DK2985025T3 - Farmaceutisk sammensætning - Google Patents
Farmaceutisk sammensætning Download PDFInfo
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- DK2985025T3 DK2985025T3 DK15179438.5T DK15179438T DK2985025T3 DK 2985025 T3 DK2985025 T3 DK 2985025T3 DK 15179438 T DK15179438 T DK 15179438T DK 2985025 T3 DK2985025 T3 DK 2985025T3
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Claims (11)
1. Farmaceutisk kombination omfattende forbindelsen 3-Z-[l-(4-(/V-((4-methylpiperazin-l-yl)methylcarbonyl)-/V-methylamino)-anilino)-l-phenyl-methylen]-6-methoxycarbonyl-2-indolinon eller et farmaceutisk acceptabelt salt deraf og forbindelsen /V-[4-[2-(2-amino-4,7-dihydro-4-oxo-l/-/-pyrrolo[2,3-c/]pyrimidin-5-yl)ethyl]benzoyl]-L-glutaminsyre eller et farmaceutisk acceptabelt salt deraf til anvendelse i en fremgangsmåde til behandling af malignt pleural eller peritonealt mesotheliom.
2. Farmaceutisk kombination til anvendelse ifølge krav 1, hvor den farmaceutiske kombination er til anvendelse i en fremgangsmåde til behandling af malignt pleural mesotheliom.
3. Farmaceutisk kombination til anvendelse ifølge krav 1 eller 2, hvori det farmaceutisk acceptable salt af forbindelsen 3-Z-[l-(4-(/V-((4-methylpiperazin-l-yl)methylcarbonyl)-/V-methylamino)-anilino)-l-phenylmethylen]-6-methoxycarbonyl-2-indolinon er dens monoethansulfonat-saltform.
4. Farmaceutisk kombination til anvendelse ifølge krav 1 eller 2, hvori det farmaceutisk acceptable salt af forbindelsen /V-[4-[2-(2-amino-4,7-dihydro-4-oxo-l/-/-pyrrolo[2,3-c/]pyrimidin-5-yl)ethyl]benzoyl]-L-glutaminsyre er dens dinatriumsaltform.
5. Farmaceutisk kombination til anvendelse ifølge krav 1 eller 2, omfattende mono-ethansulfonat-saltformen af forbindelsen 3-Z-[l-(4-(/V-((4-methylpiperazin-l-yl)methylcarbonyl)-/V-methylamino)anilino)-l-phenylmethylen]-6-methoxycarbonyl-2-indolinon og dinatriumsaltformen af forbindelsen /V-[4-[2-(2-amino-4,7-dihydro-4 oxo-lH-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutaminsyre.
6. Farmaceutisk kombination til anvendelse ifølge et hvilket som helst af kravene 1 til 5, som er i form af et kombineret præparat til samtidig, separat eller sekventiel anvendelse.
7. Farmaceutisk kombination til anvendelse ifølge et hvilket som helst af kravene 1 til 5, som yderligere er tilpasset en sambehandling med strålebehandling.
8. Forbindelsen 3-Z-[l-(4-(/V-((4-methylpiperazin-l-yl)methylcarbonyl)-/V-methylamino)anilino)-l-phenylmethylen]-6-methoxycarbonyl-2-indolinon eller et farmaceutisk acceptabelt salt deraf til anvendelse i en fremgangsmåde til behandling af malignt pleural eller peritonealt mesotheliom omfattende indgivelse til en patient i behov derfor af en virkningsfuld mængde af forbindelsen før, efter eller samtidig med en virkningsfuld mængde af Forbindelsen /V-[4-[2-(2-amino-4,7-dihydro-4-oxo-lH-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutaminsyre eller et farmaceutisk acceptabelt salt deraf.
9. Forbindelse til anvendelse ifølge krav 8, hvor forbindelsen er beregnet til anvendelse i en fremgangsmåde til behandling af malignt pleural mesotheliom.
