ES8106282A1 - Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas. - Google Patents
Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas.Info
- Publication number
- ES8106282A1 ES8106282A1 ES494302A ES494302A ES8106282A1 ES 8106282 A1 ES8106282 A1 ES 8106282A1 ES 494302 A ES494302 A ES 494302A ES 494302 A ES494302 A ES 494302A ES 8106282 A1 ES8106282 A1 ES 8106282A1
- Authority
- ES
- Spain
- Prior art keywords
- same
- preparing
- organic sulfoxides
- inhibiting compositions
- enzyme inhibiting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Polymerisation Methods In General (AREA)
- Cephalosporin Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE PRECURSORES DE ALILSULFOXIDOS INHIBIDORES DE ENZIMAS DE FORMULA ESTRUCTURAL (I), DONDE R ES FENILO, FENILO SUSTITUIDO CON UN GRUPO ACEPTOR DE ELECTRONES, TRIHALOMETILO O UN HETEROCICLO AROMATICO DE CINCO O SEIS MIEMBROS; R ELEVADO A 1 ES HIDROGENO O AMINOMETILO; R CUADRADO Y R ELEVADO A 5 SON HIDROGENO; R CUBO ES UN GRUPO FACILMENTE SALIENTE, O R CUADRADO Y R CUBO JUNTOS FORMAN UN DOBLE ENLACE; R ELEVADO A 4 ES HIDROGENO O UN GRUPO ACEPTOR DE ELECTRONES; R ELEVADO A 6 ES HIDROGENO O -COOH, Y R ELEVADO A 7 ES -OH, NH2, -SH Y -CH2OH. CONSISTE EN OXIDAR UN TIO-DERIVADO AROMATICO DE FORMULA ESTRUCTURAL (II), DONDE R Y R ELEVADO A 1-7 TIENEN EL SIGNIFICADO SEÑALADO ANTERIORMENTE, CON LA EXCEPCION DE QUE CUALQUIERA DE LOS SUSTITUYENTES R ELEVADO A 1-7 QUE SEA SENSIBLE A LA OXIDACION VA PROVISTO DE UN GRUPO PROTECTOR. DESPUES DE LA OXIDACION DICHO GRUPO PROTECTOR ES SEPARADO. EL AGENTE OXIDANTE SE SELECCIONA ENTRE 1-CLOROBENZOTRIAZOL, CL2, BR2, NAIO4, CH3COONO2O UN PERACIDO. *FORMULA* N
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6660379A | 1979-08-15 | 1979-08-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES494302A0 ES494302A0 (es) | 1981-08-01 |
| ES8106282A1 true ES8106282A1 (es) | 1981-08-01 |
Family
ID=22070551
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES494302A Expired ES8106282A1 (es) | 1979-08-15 | 1980-08-14 | Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas. |
| ES494305A Granted ES494305A0 (es) | 1979-08-15 | 1980-08-14 | Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas. |
| ES494304A Expired ES8106284A1 (es) | 1979-08-15 | 1980-08-14 | Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas. |
| ES494303A Granted ES494303A0 (es) | 1979-08-15 | 1980-08-14 | Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzimas. |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES494305A Granted ES494305A0 (es) | 1979-08-15 | 1980-08-14 | Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas. |
| ES494304A Expired ES8106284A1 (es) | 1979-08-15 | 1980-08-14 | Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas. |
| ES494303A Granted ES494303A0 (es) | 1979-08-15 | 1980-08-14 | Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzimas. |
Country Status (9)
| Country | Link |
|---|---|
| EP (4) | EP0026307B1 (es) |
| JP (4) | JPS5643260A (es) |
| AT (4) | ATE3545T1 (es) |
| DE (4) | DE3068110D1 (es) |
| DK (4) | DK351080A (es) |
| ES (4) | ES8106282A1 (es) |
| GR (4) | GR69834B (es) |
| IE (4) | IE50225B1 (es) |
| PT (4) | PT71653B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2457296A1 (fr) * | 1979-05-23 | 1980-12-19 | Rhone Poulenc Ind | Nouveaux derives de vinyl-3 cephalosporines et leur preparation |
| US4553191A (en) * | 1982-12-03 | 1985-11-12 | Xerox Corporation | Static eliminator |
| US4609744A (en) * | 1983-04-21 | 1986-09-02 | Merck Frosst Canada Inc. | 4-oxo-benzopyran carboxylic acids |
| DE3469169D1 (en) * | 1983-04-21 | 1988-03-10 | Merck Frosst Canada Inc | Leukotriene antagonists, their production and use and compositions containing them |
| FR2661909B1 (fr) * | 1990-05-09 | 1997-08-14 | Inst Nat Sante Rech Med | Nouveaux composes agonistes du recepteur h3 de l'histamine a usage therapeutique, compositions pharmaceutiques agissant comme agonistes dudit recepteur et procede de preparation. |
