DK295490D0 - SUGAR DERIVATIVES, PROCEDURE FOR THEIR PREPARATION AND APPLICATION OF THEM - Google Patents

SUGAR DERIVATIVES, PROCEDURE FOR THEIR PREPARATION AND APPLICATION OF THEM

Info

Publication number
DK295490D0
DK295490D0 DK295490A DK295490A DK295490D0 DK 295490 D0 DK295490 D0 DK 295490D0 DK 295490 A DK295490 A DK 295490A DK 295490 A DK295490 A DK 295490A DK 295490 D0 DK295490 D0 DK 295490D0
Authority
DK
Denmark
Prior art keywords
hydrogen atom
alkyl
alkyl group
formula
sugar derivatives
Prior art date
Application number
DK295490A
Other languages
Danish (da)
Other versions
DK170171B1 (en
DK295490A (en
Inventor
Ernst Nitsch
Bernhard Lotz
Original Assignee
Laevosan Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laevosan Gmbh & Co Kg filed Critical Laevosan Gmbh & Co Kg
Publication of DK295490D0 publication Critical patent/DK295490D0/en
Publication of DK295490A publication Critical patent/DK295490A/en
Application granted granted Critical
Publication of DK170171B1 publication Critical patent/DK170171B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Sugar derivatives of the general formula I and II <IMAGE> in which R1 is a hydrogen atom or an alkyl group with 1 to 7 carbon atoms, R2 and R3 are a hydrogen atom or, if R1 is an alkyl group, are also an acyl group R4CO, R is a hydrogen atom or an acyl group R5CO, and R4 and R5 are an alkyl group with 1 to 7 carbon atoms, have an excellent antiproliferative/cytotoxic activity with very low toxicity. The compounds of the formula I and II can be prepared by treating alpha- or beta-1,4-linked di- or oligosaccharides which contain at their reducing end a glucose, fructose or mannose molecule with inorganic or organic bases, isolating in a manner known per se from the resulting reaction mixture the 3-deoxy-D-glyceropentulose (3-DGP) of the formula I in which R1, R2 and R3 are a hydrogen atom, and, if required, converting the 3-DGP in a manner known per se into its glycoside (I, R1 = alkyl, R2, R3 = H), diacylglycoside (I, R1 = alkyl, R2, R3 = R4CO), dianhydride (II, R = H) or diacyl dianhydride (II, R = R5CO).
DK295490A 1989-12-15 1990-12-12 Glyceropentulose derivatives, processes for their preparation, and pharmaceutical agents containing them DK170171B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP89123301A EP0432309B1 (en) 1989-12-15 1989-12-15 Sugar derivatives, process for their preparation and their use
EP89123301 1989-12-15

Publications (3)

Publication Number Publication Date
DK295490D0 true DK295490D0 (en) 1990-12-12
DK295490A DK295490A (en) 1991-06-16
DK170171B1 DK170171B1 (en) 1995-06-06

Family

ID=8202239

Family Applications (1)

Application Number Title Priority Date Filing Date
DK295490A DK170171B1 (en) 1989-12-15 1990-12-12 Glyceropentulose derivatives, processes for their preparation, and pharmaceutical agents containing them

Country Status (7)

Country Link
EP (1) EP0432309B1 (en)
AT (1) ATE105294T1 (en)
DE (1) DE58907621D1 (en)
DK (1) DK170171B1 (en)
ES (1) ES2052878T3 (en)
FI (1) FI906181A (en)
NO (1) NO175206C (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2929509B1 (en) * 2008-04-02 2011-01-21 Lvmh Rech USE OF ALKYL GLYCOSIDES OR ALKYL GLYCOSIDE MIXTURES AS AGENTS FOR INHIBITING MICROBIAL GROWTH AND COMPOSITIONS CONTAINING SAID ALKYL GLYCOSIDES

