DK3004343T3 - CYCLIC ADENOSIN MONONPHOSPHATE INSUFFICIENT ADENYLYL CYCLE AND COMPOSITIONS AND METHODS FOR TREATING HEART WEIGHT AND INCREASING HEART FUNCTION - Google Patents

CYCLIC ADENOSIN MONONPHOSPHATE INSUFFICIENT ADENYLYL CYCLE AND COMPOSITIONS AND METHODS FOR TREATING HEART WEIGHT AND INCREASING HEART FUNCTION Download PDF

Info

Publication number
DK3004343T3
DK3004343T3 DK14808138.3T DK14808138T DK3004343T3 DK 3004343 T3 DK3004343 T3 DK 3004343T3 DK 14808138 T DK14808138 T DK 14808138T DK 3004343 T3 DK3004343 T3 DK 3004343T3
Authority
DK
Denmark
Prior art keywords
leu
ac6mut
ala
arg
gly
Prior art date
Application number
DK14808138.3T
Other languages
Danish (da)
English (en)
Inventor
H Kirk Hammond
Mei Hua Gao
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of DK3004343T3 publication Critical patent/DK3004343T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y406/00—Phosphorus-oxygen lyases (4.6)
    • C12Y406/01—Phosphorus-oxygen lyases (4.6.1)
    • C12Y406/01001—Aodenylate cyclase (4.6.1.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
DK14808138.3T 2013-06-07 2014-06-04 CYCLIC ADENOSIN MONONPHOSPHATE INSUFFICIENT ADENYLYL CYCLE AND COMPOSITIONS AND METHODS FOR TREATING HEART WEIGHT AND INCREASING HEART FUNCTION DK3004343T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361832759P 2013-06-07 2013-06-07
PCT/US2014/040948 WO2014197624A1 (en) 2013-06-07 2014-06-04 Cycle adenosine monophosphate-incompetent adenylyl cyclase and compositions and methods for treating heart failure and increasing cardiac function

Publications (1)

Publication Number Publication Date
DK3004343T3 true DK3004343T3 (en) 2019-02-04

Family

ID=52008569

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14808138.3T DK3004343T3 (en) 2013-06-07 2014-06-04 CYCLIC ADENOSIN MONONPHOSPHATE INSUFFICIENT ADENYLYL CYCLE AND COMPOSITIONS AND METHODS FOR TREATING HEART WEIGHT AND INCREASING HEART FUNCTION

Country Status (14)

