MC1240A1 - Composes tetrahydro-isoquinoleiniques myorelaxants(agents de blocage de la plaque neuro-musculaire)et preparation de ces substances - Google Patents

Composes tetrahydro-isoquinoleiniques myorelaxants(agents de blocage de la plaque neuro-musculaire)et preparation de ces substances

Info

Publication number
MC1240A1
MC1240A1 MC791358A MC1358A MC1240A1 MC 1240 A1 MC1240 A1 MC 1240A1 MC 791358 A MC791358 A MC 791358A MC 1358 A MC1358 A MC 1358A MC 1240 A1 MC1240 A1 MC 1240A1
Authority
MC
Monaco
Prior art keywords
isoquinoleinic
myorelaxant
tetrahydro
substances
compounds
Prior art date
Application number
MC791358A
Other languages
English (en)
French (fr)
Inventor
J Savarese
S Ginsburg
R Kitz
Original Assignee
Massachusetts Gen Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Gen Hospital filed Critical Massachusetts Gen Hospital
Publication of MC1240A1 publication Critical patent/MC1240A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18Aralkyl radicals
    • C07D217/20Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41Preparation of salts of carboxylic acids
    • C07C51/412Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/10Quaternary compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MC791358A 1978-07-21 1979-01-26 Composes tetrahydro-isoquinoleiniques myorelaxants(agents de blocage de la plaque neuro-musculaire)et preparation de ces substances MC1240A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92679478A 1978-07-21 1978-07-21

Publications (1)

Publication Number Publication Date
MC1240A1 true MC1240A1 (fr) 1979-10-26

Family

ID=25453730

Family Applications (1)

Application Number Title Priority Date Filing Date
MC791358A MC1240A1 (fr) 1978-07-21 1979-01-26 Composes tetrahydro-isoquinoleiniques myorelaxants(agents de blocage de la plaque neuro-musculaire)et preparation de ces substances

Country Status (14)

Country Link
EP (1) EP0010119A1 (xx)
JP (1) JPS5517367A (xx)
AU (1) AU522421B2 (xx)
CA (1) CA1125287A (xx)
DD (1) DD142547A5 (xx)
DK (1) DK34979A (xx)
ES (1) ES477257A1 (xx)
FI (1) FI790214A (xx)
IE (1) IE790108L (xx)
IL (1) IL56487A (xx)
IT (1) IT1202871B (xx)
MC (1) MC1240A1 (xx)
PL (1) PL121468B1 (xx)
ZA (1) ZA79253B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8418303D0 (en) * 1984-07-18 1984-08-22 Wellcome Found Compounds
BG41897A1 (en) * 1985-07-19 1987-09-15 Ivanov Dichlormethylate of n, n'- 4, 10- dioxa- 3, 11- bis- tetrahydropapaverine and method for its preparation
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
CN103880744A (zh) * 2012-12-21 2014-06-25 常州工程职业技术学院 一种5’-甲氧基劳丹素的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2662083A (en) * 1950-10-24 1953-12-08 Allen & Hanburys Ltd Heterocyclic polymethylene-bisquaternary ammonium salts and process for preparing same
GB863717A (en) * 1958-07-03 1961-03-22 Allen & Hanburys Ltd Tetrahydropapaverine derivatives and their preparation
GB1125619A (en) * 1965-11-15 1968-08-28 Wellcome Found Derivatives of bis-isoquinolines
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
IL55254A (en) * 1977-08-01 1983-03-31 Massachusetts Gen Hospital Bis-isoquinolinium compounds,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
JPS5517367A (en) 1980-02-06
IT1202871B (it) 1989-02-15
DK34979A (da) 1980-01-22
ZA79253B (en) 1980-06-25
PL121468B1 (en) 1982-05-31
IE790108L (en) 1980-01-21
EP0010119A1 (en) 1980-04-30
DD142547A5 (de) 1980-07-02
PL213098A1 (xx) 1980-03-24
ES477257A1 (es) 1979-08-01
FI790214A (fi) 1980-01-22
AU4368879A (en) 1980-01-24
AU522421B2 (en) 1982-06-03
IL56487A0 (en) 1979-03-12
IT7919694A0 (it) 1979-01-29
CA1125287A (en) 1982-06-08
IL56487A (en) 1983-05-15

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