DK3099364T3 - Pulverkammer til højdosis-lægemiddelindgivelse - Google Patents
Pulverkammer til højdosis-lægemiddelindgivelse Download PDFInfo
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- DK3099364T3 DK3099364T3 DK16722343.7T DK16722343T DK3099364T3 DK 3099364 T3 DK3099364 T3 DK 3099364T3 DK 16722343 T DK16722343 T DK 16722343T DK 3099364 T3 DK3099364 T3 DK 3099364T3
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Claims (13)
1. Tørpulverinhalator, som er egnet til pulmonær eller nasal indgivelse, omfattende et inhalatorlegeme (201; 801) og en patron (203; 803); hvilken inhalator omfatter: (a) inhalatorlegemet (201; 801) omfattende et mundstykke (802), et nedre kanalindløb (210; 310; 410; 510; 610; 810), en inhalationskanal (208, 808) til tilvejebringelse af fluid forbindelse imellem patientens mund, når denne er i indgreb med mundstykket (802), og det nedre kanalindløb (210; 310; 410; 510; 610; 810), i det mindste ét sideindløb (818) til at tillade direkte lufttilgang fra atmosfæren til inhalatorkanalen (208, 808); en inhalatorlegemeåbning (204; 804) udformet deri og afgrænset imellem modstående øvre (211; 811) og nedre (812) vægge og modstående sidevægge (814), idet inhalatorlegemeåbningen (204; 804) har i det mindste én åben ende, ved hjælp af hvilken patronen (203; 803) kan indsættes i åbningen (204, 804) og har i det mindste én luftindløbsåbning (815, 816) til tilførsel af luft ind i inhalatorlegemeåbningen (204; 804), organer (819) til føring af bevægelse af patronen (203; 803) i inhalatorlegemeåbningen (204, 804) i forhold til legemet (201; 801) og styre dennes bevægelse fra en opbevaringsposition til en inhalationsposition; (b) patronen (203; 803) er udformet til indgreb med inhalatorlegemeåbningen (204; 804) og har i det mindste ét i det væsentlige cylindrisk pulverkammer (205; 305; 405; 505; 605; 705; 805) udformet deri til at indeholde et pulverbaseret lægemiddel, og i det mindste én luftindløbsåbning (206, 209; 306, 309; 406, 409; 506, 509; 606, 609; 709; 806, 809); pulverkammeret har et udløb (207; 807), som muliggør fluid forbindelse med legemets inhalatorkanal (208; 808) via legemets nedre kanalindløb (210; 310; 410; 510; 610; 810) og i det mindste én stift (820) til indgreb med legemets bevægelsesførende indretning (819); hvor patronen (203; 803) kan forskydes i legemet (201; 801) imellem en opbevaringsposition, i hvilken den i det mindste ene luftindløbsåbning (206, 209; 306, 309; 406, 409; 506, 509; 606, 609; 709; 806, 809) i patronen er i det væsentlige forseglet af inhalatorlegemet således, at der ikke er nogen fluid forbindelse til patronen, til en inhalationsposition, i hvilken den eller hver luftindløbsåbning (206, 209; 306, 309; 406, 409; 506, 509; 606, 609; 709; 806, 809) i patronen er i det væsentlige oprettet med en tilknyttet luftindløbsåbning (815, 816) i inhalatorlegemet således, at der er fluid forbindelse imellem indløbsåbningen (815, 816) i inhalatorlegemet, den eller hver luftindløbsåbning (206, 209; 306, 309; 406, 409; 506, 509; 606, 609; 709; 806, 809) i patronen, patronens øvre udløb (207; 807) og mundstykkekanalen (208; 808); kendetegnet ved, at at patronen (203; 803) omfatter i det mindste to luftindløbsåbninger (206, 209; 306, 309; 406, 409; 506, 509; 606, 609; 709; 806, 809), hvoraf i det mindste én er en sideværts luftindløbsåbning (209; 309; 409; 509; 609; 709; 809) og inhalatorlegeme (201; 801) har en luftindløbsåbning (815, 816) knyttet til hver af luftindløbsåbningerne (206, 209; 306, 309; 406, 409; 506, 509; 606, 609; 709; 806, 809) i patronen, som tillader tilgang af luft fra atmosfæren ind i patronens pulverkammer (205; 305; 405; 505; 605; 705; 805), når patronen (203; 803) er i en inhalationspositionen; og inhalatorlegemes nedre kanalindløb (210; 310; 410; 510; 610; 810) omfatter yderligere i det mindste én åbning, som danner en skarp indsnævring i fluidstrømningsvejen fra patronpulverkammerets udløb (207; 807) ind i inhalationskanalen (208; 808), når pulverpatronen (203; 803) bevæges til inhalationspositionen.