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2609397B1 (en) * 1988-02-23 1991-12-13 Serobiologiques Lab Sa USE OF A CARBOHYDRATE SUBSTANCE OR COMPOSITION AS AN ACTIVE INGREDIENT OF A DERMATOLOGICAL AND / OR COSMETOLOGICAL AND / OR PHARMACEUTICAL AND / OR CELL STIMULANT COMPOSITION, AND COMPOSITION CONTAINING SUCH A CARBON SUBSTANCE OR COMPOSITION

Also Published As

Publication number Publication date
NO905417D0 (en) 1990-12-14
DK170171B1 (en) 1995-06-06
NO175206B (en) 1994-06-06
ATE105294T1 (en) 1994-05-15
NO905417L (en) 1991-06-17
EP0432309B1 (en) 1994-05-04
FI906181A (en) 1991-06-16
EP0432309A1 (en) 1991-06-19
ES2052878T3 (en) 1994-07-16
NO175206C (en) 1994-09-14
FI906181A0 (en) 1990-12-14
DE58907621D1 (en) 1994-06-09
DK295490A (en) 1991-06-16

Similar Documents

Publication Publication Date Title
Hoeksema et al. Chemical studies on lincomycin. I. The structure of lincomycin
AU4916979A (en) Sugar derivatives of c-076 compounds
NO842496L (en) PROCEDURE FOR THE PREPARATION OF FRUCTOSYLIC DACACARIDES
KR840005443A (en) Morpholinyl daunorubicin and doxorubicin derivatives and preparation method thereof
CA1129852A (en) Aminoglycoside derivatives
ES8101622A1 (en) Anthracycline derivatives, a process for their preparation and pharmaceutical compositions containing them.
OA09022A (en) Novel substituted piperazyl-2-oxo-ethylene flavonoid derivatives, processes for their preparation and pharmaceutical compositions containing them.
DK295490D0 (en) SUGAR DERIVATIVES, PROCEDURE FOR THEIR PREPARATION AND APPLICATION OF THEM
CA2366681A1 (en) Methods and compositions for the manufacture of c-3&#39; and c-4&#39; anthracycline antibiotics
US4202967A (en) N,N-pentamethylene derivatives of daunomycin and adriamycin
Rana et al. The chemical synthesis of O-α-l-fucopyranosyl-(1→ 2)-O-β-d-galactopyranosyl-(1→ 3)-O-[α-l-fucopyranosyl-(1→ 4)]-2-acetamido-2-deoxy-d-glucopyranose, the Lewis b blood-group antigenic determinant
ATE71105T1 (en) 4-SUBSTITUTED ANTHRACYCLINONES AND ANTHRACYCLINONGLYCOSIDES AND THEIR PREPARATION.
Takahashi et al. Synthesis of 3′-deoxy-3′-fluorokanamycin A and 3′, 4′-dideoxy-3′-fluorokanamycin A
NO150514C (en) HOMOSITRONIC ACID OLIGORIBOSIDE DERIVATIVE, PROCEDURE FOR ITS PREPARATION AND AGENT FOR AA PREVENT DENTAL KARIES
ES8703865A2 (en) Process for preparing H2 receptor antagonist ascorbate compounds
SE8004622L (en) ACYLAMINOBENSOESYRADERIVAT
Szarek et al. Synthesis of carbohydrate‐saccharin conjugates
EP0416327A3 (en) Chemical derivatives of antibiotics ll-e19020 alpha and beta
GB2158436B (en) Pyrano derivatives
JPS57140717A (en) Antidiabetic agent containing o- or m-aminobenzoic acid derivative
DK0485894T3 (en) Process for the preparation of the N-glycidyl-anthracycline semi-synthetic diastereomers
SE8501666D0 (en) ANTHRACYCLINE DERIVATIVES, PROCEDURES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
JPS57140719A (en) Antiarteriosclerotic agent containing o- or m- aminobenzoic acid derivative
JPS57140718A (en) Hypotensive agent containing o- or m-aminobenzoic acid derivative
KR880011190A (en) Anthracycline glycoside, preparation method thereof and use as bacteriostatic agent

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

Country of ref document: DK