DK3122800T3 - Nye polymerer og fremgangsmåde til fremstilling af membraner - Google Patents
Nye polymerer og fremgangsmåde til fremstilling af membraner Download PDFInfo
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- DK3122800T3 DK3122800T3 DK15712346.4T DK15712346T DK3122800T3 DK 3122800 T3 DK3122800 T3 DK 3122800T3 DK 15712346 T DK15712346 T DK 15712346T DK 3122800 T3 DK3122800 T3 DK 3122800T3
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- 150000003839 salts Chemical class 0.000 description 1
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- YPURUCMVRRNPHJ-UHFFFAOYSA-M sodium;3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoate Chemical compound [Na+].C12=CC=C(OCC=3N=C4C=CC=CC4=CC=3)C=C2C(SC(C)(C)C)=C(CC(C)(C)C([O-])=O)N1CC1=CC=C(Cl)C=C1 YPURUCMVRRNPHJ-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/42—Block-or graft-polymers containing polysiloxane sequences
- C08G77/452—Block-or graft-polymers containing polysiloxane sequences containing nitrogen-containing sequences
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/14—Dynamic membranes
- B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
- B01D69/142—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes with "carriers"
- B01D69/144—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes with "carriers" containing embedded or bound biomolecules
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
- B01D71/58—Other polymers having nitrogen in the main chain, with or without oxygen or carbon only
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
- B01D71/70—Polymers having silicon in the main chain, with or without sulfur, nitrogen, oxygen or carbon only
- B01D71/701—Polydimethylsiloxane
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
- B01D71/76—Macromolecular material not specifically provided for in a single one of groups B01D71/08 - B01D71/74
- B01D71/80—Block polymers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
- B01D71/76—Macromolecular material not specifically provided for in a single one of groups B01D71/08 - B01D71/74
- B01D71/82—Macromolecular material not specifically provided for in a single one of groups B01D71/08 - B01D71/74 characterised by the presence of specified groups, e.g. introduced by chemical after-treatment
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/44—Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/30—Cross-linking
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/34—Use of radiation
- B01D2323/345—UV-treatment
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/34—Molecular weight or degree of polymerisation
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Hydrology & Water Resources (AREA)
- Engineering & Computer Science (AREA)
- Environmental & Geological Engineering (AREA)
- Water Supply & Treatment (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Claims (16)
1. Blokcopolymer omfattende i det mindste én (poly)2-Ci-3alkyl-2-oxazolin-blok og i det mindste én (poly)dimethylsiloxan-blok, med i det mindste én endegruppe X, som omfatter såvel en -NH2 gruppe som en -NH-gruppe.
2. Blokcopolymer ifølge krav 1, hvor endegruppen har formlen -NHR, hvor R repræsenterer en alkylgruppe med fra 1 til 6 carbonatomer, substitueret med i det mindste én -NH2 gruppe.
3. Blokcopolymer ifølge krav 2, hvor endegruppen har formlen -NH-CH-(NH2)2 eller -NH-(CH2)n-NH2, hvor n er et heltal fra 2 til 6.
4. Blokcopolymer ifølge krav 3, hvor endegruppen har formlen -NH-(CH2)n-NH2, hvor n er 2.
5. Blokcopolymer ifølge ethvert af de foregående krav, som er en triblokcopolymer med to ydre (poly)2-Ci-3alkyl-2-oxazolinblokke og en indre (poly)dimethylsiloxanblok.
6. Blokcopolymer ifølge krav 5, hvor (poly)dimethylsiloxanblokken indeholder fra 20 til 150 dimethylsiloxanenheder og hver (poly)2-Ci-3alkyl-2-oxazolinblok indeholder fra 10 til 200 2-Ci-3alkyl-2-oxazolinenheder.
7. Blokcopolymer ifølge ethvert af de foregående krav, hvor den nævnte (poly)2-Ci-3alkyl-2-oxazolinblok er en (poly)2-methyl-2-oxazolinblok.
8. Vesikel dannet af en blokcopolymer ifølge ethvert af de foregående krav.
9. Vesikel ifølge krav 8, med transmembranproteiner inkorporeret deri.
10. Vesikel ifølge krav 9, hvor transmembranproteinet er en aquaporin.
11. Filtreringsmembran, som omfatter en porøs bærer og, kovalent bundet til en overflade deraf, et lag omfattende adskillige vesikler med transmembranproteiner inkorporeret deri, hvilke vesikler er dannede af en blokcopolymer omfattende i det mindste én (poly)2-Ci-3alkyl-2-oxazolinblok og i det mindste én (poly)dimethyl-siloxanblok; kendetegnet ved, at i det nævnte lag er vesikler kovalent indbyrdes forbundet for dannelse af en sammenhængende masse, idet i det mindste nogle af de nævnte kovalente forbindelser er blevet dannet af-NH2 grupper foreliggende i en vesikel som angivet i enten krav 9 eller krav 10.
12. Fremgangsmåde til fremstilling af en filtreringsmembran ifølge krav 11, som omfatter tilvejebringelse af en vandig suspension af vesikler som angivet i ethvert af kravene 9 eller 10; udfældning af suspensionen af vesikler på en overflade af en porøs bærer; og tilvejebringelse af reaktionsbetingelser således, at kovalente bindinger dannes imellem forskellige vesikler og imellem vesikler og overfladen.