2. Tørpulverinhalator ifølge krav 1, hvor de i det mindste to luftindløbsåbninger (206, 209; 306, 309; 406, 409; 506, 509; 606, 609; 709; 806, 809) i patronen (203; 803) omfatter en nedre indløbsslids (206; 306; 406; 506; 606; 806); og hvor inhalatorlegemet (201, 801) omfatter en nedre åbning (815), som oprettes med den nedre indløbsslids (206; 306; 406; 506; 606; 806), når patronen (203; 703) er i inhalationspositionen.
3. Tørpulverinhalator ifølge krav 1 eller krav 2, hvor de i det mindste to luftindløbsåbninger (206, 209; 306, 309; 406, 409; 506, 509; 606, 609; 709; 806, 809) i patronen (203; 803) omfatter i det mindste ét par sideværts luftåbninger (209; 309; 409; 509; 609; 709; 809) udformede i sidevæggene i patronen; og hvor luftindløbsåbningerne (815, 816) i inhalataorlegemet (201; 801) omfatter i det mindste ét par sideåbninger (816) udformede i sidevæggene (814) i legemeåbningen (204, 804), idet hver sideåbning (816) oprettes med i det mindste én tilknyttet sideværts luftåbning i patronen, når patronen er i inhalationspositionen.
4. Tørpulverinhalator ifølge krav 3, hvor den eller hvert par af sideværts luftåbninger (209; 309; 409; 509; 609; 709; 809) er placerede på modstående sider af kammeret (205, 305, 405, 505, 605, 705, 805) og de sideværts luftåbninger (209; 309; 409; 509; 609; 709; 809), som danner hvert par, er forskudt i forhold til hinanden således, at der tillades en ikke-tangentiel indføring af luft.
5. Tørpulverinhalator ifølge ethvert af de foregående krav, hvor hver sideværts åbning (209, 309, 409, 509, 609, 709, 809) i patronpulverkammeret har en bredde på imellem 0,1 og 2 mm.
6. Tørpulverinhalator ifølge krav 5, hvor hver sideværts åbning (209,309,409, 509,609, 709, 809) i patronpulverkammeret har en bredde på mindre end 1 mm.
7. Tørpulverinhalator ifølge ethvert af de foregående krav, hvor hver sideåbning (816) i inhalatorlegemet (201, 801) er knyttet til adskillige sideværts åbninger (209, 309, 409, 509, 609, 709, 809).
8. Tørpulverinhalator ifølge ethvert af de foregående krav, hvor hver sideværts åbning (209, 309, 409, 509, 609, 709, 809) i patronpulverkammeret tilspidses indad imod den indvendige overflade af kammeret (205, 305, 405, 505, 605, 705, 805) for derved at koncentrere luften når denne passerer igennem åbningen ind i kammeret.
9. Tørpulverinhalator ifølge ethvert af de foregående krav, hvor inhalatorlegemes nedre kanalindløb (210, 310, 410, 510, 610, 810) omfatter adskillige åbninger.
10. Tørpulverinhalator ifølge krav 9, hvor de adskillige åbninger er anbragt til at danne et struktureret gitter.
11. Tørpulverinhalator ifølge ethvert af de foregående krav, hvor patronpulverkammeret (205, 305, 405, 505, 605, 705, 805) omfatter et sideværts fremspring (813) i området ved den eller hver luftindløbsåbning (206, 209, 306, 309, 406, 409, 506, 509, 606, 609, 709, 806, 809), som tilvejebringer mekanisk kontakt og fast sampasning med øvre (211, 811), nedre (812) og sidevægge (814) i legemeåbningen (204, 804), når patronen (203, 803) er i opbevaringspositionen for derved at tætne hver af de nævnte luftindløbsåbninger.
12. Tørpulverinhalator ifølge ethvert af de foregående krav, hvor inhalatorlegemets nedre kanalindløb (210, 310, 410, 510, 610, 810) tilvejebringer en geometrisk indsnævring i fluidkanalpassageområdet, hvor tværsnitsarealet af indsnævringen er imellem 30% og 99% af tværsnitsarealet af pulverkammerets udløb (207, 807).
