DK2968457T3 - Faktor h til transplantation - Google Patents
Faktor h til transplantation Download PDFInfo
- Publication number
- DK2968457T3 DK2968457T3 DK14721085.0T DK14721085T DK2968457T3 DK 2968457 T3 DK2968457 T3 DK 2968457T3 DK 14721085 T DK14721085 T DK 14721085T DK 2968457 T3 DK2968457 T3 DK 2968457T3
- Authority
- DK
- Denmark
- Prior art keywords
- factor
- composition
- allograft
- recipient
- rejection
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/01002—Fumarate hydratase (4.2.1.2)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Claims (15)
1. Sammensætning omfattende Faktor H (FH) til anvendelsen i en fremgangsmåde til at forebygge eller inhibere allograft-afstødning afen modtager af nævnte allograft, hvor nævnte modtager yderligere behandles med en første immunhæmmende sammensætning omfattende et element valgt fra sirolimus (Rapamycin), FK506 (FK), cyclosporin, og tacrolimus.
2. Sammensætningen ifølge krav 1, til anvendelsen ifølge krav 1, hvor nævnte FH er plasma-afledt FH eller rekombinant FH.
3. Sammensætningen ifølge krav 1 eller krav 2, til anvendelsen ifølge krav 1 eller krav 2, hvor nævnte modtager yderligere behandles med et andet forskelligt immunhæmmende middel omfattende et element uafhængigt valgt fra sirolimus (Rapamycin), FK506 (FK), cyclosporin, og tacrolimus.
4. Sammensætningen ifølge kravene 1-3, til anvendelsen ifølge kravene 1-3, hvor nævnte fremgangsmåde omfatter behandling af nævnte modtager med en sammensætning omfattende FH, en sammensætning omfattende FK, og en sammensætning omfattende Rapamycin.
5. Sammensætningen ifølge kravene 1-4, til anvendelsen ifølge kravene 1-4, hvor nævnte allograft-afstødning er en antistof-medieret afstødning eller en kombination af antistof- og celle-medieret afstødning.
6. Sammensætningen ifølge kravene 1-5, til anvendelsen ifølge kravene 1-5, hvor nævnte forebyggelse eller inhibering af allograft-afstødning omfatter at forlænge allograft-overlevelse og/eller -funktion i et forudbestemt antal dage.
7. Sammensætningen ifølge kravene 1-6, til anvendelsen ifølge kravene 1-6, hvor nævnte forebyggelse eller inhibering af allograft-afstødning omfatter forebyggelse eller inhibering af en stigning i niveauer af markører for allograft-afstødning.
8. Sammensætningen ifølge kravene 1-7, til anvendelsen ifølge kravene 1-7, hvor nævnte allograft-afstødning er akut antistof-medie ret afstødning.
9. Sammensætningen ifølge krav 7, til anvendelsen ifølge krav 7, hvor nævnte modtager behandles med FH ved modtagelse af nævnte allograft, indtil nævnte allograft fungerer normalt.
10. Sammensætningen ifølge krav 9, til anvendelsen ifølge krav 9, hvor normal funktion af nævnte allograft bestemmes ved modtager-kreatinniveau og/eller negativ C4d-biopsi-testning.
11. Sammensætningen ifølge kravene 1-7, til anvendelsen ifølge kravene 1-7, hvor nævnte allograft-afstødning forekommer 3-6 måneder efter modtagelse af nævnte allograft.
12. Sammensætningen ifølge kravene 1-11, til anvendelsen ifølge kravene 1-11, hvor nævnte allograft omfatter et organ eller væv.
13. Sammensætningen ifølge krav 12, til anvendelsen ifølge krav 12, hvor nævnte organ er et helt organ.
14. Sammensætningen ifølge krav 13, til anvendelsen ifølge krav 13, hvor nævnte hele organ er et element valgt fra nyre, hjerte, lever, tarm, bugspytkirtel og lunge.
