ATE51864T1 - Alicyclische substituierte oxazolidin-2,4-dione mit hypoglykaemischer wirkung. - Google Patents

Alicyclische substituierte oxazolidin-2,4-dione mit hypoglykaemischer wirkung.

Info

Publication number
ATE51864T1
ATE51864T1 AT83303331T AT83303331T ATE51864T1 AT E51864 T1 ATE51864 T1 AT E51864T1 AT 83303331 T AT83303331 T AT 83303331T AT 83303331 T AT83303331 T AT 83303331T AT E51864 T1 ATE51864 T1 AT E51864T1
Authority
AT
Austria
Prior art keywords
diones
oxazolidine
alicyclic
substitute
sub
Prior art date
Application number
AT83303331T
Other languages
English (en)
Inventor
Gerald Fagan Holland
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE51864T1 publication Critical patent/ATE51864T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/513—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an etherified hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/42—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings with a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/45—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT83303331T 1982-06-23 1983-06-09 Alicyclische substituierte oxazolidin-2,4-dione mit hypoglykaemischer wirkung. ATE51864T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/391,220 US4430337A (en) 1982-06-23 1982-06-23 Alicyclic substituted oxazolidine-2,4-diones having hypoglycemic activity
EP83303331A EP0097453B1 (de) 1982-06-23 1983-06-09 Alicyclische substituierte Oxazolidin-2,4-dione mit hypoglykämischer Wirkung

Publications (1)

Publication Number Publication Date
ATE51864T1 true ATE51864T1 (de) 1990-04-15

Family

ID=23545772

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83303331T ATE51864T1 (de) 1982-06-23 1983-06-09 Alicyclische substituierte oxazolidin-2,4-dione mit hypoglykaemischer wirkung.

Country Status (10)

Country Link
US (1) US4430337A (de)
EP (1) EP0097453B1 (de)
JP (1) JPS5916881A (de)
AT (1) ATE51864T1 (de)
CA (1) CA1197513A (de)
DE (1) DE3381437D1 (de)
DK (1) DK287883A (de)
ES (1) ES523521A0 (de)
GR (1) GR79300B (de)
IE (1) IE55837B1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0306525A4 (en) * 1987-03-20 1991-04-24 Alcon Laboratories Inc Use of aldose reductase inhibitors to enhance insulin sensitivity in diabetes mellitus
US4968707A (en) * 1987-06-10 1990-11-06 Pfizer Inc. Oxazolidin-2-one derivatives as hypoglycemic agents
WO1991007107A1 (en) * 1989-11-13 1991-05-30 Pfizer Inc. Oxazolidinedione hypoglycemic agents
GB9017218D0 (en) * 1990-08-06 1990-09-19 Beecham Group Plc Novel compounds
US5498621A (en) * 1992-05-01 1996-03-12 Pfizer Inc. Oxazolidinedione hypoglycemic agents
US5221686A (en) * 1992-08-04 1993-06-22 American Home Products Corporation Spiro[1,2-benzisothiazole-3(2H),5'-oxazolidine]-2',4'-dione 1,1-dioxides as antihyperglycemic agents
TW268952B (de) * 1993-02-26 1996-01-21 Takeda Pharm Industry Co Ltd
US5614544A (en) * 1993-09-14 1997-03-25 Takeda Chemical Industries, Ltd. Oxazolidinedione derivatives and their use
TW403748B (en) 1994-11-02 2000-09-01 Takeda Chemical Industries Ltd An oxazolidinedione derivative, its production and a pharmaceutical composition for lowering blood sugar and lipid in blood comprising the same
AU6331199A (en) * 1998-09-30 2000-04-17 Roche Diagnostics Gmbh Oxazolidine derivatives for the treatment and prevention of metabolic bone disorders
CA2376919C (en) 1999-06-18 2008-11-04 Merck & Co., Inc. Arylthiazolidinedione and aryloxazolidinedione derivatives
DE60032898T2 (de) 1999-06-18 2007-10-25 Merck & Co., Inc. Arylthiazolidindion- und aryloxazolidinderivate

