DK3395817T3 - Pyrido[1,2-a]pyrimidonanalog, krystalform deraf, mellemprodukt deraf og fremgangsmåde til fremstilling deraf - Google Patents
Pyrido[1,2-a]pyrimidonanalog, krystalform deraf, mellemprodukt deraf og fremgangsmåde til fremstilling deraf Download PDFInfo
- Publication number
- DK3395817T3 DK3395817T3 DK16874904.2T DK16874904T DK3395817T3 DK 3395817 T3 DK3395817 T3 DK 3395817T3 DK 16874904 T DK16874904 T DK 16874904T DK 3395817 T3 DK3395817 T3 DK 3395817T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyrido
- manufacture
- crystal shape
- pyrimidone
- analog
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510951482 | 2015-12-16 | ||
| PCT/CN2016/110284 WO2017101847A1 (zh) | 2015-12-16 | 2016-12-16 | 吡啶并[1,2-a]嘧啶酮类似物、其晶型、其中间体及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3395817T3 true DK3395817T3 (da) | 2022-03-21 |
Family
ID=59055711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16874904.2T DK3395817T3 (da) | 2015-12-16 | 2016-12-16 | Pyrido[1,2-a]pyrimidonanalog, krystalform deraf, mellemprodukt deraf og fremgangsmåde til fremstilling deraf |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10479789B2 (da) |
| EP (1) | EP3395817B1 (da) |
| JP (1) | JP7037483B2 (da) |
| KR (1) | KR20180095565A (da) |
| CN (1) | CN108602815B (da) |
| AU (1) | AU2016369835B2 (da) |
| CA (1) | CA3008689A1 (da) |
| DK (1) | DK3395817T3 (da) |
| ES (1) | ES2908498T3 (da) |
| HK (1) | HK1256044A1 (da) |
| PL (1) | PL3395817T3 (da) |
| RU (1) | RU2753696C2 (da) |
| WO (1) | WO2017101847A1 (da) |
| ZA (1) | ZA201804007B (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220213060A1 (en) * | 2019-05-13 | 2022-07-07 | Luoxin Healthcare Science and Technology Development (Beijing) Ltd. | Crystal Form of Quinazolinone Compound and Preparation Method Therefor |
| EP4119557A4 (en) * | 2020-03-10 | 2024-04-10 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | PHARMACEUTICAL COMBINATION WITH A PYRIDINO[1,2-A PYRIMIDINONE COMPOUND |
| EP4197539A1 (en) * | 2020-09-15 | 2023-06-21 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Use of pyrido[1,2-a]pyrimidinone compound in treating peripheral t cell lymphoma |
| WO2022121929A1 (zh) * | 2020-12-08 | 2022-06-16 | 正大天晴药业集团股份有限公司 | 吡啶并[1,2-a]嘧啶酮化合物的治疗妇科肿瘤的用途 |
| CN115671289B (zh) * | 2021-07-27 | 2024-04-26 | 广州嘉越医药科技有限公司 | 药物组合及其应用 |
| WO2023169488A1 (zh) * | 2022-03-09 | 2023-09-14 | 正大天晴药业集团股份有限公司 | 包括吡啶并[1,2-a]嘧啶酮化合物和EGFR抑制剂的药物组合 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP1699A (en) | 2001-03-21 | 2006-12-26 | Warner Lambert Co | New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors |
| EP2211615A4 (en) | 2007-10-22 | 2010-10-13 | Glaxosmithkline Llc | PYRIDOSULFONAMIDE DERIVATIVES AS PI3 KINASE INHIBITORS |
| CN102206222B (zh) | 2011-04-14 | 2013-04-10 | 中山大学 | 一种双脂肪氨基取代吲哚喹啉衍生物及其制备方法和制备抗肿瘤药物中的应用 |
| CN103539777B (zh) | 2012-07-13 | 2016-03-02 | 广东东阳光药业有限公司 | Pi3激酶调节剂及其使用方法和用途 |
| WO2014022128A1 (en) | 2012-07-29 | 2014-02-06 | Calitor Sciences, Llc | Pi3 kinase modulators and methods of use |
| CN103788071A (zh) | 2012-11-01 | 2014-05-14 | 中国人民解放军第二军医大学 | N-(5-(喹啉-6-基)吡啶-3-基)苯磺酰胺衍生物、制备方法及治疗用途 |
| US9868737B2 (en) | 2014-06-17 | 2018-01-16 | Cisen Pharmaceutical Co., Ltd. | Pyridino[1,2-A]pyrimidone analogue used as MTOR/P13K inhibitor |
| CN105461711B (zh) * | 2014-06-17 | 2018-11-06 | 正大天晴药业集团股份有限公司 | 作为PI3K抑制剂的吡啶并[1,2-a]嘧啶酮类似物 |
| US9856256B2 (en) | 2014-06-17 | 2018-01-02 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Pyridino[1,2-A]pyrimidone analogue used as P13K inhibitor |
-
2016
- 2016-12-16 CN CN201680072381.1A patent/CN108602815B/zh active Active
- 2016-12-16 RU RU2018125475A patent/RU2753696C2/ru active
- 2016-12-16 JP JP2018531358A patent/JP7037483B2/ja active Active
- 2016-12-16 DK DK16874904.2T patent/DK3395817T3/da active
- 2016-12-16 WO PCT/CN2016/110284 patent/WO2017101847A1/zh active Application Filing
- 2016-12-16 ES ES16874904T patent/ES2908498T3/es active Active
- 2016-12-16 EP EP16874904.2A patent/EP3395817B1/en active Active
- 2016-12-16 AU AU2016369835A patent/AU2016369835B2/en active Active
- 2016-12-16 CA CA3008689A patent/CA3008689A1/en active Pending
- 2016-12-16 US US16/061,279 patent/US10479789B2/en active Active
- 2016-12-16 KR KR1020187019466A patent/KR20180095565A/ko not_active Application Discontinuation
- 2016-12-16 PL PL16874904T patent/PL3395817T3/pl unknown
-
2018
- 2018-06-15 ZA ZA2018/04007A patent/ZA201804007B/en unknown
- 2018-11-26 HK HK18115096.1A patent/HK1256044A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201804007B (en) | 2019-05-29 |
| RU2018125475A3 (da) | 2020-02-28 |
| EP3395817A1 (en) | 2018-10-31 |
| US10479789B2 (en) | 2019-11-19 |
| CN108602815A (zh) | 2018-09-28 |
| CA3008689A1 (en) | 2017-06-22 |
| AU2016369835B2 (en) | 2020-10-15 |
| RU2018125475A (ru) | 2020-01-16 |
| EP3395817B1 (en) | 2022-02-23 |
| AU2016369835A1 (en) | 2018-07-19 |
| WO2017101847A1 (zh) | 2017-06-22 |
| HK1256044A1 (zh) | 2019-09-13 |
| JP7037483B2 (ja) | 2022-03-16 |
| KR20180095565A (ko) | 2018-08-27 |
| ES2908498T3 (es) | 2022-04-29 |
| EP3395817A4 (en) | 2019-08-07 |
| RU2753696C2 (ru) | 2021-08-19 |
| PL3395817T3 (pl) | 2022-05-02 |
| US20180319799A1 (en) | 2018-11-08 |
| CN108602815B (zh) | 2020-07-28 |
| JP2018537497A (ja) | 2018-12-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA201802976B (en) | N-sulfonylated pyrazolo[3,4-b]pyridin-6-carboxamides and method of use | |
| DK3395817T3 (da) | Pyrido[1,2-a]pyrimidonanalog, krystalform deraf, mellemprodukt deraf og fremgangsmåde til fremstilling deraf | |
| DK3889145T3 (da) | 8-cyano-5-piperidino-quinoliner som TLR7/8-antagonister og anvendelser deraf til behandling af immunsygdomme | |
| EP3214437A4 (en) | Sample supporting body and method of manufacturing sample supporting body | |
| HK1254057A1 (zh) | 用於製備膽汁酸衍生物的方法和中間體 | |
| LT3447137T (lt) | Skystas fermento preparatas ir jo gamybos būdas | |
| EP3421503A4 (en) | SUGAMMADEX MANUFACTURE AND CLEANING PROCEDURE | |
| DK3305785T3 (da) | Pyrido[3,4-d]pyrimidinderivat og farmaceutisk acceptabelt salt deraf | |
| HK1208144A1 (en) | Artificial biological heart valve and the production methods thereof | |
| EP3196328A4 (en) | Enamel steel having high-temperature baking hardenability and manufacturing method therefor | |
| EP3251635A4 (en) | ADJUSTABLE HEIGHT SPINDLE AND METHOD FOR MANUFACTURING THE SAME | |
| DK3348557T3 (da) | Imidazo[1,2-a]pyridiner til behandling eller forebyggelse af hyperurekæmi eller gigt | |
| HK1225723A1 (zh) | 取代的咪唑並[1，2-a]吡啶甲酰胺及其用途 | |
| DK3315181T3 (da) | Sammensat emne og fremgangsmåde til at fremstille samme | |
| EP3395329A4 (en) | PROCESS FOR THE PREPARATION OF LIPID BODIES AND THEIR USE | |
| HK1246279A1 (zh) | C14-位羥基酯化的雷公藤甲素氨基酸衍生物、及其製備方法和應用 | |
| IL266609A (en) | Red blood cell targeted factor viii and method of using the same | |
| EP3337845A4 (en) | Non-isocyanate polyurethanes and process for the preparation and use thereof | |
| EP3297573A4 (en) | STENT AND METHOD OF USE | |
| DK3481827T3 (da) | Imidazo[1,2-a]pyridinderivater, fremgangsmåder til fremstilling og anvendelse deraf | |
| GB201802644D0 (en) | Monocyclic,thieno, pyrido and pyrrolo pyrimidine compounds and methods of use and manufacture of the same | |
| EP3285797A4 (en) | Gal-1 variants having immuno-modulating properties and methods of using the same | |
| IL248033A0 (en) | Sky compass and method for its calibration | |
| EP3279182A4 (en) | Acetylsalicylic acid derivative crystal and preparation method and use thereof | |
| EP3615337A4 (en) | SEQUENCING LOADS USING TEMPERATURE |