DK287883D0 - Fremgangsmade til fremstilling af alicyclisk substituerede oxazolidin-2,4-dion-forbindelser eller farmaceutisk acceptable kationsalte deraf og tilsvarende substituerede alfa-hydroxyacetamider og 2-hydroxyacetonitriler der er nyttige som mellemprodukter - Google Patents

Fremgangsmade til fremstilling af alicyclisk substituerede oxazolidin-2,4-dion-forbindelser eller farmaceutisk acceptable kationsalte deraf og tilsvarende substituerede alfa-hydroxyacetamider og 2-hydroxyacetonitriler der er nyttige som mellemprodukter

Info

Publication number
DK287883D0
DK287883D0 DK2878/83A DK287883A DK287883D0 DK 287883 D0 DK287883 D0 DK 287883D0 DK 2878/83 A DK2878/83 A DK 2878/83A DK 287883 A DK287883 A DK 287883A DK 287883 D0 DK287883 D0 DK 287883D0
Authority
DK
Denmark
Prior art keywords
substituted
preparation
hydroxytyretyd
eyetrodyxetamide
coatal
Prior art date
Application number
DK2878/83A
Other languages
English (en)
Other versions
DK287883A (da
Inventor
Gerald Fagan Holland
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK287883D0 publication Critical patent/DK287883D0/da
Publication of DK287883A publication Critical patent/DK287883A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/513—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an etherified hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/42—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings with a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/45—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK287883A 1982-06-23 1983-06-22 Fremgangsmaade til fremstilling af alicyclisk substituerede oxazolidin-2,4-dion-forbindelser eller farmaceutisk acceptable kationsalte deraf og tilsvarende substituerede alfa-hydroxyacetamider og 2-hydroxyacetonitriler der er nyttige som mellemprodukter DK287883A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/391,220 US4430337A (en) 1982-06-23 1982-06-23 Alicyclic substituted oxazolidine-2,4-diones having hypoglycemic activity

Publications (2)

Publication Number Publication Date
DK287883D0 true DK287883D0 (da) 1983-06-22
DK287883A DK287883A (da) 1983-12-24

Family

ID=23545772

Family Applications (1)

Application Number Title Priority Date Filing Date
DK287883A DK287883A (da) 1982-06-23 1983-06-22 Fremgangsmaade til fremstilling af alicyclisk substituerede oxazolidin-2,4-dion-forbindelser eller farmaceutisk acceptable kationsalte deraf og tilsvarende substituerede alfa-hydroxyacetamider og 2-hydroxyacetonitriler der er nyttige som mellemprodukter

Country Status (10)

Country Link
US (1) US4430337A (da)
EP (1) EP0097453B1 (da)
JP (1) JPS5916881A (da)
AT (1) ATE51864T1 (da)
CA (1) CA1197513A (da)
DE (1) DE3381437D1 (da)
DK (1) DK287883A (da)
ES (1) ES523521A0 (da)
GR (1) GR79300B (da)
IE (1) IE55837B1 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU598366B2 (en) * 1987-03-20 1990-06-21 Alcon Laboratories, Inc. Use of aldose reductase inhibitors to enhance insulin sensitivity in diabetes
WO1988009661A1 (en) * 1987-06-10 1988-12-15 Pfizer Inc. Oxazolidin-2-one derivatives as hypoglycemic agents
WO1991007107A1 (en) * 1989-11-13 1991-05-30 Pfizer Inc. Oxazolidinedione hypoglycemic agents
GB9017218D0 (en) * 1990-08-06 1990-09-19 Beecham Group Plc Novel compounds
US5498621A (en) * 1992-05-01 1996-03-12 Pfizer Inc. Oxazolidinedione hypoglycemic agents
US5221686A (en) * 1992-08-04 1993-06-22 American Home Products Corporation Spiro[1,2-benzisothiazole-3(2H),5'-oxazolidine]-2',4'-dione 1,1-dioxides as antihyperglycemic agents
TW268952B (da) * 1993-02-26 1996-01-21 Takeda Pharm Industry Co Ltd
US5614544A (en) * 1993-09-14 1997-03-25 Takeda Chemical Industries, Ltd. Oxazolidinedione derivatives and their use
TW403748B (en) * 1994-11-02 2000-09-01 Takeda Chemical Industries Ltd An oxazolidinedione derivative, its production and a pharmaceutical composition for lowering blood sugar and lipid in blood comprising the same
AU6331199A (en) * 1998-09-30 2000-04-17 Roche Diagnostics Gmbh Oxazolidine derivatives for the treatment and prevention of metabolic bone disorders
ATE333448T1 (de) 1999-06-18 2006-08-15 Merck & Co Inc Arylthiazolidinedione und aryloxa zolidinedion- derivate
CA2377246A1 (en) 1999-06-18 2000-12-28 Ranjit C. Desai Arylthiazolidinedione and aryloxazolidinedione derivatives

