DK3505638T3 - Mikrofluid indretning, system og fremgangsmåde til studie af organismer - Google Patents

Mikrofluid indretning, system og fremgangsmåde til studie af organismer Download PDF

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Publication number
DK3505638T3
DK3505638T3 DK19153553.3T DK19153553T DK3505638T3 DK 3505638 T3 DK3505638 T3 DK 3505638T3 DK 19153553 T DK19153553 T DK 19153553T DK 3505638 T3 DK3505638 T3 DK 3505638T3
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DK
Denmark
Prior art keywords
organisms
study
microfluidic device
microfluidic
Prior art date
Application number
DK19153553.3T
Other languages
English (en)
Inventor
Matteo Cornaglia
Daniel Migliozzi
Martin Gijs
Original Assignee
Ecole Polytechnique Fed Lausanne Epfl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ecole Polytechnique Fed Lausanne Epfl filed Critical Ecole Polytechnique Fed Lausanne Epfl
Application granted granted Critical
Publication of DK3505638T3 publication Critical patent/DK3505638T3/da

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5085—Supracellular entities, e.g. tissue, organisms of invertebrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0663—Stretching or orienting elongated molecules or particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Fluid Mechanics (AREA)
  • Biophysics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DK19153553.3T 2014-10-20 2015-10-19 Mikrofluid indretning, system og fremgangsmåde til studie af organismer DK3505638T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2014065472 2014-10-20
EP15807695.0A EP3209790B1 (en) 2014-10-20 2015-10-19 Microfluidic device, system and method for the study of organisms

Publications (1)

Publication Number Publication Date
DK3505638T3 true DK3505638T3 (da) 2021-02-15

Family

ID=54838379

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19153553.3T DK3505638T3 (da) 2014-10-20 2015-10-19 Mikrofluid indretning, system og fremgangsmåde til studie af organismer

Country Status (5)

Country Link
US (2) US11596945B2 (da)
EP (2) EP3505638B1 (da)
DK (1) DK3505638T3 (da)
ES (2) ES2795991T3 (da)
WO (1) WO2016063199A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018047959A1 (ja) 2016-09-12 2018-03-15 株式会社Ｈｉｒｏｔｓｕバイオサイエンス 線虫の嗅覚に基づく匂い物質に対する走性行動の評価方法、並びに該評価方法に用いるシャーレおよび行動評価系
JP6164622B1 (ja) * 2016-09-12 2017-07-19 株式会社Ｈｉｒｏｔｓｕバイオサイエンス 線虫の嗅覚に基づく匂い物質に対する走性行動の評価方法、および該評価方法に用いるシャーレ
WO2018140999A1 (en) * 2017-01-31 2018-08-09 Genea Ip Holdings Pty Limited Method and system for processing a biological sample
WO2018183744A1 (en) 2017-03-29 2018-10-04 The Research Foundation For The State University Of New York Microfluidic device and methods
WO2019133098A2 (en) * 2017-10-20 2019-07-04 President And Fellows Of Harvard College Microfluidic platform for time-resolved tissue and organism analysis
CN107570246B (zh) * 2017-10-23 2022-11-11 广东第二师范学院 一种用于抗菌药物筛选的线虫芯片及其微流控方法
CN110465336A (zh) * 2018-05-11 2019-11-19 中国石油化工股份有限公司 芯片反应装置和手动进样方法及其应用
WO2020005802A1 (en) * 2018-06-24 2020-01-02 University Of Oregon Microinjection chip, device, system and uses thereof for unicellular or multicellular organisms
GB2578144A (en) 2018-10-18 2020-04-22 The Univ Of Durham Method and apparatus for tracking nematode worms
CN109439514A (zh) * 2018-12-14 2019-03-08 贵州大学 一种用于阵列微流体点样微流控制装置的支撑装置
JP2022523394A (ja) * 2019-03-05 2022-04-22 テキサス テック ユニヴァーシティー システム 線虫における寿命及び健康寿命の分析のための自動マイクロ流体システム
CN110940821B (zh) * 2019-12-13 2024-01-26 大连海事大学 一种便携式单线虫并行分析微流控芯片系统及其使用方法
EP4137555A1 (en) 2021-08-17 2023-02-22 Nagi Bioscience SA Apparatus for biological microorganism observation
EP4137558A1 (en) 2021-08-17 2023-02-22 Nagi Bioscience SA Apparatus for microscopic worm observation
CN114208780A (zh) * 2021-12-30 2022-03-22 南通大学 一种可用于线虫培养及即时固定的微流控芯片装置
CN115997732A (zh) * 2022-12-19 2023-04-25 西交利物浦大学 一种微流控线虫培养测试系统

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8961877B2 (en) 2007-08-09 2015-02-24 Massachusetts Institute Of Technology High-throughput, whole-animal screening system
WO2009039284A1 (en) 2007-09-18 2009-03-26 Georgia Tech Research Corporation Systems and methods for high-throughput detection and sorting
US8702939B2 (en) 2010-09-15 2014-04-22 Mcmaster University Electrotaxis methods and devices
CN102669058A (zh) 2011-03-18 2012-09-19 中国科学院大连化学物理研究所 基于微阀的秀丽隐杆线虫长期培养及双检测微流控芯片
US9723817B2 (en) 2011-11-10 2017-08-08 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Electropharyngeogram arrays and methods of use
CN103461279B (zh) 2012-06-08 2015-11-18 中国科学院上海生命科学研究院 用于线虫培养和/或观察的微流芯片和设备及其应用
CN102972351A (zh) 2012-11-06 2013-03-20 中国科学院大连化学物理研究所 基于微流控芯片的秀丽隐杆线虫单卵捕获及培养方法

Also Published As

Publication number Publication date
EP3209790B1 (en) 2020-01-08
EP3505638B1 (en) 2020-11-11
US11596945B2 (en) 2023-03-07
EP3505638A1 (en) 2019-07-03
WO2016063199A1 (en) 2016-04-28
EP3209790A1 (en) 2017-08-30
ES2795991T3 (es) 2020-11-25
US20230149927A1 (en) 2023-05-18
US20170312748A1 (en) 2017-11-02
ES2850881T3 (es) 2021-09-01

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