Country Link
US (1) US11040091B2 (cg-RX-API-DMAC10.html)
EP (1) EP3004343B1 (cg-RX-API-DMAC10.html)
JP (1) JP6571069B2 (cg-RX-API-DMAC10.html)
KR (1) KR20160032090A (cg-RX-API-DMAC10.html)
CN (1) CN105452458A (cg-RX-API-DMAC10.html)
AU (1) AU2014274902B2 (cg-RX-API-DMAC10.html)
BR (1) BR112015030355A8 (cg-RX-API-DMAC10.html)
CA (1) CA2914029A1 (cg-RX-API-DMAC10.html)
DK (1) DK3004343T3 (cg-RX-API-DMAC10.html)
HK (1) HK1222884A1 (cg-RX-API-DMAC10.html)
IL (1) IL242885B (cg-RX-API-DMAC10.html)
RU (1) RU2015155831A (cg-RX-API-DMAC10.html)
WO (1) WO2014197624A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201508942B (cg-RX-API-DMAC10.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6878301B2 (ja) * 2015-04-09 2021-05-26 コーネル ユニヴァーシティー アレルゲンに対する反応を予防するための遺伝子治療
EP3530278A4 (en) * 2016-10-24 2019-10-30 Gwangju Institute of Science and Technology COMPOSITION WITH PROTEIN-PHOSPHATASE-1-INHIBITING PEPTIDE FOR THE TREATMENT OF VASCULAR DISEASES
WO2018090036A1 (en) * 2016-11-14 2018-05-17 Renova Therapeutics, Inc. Method of protection for cardiac tissue
US11760987B2 (en) 2017-09-07 2023-09-19 The Regents Of The University Of California Compositions and methods for the treatment or prevention of heart failure
EP3689363A4 (en) * 2017-09-29 2021-05-19 BethphaGen Inc. PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF CARDIAC ARRHYTHMIA
CN112272705A (zh) * 2018-06-08 2021-01-26 佛罗里达大学研究基金会有限公司 用于心肌病的aav心脏基因治疗
CN109010799B (zh) * 2018-07-09 2021-07-06 沣潮医药科技（上海）有限公司 RyR2蛋白或RyR2重组蛋白在制备抗心力衰竭药物中的用途
CN109191052B (zh) * 2018-10-22 2020-09-25 山东大学 一种多车型车辆路径优化方法、服务器及系统
MX2023001109A (es) 2020-07-27 2023-04-24 Anjarium Biosciences Ag Composiciones de moleculas de adn, metodos para elaborar las mismas, y metodos de usos de las mismas.
CN116867512A (zh) 2020-12-23 2023-10-10 佛罗里达州大学研究基金会 包装效率提高的用于心脏基因治疗的载体
CN116411064A (zh) * 2023-02-24 2023-07-11 山东大学齐鲁医院 Gsα基因在制备用于预防和治疗动脉粥样硬化药物中的应用
CN116590398A (zh) * 2023-04-20 2023-08-15 青岛大学 Atf7基因在制备心脏疾病诊断产品中的应用和药物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020103147A1 (en) 1997-09-05 2002-08-01 Hammond H. Kirk Gene therapy for congestive heart failure

Also Published As

Publication number Publication date
HK1222884A1 (zh) 2017-07-14
BR112015030355A2 (pt) 2017-07-25
CA2914029A1 (en) 2014-12-11
JP2016521708A (ja) 2016-07-25
EP3004343B1 (en) 2018-10-10
US20160101164A1 (en) 2016-04-14
RU2015155831A3 (cg-RX-API-DMAC10.html) 2018-03-28
ZA201508942B (en) 2019-05-29
RU2015155831A (ru) 2017-07-14
EP3004343A4 (en) 2017-01-04
IL242885B (en) 2019-12-31
KR20160032090A (ko) 2016-03-23
EP3004343A1 (en) 2016-04-13
AU2014274902B2 (en) 2020-06-04
CN105452458A (zh) 2016-03-30
US11040091B2 (en) 2021-06-22
AU2014274902A1 (en) 2015-12-24
BR112015030355A8 (pt) 2019-12-24
JP6571069B2 (ja) 2019-09-04
WO2014197624A1 (en) 2014-12-11

Similar Documents

Publication Publication Date Title
AU2014274902B2 (en) Cycle adenosine monophosphate-incompetent adenylyl cyclase and compositions and methods for treating heart failure and increasing cardiac function
KR102107482B1 (ko) 심혈관 질환 및 다른 증상에 대한 파라크린 유전자의 전신 전달 및 조절 발현
US20160166651A1 (en) Systemic delivery of virus vectors encoding urocortin-2 and related genes to treat diabetes-related cardiac dysfunctions and congestive heart failure
US11760987B2 (en) Compositions and methods for the treatment or prevention of heart failure
JP7541003B2 (ja) 心不全の治療及び予防における使用のためのリラキシン受容体１
EP3689896A1 (en) Grk2 modulating mirnas
WO2015153357A1 (en) Compositions and methods for improving cardiac function
HK1257863A1 (en) Systemic delivery and regulated expression of paracrine genes for cardiovascular diseases and other conditions
Hellström Combinations of Gene Therapy, Tissue Transplantation and Pharmacotherapeutic Techniques in Visual System Repair
HK1203845B (en) Systemic delivery and regulated expression of paracrine genes for cardiovascular diseases and other conditions