| US5744485A (en) * | 1994-03-25 | 1998-04-28 | Vertex Pharmaceuticals Incorporated | Carbamates and ureas as modifiers of multi-drug resistance |
| US6599938B1 (en) * | 1999-10-29 | 2003-07-29 | The Picower Institute Of Medical Research | Compounds having MIF antagonist activity |
| JP5733856B2 (ja) | 2007-10-09 | 2015-06-10 | ソファーミア，インコーポレイテッド | 広帯域β−ラクタマーゼ阻害薬 |
| ES2700575T3 (es) | 2013-03-12 | 2019-02-18 | Gladius Pharmaceuticals Corp | 3-Estiril-cefalosporinas derivadas |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3419606A (en) * | 1964-05-13 | 1968-12-31 | Merck & Co Inc | 4-(2-methylenealkanoyl)phenylsulfinyl alkanoic acids |
| CH496639A (fr) * | 1968-01-05 | 1970-09-30 | Pfizer & Co C | Procédé de préparation des aryl halogénocarbonyl cétènes |
| CH568708A5 (es) * | 1969-04-30 | 1975-11-14 | Hoffmann La Roche | |
| GB1357154A (en) * | 1970-09-25 | 1974-06-19 | Shell Int Research | Alkylthio-nitro-aniline compounds and herbicidal 'ompositions containing them |
| GB1463077A (en) * | 1973-04-19 | 1977-02-02 | Glaxo Lab Ltd | 7-substituted-ethyl-cephalosporin derivatives |
| US4049806A (en) * | 1975-08-15 | 1977-09-20 | Syntex (U.S.A.) Inc. | Cephalosporin type antibacterials |
| JPS5253890A (en) * | 1975-10-14 | 1977-04-30 | Syntex Inc | Production of cephalosporin type compound |
| US4155907A (en) * | 1976-08-16 | 1979-05-22 | The Dow Chemical Company | Method for inhibiting ADP-induced platelet aggregation using phenylthioalkylamines |
| JPS5350326A (en) * | 1976-10-18 | 1978-05-08 | Kao Corp | Herbicides |
| AU4091178A (en) * | 1977-10-25 | 1980-04-24 | Merck & Co Inc | Substituted mercapto acid amides |
-
1980
- 1980-08-05 PT PT71653A patent/PT71653B/pt unknown
- 1980-08-05 PT PT71654A patent/PT71654B/pt unknown
- 1980-08-05 PT PT71652A patent/PT71652B/pt unknown
- 1980-08-05 PT PT71651A patent/PT71651B/pt unknown
- 1980-08-12 GR GR62659A patent/GR69834B/el unknown
- 1980-08-12 GR GR62658A patent/GR69833B/el unknown
- 1980-08-12 GR GR62656A patent/GR69805B/el unknown
- 1980-08-12 GR GR62657A patent/GR69832B/el unknown
- 1980-08-13 IE IE1708/80A patent/IE50225B1/en unknown
- 1980-08-13 IE IE1705/80A patent/IE50150B1/en unknown
- 1980-08-13 IE IE1706/80A patent/IE50151B1/en unknown
- 1980-08-13 IE IE1707/80A patent/IE50152B1/en unknown
- 1980-08-14 DE DE8080104805T patent/DE3068110D1/de not_active Expired
- 1980-08-14 DE DE8080104802T patent/DE3065684D1/de not_active Expired
- 1980-08-14 ES ES494302A patent/ES8106282A1/es not_active Expired
- 1980-08-14 DE DE8080104803T patent/DE3064411D1/de not_active Expired
- 1980-08-14 DK DK351080A patent/DK351080A/da not_active Application Discontinuation
- 1980-08-14 ES ES494305A patent/ES494305A0/es active Granted
- 1980-08-14 DK DK351180A patent/DK351180A/da not_active Application Discontinuation
- 1980-08-14 AT AT80104806T patent/ATE3545T1/de not_active IP Right Cessation
- 1980-08-14 AT AT80104805T patent/ATE7785T1/de active
- 1980-08-14 DE DE8080104806T patent/DE3063503D1/de not_active Expired
- 1980-08-14 EP EP80104802A patent/EP0026307B1/en not_active Expired
- 1980-08-14 EP EP80104805A patent/EP0024639B1/en not_active Expired
- 1980-08-14 AT AT80104802T patent/ATE5403T1/de not_active IP Right Cessation
- 1980-08-14 AT AT80104803T patent/ATE4316T1/de not_active IP Right Cessation
- 1980-08-14 ES ES494304A patent/ES8106284A1/es not_active Expired
- 1980-08-14 DK DK351280A patent/DK351280A/da not_active Application Discontinuation
- 1980-08-14 EP EP80104806A patent/EP0024347B1/en not_active Expired
- 1980-08-14 EP EP80104803A patent/EP0025857B1/en not_active Expired
- 1980-08-14 ES ES494303A patent/ES494303A0/es active Granted
- 1980-08-14 DK DK350980A patent/DK350980A/da not_active Application Discontinuation
- 1980-08-15 JP JP11186580A patent/JPS5643260A/ja active Pending
- 1980-08-15 JP JP11186780A patent/JPS5663989A/ja active Pending
- 1980-08-15 JP JP11186680A patent/JPS5630961A/ja active Pending
- 1980-08-15 JP JP11186480A patent/JPS5630960A/ja active Pending
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