DK351280A - Allysulfoxid-enzyminhibitor og fremgangsmaade til fremstilling deraf - Google Patents

Allysulfoxid-enzyminhibitor og fremgangsmaade til fremstilling deraf

Info

Publication number
DK351280A
DK351280A DK351280A DK351280A DK351280A DK 351280 A DK351280 A DK 351280A DK 351280 A DK351280 A DK 351280A DK 351280 A DK351280 A DK 351280A DK 351280 A DK351280 A DK 351280A
Authority
DK
Denmark
Prior art keywords
enzymin
allysulfoxide
inhibitor
preparing
deesterification
Prior art date
Application number
DK351280A
Other languages
English (en)
Inventor
R A Firestone
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK351280A publication Critical patent/DK351280A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polymerisation Methods In General (AREA)
  • Cephalosporin Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK351280A 1979-08-15 1980-08-14 Allysulfoxid-enzyminhibitor og fremgangsmaade til fremstilling deraf DK351280A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6660379A 1979-08-15 1979-08-15

Publications (1)

Publication Number Publication Date
DK351280A true DK351280A (da) 1981-02-16

Family

ID=22070551

Family Applications (4)

Application Number Title Priority Date Filing Date
DK351080A DK351080A (da) 1979-08-15 1980-08-14 Allylsulfoxidenzym-inhibitor og fremgangsmaade til fremstilling deraf
DK351180A DK351180A (da) 1979-08-15 1980-08-14 Allylsulfoxid-enzyminhibitor og fremgangsmaade til fremstilling deraf
DK351280A DK351280A (da) 1979-08-15 1980-08-14 Allysulfoxid-enzyminhibitor og fremgangsmaade til fremstilling deraf
DK350980A DK350980A (da) 1979-08-15 1980-08-14 Allylsulfoxid-enzyminhibitor og fremgangsmaade til fremstilling deraf

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK351080A DK351080A (da) 1979-08-15 1980-08-14 Allylsulfoxidenzym-inhibitor og fremgangsmaade til fremstilling deraf
DK351180A DK351180A (da) 1979-08-15 1980-08-14 Allylsulfoxid-enzyminhibitor og fremgangsmaade til fremstilling deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK350980A DK350980A (da) 1979-08-15 1980-08-14 Allylsulfoxid-enzyminhibitor og fremgangsmaade til fremstilling deraf

Country Status (9)

Country Link
EP (4) EP0026307B1 (da)
JP (4) JPS5643260A (da)
AT (4) ATE3545T1 (da)
DE (4) DE3068110D1 (da)
DK (4) DK351080A (da)
ES (4) ES8106282A1 (da)
GR (4) GR69834B (da)
IE (4) IE50225B1 (da)
PT (4) PT71653B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2457296A1 (fr) * 1979-05-23 1980-12-19 Rhone Poulenc Ind Nouveaux derives de vinyl-3 cephalosporines et leur preparation
US4553191A (en) * 1982-12-03 1985-11-12 Xerox Corporation Static eliminator
US4609744A (en) * 1983-04-21 1986-09-02 Merck Frosst Canada Inc. 4-oxo-benzopyran carboxylic acids
DE3469169D1 (en) * 1983-04-21 1988-03-10 Merck Frosst Canada Inc Leukotriene antagonists, their production and use and compositions containing them
FR2661909B1 (fr) * 1990-05-09 1997-08-14 Inst Nat Sante Rech Med Nouveaux composes agonistes du recepteur h3 de l'histamine a usage therapeutique, compositions pharmaceutiques agissant comme agonistes dudit recepteur et procede de preparation.
US5744485A (en) * 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
US6599938B1 (en) * 1999-10-29 2003-07-29 The Picower Institute Of Medical Research Compounds having MIF antagonist activity
JP5733856B2 (ja) 2007-10-09 2015-06-10 ソファーミア，インコーポレイテッド 広帯域β−ラクタマーゼ阻害薬
ES2700575T3 (es) 2013-03-12 2019-02-18 Gladius Pharmaceuticals Corp 3-Estiril-cefalosporinas derivadas

