DK2948757T3 - Kemisk detektionsindretning - Google Patents

Kemisk detektionsindretning Download PDF

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Publication number
DK2948757T3
DK2948757T3 DK13872987.6T DK13872987T DK2948757T3 DK 2948757 T3 DK2948757 T3 DK 2948757T3 DK 13872987 T DK13872987 T DK 13872987T DK 2948757 T3 DK2948757 T3 DK 2948757T3
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DK
Denmark
Prior art keywords
metal
nanostructures
functional group
detection device
coating
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DK13872987.6T
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English (en)
Inventor
Zhang-Lin Zhou
Zhiyong Li
Steven J Barcelo
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Hewlett Packard Development Co Lp
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Publication of DK2948757T3 publication Critical patent/DK2948757T3/da

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G01N21/554—Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/651—Cuvettes therefore

Claims (10)

1. Kemisk detektionsindretning (100; 200; 300), som omfatter: et substrat (102); en flerhed af aflange nanostrukturer (104), hvor hver af de aflange nanostrukturer (104) har en fastgørelsesende og en fri ende modsat fastgørelsesenden, idet fastgørelsesenden er fastgjort til substratet (102), og den frie ende omfatter et metal; hvor hver af de aflange nanostrukturer (104) er en struktur, som har et dimensionsforhold med en længde, der er mindst dobbelt så lang som den korteste bredde; hvor de aflange nanostrukturer (104) er bøjelige og arrangeret således, at de er i stand til at bøje sig og indfange molekyler; hvor metallet er en metalbelægning eller metalhætte (108) på den frie ende; og hvor de aflange nanostrukturer (104) omfatter nanokegler, nanopyramider, nanostave, nanostænger, nanofingre, nanopæle eller nanogræs; og hvor udtrykket nanostruktur henviser til en hvilken som helst struktur, hvis bredde eller diameter har en størrelse på mindre end 1 mikrometer, kendetegnet ved, at hver af de aflange nanostrukturer (104) er belagt med en forsætligt påført metaloxidbelægning (110), hvilken metaloxidbelægning (110) har en tykkelse i intervallet fra 1 nm til 200 nm.
2. Kemisk detektionsindretning (200; 300) ifølge krav 1, som yderligere omfatter en funktionel gruppe (112), der er bundet til belægningen ved kovalent binding; og hvor den funktionelle gruppe (112) omfatter en fastgørelsesfunktionel gruppe A, en afstandsgruppe B og en målfunktionel gruppe FG ifølge formlen I:
hvor A er en organisk funktionel gruppe, som er bundet til nanostrukturen (104), B er substitueret eller usubstitueret, lineær eller forgrenet alkyl eller aryl, og FG er en organisk funktionel gruppe, der er i stand til at adsorbere et målmolekyle.
3. Kemisk detektionsindretning (200; 300) ifølge krav 2, hvor den funktionelle gruppe (112) er formuleret til at binde sig selektivt til en metalion, en organisk forbindelse eller en hydrogenion.
4. Kemisk detektionsindretning (100; 200; 300) ifølge krav 1, hvor metaloxidet er valgt fra gruppen bestående af siliciumoxid, titanoxid, zinkoxid, aluminiumoxid, galliumoxid, indiumoxid, zirconiumoxid, hafniumoxid, tantaloxid og blandinger deraf.
5. Kemisk detektionsindretning (100; 200; 300) ifølge krav 1, hvor metallet er valgt fra gruppen bestående af guld, sølv, kobber, aluminium, platin og blandinger deraf.
6. Kemisk detektionsindretning (300) ifølge krav 1, som yderligere omfatter en detektor (118), der er operativt koblet til flerheden af aflange nanostrukturer (104), hvor detektoren (118) er valgt fra gruppen bestående af et kolorimeter, et reflektometer, et spektrometer, et spektrofotometer, et Raman-spektrometer, et lysmikroskop og et instrument til at måle luminescens.
7. Kemisk detektionsindretning (300) ifølge krav 1, hvor flerheden af aflange nanostrukturer (104) udgør et array (114).
8. Kemisk detektionsindretning (300) ifølge krav 7, hvorarrayet indbefatter underarrays (116), hvilke underarrays (116) har individuel selektivitet for et målmolekyle, hvilket målmolekyle er individuelt valgt fra gruppen bestående af en metalion, en organisk forbindelse og en hydrogenion.
9. Fremgangsmåde til fremstilling af en kemisk detektionsindretning (100; 200; 300) ifølge det foreliggende krav 1, hvilken fremgangsmåde omfatter: at anbringe en flerhed af aflange nanostrukturer (104) på et substrat (102) således, at hver af de aflange nanostrukturer (104) har en fastgørelsesende fastgjort til substratet (102) og en fri ende modsat fastgørelsesenden; at afsætte et metal på den frie ende af hver af de aflange nanostrukturer (104); og belægge hver af de aflange nanostrukturer (104) med en forsætligt påført metaloxidbelægning (110); hvor hver af de aflange nanostrukturer (104) er en struktur, som har et dimensionsforhold med en længde, der er mindst dobbelt så lang som den korteste bredde; hvor de aflange nanostrukturer (104) er bøjelige, og hvor de bøjelige nanostrukturer er arrangeret således, at de er i stand til at bøje sig og indfange molekyler; hvor metallet er en metalbelægning eller metalhætte (108) på den frie ende; og hvor metaloxidbelægningen (110) har en tykkelse i intervallet fra 1 nm til 200 nm, hvor de aflange nanostrukturer (104) er valgt blandt nanokegler, nanopyramider, nanostave, nanostænger, nanofingre, nanopæle og nanogræs; og hvor udtrykket nanostruktur henviser til en hvilken som helst struktur, hvis bredde eller diameter har en størrelse på mindre end 1 mikrometer.
10. Fremgangsmåde ifølge krav 9, som yderligere omfatter trinet til at fastgøre en funktionel gruppe (112) til metaloxidbelægningen (110) på den frie ende af nanostrukturen (104).
DK13872987.6T 2013-01-25 2013-01-25 Kemisk detektionsindretning DK2948757T3 (da)

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PCT/US2013/023266 WO2014116238A1 (en) 2013-01-25 2013-01-25 Chemical sensing device

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DK2948757T3 true DK2948757T3 (da) 2017-06-06

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US (1) US9567214B2 (da)
EP (2) EP2948757B1 (da)
JP (1) JP5969711B2 (da)
CN (2) CN104937391A (da)
DK (1) DK2948757T3 (da)
WO (1) WO2014116238A1 (da)

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Publication number Publication date
EP3214431A1 (en) 2017-09-06
US20150355097A1 (en) 2015-12-10
EP2948757A4 (en) 2015-12-23
JP5969711B2 (ja) 2016-08-17
CN107655860A (zh) 2018-02-02
JP2016510405A (ja) 2016-04-07
EP2948757A1 (en) 2015-12-02
WO2014116238A1 (en) 2014-07-31
CN104937391A (zh) 2015-09-23
US9567214B2 (en) 2017-02-14
EP2948757B1 (en) 2017-04-26
EP3214431B1 (en) 2021-03-03

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