15. Sammensætningen ifølge kravene 1-11, til anvendelsen ifølge kravene 1-11, hvor nævnte allograft er et element valgt fra en hudgraft, en knoglegraft, en hjerteklap, og knoglemarv.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361785977P | 2013-03-14 | 2013-03-14 | |
PCT/US2014/026677 WO2014151919A1 (en) | 2013-03-14 | 2014-03-13 | Factor h for transplantation |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2968457T3 true DK2968457T3 (da) | 2018-10-29 |
Family
ID=50631029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14721085.0T DK2968457T3 (da) | 2013-03-14 | 2014-03-13 | Faktor h til transplantation |
Country Status (14)
Country | Link |
---|---|
US (1) | US9138466B2 (da) |
EP (1) | EP2968457B1 (da) |
JP (1) | JP6373963B2 (da) |
AU (1) | AU2014236778B2 (da) |
CA (1) | CA2906527A1 (da) |
DK (1) | DK2968457T3 (da) |
ES (1) | ES2703382T3 (da) |
HR (1) | HRP20181451T1 (da) |
HU (1) | HUE039464T2 (da) |
LT (1) | LT2968457T (da) |
PL (1) | PL2968457T3 (da) |
PT (1) | PT2968457T (da) |
SI (1) | SI2968457T1 (da) |
WO (1) | WO2014151919A1 (da) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3526249A4 (en) * | 2016-10-17 | 2020-07-01 | Musc Foundation for Research Development | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING TRANSPLANT-ASSOCIATED LESION |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5624946A (en) * | 1994-07-05 | 1997-04-29 | Williams; James | Use of leflunomide to control and reverse chronic allograft rejection |
WO2000052479A2 (en) | 1999-03-05 | 2000-09-08 | University Of Iowa Research Foundation | Diagnostics and therapeutics for drusen associated ocular disorders |
AU6110301A (en) | 2000-04-29 | 2001-11-12 | Univ Iowa Res Found | Diagnostics and therapeutics for macular degeneration-related disorders |
WO2006062716A2 (en) | 2004-11-18 | 2006-06-15 | Yale University | Methods and compositions for treating ocular disorders |
EP2357254A1 (en) | 2005-02-14 | 2011-08-17 | University of Iowa Research Foundation | Methods and reagents for treatment and diagnosis of age-related macular degeneration |
FR2894145B1 (fr) | 2005-12-07 | 2008-10-17 | Lab Francais Du Fractionnement | Utilisation de facteur h du complement a titre de medicament |
CN101563363B (zh) * | 2006-06-21 | 2013-01-02 | 南卡罗来纳医疗大学研究发展基金会 | 用于治疗疾病的靶向补体因子h |
WO2008113589A1 (en) | 2007-03-20 | 2008-09-25 | Csl Behring Gmbh | Methods for industrial scale production of therapeutic complement factor h preparations from human plasma |
CN109045296A (zh) * | 2008-11-10 | 2018-12-21 | 阿雷克森制药公司 | 用于治疗补体相关障碍的方法和组合物 |
AT514675B1 (de) * | 2009-07-23 | 2019-05-15 | Baxalta Inc | Herstellung von faktor h (fh) und fh-derivaten aus plasma |
WO2012095519A1 (en) * | 2011-01-13 | 2012-07-19 | Leibniz-Institut Für Naturstoff-Forschung Und Infektionsbiologie | Potent inhibitors of complement activation |
EP2557089A2 (en) * | 2011-07-15 | 2013-02-13 | Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Compositions and methods for immunomodulation |
-
2014
- 2014-03-13 PT PT14721085T patent/PT2968457T/pt unknown
- 2014-03-13 ES ES14721085T patent/ES2703382T3/es active Active
- 2014-03-13 WO PCT/US2014/026677 patent/WO2014151919A1/en active Application Filing
- 2014-03-13 CA CA2906527A patent/CA2906527A1/en not_active Abandoned
- 2014-03-13 LT LTEP14721085.0T patent/LT2968457T/lt unknown
- 2014-03-13 JP JP2016502210A patent/JP6373963B2/ja not_active Expired - Fee Related
- 2014-03-13 EP EP14721085.0A patent/EP2968457B1/en not_active Not-in-force
- 2014-03-13 AU AU2014236778A patent/AU2014236778B2/en not_active Ceased
- 2014-03-13 US US14/210,076 patent/US9138466B2/en not_active Expired - Fee Related
- 2014-03-13 SI SI201430902T patent/SI2968457T1/sl unknown
- 2014-03-13 PL PL14721085T patent/PL2968457T3/pl unknown
- 2014-03-13 HU HUE14721085A patent/HUE039464T2/hu unknown
- 2014-03-13 DK DK14721085.0T patent/DK2968457T3/da active
-
2018
- 2018-09-11 HR HRP20181451TT patent/HRP20181451T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
WO2014151919A1 (en) | 2014-09-25 |
HRP20181451T1 (hr) | 2018-12-28 |
SI2968457T1 (sl) | 2018-11-30 |
EP2968457A1 (en) | 2016-01-20 |
US20140335113A1 (en) | 2014-11-13 |
AU2014236778A1 (en) | 2015-10-15 |
PT2968457T (pt) | 2018-11-07 |
US9138466B2 (en) | 2015-09-22 |
JP6373963B2 (ja) | 2018-08-15 |
EP2968457B1 (en) | 2018-08-29 |
JP2016514158A (ja) | 2016-05-19 |
ES2703382T3 (es) | 2019-03-08 |
CA2906527A1 (en) | 2014-09-25 |
PL2968457T3 (pl) | 2018-12-31 |
HUE039464T2 (hu) | 2019-01-28 |
LT2968457T (lt) | 2018-10-25 |
AU2014236778B2 (en) | 2019-01-03 |
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