EP3274473B1 (en) | 2015-03-24 | 2020-10-28 | Pacific Biosciences of California, Inc. | Methods and compositions for single molecule composition loading |
| US9881786B2 (en) | 2015-04-02 | 2018-01-30 | Micron Technology, Inc. | Methods of forming nanostructures using self-assembled nucleic acids, and nanostructures thereof |
| WO2016174525A1 (en) | 2015-04-29 | 2016-11-03 | Biosims Technologies | Enhanced sensitivity in ligand binding assays performed with secondary ion mass spectrometry |
| EP3298135B1 (en) | 2015-05-18 | 2023-06-07 | The Regents of the University of California | Systems and methods for predicting glycosylation on proteins |
| WO2017127762A1 (en) | 2016-01-20 | 2017-07-27 | Vitrisa Therapeutics, Inc. | Methods for improved aptamer selection |
| EP3452591B1 (en) | 2016-05-02 | 2023-08-16 | Encodia, Inc. | Macromolecule analysis employing nucleic acid encoding |
| EP3548652B1 (en) | 2016-12-01 | 2024-04-03 | Nautilus Subsidiary, Inc. | Methods of assaying proteins |
| CN111566261B (zh) | 2017-08-18 | 2025-03-25 | 诺迪勒思附属公司 | 选择结合试剂的方法 |
| US11125748B2 (en) | 2017-09-01 | 2021-09-21 | University Of British Columbia | Method for organizing individual molecules on a patterned substrate and structures assembled thereby |
| US11391734B2 (en) | 2017-09-25 | 2022-07-19 | California Institute Of Technology | Surface-immobilized bistable polynucleotide devices for the sensing and quantification of molecular events |
| WO2019083856A1 (en) | 2017-10-23 | 2019-05-02 | Ignite Biosciences, Inc. | METHODS AND SYSTEMS FOR PROTEIN IDENTIFICATION |
| US11721412B2 (en) | 2017-10-23 | 2023-08-08 | Nautilus Subsidiary, Inc. | Methods for identifying a protein in a sample of unknown proteins |
| JP7390027B2 (ja) | 2017-10-31 | 2023-12-01 | エンコディア， インコーポレイテッド | 核酸エンコーディングおよび／または標識を使用する解析のためのキット |
| CA3081446A1 (en) | 2017-10-31 | 2019-05-09 | Encodia, Inc. | Methods and compositions for polypeptide analysis |
| SG11202003923PA (en) | 2017-10-31 | 2020-05-28 | Encodia Inc | Methods and kits using nucleic acid encoding and/or label |
| KR20250152680A (ko) | 2017-12-29 | 2025-10-23 | 노틸러스 서브시디어리, 인크. | 단백질 식별을 위한 디코딩 접근법 |
| EP3775196A4 (en) | 2018-04-04 | 2021-12-22 | Nautilus Biotechnology, Inc. | METHOD FOR GENERATING NANOARRAYS AND MICROARRAYS |
| US20210239705A1 (en) | 2018-06-06 | 2021-08-05 | Nautilus Biotechnology, Inc. | Methods and applications of protein identification |
| US11993865B2 (en) | 2018-11-20 | 2024-05-28 | Nautilus Subsidiary, Inc. | Selection of affinity reagents |
| CA3135206A1 (en) | 2019-04-29 | 2020-11-05 | Pierre Indermuhle | Methods and systems for integrated on-chip single-molecule detection |
| WO2021003470A1 (en) | 2019-07-03 | 2021-01-07 | Nautilus Biotechnology, Inc. | Decoding approaches for protein and peptide identification |
| WO2021087402A1 (en) | 2019-10-30 | 2021-05-06 | Nautilus Biotechnology, Inc. | Flow cell systems and methods |
| WO2021252800A1 (en) | 2020-06-11 | 2021-12-16 | Nautilus Biotechnology, Inc. | Methods and systems for computational decoding of biological, chemical, and physical entities |