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB226529A (en) 1923-12-18 1925-08-13 Arnold I Van Den Bergh S Embal Improvements in and relating to edge trimming and moulding machines for planks and laths
US2338064A (en) 1940-02-10 1943-12-28 Mallinckrodt Chemical Works Derivatives of 2,4-oxazolidinedione
US2349795A (en) 1942-01-14 1944-05-23 Mallinckrodt Chemical Works Derivatives of 2,4-oxazolidinedione
US2349796A (en) 1942-01-14 1944-05-23 Mallinckrodt Chemical Works Derivatives of 2,4-oxazolidinedione
US2349313A (en) 1943-03-01 1944-05-23 Mallinckrodt Chemical Works Derivatives of 2, 4-oxazolidinedione
US2575692A (en) 1947-10-11 1951-11-20 Abbott Lab N-methyl oxazolidine-2, 4-diones
US2575694A (en) 1949-03-02 1951-11-20 Abbott Lab 3, 5, 5-trimethyloxazolidine-2, 4-dione
US2575693A (en) 1949-03-02 1951-11-20 Abbott Lab 3, 5-dimethyl-5-ethyloxazolidine-2, 4-dione
US2961377A (en) 1957-08-05 1960-11-22 Us Vitamin Pharm Corp Oral anti-diabetic compositions and methods
US3699229A (en) * 1970-12-18 1972-10-17 Abbott Lab 2-oxo-5-phenyl-4-oxazolidinone as an anti-depressant agent
US4200642A (en) 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
GT198170554A (es) * 1980-07-28 1983-01-12 5-oxazolidin-2-4-dionas hipoglicemicas substituidas.
US4367234A (en) * 1980-07-28 1983-01-04 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4332952A (en) 1980-07-28 1982-06-01 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones

Also Published As

Publication number Publication date
EP0097453B1 (en) 1990-04-11
IE55837B1 (en) 1991-01-30
GR79300B (da) 1984-10-22
ATE51864T1 (de) 1990-04-15
EP0097453A3 (en) 1985-06-12
IE831461L (en) 1983-12-23
US4430337A (en) 1984-02-07
DE3381437D1 (de) 1990-05-17
ES8500918A1 (es) 1984-11-01
DK287883A (da) 1983-12-24
JPS5916881A (ja) 1984-01-28
JPS6230993B2 (da) 1987-07-06
CA1197513A (en) 1985-12-03
EP0097453A2 (en) 1984-01-04
ES523521A0 (es) 1984-11-01

Similar Documents

Publication Publication Date Title
DK287883D0 (da) Fremgangsmade til fremstilling af alicyclisk substituerede oxazolidin-2,4-dion-forbindelser eller farmaceutisk acceptable kationsalte deraf og tilsvarende substituerede alfa-hydroxyacetamider og 2-hydroxyacetonitriler der er nyttige som mellemprodukter
DK151882C (da) Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive 5-substituerede oxazolidin-2,4-dioner eller 3-acylforbindelser eller kationsalte deraf og carboximidat-forbindelser til anvendelse som udgangsmateriale ved fremgangsmaaden
IS2845A7 (is) Forefni til framleiðslu á omeprazole
DK159146C (da) Analogifremgangsmaade til fremstilling af 1,2-diaminocyclobuten-3,4-dioner og cyclobuten-3,4-dionderivater til anvendelse som mellemprodukter i fremgangsmaaden
MX7604E (es) Procedimiento para la infusion de fruta con solutos de azucar
DK303481A (da) Fremgangsmaade til fremstilling af amider af hydroxyfenyl-alkylaminoaetanoler eller terapeutisk acceptable salte deraf
DK164937C (da) Analogifremgangsmaade til fremstilling af 1-alkyl-2-aminotetralinderivater eller farmaceutisk acceptable syreadditionssalte deraf samt 1-alkyl-2-aminotetralinderivater til anvendelse som udgangsmateriale i fremgangsmaaden
DK239388A (da) Fremgangsmaade til behandling af ikke-specifik inflammation
DK157022C (da) Analogifremgangsmaade til fremstilling af 9-hydrazono-6,7,8,9-tetrahydro-4h-pyrido oe1,2-aaapyrimidinderivater eller farmaceutisk acceptable salte, hydrater, stereoisomere, optisk aktive isomere, geometriske isomere og tautomere deraf
DK334781A (da) Fremgangsmaade til fremstilling af racemiske eller optisk aktive 5-substituerede oxazolidin-2,4-dioner eller 3-acylforbindelser deraf eller salte deraf og mellemprodukter ved fremgangsmaaden
NO874292D0 (no) Fremgangsmaate for fremstilling av forbindelser som er analoge med faktor viii-c.
DK164379A (da) Fremgangsmaade til fremstilling af 7-methoxy-5-oxo-5h-thiazolo(2,3-b)quinazolin-2-carboxylsyre eller farmaceutisk anvendelige salte deraf
DK163427C (da) Saerlig fremgangsmaade til fremstilling af alfa-arylalkansyrer og salte heraf ved omlejring af alfa-halogenalkylarylketaler
DK532679A (da) Fremgangsmaade til fremstilling af 2-aryl-3,4-diaza-bicyclo (4,1,0)hepten-(2)-on-(5).
MX173047B (es) Procedimiento para preparar un compuesto de trifluormetilvinilo
DK16783D0 (da) Fremgangsmade til fremstilling af 3-(1h-tetrazol-5-yl)-4(3h)-quinazolinoner
IT1121010B (it) Procedimento per la carbonilazione di diolefine
DK259689D0 (da) Anvendelse af optiske rene bicyklo(2,2,2)oct-5-en-2-oner til fremstilling af rene enantiomerer ved hjaelp af fotoreaktion
DK413180A (da) Fremgangsmaade til fremstilling af n-(5-tetrazolyl)-1-oxo-1h-thiazolo (3,2-a)pyrimidin-2-carboxamider eller farmaceutisk acceptable kationsalte deraf samt mellemprodukter ved fremgangsmaaden
SE7713586L (sv) Forfarande for framstellning av oxazolidindionderivat av vinkaalkaloider
DK452583D0 (da) Fremgangsmade til fremstilling af et middel til frembringelse af immunosuppression eller immunoregulering af immunreaktionen pa et antigen
DK132283A (da) Fremgangsmaade til fremstilling af indolizino(8,7-b)indolderivater
DK151797C (da) Analogifremgangsmaade til fremstilling af terbutalinderivater eller terapeutisk acceptable salte deraf
SU646994A1 (ru) Канюл дл соединени сердечнососудистой системы с аппаротом искусственного кровообращени
DK216983A (da) Fremgangsmaade til fremstilling af 2-substituerede 5-aryl-1,2,3,4-tetrahydro-gamma-carbolin-derivater og forbindelser der er nyttige som mellemprodukter derved

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment