NO175206C - Analogous Process for Preparing Therapeutically Active Sugar Derivatives - Google Patents

Analogous Process for Preparing Therapeutically Active Sugar Derivatives

Info

Publication number
NO175206C
NO175206C NO905417A NO905417A NO175206C NO 175206 C NO175206 C NO 175206C NO 905417 A NO905417 A NO 905417A NO 905417 A NO905417 A NO 905417A NO 175206 C NO175206 C NO 175206C
Authority
NO
Norway
Prior art keywords
hydrogen atom
alkyl
sugar derivatives
alkyl group
formula
Prior art date
Application number
NO905417A
Other languages
Norwegian (no)
Other versions
NO175206B (en
NO905417D0 (en
NO905417L (en
Inventor
Ernst Nitsch
Bernhard Lotz
Original Assignee
Laevosan Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laevosan Gmbh filed Critical Laevosan Gmbh
Publication of NO905417D0 publication Critical patent/NO905417D0/en
Publication of NO905417L publication Critical patent/NO905417L/en
Publication of NO175206B publication Critical patent/NO175206B/no
Publication of NO175206C publication Critical patent/NO175206C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Sugar derivatives of the general formula I and II <IMAGE> in which R1 is a hydrogen atom or an alkyl group with 1 to 7 carbon atoms, R2 and R3 are a hydrogen atom or, if R1 is an alkyl group, are also an acyl group R4CO, R is a hydrogen atom or an acyl group R5CO, and R4 and R5 are an alkyl group with 1 to 7 carbon atoms, have an excellent antiproliferative/cytotoxic activity with very low toxicity. The compounds of the formula I and II can be prepared by treating alpha- or beta-1,4-linked di- or oligosaccharides which contain at their reducing end a glucose, fructose or mannose molecule with inorganic or organic bases, isolating in a manner known per se from the resulting reaction mixture the 3-deoxy-D-glyceropentulose (3-DGP) of the formula I in which R1, R2 and R3 are a hydrogen atom, and, if required, converting the 3-DGP in a manner known per se into its glycoside (I, R1 = alkyl, R2, R3 = H), diacylglycoside (I, R1 = alkyl, R2, R3 = R4CO), dianhydride (II, R = H) or diacyl dianhydride (II, R = R5CO).
NO905417A 1989-12-15 1990-12-14 Analogous Process for Preparing Therapeutically Active Sugar Derivatives NO175206C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP89123301A EP0432309B1 (en) 1989-12-15 1989-12-15 Sugar derivatives, process for their preparation and their use

Publications (4)

Publication Number Publication Date
NO905417D0 NO905417D0 (en) 1990-12-14
NO905417L NO905417L (en) 1991-06-17
NO175206B NO175206B (en) 1994-06-06
NO175206C true NO175206C (en) 1994-09-14

Family

ID=8202239

Family Applications (1)

Application Number Title Priority Date Filing Date
NO905417A NO175206C (en) 1989-12-15 1990-12-14 Analogous Process for Preparing Therapeutically Active Sugar Derivatives

Country Status (7)

Country Link
EP (1) EP0432309B1 (en)
AT (1) ATE105294T1 (en)
DE (1) DE58907621D1 (en)
DK (1) DK170171B1 (en)
ES (1) ES2052878T3 (en)
FI (1) FI906181A (en)
NO (1) NO175206C (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2929509B1 (en) * 2008-04-02 2011-01-21 Lvmh Rech USE OF ALKYL GLYCOSIDES OR ALKYL GLYCOSIDE MIXTURES AS AGENTS FOR INHIBITING MICROBIAL GROWTH AND COMPOSITIONS CONTAINING SAID ALKYL GLYCOSIDES

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2609397B1 (en) * 1988-02-23 1991-12-13 Serobiologiques Lab Sa USE OF A CARBOHYDRATE SUBSTANCE OR COMPOSITION AS AN ACTIVE INGREDIENT OF A DERMATOLOGICAL AND / OR COSMETOLOGICAL AND / OR PHARMACEUTICAL AND / OR CELL STIMULANT COMPOSITION, AND COMPOSITION CONTAINING SUCH A CARBON SUBSTANCE OR COMPOSITION

Also Published As

Publication number Publication date
FI906181A (en) 1991-06-16
DE58907621D1 (en) 1994-06-09
ATE105294T1 (en) 1994-05-15
EP0432309B1 (en) 1994-05-04
FI906181A0 (en) 1990-12-14
DK295490A (en) 1991-06-16
ES2052878T3 (en) 1994-07-16
EP0432309A1 (en) 1991-06-19
DK295490D0 (en) 1990-12-12
NO175206B (en) 1994-06-06
DK170171B1 (en) 1995-06-06
NO905417D0 (en) 1990-12-14
NO905417L (en) 1991-06-17

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