13. Tørpulverinhalator ifølge krav 12, hvor tværsnitsarealet af indsnævringen (210, 310, 410, 510, 610, 810) er imellem 80% og 98% af tværsnitsarealet af pulverkammerudløbet (207, 807).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| PT108426A PT108426B (pt) | 2015-04-30 | 2015-04-30 | Inalador de pó para administração de doses elevadas de fármacos |
| PCT/GB2016/051073 WO2016174393A1 (en) | 2015-04-30 | 2016-04-28 | Powder compartment for high dosage drug delivery |
Publications (1)
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| DK3099364T3 true DK3099364T3 (da) | 2018-02-26 |
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| DK16722343.7T DK3099364T3 (da) | 2015-04-30 | 2016-04-28 | Pulverkammer til højdosis-lægemiddelindgivelse |
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| EP (1) | EP3099364B1 (da) |
| JP (1) | JP6219542B2 (da) |
| CN (1) | CN107847692B (da) |
| AU (1) | AU2016256655B2 (da) |
| CA (1) | CA2981414C (da) |
| DK (1) | DK3099364T3 (da) |
| ES (1) | ES2656840T3 (da) |
| HR (1) | HRP20180099T1 (da) |
| HU (1) | HUE036266T2 (da) |
| IL (1) | IL254733A0 (da) |
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| PL (1) | PL3099364T3 (da) |
| PT (2) | PT108426B (da) |
| RU (1) | RU2675686C1 (da) |
| WO (1) | WO2016174393A1 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10874818B2 (en) * | 2016-12-29 | 2020-12-29 | Philip Morris Usa Inc. | Aerosol delivery system |
| CN109821117B (zh) * | 2017-11-23 | 2024-06-28 | 正大天晴药业集团股份有限公司 | 粉末释放装置及方法 |
| CN109821118A (zh) | 2017-11-23 | 2019-05-31 | 正大天晴药业集团股份有限公司 | 新型肺部药物输送系统 |
| DE102018108958A1 (de) * | 2018-04-16 | 2019-10-17 | Emphasys Importadora Exportadora E Distribuidora Ltda. | Trockenpulverinhalator |
| US20220023553A1 (en) * | 2018-12-04 | 2022-01-27 | Hovione Technology Ltd | Large dose disposable inhaler and method of simple filling |
| US12064547B2 (en) * | 2019-01-14 | 2024-08-20 | Philip Morris Products S.A. | Dry powder inhaler device |
| GB2586301B (en) * | 2020-04-07 | 2021-08-25 | Splash Tm Gmbh | Stable-Foam inhalation Device and Cartridge |
| WO2022044514A1 (ja) | 2020-08-26 | 2022-03-03 | トキコシステムソリューションズ株式会社 | 薬剤吸入器 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5239991A (en) | 1989-06-21 | 1993-08-31 | Fisons Plc | Disposable powder medicament inhalation device with peel-off cover |
| US5042472A (en) | 1990-10-15 | 1991-08-27 | Merck & Co., Inc. | Powder inhaler device |
| GB2253200A (en) | 1991-02-01 | 1992-09-02 | Harris Pharma Ltd | Inhalation apparatus and fracturable capsule for use therewith |
| ES2089474T3 (es) * | 1991-08-16 | 1996-10-01 | Sandoz Ltd | Inhalador para la administracion de sustancias en polvo. |
| IL108780A (en) * | 1993-02-27 | 1999-06-20 | Fisons Plc | inhaler |
| ZA954936B (en) * | 1994-06-17 | 1996-02-27 | Trudell Medical Ltd | Nebulizing catheter system and methods of use and manufacture |
| US5797392C1 (en) | 1996-01-22 | 2001-01-09 | Direct Haler As | Inhaler |
| JP3328131B2 (ja) * | 1996-03-15 | 2002-09-24 | 株式会社ユニシアジェックス | 吸入式投薬器 |
| SE9700421D0 (sv) | 1997-02-07 | 1997-02-07 | Astra Ab | Single dose inhaler I |
| NL1008031C2 (nl) * | 1998-01-15 | 1999-07-21 | Pharmachemie Bv | Inrichting voor het inhaleren van medicament. |
| GB9810126D0 (da) | 1998-05-13 | 1998-07-08 | Glaxo Group Ltd | |
| US6810872B1 (en) | 1999-12-10 | 2004-11-02 | Unisia Jecs Corporation | Inhalant medicator |
| US6941947B2 (en) | 2002-12-18 | 2005-09-13 | Quadrant Technologies Limited | Unit dose dry powder inhaler |
