DK34979A - Fremgangsmaade til fremstilling af neuromuskulaere blokeringsmidler og mellemprodukter til anvendelse derved - Google Patents

Fremgangsmaade til fremstilling af neuromuskulaere blokeringsmidler og mellemprodukter til anvendelse derved

Info

Publication number
DK34979A
DK34979A DK34979A DK34979A DK34979A DK 34979 A DK34979 A DK 34979A DK 34979 A DK34979 A DK 34979A DK 34979 A DK34979 A DK 34979A DK 34979 A DK34979 A DK 34979A
Authority
DK
Denmark
Prior art keywords
intermediates
procedure
manufacturing
blocking agents
neuromuscular blocking
Prior art date
Application number
DK34979A
Other languages
Danish (da)
English (en)
Inventor
J J Savarese
R J Kitz
S Ginsburg
Original Assignee
Massachusetts Gen Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Gen Hospital filed Critical Massachusetts Gen Hospital
Publication of DK34979A publication Critical patent/DK34979A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18Aralkyl radicals
    • C07D217/20Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41Preparation of salts of carboxylic acids
    • C07C51/412Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/10Quaternary compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK34979A 1978-07-21 1979-01-26 Fremgangsmaade til fremstilling af neuromuskulaere blokeringsmidler og mellemprodukter til anvendelse derved DK34979A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92679478A 1978-07-21 1978-07-21

Publications (1)

Publication Number Publication Date
DK34979A true DK34979A (da) 1980-01-22

Family

ID=25453730

Family Applications (1)

Application Number Title Priority Date Filing Date
DK34979A DK34979A (da) 1978-07-21 1979-01-26 Fremgangsmaade til fremstilling af neuromuskulaere blokeringsmidler og mellemprodukter til anvendelse derved

Country Status (14)

Country Link
EP (1) EP0010119A1 (es)
JP (1) JPS5517367A (es)
AU (1) AU522421B2 (es)
CA (1) CA1125287A (es)
DD (1) DD142547A5 (es)
DK (1) DK34979A (es)
ES (1) ES477257A1 (es)
FI (1) FI790214A (es)
IE (1) IE790108L (es)
IL (1) IL56487A (es)
IT (1) IT1202871B (es)
MC (1) MC1240A1 (es)
PL (1) PL121468B1 (es)
ZA (1) ZA79253B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8418303D0 (en) * 1984-07-18 1984-08-22 Wellcome Found Compounds
BG41897A1 (en) * 1985-07-19 1987-09-15 Ivanov Dichlormethylate of n, n'- 4, 10- dioxa- 3, 11- bis- tetrahydropapaverine and method for its preparation
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
CN103880744A (zh) * 2012-12-21 2014-06-25 常州工程职业技术学院 一种5’-甲氧基劳丹素的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2662083A (en) * 1950-10-24 1953-12-08 Allen & Hanburys Ltd Heterocyclic polymethylene-bisquaternary ammonium salts and process for preparing same
GB863717A (en) * 1958-07-03 1961-03-22 Allen & Hanburys Ltd Tetrahydropapaverine derivatives and their preparation
GB1125619A (en) * 1965-11-15 1968-08-28 Wellcome Found Derivatives of bis-isoquinolines
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
IL55254A (en) * 1977-08-01 1983-03-31 Massachusetts Gen Hospital Bis-isoquinolinium compounds,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
JPS5517367A (en) 1980-02-06
IT1202871B (it) 1989-02-15
MC1240A1 (fr) 1979-10-26
ZA79253B (en) 1980-06-25
PL121468B1 (en) 1982-05-31
IE790108L (en) 1980-01-21
EP0010119A1 (en) 1980-04-30
DD142547A5 (de) 1980-07-02
PL213098A1 (es) 1980-03-24
ES477257A1 (es) 1979-08-01
FI790214A (fi) 1980-01-22
AU4368879A (en) 1980-01-24
AU522421B2 (en) 1982-06-03
IL56487A0 (en) 1979-03-12
IT7919694A0 (it) 1979-01-29
CA1125287A (en) 1982-06-08
IL56487A (en) 1983-05-15

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Legal Events

Date Code Title Description
ATS Application withdrawn