DK2978760T3 - Cyklisk n-acyl-o-aminophenol-cbi-derivat - Google Patents

Cyklisk n-acyl-o-aminophenol-cbi-derivat Download PDF

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Publication number
DK2978760T3
DK2978760T3 DK14772747.3T DK14772747T DK2978760T3 DK 2978760 T3 DK2978760 T3 DK 2978760T3 DK 14772747 T DK14772747 T DK 14772747T DK 2978760 T3 DK2978760 T3 DK 2978760T3
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DK
Denmark
Prior art keywords
aminophenol
acyl
cyclic
cbi derivative
cbi
Prior art date
Application number
DK14772747.3T
Other languages
English (en)
Inventor
Dale L Boger
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of DK2978760T3 publication Critical patent/DK2978760T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06Peri-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK14772747.3T 2013-03-28 2014-03-20 Cyklisk n-acyl-o-aminophenol-cbi-derivat DK2978760T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361806212P 2013-03-28 2013-03-28
PCT/US2014/031338 WO2014160586A1 (en) 2013-03-28 2014-03-20 Cyclic n-acyl o-amino phenol cbi derivative

Publications (1)

Publication Number Publication Date
DK2978760T3 true DK2978760T3 (da) 2019-05-13

Family

ID=51625457

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14772747.3T DK2978760T3 (da) 2013-03-28 2014-03-20 Cyklisk n-acyl-o-aminophenol-cbi-derivat

Country Status (10)

Country Link
US (1) US9586974B2 (da)
EP (1) EP2978760B1 (da)
JP (1) JP6173559B2 (da)
AU (1) AU2014241731B2 (da)
CA (1) CA2907676C (da)
DK (1) DK2978760T3 (da)
ES (1) ES2719796T3 (da)
PT (1) PT2978760T (da)
TR (1) TR201904426T4 (da)
WO (1) WO2014160586A1 (da)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU727608B2 (en) * 1995-10-03 2000-12-14 Scripps Research Institute, The CBI analogs of CC-1065 and the duocarmycins
WO2009064913A1 (en) * 2007-11-13 2009-05-22 The Scripps Research Institute Chimer containing a targeting portion linked to a scission-activated duocarmycin-type prodrug

Also Published As

Publication number Publication date
JP6173559B2 (ja) 2017-08-02
CA2907676A1 (en) 2014-10-02
WO2014160586A8 (en) 2014-11-06
AU2014241731B2 (en) 2017-08-31
WO2014160586A1 (en) 2014-10-02
CA2907676C (en) 2017-11-07
PT2978760T (pt) 2019-05-31
AU2014241731A1 (en) 2015-09-24
EP2978760A4 (en) 2016-11-16
ES2719796T3 (es) 2019-07-16
US20160016972A1 (en) 2016-01-21
TR201904426T4 (tr) 2019-04-22
US9586974B2 (en) 2017-03-07
EP2978760A1 (en) 2016-02-03
JP2016515577A (ja) 2016-05-30
EP2978760B1 (en) 2019-02-27

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