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3419606A (en) * 1964-05-13 1968-12-31 Merck & Co Inc 4-(2-methylenealkanoyl)phenylsulfinyl alkanoic acids
CH496639A (fr) * 1968-01-05 1970-09-30 Pfizer & Co C Procédé de préparation des aryl halogénocarbonyl cétènes
CH568708A5 (da) * 1969-04-30 1975-11-14 Hoffmann La Roche
GB1357154A (en) * 1970-09-25 1974-06-19 Shell Int Research Alkylthio-nitro-aniline compounds and herbicidal 'ompositions containing them
GB1463077A (en) * 1973-04-19 1977-02-02 Glaxo Lab Ltd 7-substituted-ethyl-cephalosporin derivatives
US4049806A (en) * 1975-08-15 1977-09-20 Syntex (U.S.A.) Inc. Cephalosporin type antibacterials
JPS5253890A (en) * 1975-10-14 1977-04-30 Syntex Inc Production of cephalosporin type compound
US4155907A (en) * 1976-08-16 1979-05-22 The Dow Chemical Company Method for inhibiting ADP-induced platelet aggregation using phenylthioalkylamines
JPS5350326A (en) * 1976-10-18 1978-05-08 Kao Corp Herbicides
AU4091178A (en) * 1977-10-25 1980-04-24 Merck & Co Inc Substituted mercapto acid amides

Also Published As

Publication number Publication date
PT71654A (en) 1980-09-01
JPS5643260A (en) 1981-04-21
ES494304A0 (es) 1981-08-01
EP0026307B1 (en) 1983-11-23
ATE3545T1 (de) 1983-06-15
PT71652A (en) 1980-09-01
PT71654B (en) 1982-01-22
ES8106283A1 (es) 1981-08-01
ES494302A0 (es) 1981-08-01
PT71653A (en) 1980-09-01
ES8106285A1 (es) 1981-08-01
DK351080A (da) 1981-02-16
PT71651A (en) 1980-09-01
EP0024347B1 (en) 1983-05-25
DE3065684D1 (en) 1983-12-29
ES8106284A1 (es) 1981-08-01
IE50225B1 (en) 1986-03-05
EP0026307A1 (en) 1981-04-08
EP0024639A1 (en) 1981-03-11
ES494305A0 (es) 1981-08-01
IE801708L (en) 1981-02-15
IE50152B1 (en) 1986-02-19
DE3068110D1 (en) 1984-07-12
EP0025857B1 (en) 1983-07-27
EP0024639B1 (en) 1984-06-06
JPS5663989A (en) 1981-05-30
PT71651B (en) 1982-01-21
IE50150B1 (en) 1986-02-19
ES8106282A1 (es) 1981-08-01
PT71652B (en) 1982-01-21
PT71653B (en) 1982-01-21
GR69833B (da) 1982-07-19
IE801707L (en) 1981-02-15
DK351180A (da) 1981-02-16
DE3063503D1 (en) 1983-07-07
GR69834B (da) 1982-07-19
DK350980A (da) 1981-02-16
DE3064411D1 (en) 1983-09-01
GR69805B (da) 1982-07-12
ATE7785T1 (de) 1984-06-15
ES494303A0 (es) 1981-08-01
JPS5630960A (en) 1981-03-28
IE50151B1 (en) 1986-02-19
ATE4316T1 (de) 1983-08-15
IE801706L (en) 1981-02-15
JPS5630961A (en) 1981-03-28
EP0024347A1 (en) 1981-03-04
IE801705L (en) 1981-02-15
ATE5403T1 (de) 1983-12-15
GR69832B (da) 1982-07-19
EP0025857A1 (en) 1981-04-01

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