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB226529A (en) 1923-12-18 1925-08-13 Arnold I Van Den Bergh S Embal Improvements in and relating to edge trimming and moulding machines for planks and laths
US2338064A (en) 1940-02-10 1943-12-28 Mallinckrodt Chemical Works Derivatives of 2,4-oxazolidinedione
US2349795A (en) 1942-01-14 1944-05-23 Mallinckrodt Chemical Works Derivatives of 2,4-oxazolidinedione
US2349796A (en) 1942-01-14 1944-05-23 Mallinckrodt Chemical Works Derivatives of 2,4-oxazolidinedione
US2349313A (en) 1943-03-01 1944-05-23 Mallinckrodt Chemical Works Derivatives of 2, 4-oxazolidinedione
US2575692A (en) 1947-10-11 1951-11-20 Abbott Lab N-methyl oxazolidine-2, 4-diones
US2575694A (en) 1949-03-02 1951-11-20 Abbott Lab 3, 5, 5-trimethyloxazolidine-2, 4-dione
US2575693A (en) 1949-03-02 1951-11-20 Abbott Lab 3, 5-dimethyl-5-ethyloxazolidine-2, 4-dione
US2961377A (en) 1957-08-05 1960-11-22 Us Vitamin Pharm Corp Oral anti-diabetic compositions and methods
US3699229A (en) * 1970-12-18 1972-10-17 Abbott Lab 2-oxo-5-phenyl-4-oxazolidinone as an anti-depressant agent
US4200642A (en) 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
US4367234A (en) 1980-07-28 1983-01-04 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
GT198170554A (es) * 1980-07-28 1983-01-12 5-oxazolidin-2-4-dionas hipoglicemicas substituidas.
US4332952A (en) 1980-07-28 1982-06-01 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones

Also Published As

Publication number Publication date
IE831461L (en) 1983-12-23
JPS6230993B2 (de) 1987-07-06
DK287883A (da) 1983-12-24
DE3381437D1 (de) 1990-05-17
CA1197513A (en) 1985-12-03
JPS5916881A (ja) 1984-01-28
EP0097453A3 (en) 1985-06-12
ES8500918A1 (es) 1984-11-01
DK287883D0 (da) 1983-06-22
US4430337A (en) 1984-02-07
ES523521A0 (es) 1984-11-01
IE55837B1 (en) 1991-01-30
GR79300B (de) 1984-10-22
EP0097453A2 (de) 1984-01-04
EP0097453B1 (de) 1990-04-11

Similar Documents

Publication Publication Date Title
ATE51864T1 (de) Alicyclische substituierte oxazolidin-2,4-dione mit hypoglykaemischer wirkung.
ES8306133A1 (es) Un procedimiento para la preparacion de oxazolidin-2,4-dionas 5-fenil y 5-naftil sustituidas.
ES2052617T3 (es) Emulsion de producto quimico fluorado oxigenado para uso en el tratamiento de radiacion de celulas tumorales hipoxicas de mamiferos.
DE3381465D1 (de) Sebum-auffang und steuermittel.
DE69229278T2 (de) Humanisierter b-b10, ein anti-il-2-rezeptor-antikörper
AU7343581A (en) Hypoglycemic 5-substituted oxazolidine-2,4-diones
YU91983A (en) Process for obtaining hypoglycemic 5-substituted oxazolidine-2,4-diones
MX7732E (es) Procedimiento para obtener etanol por fermentacion a partir de xilosa
DK205883A (da) Fremgangsmaade til fremstilling af 2-guanidino-4-(2-(substitueret-amino)-4-imidazolyl)-thiazoler
DK0413329T3 (da) 5-methyl-isoxazol-4-carboxylsyreanilider og 2-hydroxyethyliden-cyaneddikesyreanilider til behandling af øjensygdomme
FR2355505A1 (fr) Nouvel agent adjuvant immunitaire
DE58908815D1 (de) Monoklonaler Antikörper gegen Pseudomonas aeruginosa, seine Herstellung und Verwendung.
IT1121010B (it) Procedimento per la carbonilazione di diolefine
BE848267A (fr) Matieres de revetement durcissables sous l'action d'un rayonnement,
SE8404090D0 (sv) Raffinerat detoxifierat endotoxin
FR2261790A1 (en) Stable underside of skis - made of light stabilised ethylene propylene copolymer
SU852932A1 (ru) Способ получени олефиновыхуглЕВОдОРОдОВ
ES513508A0 (es) "un aparato para su uso en el ajuste de la regulacion de la inyeccion de combustible".
EP0342422A3 (de) Verfahren zur Herstellung von 2',3'-Dideoxynucleosiden und dabei verwendete neue Zwischenprodukte
JPS57131179A (en) Solidstate image pickup device
DK367188A (da) Intraokulaere linser med indstillelig styrke til indsaettelse gennem smaa snit
Suciu et al. Blood parasites(Rickettsiales) of small mammals(Insectivora and Rodentia in agroecosystems in Romania.).
PH19469A (en) Intermediates for the preparation of hypoglycemic 5-subatituted oxazolidine-2,4-diones
YU92183A (en) Process for obtaining hypoglycemic 5-substituted oxazolidine-2,4-diones
IE842427L (en) Intermediates for hypoglycemic oxazolidine-2, 4-diones

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee