DK2905288T3 - Syntetiske kunstige peptider med antimikrobiel virkning - Google Patents

Syntetiske kunstige peptider med antimikrobiel virkning Download PDF

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Publication number
DK2905288T3
DK2905288T3 DK15153281.9T DK15153281T DK2905288T3 DK 2905288 T3 DK2905288 T3 DK 2905288T3 DK 15153281 T DK15153281 T DK 15153281T DK 2905288 T3 DK2905288 T3 DK 2905288T3
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DK
Denmark
Prior art keywords
peptide
peptides
amino acids
antimicrobial
seq
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DK15153281.9T
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English (en)
Inventor
Karsten Rapsch
Nickisch-Rosenegk Markus V
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Fraunhofer Ges Forschung
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Claims (14)

1. Et peptid med et aminoterminalt område A, et carboxyterminalt område C og et derimellem liggende område B med den almene formel AxByCz f med x, z > 1, idet x > 3 og/eller z > 3, y>3ogx + y+ z< 50, idet A og C hver især uafhængigt af hinanden har i det mindste 65%, 75% eller 80% basiske aminosyrer, idet B har i det mindste 80% hydrofobe og/eller upolære aminosyrer udvalgt af gruppen bestående af Val, Ile, Phe og vilkårlige kombinationer af Val, Leu, Ile og Phe og omfatter en direkte rækkefølge efter hinanden af i det mindste tre, fire eller fem hydrofobe aminosyrer.
2. Peptid ifølge krav 1 med y > 4 eller y > 5.
3. Peptid ifølge et af kravene 1 eller 2, idet den aminoterminale aminosyre i A og/eller den carboxyterminale aminosyre i C er en basisk aminosyre.
4. Peptid ifølge et af kravene 1 til 3, idet de basiske aminosyrer uafhængigt af hinanden er udvalgt af gruppen bestående af Lys, Arg og His eller af Lys og Arg.
5. Peptid ifølge et af kravene 1 til 4, idet A og/eller C udelukkende omfatter basiske aminosyrer, og/eller idet B udelukkende omfatter hydrofobe og/eller upolære aminosyrer.
6. Peptid ifølge et af kravene 1 til 5 med y < 20, y < 15 eller y < 10 og/eller med x + y + z < 30 eller x + y + z < 20.
7. Peptid ifølge et af kravene 1 til 6, idet peptidet i et vandigt miljø i det mindste delvist er udformet som beta-streng, fortrinsvis i det mindste 50%, 65%, 75% eller 80% af aminosyrerne i peptidet er omfattet i en enkelt beta-streng.
8. Peptid ifølge et af kravene 1 til 7, idet peptidet i et vandigt miljø ikke har nogen alpha-helix.
9. Peptid ifølge et af kravene 1 til 8, idet peptidet på C-terminalen er udformet som carboxylsyreamid.
10. Peptid ifølge et af kravene 1 til 9 med 3 d x, z < 7 og 5 < y < 10, idet A og C uafhængigt af hinanden er udvalgt af gruppen bestående af Lys, Arg og kombinationer heraf, og idet B er udvalgt af gruppen bestående af Val, Ile, Phe og vilkårlige kombinationer af Val, Leu, Ile og Phe.
11. Peptid ifølge et af kravene 1 til 10, idet peptidet har i det mindste 90% eller i det mindste 95% sekvensidentitet med en sekvens udvalgt af gruppen bestående af SEQ ID NO: 1-13, 15, 16, 19-25 og 27-49.
12. Peptid ifølge et af kravene 1 til 11 til anvendelse som medikament.
13. Et konjugat omfattende peptidet ifølge et af kravene 1 til 11 og i det mindste en yderligere bestanddel, hvortil peptidet foreligger bundet kovalent og/eller adsorptivt
14. En antimikrobiel sammensætning omfattende peptidet ifølge et af kravene 1 til 11.
DK15153281.9T 2014-02-11 2015-01-30 Syntetiske kunstige peptider med antimikrobiel virkning DK2905288T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102014101663.7A DE102014101663A1 (de) 2014-02-11 2014-02-11 Synthetische artifizielle Peptide mit antimikrobieller Wirkung

Publications (1)

Publication Number Publication Date
DK2905288T3 true DK2905288T3 (da) 2019-04-15

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US (1) US10556926B2 (da)
EP (1) EP2905288B1 (da)
DE (1) DE102014101663A1 (da)
DK (1) DK2905288T3 (da)

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GB2463181B (en) 2007-05-14 2013-03-27 Univ New York State Res Found Induction of a physiological dispersion response in bacterial cells in a biofilm
AU2013235336B2 (en) 2012-03-23 2016-09-08 Amicrobe, Inc. Compositions and uses of antimicrobial materials with tissue-compatible properties
CA3058901A1 (en) 2017-04-06 2018-10-11 Amicrobe, Inc. Compositions and uses of locally applied antimicrobials with enhanced performance and safety
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance

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SE8900130D0 (sv) 1989-01-16 1989-01-16 Klaus Mosback Konceptet att med hjaelp av molekylavtrycksmetoden framstaella konstgjorda antikroppar genom imprinting av t ex antigener samt att framstaella konstgjorda entzymer genom imprintning med transition state analoger
US5958786A (en) 1997-08-05 1999-09-28 Bayer Corporation Fluorescent polymeric sensor for the detection of creatinine
JP2003520843A (ja) 2000-01-28 2003-07-08 エムアイピー・テクノロジーズ・エービー 分子を認識および触媒するための官能性モノマー
WO2001090733A1 (en) 2000-05-23 2001-11-29 Radiometer Medical A/S A sensor membrane, a method for the preparation thereof, a sensor and a layered membrane structure for such sensor
WO2003092736A2 (en) * 2002-05-01 2003-11-13 Pantheco A/S Peptide nucleic acid conjugates with transporter peptides
US20080131451A1 (en) * 2004-03-05 2008-06-05 Giancarlo Tanzi Epitope escape mutations
JP2006067968A (ja) * 2004-09-06 2006-03-16 Osaka Bioscience Institute ヒト癌細胞の浸潤と転移を阻害する物質およびそのスクリーニング方法
JP2008516235A (ja) 2004-10-05 2008-05-15 バイエル ヘルスケア エルエルシー 安定な３酵素クレアチニンバイオセンサー
DE102004049805A1 (de) 2004-10-12 2006-04-13 Universität Dortmund Verfahren zur Herstellung von molekulargeprägten Polymeren zur Erkennung von Zielmolekülen
EP2116603A3 (en) * 2004-11-12 2010-02-17 The University Of British Columbia Antimicrobial peptides
WO2006127048A2 (en) * 2004-12-17 2006-11-30 Kansas State University Research Foundation NOVEL pH DEPENDENT ADHESIVE PEPTIDES
EP1757942A1 (en) * 2005-08-26 2007-02-28 Max-Delbrück-Centrum Array for identification of protein-protein interactions and method for manufacturing the same
EP2061886B1 (en) * 2006-08-21 2014-05-07 The University Of British Columbia Small cationic immunomodulatory peptides
DK2212020T3 (da) 2007-11-12 2018-10-01 Surecapture Tech Ab Prægede polymere med affinitet til phoshorylerede peptider og proteiner
EP2168590A1 (en) * 2008-09-24 2010-03-31 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Antimicrobial peptides
CN102206250B (zh) * 2010-03-29 2017-03-15 翔升科技股份有限公司 低血球溶解性的抗微生物肽、药物组合物及其用途
GB201016733D0 (en) * 2010-10-05 2010-11-17 Novabiotics Ltd Compounds and their use
WO2012145680A2 (en) * 2011-04-21 2012-10-26 George Mason Intellectual Properties, Inc. Anti-microbial peptides and uses therefore

Also Published As

Publication number Publication date
US10556926B2 (en) 2020-02-11
DE102014101663A1 (de) 2015-08-13
EP2905288B1 (de) 2018-12-26
US20150225458A1 (en) 2015-08-13
EP2905288A1 (de) 2015-08-12

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