DK3165607T3 - Biologisk aktive oligonukleotider, der kan modulere immunsystemet - Google Patents

Biologisk aktive oligonukleotider, der kan modulere immunsystemet Download PDF

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Publication number
DK3165607T3
DK3165607T3 DK16202636.3T DK16202636T DK3165607T3 DK 3165607 T3 DK3165607 T3 DK 3165607T3 DK 16202636 T DK16202636 T DK 16202636T DK 3165607 T3 DK3165607 T3 DK 3165607T3
Authority
DK
Denmark
Prior art keywords
modulate
biologically active
immune system
active oligonucleotides
oligonucleotides
Prior art date
Application number
DK16202636.3T
Other languages
English (en)
Inventor
Arezou Zargari
Nikolai Kouznetsov
Charlotte Admyre
Stein Petra Von
Stein Oliver Von
Original Assignee
Index Pharmaceuticals Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP10196273A external-priority patent/EP2468866A1/en
Priority claimed from EP10196290A external-priority patent/EP2468867A1/en
Application filed by Index Pharmaceuticals Ab filed Critical Index Pharmaceuticals Ab
Application granted granted Critical
Publication of DK3165607T3 publication Critical patent/DK3165607T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6866—Interferon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/313—Phosphorodithioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK16202636.3T 2010-12-21 2011-12-20 Biologisk aktive oligonukleotider, der kan modulere immunsystemet DK3165607T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP10196273A EP2468866A1 (en) 2010-12-21 2010-12-21 Biologically active oligonucleotides capable of modulating the immune system
EP10196290A EP2468867A1 (en) 2010-12-21 2010-12-21 Methods for identifying biologically active oligonucleotides capable of modulating the immune system
EP10196285 2010-12-21
EP11802929.7A EP2655622B1 (en) 2010-12-21 2011-12-20 Methods for identifying biologically active oligonucleotides capable of modulating the immune system

Publications (1)

Publication Number Publication Date
DK3165607T3 true DK3165607T3 (da) 2021-05-31

Family

ID=45440530

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16202636.3T DK3165607T3 (da) 2010-12-21 2011-12-20 Biologisk aktive oligonukleotider, der kan modulere immunsystemet

Country Status (6)

Country Link
US (2) US9157919B2 (da)
EP (2) EP2655622B1 (da)
CA (1) CA2859698C (da)
DK (1) DK3165607T3 (da)
ES (1) ES2870458T3 (da)
WO (1) WO2012084996A2 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019535839A (ja) 2016-11-29 2019-12-12 ピュアテック ヘルス エルエルシー 治療剤の送達のためのエクソソーム
KR20200028392A (ko) * 2017-06-12 2020-03-16 유니버시티 오브 마이애미 질환의 치료를 위한 sting-의존성 활성화제

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040224405A1 (en) * 2003-05-06 2004-11-11 Dharmacon Inc. siRNA induced systemic gene silencing in mammalian systems
DE602005012948D1 (de) * 2004-05-06 2009-04-09 Us Gov Health & Human Serv Verfahren und zusammensetzungen zur behandlung von uveitis
CN1865275B (zh) * 2005-05-17 2011-06-15 长春华普生物技术有限公司 对人b细胞肿瘤有治疗作用的人工合成的单链脱氧核苷酸
ES2581480T3 (es) * 2007-05-04 2016-09-06 Index Pharmaceuticals Ab Compuestos inhibidores de crecimiento tumoral y métodos de uso de los mismos
DK2656850T3 (da) * 2007-10-05 2016-11-28 Index Pharmaceuticals Ab Oligonukleotider til behandling eller lindring af ødem
AU2009311748B2 (en) 2008-11-04 2014-08-21 Index Pharmaceuticals Ab Compounds and methods for reducing the recruitment and/or migration of polymorphonuclear cells
US20110280934A1 (en) * 2008-11-04 2011-11-17 Asa Karlsson Increased Expression of Specific Antigens

Also Published As

Publication number Publication date
US20160024508A1 (en) 2016-01-28
ES2870458T3 (es) 2021-10-27
US9593337B2 (en) 2017-03-14
CA2859698A1 (en) 2012-06-28
CA2859698C (en) 2021-03-02
US9157919B2 (en) 2015-10-13
EP3165607A2 (en) 2017-05-10
WO2012084996A3 (en) 2012-08-16
US20130281519A1 (en) 2013-10-24
EP2655622A2 (en) 2013-10-30
EP3165607A3 (en) 2017-07-26
EP2655622B1 (en) 2017-01-11
WO2012084996A2 (en) 2012-06-28
EP3165607B1 (en) 2021-04-07

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