DK3313987T3 - Fremgangsmåde til produktion i stor målestok samt oprensning af parvovirus - Google Patents
Fremgangsmåde til produktion i stor målestok samt oprensning af parvovirus Download PDFInfo
- Publication number
- DK3313987T3 DK3313987T3 DK16736792.9T DK16736792T DK3313987T3 DK 3313987 T3 DK3313987 T3 DK 3313987T3 DK 16736792 T DK16736792 T DK 16736792T DK 3313987 T3 DK3313987 T3 DK 3313987T3
- Authority
- DK
- Denmark
- Prior art keywords
- parvovirus
- purification
- procedure
- large scale
- scale production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14311—Parvovirus, e.g. minute virus of mice
- C12N2750/14323—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14311—Parvovirus, e.g. minute virus of mice
- C12N2750/14351—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14311—Parvovirus, e.g. minute virus of mice
- C12N2750/14361—Methods of inactivation or attenuation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15173385 | 2015-06-23 | ||
| PCT/EP2016/001066 WO2016206807A1 (en) | 2015-06-23 | 2016-06-22 | Method for large scale production and purification of parvovirus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3313987T3 true DK3313987T3 (da) | 2020-02-03 |
Family
ID=53488222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16736792.9T DK3313987T3 (da) | 2015-06-23 | 2016-06-22 | Fremgangsmåde til produktion i stor målestok samt oprensning af parvovirus |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10266810B2 (da) |
| EP (1) | EP3313987B1 (da) |
| JP (1) | JP6608969B2 (da) |
| AU (1) | AU2016284488B2 (da) |
| CA (1) | CA2988446C (da) |
| DK (1) | DK3313987T3 (da) |
| ES (1) | ES2765999T3 (da) |
| WO (1) | WO2016206807A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018227883B2 (en) * | 2017-03-03 | 2022-08-04 | Takeda Pharmaceutical Company Limited | Methods for determining potency of Adeno-associated virus preparations |
| EP3768865B1 (en) * | 2018-03-23 | 2022-12-14 | Life Technologies Corporation | Methods and kits to detect viral particle heterogeneity |
| EP3754015A1 (en) | 2019-06-17 | 2020-12-23 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Optimized parvovirus h-1 production |
| CN112359140A (zh) * | 2020-11-06 | 2021-02-12 | 苏州药明检测检验有限责任公司 | 一种利用空斑染色测定鼠细小病毒滴度的方法 |
| WO2023052429A1 (en) * | 2021-09-30 | 2023-04-06 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Method for further upscaling the large-scale production of the oncolytic h-1 protoparvovirus (h-1pv) using a carrier-based production process combined with an optimized cell culture medium |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1944362T3 (da) * | 1997-09-05 | 2016-01-25 | Genzyme Corp | Fremgangsmåder til fremstilling af hjælpevirusfri præparater med høj titer af rekombinante AAV-vektorer |
| US20100303776A1 (en) * | 2009-04-16 | 2010-12-02 | The University Of North Carolina At Chapel Hill | Methods and compositions for regulated expression of multiple nucleic acids |
| DK2332986T3 (da) * | 2009-12-11 | 2013-12-16 | Deutsches Krebsforsch | Antistof som binder til H-1 parvovirus |
| EP2397542A1 (en) * | 2010-06-17 | 2011-12-21 | Deutsches Krebsforschungszentrum | Modified parvovirus having enhanced anti-tumour efficacy |
| EP2404609A1 (en) | 2010-07-07 | 2012-01-11 | Deutsches Krebsforschungszentrum | Use of parvovirus for eliminating cancer stem cells (CSCs) |
| EP2535055A1 (en) * | 2011-06-15 | 2012-12-19 | Deutsches Krebsforschungszentrum | Oncolytic virotherapy for therapy of bone cancer |
| US11078464B2 (en) | 2013-08-30 | 2021-08-03 | Amgen Inc. | High titer recombinant AAV vector production in adherent and suspension cells |
-
2016
- 2016-06-22 US US15/739,684 patent/US10266810B2/en active Active
- 2016-06-22 AU AU2016284488A patent/AU2016284488B2/en active Active
- 2016-06-22 CA CA2988446A patent/CA2988446C/en active Active
- 2016-06-22 DK DK16736792.9T patent/DK3313987T3/da active
- 2016-06-22 WO PCT/EP2016/001066 patent/WO2016206807A1/en active Application Filing
- 2016-06-22 ES ES16736792T patent/ES2765999T3/es active Active
- 2016-06-22 EP EP16736792.9A patent/EP3313987B1/en active Active
- 2016-06-22 JP JP2017566843A patent/JP6608969B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016284488B2 (en) | 2018-05-31 |
| ES2765999T3 (es) | 2020-06-11 |
| AU2016284488A1 (en) | 2018-01-18 |
| EP3313987B1 (en) | 2019-10-23 |
| WO2016206807A1 (en) | 2016-12-29 |
| US20180187166A1 (en) | 2018-07-05 |
| JP6608969B2 (ja) | 2019-11-20 |
| JP2018523992A (ja) | 2018-08-30 |
| CA2988446A1 (en) | 2016-12-29 |
| CA2988446C (en) | 2020-07-21 |
| EP3313987A1 (en) | 2018-05-02 |
| US10266810B2 (en) | 2019-04-23 |
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