DK3307277T3 - Enkeltstrengede oligonukleotider til anvendelse i medicinsk behandling af hudlidelser - Google Patents

Enkeltstrengede oligonukleotider til anvendelse i medicinsk behandling af hudlidelser Download PDF

Info

Publication number
DK3307277T3
DK3307277T3 DK16734570.1T DK16734570T DK3307277T3 DK 3307277 T3 DK3307277 T3 DK 3307277T3 DK 16734570 T DK16734570 T DK 16734570T DK 3307277 T3 DK3307277 T3 DK 3307277T3
Authority
DK
Denmark
Prior art keywords
medical treatment
skin disorders
stranded oligonucleotides
oligonucleotides
stranded
Prior art date
Application number
DK16734570.1T
Other languages
English (en)
Inventor
Holmgren Anna-Lena Spetz
Peter Järver
Annette Sköld
Original Assignee
Tirmed Pharma Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tirmed Pharma Ab filed Critical Tirmed Pharma Ab
Application granted granted Critical
Publication of DK3307277T3 publication Critical patent/DK3307277T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7125Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/17Immunomodulatory nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3212'-O-R Modification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/346Spatial arrangement of the modifications having a combination of backbone and sugar modifications

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK16734570.1T 2015-06-15 2016-06-14 Enkeltstrengede oligonukleotider til anvendelse i medicinsk behandling af hudlidelser DK3307277T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE1550814 2015-06-15
PCT/EP2016/063596 WO2016202779A1 (en) 2015-06-15 2016-06-14 Single-stranded oligonucleotides for use in the medical treatment of skin disorders

Publications (1)

Publication Number Publication Date
DK3307277T3 true DK3307277T3 (da) 2020-12-07

Family

ID=56345083

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16734570.1T DK3307277T3 (da) 2015-06-15 2016-06-14 Enkeltstrengede oligonukleotider til anvendelse i medicinsk behandling af hudlidelser

Country Status (15)

Country Link
US (1) US10626401B2 (da)
EP (1) EP3307277B1 (da)
AU (1) AU2016280663B2 (da)
CA (1) CA2989371C (da)
CY (1) CY1123639T1 (da)
DK (1) DK3307277T3 (da)
ES (1) ES2834906T3 (da)
HR (1) HRP20202066T1 (da)
HU (1) HUE051875T2 (da)
LT (1) LT3307277T (da)
PL (1) PL3307277T3 (da)
PT (1) PT3307277T (da)
RS (1) RS61274B1 (da)
SI (1) SI3307277T1 (da)
WO (1) WO2016202779A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201504124D0 (en) 2015-03-11 2015-04-22 Proqr Therapeutics B V Oligonucleotides
EA036393B1 (ru) 2015-05-21 2020-11-05 Вингс Терапьютикс, Инк. Антисмысловые олигонуклеотиды для лечения дистрофического буллезного эпидермолиза
GB201714330D0 (en) * 2017-09-06 2017-10-18 Järver Peter Oligonucleotides
WO2019199720A1 (en) * 2018-04-09 2019-10-17 The Trustees Of Princeton University Compositions comprising immune system activators and method of using same
WO2022229350A2 (en) 2021-04-30 2022-11-03 Tirmed Pharma Ab Single-stranded oligonucleotides for use in the medical treatment and/or prophylaxis of virus infections

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US8101345B1 (en) * 2005-03-25 2012-01-24 Isis Pharmaceuticals, Inc. Proinflammatory nucleic acids
WO2008147956A2 (en) 2007-05-25 2008-12-04 Centocor, Inc. Toll-like receptor 3 modulators and uses thereof
US20100040576A1 (en) 2007-12-18 2010-02-18 The Texas A&M University System Modified Oligonucleotides For The Treatment Of Hepatitis C Infection

Also Published As

Publication number Publication date
AU2016280663B2 (en) 2021-04-29
PT3307277T (pt) 2020-12-30
HUE051875T2 (hu) 2021-04-28
SI3307277T1 (sl) 2021-02-26
PL3307277T3 (pl) 2021-03-08
EP3307277A1 (en) 2018-04-18
WO2016202779A1 (en) 2016-12-22
US20180142246A1 (en) 2018-05-24
ES2834906T3 (es) 2021-06-21
CA2989371A1 (en) 2016-12-22
RS61274B1 (sr) 2021-01-29
CA2989371C (en) 2024-02-06
CY1123639T1 (el) 2022-03-24
US10626401B2 (en) 2020-04-21
EP3307277B1 (en) 2020-10-07
HRP20202066T1 (hr) 2021-04-30
AU2016280663A1 (en) 2018-01-18
LT3307277T (lt) 2020-12-28

Similar Documents

Publication Publication Date Title
DK3347030T3 (da) Brug af pasteuriseret akkermansia til behandling af stofskiftesygdomme
DK3334422T3 (da) Anvendelse af cannabidiolsyre i behandling af epilepsi
DK3516060T3 (da) Antisense-oligonukleotider til behandling af øjensygdom
DK3212233T3 (da) Kombinationsterapi til behandling af sygdom
DK3119397T3 (da) Heterocykliske forbindelser til anvendelse i behandling af PI3K-gamma-medierede lidelser
DK3307262T3 (da) Forbindelser til anvendelse ved behandling af neuromuskulære lidelser
DK3882250T3 (da) Tetrahydropyranyl-amino-pyrrolopyrimidinon til anvendelse i behandling af btk-medierede forstyrrelser
DK3668513T3 (da) Pyruvatkinase-aktiveringsmidler til anvendelse til behandling af blodsygdomme
SG11201700552SA (en) Precision chemical ablation and treatment of tissues
DK3302519T3 (da) Ornithodoros-moubata-komplement-inhibitor til anvendelse i behandlingen af akut graft-versus-host-sygdom
DK3391902T3 (da) Plasminogen til anvendelse i behandlingen af diabetisk angiokardiopati
DK3307277T3 (da) Enkeltstrengede oligonukleotider til anvendelse i medicinsk behandling af hudlidelser
DK3097085T3 (da) Benzoxazinonderivater til behandling af hudsygdomme
GB2542155B (en) Use of cannabidiol in the treatment of mental disorders
DK3125874T3 (da) Et terapeutisk middel til anvendelse i behandlingen af infektioner
FR3022139B1 (fr) Nouvelles compositions pour le traitement des rougeurs cutanees et de la rosacee
DK3389653T3 (da) 2-iminobiotin til anvendelse i behandling af hjernecellelæsion
HK1252359A1 (zh) 用於治療疼痛的曲唑酮和加巴噴丁的組合
IL256413B (en) IL-8 inhibitors for use in the treatment of certain urological disorders
KR20180085033A (ko) 피부 질환 치료용 약학적 제형 및 이의 제조 방법
DE112015003211A5 (de) Mittel zur Behandlung retroviraler Infektionserkrankungen
DE112015003204A5 (de) Mittel zur Behandlung retroviraler Infektionserkrankungen
FR3016881B1 (fr) Traitement des degenerescences et des lesions photo-induites de la retine
IT201600130064A1 (it) Composizioni per il trattamento di lesioni cutanee
TH182641B (th) องค์ประกอบและวิธีการเพื่อการบำบัดภาวะฮีโมโกลบินผิดปกติ