| EP4281774B1 (en) | 2021-01-20 | 2025-11-26 | Nautilus Subsidiary, Inc. | Biomolecule quantitation |
-
2017
- 2017-12-01 EP EP17877076.4A patent/EP3548652B1/en active Active
- 2017-12-01 CN CN201780085386.2A patent/CN110249082B/zh active Active
- 2017-12-01 EP EP25189727.8A patent/EP4614155A3/en active Pending
- 2017-12-01 DK DK17877076.4T patent/DK3548652T3/da active
- 2017-12-01 JP JP2019550552A patent/JP2020514746A/ja active Pending
- 2017-12-01 EP EP24163221.5A patent/EP4365597B1/en active Active
- 2017-12-01 WO PCT/US2017/064322 patent/WO2018102759A1/en not_active Ceased
-
2019
- 2019-05-30 US US16/426,917 patent/US10473654B1/en active Active
- 2019-10-21 US US16/659,132 patent/US10948488B2/en active Active
-
2020
- 2020-02-12 US US16/788,536 patent/US10921317B2/en active Active
-
2021
- 2021-01-20 US US17/153,877 patent/US11754559B2/en active Active
- 2021-03-03 US US17/191,632 patent/US11579144B2/en active Active
- 2021-07-30 US US17/390,666 patent/US11549942B2/en active Active
- 2021-11-23 US US17/534,405 patent/US11448647B2/en active Active
-
2022
- 2022-09-16 US US17/933,051 patent/US20230019467A1/en active Pending
- 2022-12-23 JP JP2022206984A patent/JP2023030135A/ja active Pending
-
2023
- 2023-01-06 US US18/151,256 patent/US11768201B1/en active Active
-
2024
- 2024-08-30 JP JP2024150202A patent/JP2024170480A/ja active Pending
-
2025
- 2025-06-17 US US19/240,418 patent/US20250369984A1/en active Pending
- 2025-08-28 US US19/313,676 patent/US20250383361A1/en active Pending
- 2025-09-09 US US19/323,753 patent/US20250389716A1/en active Pending
- 2025-09-18 US US19/332,786 patent/US20260056194A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3548652T3 (da) | Fremgangsmåder til proteinanalyse | |
| EP3428031C0 (en) | DRIVER ASSISTANCE DESIGN ANALYSIS SYSTEM | |
| DK3538864T3 (da) | Mikrotom | |
| EP3472757C0 (en) | COMPUTERIZED MICROEXPRESSION ANALYSIS | |
| IL254516A0 (en) | Proteins specific for cd137 | |
| EP3372985C0 (en) | ANALYSIS DEVICE | |
| DK3384274T3 (da) | Fremgangsmåder til prøvekarakterisering | |
| IL299926A (en) | Neoantigens and methods of their use | |
| EP3725893C0 (en) | COMPOSITIONS FOR THE ANALYSIS OF CELLULAR COMPONENTS | |
| LT3334841T (lt) | Nukleorūgščių tyrimo būdai | |
| DK3313876T3 (da) | Multispecifikke antigenbindende proteiner | |
| DK3140653T3 (da) | Direkte immunhistokemianalyse | |
| DK3227336T3 (da) | Anti-CD79b-antistoffer og fremgangsmåder til anvendelse | |
| DK3266792T3 (da) | Fremgangsmåde til peptidsyntese | |
| DK3160994T3 (da) | Multispecifikke antigenbindende proteiner | |
| DK3072835T3 (da) | Fremgangsmåde til fremføring | |
| EP3108229C0 (en) | NANOPORES-BASED ANALYSIS OF PROTEIN CHARACTERISTICS | |
| EP3415921A4 (en) | AUTOMATED ANALYZER | |
| EP2998732C0 (en) | ANALYSIS PROCESS | |
| EP3557264A4 (en) | AUTOMATIC ANALYZER | |
| EP3551764A4 (en) | ELECTROPHEROGRAM ANALYSIS | |
| EP3438670A4 (en) | AUTOMATED ANALYZER | |
| DK3099791T3 (da) | Protein | |
| EP3312614C0 (en) | SAMPLE ANALYZER | |
| DK3340796T3 (da) | Sonder til afbildning af huntingtin-protein |