DK2858664T3 - Hgh-xten-fusionsprotein og anvendelse deraf i behandling af væksthormonmangel - Google Patents
Hgh-xten-fusionsprotein og anvendelse deraf i behandling af væksthormonmangel Download PDFInfo
- Publication number
- DK2858664T3 DK2858664T3 DK13712656.1T DK13712656T DK2858664T3 DK 2858664 T3 DK2858664 T3 DK 2858664T3 DK 13712656 T DK13712656 T DK 13712656T DK 2858664 T3 DK2858664 T3 DK 2858664T3
- Authority
- DK
- Denmark
- Prior art keywords
- hgh
- treatment
- application
- fusion protein
- growth hormone
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title 1
- 108010051696 Growth Hormone Proteins 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 239000000122 growth hormone Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261689390P | 2012-06-05 | 2012-06-05 | |
| US201261663475P | 2012-06-22 | 2012-06-22 | |
| US201361763753P | 2013-02-12 | 2013-02-12 | |
| PCT/US2013/031673 WO2013184216A1 (en) | 2012-06-05 | 2013-03-14 | Hgh-xten fusion protein and its use in the treatment of growth hormone deficiency |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2858664T3 true DK2858664T3 (da) | 2019-07-08 |
Family
ID=47998551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13712656.1T DK2858664T3 (da) | 2012-06-05 | 2013-03-14 | Hgh-xten-fusionsprotein og anvendelse deraf i behandling af væksthormonmangel |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20140162949A1 (https=) |
| EP (1) | EP2858664B1 (https=) |
| JP (2) | JP2015520188A (https=) |
| KR (1) | KR20150021072A (https=) |
| CN (2) | CN104519903A (https=) |
| AU (1) | AU2013272220A1 (https=) |
| BR (1) | BR112014030404A2 (https=) |
| CA (1) | CA2875827A1 (https=) |
| DK (1) | DK2858664T3 (https=) |
| ES (1) | ES2733220T3 (https=) |
| HK (1) | HK1208629A1 (https=) |
| IL (1) | IL236070A0 (https=) |
| MX (1) | MX2014014927A (https=) |
| NZ (1) | NZ702557A (https=) |
| PH (1) | PH12014502738A1 (https=) |
| SG (1) | SG11201408152VA (https=) |
| WO (1) | WO2013184216A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
| ES2610356T3 (es) | 2009-02-03 | 2017-04-27 | Amunix Operating Inc. | Polipéptidos recombinantes extendidos y composiciones que comprenden los mismos |
| US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
| JP2016514132A (ja) * | 2013-03-11 | 2016-05-19 | アムニクス オペレーティング インコーポレイテッド | ヒト成長ホルモン類似体を用いた小児成長ホルモン分泌不全症の治療 |
| IL319047A (en) | 2015-08-28 | 2025-04-01 | Amunix Operating Inc | Chimeric polypeptide composition and methods for its preparation and use |
| WO2017136583A1 (en) | 2016-02-02 | 2017-08-10 | Versartis, Inc. | Growth hormone treatment adherence system |
| CN109152816B (zh) * | 2016-02-17 | 2022-08-16 | 株式会社吉耐森 | 用于治疗生长激素缺乏症的包含重组hgh的药物组合物 |
| WO2017142331A1 (en) * | 2016-02-17 | 2017-08-24 | Genexine, Inc. | Pharmaceutical composition comprising recombinant hgh for the treatment of growth hormone deficiency |
| JP2019525931A (ja) * | 2016-07-27 | 2019-09-12 | アムニクス ファーマシューティカルズ， インコーポレイテッド | ヒト成長ホルモンアナログによる成人成長ホルモン欠乏症の処置 |
| RU2748402C2 (ru) | 2016-08-30 | 2021-05-25 | Дженексин,Инк. | ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ ДЛЯ ТЕРАПИИ ДЕФИЦИТА ГОРМОНА РОСТА, СОДЕРЖАЩАЯ СЛИТЫЙ БЕЛОК hGH |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| AU2018393111B2 (en) | 2017-12-21 | 2025-07-10 | Amunix Pharmaceuticals, Inc. | Release segments and binding compositions comprising same |
| CN119264211A (zh) | 2018-08-27 | 2025-01-07 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| EP4085077A4 (en) | 2019-12-31 | 2024-01-17 | Beijing QL Biopharmaceutical Co., Ltd. | Fusion proteins of glp-1 and gdf15 and conjugates thereof |
| CN113728013B (zh) | 2020-01-11 | 2022-06-14 | 北京质肽生物医药科技有限公司 | Glp-1和fgf21的融合蛋白的缀合物 |
| CN114729060B (zh) | 2020-09-30 | 2022-11-25 | 北京质肽生物医药科技有限公司 | 多肽缀合物和使用方法 |
| CN116554343B (zh) * | 2022-01-30 | 2024-07-12 | 领诺(上海)医药科技有限公司 | 一种长效重组人生长激素及其应用 |
| EP4323413A4 (en) | 2022-03-30 | 2025-10-15 | Beijing Ql Biopharmaceutical Co Ltd | LIQUID PHARMACEUTICAL COMPOSITIONS OF POLYPEPTIDE CONJUGATES AND METHODS OF USE THEREOF |
| CN116003632B (zh) * | 2022-12-07 | 2026-02-24 | 北京大学 | 长效缓释型人重组生长激素融合蛋白及其药物组合物和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4898830A (en) | 1979-07-05 | 1990-02-06 | Genentech, Inc. | Human growth hormone DNA |
| US5206161A (en) | 1991-02-01 | 1993-04-27 | Genentech, Inc. | Human plasma carboxypeptidase B |
| EP0983303B1 (en) | 1997-05-21 | 2006-03-08 | Biovation Limited | Method for the production of non-immunogenic proteins |
| US6406632B1 (en) | 1998-04-03 | 2002-06-18 | Symyx Technologies, Inc. | Rapid characterization of polymers |
| GB9815157D0 (en) | 1998-07-13 | 1998-09-09 | Metron Designs Ltd | High resolution pulse width setting from relatively low frequency clocks |
| US20030228309A1 (en) | 2000-11-08 | 2003-12-11 | Theodora Salcedo | Antibodies that immunospecifically bind to TRAIL receptors |
| WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| US7294513B2 (en) | 2002-07-24 | 2007-11-13 | Wyatt Technology Corporation | Method and apparatus for characterizing solutions of small particles |
| ES2610356T3 (es) * | 2009-02-03 | 2017-04-27 | Amunix Operating Inc. | Polipéptidos recombinantes extendidos y composiciones que comprenden los mismos |
| US8680050B2 (en) * | 2009-02-03 | 2014-03-25 | Amunix Operating Inc. | Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same |
| US8703717B2 (en) * | 2009-02-03 | 2014-04-22 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
| KR101813727B1 (ko) * | 2009-06-08 | 2018-01-02 | 아뮤닉스 오퍼레이팅 인코포레이티드 | 성장 호르몬 폴리펩타이드 및 이를 제조하고 사용하는 방법 |
-
2013
- 2013-03-14 CN CN201380041556.9A patent/CN104519903A/zh active Pending
- 2013-03-14 EP EP13712656.1A patent/EP2858664B1/en active Active
- 2013-03-14 ES ES13712656T patent/ES2733220T3/es active Active
- 2013-03-14 SG SG11201408152VA patent/SG11201408152VA/en unknown
- 2013-03-14 WO PCT/US2013/031673 patent/WO2013184216A1/en not_active Ceased
- 2013-03-14 MX MX2014014927A patent/MX2014014927A/es unknown
- 2013-03-14 DK DK13712656.1T patent/DK2858664T3/da active
- 2013-03-14 KR KR20147036167A patent/KR20150021072A/ko not_active Withdrawn
- 2013-03-14 JP JP2015516010A patent/JP2015520188A/ja active Pending
- 2013-03-14 AU AU2013272220A patent/AU2013272220A1/en not_active Abandoned
- 2013-03-14 NZ NZ702557A patent/NZ702557A/en not_active IP Right Cessation
- 2013-03-14 CN CN201710596161.5A patent/CN107320719A/zh not_active Withdrawn
- 2013-03-14 CA CA2875827A patent/CA2875827A1/en not_active Abandoned
- 2013-03-14 BR BR112014030404A patent/BR112014030404A2/pt not_active IP Right Cessation
- 2013-03-14 HK HK15109368.8A patent/HK1208629A1/xx unknown
- 2013-03-14 US US13/829,369 patent/US20140162949A1/en not_active Abandoned
-
2014
- 2014-12-04 IL IL236070A patent/IL236070A0/en unknown
- 2014-12-05 PH PH12014502738A patent/PH12014502738A1/en unknown
-
2017
- 2017-03-08 JP JP2017043512A patent/JP2017125051A/ja active Pending
- 2017-07-13 US US15/648,967 patent/US20180051063A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2875827A1 (en) | 2013-12-12 |
| CN107320719A (zh) | 2017-11-07 |
| AU2013272220A1 (en) | 2015-01-15 |
| US20140162949A1 (en) | 2014-06-12 |
| JP2017125051A (ja) | 2017-07-20 |
| MX2014014927A (es) | 2015-05-15 |
| SG11201408152VA (en) | 2015-01-29 |
| NZ702557A (en) | 2017-06-30 |
| US20180051063A1 (en) | 2018-02-22 |
| PH12014502738A1 (en) | 2015-02-02 |
| EP2858664B1 (en) | 2019-05-08 |
| IL236070A0 (en) | 2015-01-29 |
| WO2013184216A1 (en) | 2013-12-12 |
| EP2858664A1 (en) | 2015-04-15 |
| BR112014030404A2 (pt) | 2017-06-27 |
| HK1208629A1 (en) | 2016-03-11 |
| JP2015520188A (ja) | 2015-07-16 |
| CN104519903A (zh) | 2015-04-15 |
| KR20150021072A (ko) | 2015-02-27 |
| ES2733220T3 (es) | 2019-11-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2858664T3 (da) | Hgh-xten-fusionsprotein og anvendelse deraf i behandling af væksthormonmangel | |
| IL285985B1 (en) | Therapeutic nuclease compositions and methods | |
| DK3744835T5 (da) | Dna modificerende fusionsproteiner og metoder til anvendelse deraf | |
| DK3489254T3 (da) | Målrettede/immunmodulatoriske fusionsproteiner og fremgangsmåder til fremstilling deraf | |
| DK3909972T3 (da) | Pd1-cd28-fusionsproteiner og disses anvendelse i medicin | |
| DK3604339T3 (da) | Terapeutiske antistoffer mod ror-1-protein og fremgangsmåder til anvendelse af samme | |
| DK3321287T3 (da) | Fusionsproteiner og kombinationsvacciner | |
| CL2014003605A1 (es) | Proteínas de fusión de interleuquina-10 y usos de las mismas | |
| DK3434775T3 (da) | Protein med nukleaseaktivitet, fusionsproteiner og anvendelser deraf | |
| SI2726092T1 (sl) | Serpin fuzijski polipeptidi in načini njihove uporabe | |
| DK2970398T3 (da) | Præfusions-rsv-f-proteiner og anvendelse deraf | |
| DK3199547T3 (da) | Antistoflignende bindingsproteiner med dobbelt variabel region og overkrydsende orientering af bindingsregion | |
| DK3019533T3 (da) | Dobbeltspiraliserede immunoglobulinfusionproteiner og sammensætninger deraf | |
| DK3060237T3 (da) | Modificeret omprogrammeringsprotein til anvendelse i behandling af cancer | |
| DK2780022T4 (da) | Farmaceutiske præparater af humane rpe-celler og anvendelser deraf | |
| DK2945647T3 (da) | Immunogene wt-1-peptider og anvendelsesmetoder deraf | |
| DK2806892T3 (da) | Kombineret terapeutisk anvendelse af antistoffer og endoglycosidaser | |
| DK3088353T3 (da) | Bilirubinpartikler og deres fremstilling til anvendelse i terapi | |
| HRP20181351T1 (hr) | Ciljani terapeutski fuzijski proteini lizosomalnog enzima i njihova uporaba | |
| IL229723A0 (en) | Human fusion proteins including interferons and modified targeted ubiquitin proteins | |
| DK3173102T3 (da) | FGFR-FC-fusionsprotein og anvendelse deraf | |
| DK3074008T3 (da) | Forbindelser, farmaceutisk sammensætning og fremgangsmåder til anvendelse i behandling af inflammation | |
| DK2782598T3 (da) | Rekombinante proteiner og terapeutiske anvendelser deraf | |
| DK2914630T3 (da) | Hidtil ukendte antigen-bindende proteiner og deres anvendelse som adresseringsprodukt til behandling af kræft | |
| HRP20181210T1 (hr) | Fuzijski protein koji sadrži interleukin 4 i interleukin 10 |