DK3099692T5 - Bifunktionelle cytotoksiske midler - Google Patents
Bifunktionelle cytotoksiske midler Download PDFInfo
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- DK3099692T5 DK3099692T5 DK15708273.6T DK15708273T DK3099692T5 DK 3099692 T5 DK3099692 T5 DK 3099692T5 DK 15708273 T DK15708273 T DK 15708273T DK 3099692 T5 DK3099692 T5 DK 3099692T5
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- cytotoxic agents
- bifunctional
- bifunctional cytotoxic
- agents
- cytotoxic
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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| US201461932118P | 2014-01-27 | 2014-01-27 | |
| US201462046685P | 2014-09-05 | 2014-09-05 | |
| PCT/IB2015/050280 WO2015110935A1 (en) | 2014-01-27 | 2015-01-14 | Bifunctional cytotoxic agents |
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| DK3099692T3 DK3099692T3 (en) | 2019-04-23 |
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| SG11201605437YA (en) * | 2014-01-27 | 2016-08-30 | Pfizer | Bifunctional cytotoxic agents |
| EP3160513B1 (en) | 2014-06-30 | 2020-02-12 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| PL3185908T3 (pl) | 2014-08-28 | 2020-09-07 | Pfizer Inc. | Łączniki modulujące stabilność do stosowania z koniugatami przeciwciało-lek |
| SG11201701128YA (en) | 2014-09-12 | 2017-03-30 | Genentech Inc | Cysteine engineered antibodies and conjugates |
| US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| US10870706B2 (en) * | 2015-03-20 | 2020-12-22 | Pfizer Inc. | Bifunctional cytotoxic agents containing the CTI pharmacophore |
| RU2021101009A (ru) | 2015-08-12 | 2021-02-20 | Пфайзер Инк. | Кэпированные и некэпированные цистеины антитела, и их применение в конъюгации антитело - лекарственное средство |
| MA43354A (fr) * | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
| DE102016105449A1 (de) | 2015-10-29 | 2017-05-04 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts | Bifunktionale Prodrugs |
| TWI727380B (zh) | 2015-11-30 | 2021-05-11 | 美商輝瑞股份有限公司 | 位點專一性her2抗體藥物共軛體 |
| CN109071409B (zh) * | 2016-03-14 | 2021-09-17 | 斯帕罗化学股份公司 | 制备取代的双环[1 1 1]戊烷的方法 |
| JP7031934B2 (ja) | 2016-05-11 | 2022-03-08 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックス |
| US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
| WO2017194592A1 (en) | 2016-05-11 | 2017-11-16 | Ge Healthcare Bioprocess R&D Ab | Method of storing a separation matrix |
| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| US10513537B2 (en) | 2016-05-11 | 2019-12-24 | Ge Healthcare Bioprocess R&D Ab | Separation matrix |
| WO2017194593A1 (en) | 2016-05-11 | 2017-11-16 | Ge Healthcare Bioprocess R&D Ab | Method of cleaning and/or sanitizing a separation matrix |
| WO2018025168A1 (en) | 2016-08-03 | 2018-02-08 | Pfizer Inc. | Heteroaryl sulfone-based conjugation handles, methods for their preparation, and their use in synthesizing antibody drug conjugates |
| US12448411B2 (en) | 2016-09-30 | 2025-10-21 | Cytiva Bioprocess R&D Ab | Separation method |
| US11419944B2 (en) | 2016-10-11 | 2022-08-23 | Byondis B.V. | Non-linear self-immolative linkers and conjugates thereof |
| ES3007557T3 (en) | 2016-10-17 | 2025-03-20 | Pfizer | Anti-edb antibodies and antibody-drug conjugates |
| SG10202110182PA (en) * | 2017-03-15 | 2021-10-28 | Silverback Therapeutics Inc | Benzazepine compounds, conjugates, and uses thereof |
| US11364303B2 (en) | 2017-09-29 | 2022-06-21 | Pfizer Inc. | Cysteine engineered antibody drug conjugates |
| MX2020004381A (es) * | 2017-10-27 | 2020-08-20 | Pfizer | Anticuerpos y conjugados de anticuerpo-farmaco especificos para cd123 y usos de los mismos. |
| US20200384002A1 (en) * | 2017-12-06 | 2020-12-10 | Yale University | Prodrugs Activated by Reduction in the Cytosol |
| IL283313B2 (en) * | 2018-11-20 | 2025-08-01 | Regeneron Pharma | Bis-octahydrophenanthrene carboxamide derivatives and protein conjugates thereof for use as lxr agonists |
| CN112986575B (zh) * | 2020-12-29 | 2023-03-17 | 上海药明康德新药开发有限公司 | 一种串联式验证dna编码苗头化合物修饰抗体的方法 |
| GB202306325D0 (en) * | 2023-04-28 | 2023-06-14 | Iksuda Therapeutics Ltd | Antibody-drug conjugate compounds, and methods of use and treatment |
| EP4494656A1 (en) * | 2023-07-21 | 2025-01-22 | Simris Biologics GmbH | Organic cytotoxin oligomers and uses thereof as a payload in antibody-drug conjugates |
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| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
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| CA2813411C (en) | 2010-11-05 | 2016-08-02 | Rinat Neuroscience Corporation | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
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| SG11201400770SA (en) | 2011-09-20 | 2014-04-28 | Spirogen Sarl | Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates |
| TWI495644B (zh) | 2011-11-11 | 2015-08-11 | Rinat Neuroscience Corp | 營養層細胞表面抗原(Trop-2)之專一性抗體類及彼等之用途 |
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| WO2014144878A2 (en) | 2013-03-15 | 2014-09-18 | The Scripps Research Institute | Novel thiol & amino modifying reagents for protein chemistry and methods of use thereof |
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| SG11201605437YA (en) * | 2014-01-27 | 2016-08-30 | Pfizer | Bifunctional cytotoxic agents |
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- 2015-01-14 DK DK15708273.6T patent/DK3099692T5/da active
- 2015-01-14 EP EP19153691.1A patent/EP3521292A1/en not_active Withdrawn
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2018
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