| GB0520794D0 (en) | 2005-10-12 | 2005-11-23 | Innovata Biomed Ltd | Inhaler |
| PT103481B (pt) | 2006-05-16 | 2008-08-01 | Hovione Farmaciencia S A | Inalador de uso simples e método de inalação |
| US7806117B2 (en) | 2006-06-07 | 2010-10-05 | Shin Nippon Biomedical Laboratories, Ltd. | Peroral powder delivery device |
| CA2655477C (en) * | 2006-06-16 | 2015-05-05 | Cipla Limited | Vibration assisted release of encapsulated inhalable powder |
| EP2043717A1 (en) | 2006-07-14 | 2009-04-08 | Astra Zeneca AB | Inhalation system and delivery device for the administration of a drug in the form of dry powder |
| EP2020249A1 (de) * | 2007-08-01 | 2009-02-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Inhalator |
| PT105065B (pt) * | 2010-04-26 | 2012-07-31 | Hovione Farmaciencia S A | Um inalador simples de cápsulas |
| JP6037315B2 (ja) * | 2011-05-27 | 2016-12-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 吸入器及び吸入器用カプセル |
| US10463815B2 (en) * | 2012-02-21 | 2019-11-05 | Respira Therapeutics, Inc. | Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents |
| US9845187B2 (en) | 2012-06-06 | 2017-12-19 | Aerodesigns, Inc. | Aerosol dispenser with replaceable cartridge |
| SE1300485A1 (sv) | 2013-04-23 | 2014-10-24 | Simplified Solutions Sweden Ab | Engångs-inhalator för ämnen i pulverform |
| US20150014428A1 (en) | 2013-07-10 | 2015-01-15 | Woodpecker Laboratories, LLC | Portable devices and methods for providing scents |
-
2015
- 2015-04-30 PT PT108426A patent/PT108426B/pt active IP Right Grant
-
2016
- 2016-04-28 RU RU2017134634A patent/RU2675686C1/ru not_active IP Right Cessation
- 2016-04-28 ES ES16722343.7T patent/ES2656840T3/es active Active
- 2016-04-28 PT PT167223437T patent/PT3099364T/pt unknown
- 2016-04-28 EP EP16722343.7A patent/EP3099364B1/en active Active
- 2016-04-28 US US15/117,571 patent/US10478572B2/en active Active
- 2016-04-28 DK DK16722343.7T patent/DK3099364T3/da active
- 2016-04-28 CN CN201680024936.5A patent/CN107847692B/zh active Active
- 2016-04-28 NO NO16722343A patent/NO3099364T3/no unknown
- 2016-04-28 AU AU2016256655A patent/AU2016256655B2/en not_active Ceased
- 2016-04-28 PL PL16722343T patent/PL3099364T3/pl unknown
- 2016-04-28 JP JP2016563123A patent/JP6219542B2/ja active Active
- 2016-04-28 CA CA2981414A patent/CA2981414C/en active Active
- 2016-04-28 WO PCT/GB2016/051073 patent/WO2016174393A1/en active Application Filing
- 2016-04-28 HU HUE16722343A patent/HUE036266T2/hu unknown
-
2017
- 2017-09-27 IL IL254733A patent/IL254733A0/en unknown
-
2018
- 2018-01-18 HR HRP20180099TT patent/HRP20180099T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016256655A1 (en) | 2017-10-19 |
| US20180036497A1 (en) | 2018-02-08 |
| CA2981414C (en) | 2019-06-11 |
| CN107847692A (zh) | 2018-03-27 |
| AU2016256655B2 (en) | 2018-02-15 |
| PT108426B (pt) | 2017-07-24 |
| CA2981414A1 (en) | 2016-11-03 |
| IL254733A0 (en) | 2017-11-30 |
| PT108426A (pt) | 2016-10-31 |
| EP3099364A1 (en) | 2016-12-07 |
| NO3099364T3 (da) | 2018-04-21 |
| EP3099364B1 (en) | 2017-11-22 |
| ES2656840T3 (es) | 2018-02-28 |
| HUE036266T2 (hu) | 2018-06-28 |
| HRP20180099T1 (hr) | 2018-02-23 |
| JP2017516518A (ja) | 2017-06-22 |
| RU2675686C1 (ru) | 2018-12-21 |
| PT3099364T (pt) | 2018-02-26 |
| US10478572B2 (en) | 2019-11-19 |
| CN107847692B (zh) | 2019-05-10 |
| JP6219542B2 (ja) | 2017-10-25 |
| PL3099364T3 (pl) | 2018-07-31 |
| WO2016174393A1 (en) | 2016-11-03 |
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