13. Fremgangsmåde ifølge krav 12, som omfatter: (a) tilvejebringelse af en første vandig suspension af vesikler som angivet i enten krav 9 eller krav 10; (b) tilvejebringelse af en anden vandig suspension af vesikler med transmembranproteiner inkorporerede deri, hvilke vesikler er dannede af blokcopolymere omfattende i det mindste én (poly)2-Ci-3alkyl-2-oxazolinblok og i det mindste én (poly)dimethylsiloxanblok og med endegrupper Y, som er reaktive med polymerendegrupperne X foreliggende i vesiklerne fra trin (a); (c) udfældning af suspensionerne af vesikler på en bærer med en overflade, som er reaktiv med enten polymerendegrupper X eller Y; og (d) tilvejebringelse af en reaktion af endegrupper X med endegrupper Y og enten endegruppeer X eller endegrupper Y med overfladen på bæreren; eller som omfatter: (a) tilvejebringelse af en vandig suspension af vesikler som angivet i enten krav 9 eller krav 10; (b) tilvejebringelse af et multifunktionelt forbindelsesmiddel med i det mindste to reaktive grupper Y, som er reaktive med polymerendegrupper X på vesiklerne fra trin (a); (c) udfældning af suspensionen af vesikler og det multifunktionelle forbindelsesmiddel på en bærer med en overflade, som er reaktiv med enten polymerendegrupper X eller reaktive grupper Y; og (d) tilvejebringelse af reaktion af endegrupper X med grupper Y og enten endegrupper X eller grupper Y med overfladen på bæreren.
14. Fremgangsmåde som angivet i krav 13, hvor grupper Y er carboxylsyre-, aktiveret carboxylsyre-, og/eller azid-grupper.
15. Fremgangsmåde ifølge krav 13, hvor det multifunktionelle forbindelsesmiddel omfatter en grupper Y, som er en aktiveret carboxylsyregruppe og en anden gruppe Y, som er en azid-gruppe.
16. Fremgangsmåde ifølge krav 15, hvor det multifunktionelle forbindelsesmiddel er N-sulfosuccinimidyl-6-(4'-azido-2'-nitrophenylamino)hexanoat.
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| US10865278B2 (en) | 2015-03-24 | 2020-12-15 | Applied Biomimetic A/S | Vesicles formed from block copolymers, and novel block copolymers |
| CN105727772B (zh) * | 2016-02-22 | 2019-07-12 | 博通分离膜技术（北京）有限公司 | 一种复合反渗透膜及其制备方法 |
| CN110430937B (zh) * | 2017-02-06 | 2022-03-11 | 水通道蛋白有限公司 | 包含水通道蛋白水通道的二嵌段共聚物囊泡和分离膜及其制备和使用方法 |
| CN111871236A (zh) * | 2020-07-27 | 2020-11-03 | 四川春语环保科技有限公司 | 一种双膜联用膜分离与生物活性法处理废水系统 |
| CN112263917B (zh) * | 2020-10-19 | 2022-12-06 | 天津工业大学 | 一种草酸和京尼平交联的水凝胶过滤膜及其在高盐度下分子离子分离中的应用 |
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| US6916488B1 (en) * | 1999-11-05 | 2005-07-12 | Biocure, Inc. | Amphiphilic polymeric vesicles |
| IL166509A0 (en) | 2002-07-29 | 2006-01-15 | Mt Technologies Inc | Biomimetic membranes |
| JP2009510301A (ja) | 2005-09-20 | 2009-03-12 | アクアポリン エーピーエス | 塩分濃度差電力の生成において使用されるアクアポリンを備える生体模倣水性膜 |
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| US20080305149A1 (en) * | 2007-06-11 | 2008-12-11 | Thomas Hirt | Mucoadhesive vesicles for drug delivery |
| WO2009076174A1 (en) | 2007-12-05 | 2009-06-18 | The Board Of Trustees Of The University Of Illinois | Highly permeable polymer membranes |
| US9359230B2 (en) | 2009-02-03 | 2016-06-07 | Applied Biomimetic A/S | Nanofabricated membrane using polymerized proteoliposomes |
| DK177144B1 (en) | 2009-06-19 | 2012-02-06 | Aquaporin As | A liquid membrane suitable for water extraction |
| SG11201400825XA (en) * | 2011-09-21 | 2014-04-28 | Univ Nanyang Tech | Aquaporin based thin film composite membranes |
| US20150136690A1 (en) | 2012-06-01 | 2015-05-21 | National Unibersity of Singapore | Method of making a membrane and a membrane for water filtration |
| CN103588940B (zh) * | 2013-11-07 | 2016-01-20 | 中国科学技术大学 | 两亲性嵌段聚合物、聚合物囊泡及其制备方法和应用 |
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| AU2015238408A1 (en) | 2016-09-22 |
| EP3122800B1 (en) | 2018-04-25 |
| CN106232686B (zh) | 2019-09-17 |
| AU2015238408B9 (en) | 2018-05-10 |
| CA2941345A1 (en) | 2015-10-01 |
| US9994682B2 (en) | 2018-06-12 |
| ZA201606130B (en) | 2017-11-29 |
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