10. Forbindelse til anvendelse ifølge krav 8 eller 9, hvor det farmaceutisk acceptable salt af forbindelsen 3-Z-[l-(4-(/V-((4-methylpiperazin-l-yl)-methylcarbonyl)-/V-methylamino)-anilino)-l-phenylmethylen]-6-methoxycarbonyl-2-indolinon er dens mono- ethan-sulfonatsalt.
11. Forbindelse til anvendelse ifølge krav 8 eller 9, hvor det farmaceutisk acceptable salt af forbindelsen /V-[4-[2-(2-amino-4,7-dihydro-4-oxo-l/-/-pyrrolo[2, 3-cf]pyrimidin-5-yl)ethyl]benzoyl]-L-glutaminsyre er dens dinatriumsalt.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08157749 | 2008-06-06 | ||
| US7888208P | 2008-07-08 | 2008-07-08 | |
| EP09757599.7A EP2293795B1 (en) | 2008-06-06 | 2009-06-04 | Pharmaceutical combination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2985025T3 true DK2985025T3 (da) | 2018-03-19 |
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ID=40912046
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15179438.5T DK2985025T3 (da) | 2008-06-06 | 2009-06-04 | Farmaceutisk sammensætning |
| DK09757599.7T DK2293795T3 (da) | 2008-06-06 | 2009-06-04 | Farmaceutisk kombination. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09757599.7T DK2293795T3 (da) | 2008-06-06 | 2009-06-04 | Farmaceutisk kombination. |
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| Country | Link |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| UA107560C2 (uk) * | 2008-06-06 | 2015-01-26 | Фармацевтична лікарська форма для негайного вивільнення похідної індолінону | |
| US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
| LT2299987T (lt) * | 2008-06-06 | 2018-05-25 | Boehringer Ingelheim International Gmbh | Farmacinės vaisto formos kapsulė, apimanti indolinono darinio suspensijos kompoziciją |
| US20140350022A1 (en) | 2013-05-10 | 2014-11-27 | Boehringer Ingelheim International Gmbh | Efficacious treatment of NSCLC and predictive clinical marker of the responsiveness of a tumour to a treatment |
| US20150044288A1 (en) | 2013-07-31 | 2015-02-12 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
| EP3365180B1 (en) * | 2015-10-21 | 2019-12-18 | Capsugel Belgium NV | Printing process for oral dosage forms |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL96531A (en) * | 1989-12-11 | 1995-08-31 | Univ Princeton | History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them) |
| WO2005070469A1 (en) * | 2004-01-23 | 2005-08-04 | Sarissa, Inc. | Methods of treating mesothelioma using an antisense oligonucleotide to thymidylate synthase |
| EP1212325A2 (en) * | 1999-08-23 | 2002-06-12 | Eli Lilly And Company | A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor |
| UA75054C2 (uk) | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
| DE10233500A1 (de) * | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel |
| US20040204458A1 (en) * | 2002-08-16 | 2004-10-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of Lck inhibitors for treatment of immunologic diseases |
| DE10237423A1 (de) * | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
| US7148249B2 (en) * | 2002-09-12 | 2006-12-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments |
| US20050043233A1 (en) * | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| US20060058311A1 (en) * | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
| WO2006023010A1 (en) * | 2004-08-18 | 2006-03-02 | Salmedix, Inc. | Alanosine formulations and methods of use |
| PE20060777A1 (es) * | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| WO2007057397A1 (en) * | 2005-11-15 | 2007-05-24 | Boehringer Ingelheim International Gmbh | Treatment of cancer |
| EP1870400A1 (en) | 2006-06-08 | 2007-12-26 | Boehringer Ingelheim Pharma GmbH & Co. KG | Salts and crystalline salt forms of an 2-indolinone derivative |
| WO2008021410A2 (en) * | 2006-08-14 | 2008-02-21 | Sicor Inc. | Highly pure pemetrexed diacid and processes for the preparation thereof |
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