KR20150021072A - 성장 호르몬 결핍의 치료에 있어서 hgh-xten 융합 단백질 및 이의 용도 - Google Patents
성장 호르몬 결핍의 치료에 있어서 hgh-xten 융합 단백질 및 이의 용도 Download PDFInfo
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- KR20150021072A KR20150021072A KR20147036167A KR20147036167A KR20150021072A KR 20150021072 A KR20150021072 A KR 20150021072A KR 20147036167 A KR20147036167 A KR 20147036167A KR 20147036167 A KR20147036167 A KR 20147036167A KR 20150021072 A KR20150021072 A KR 20150021072A
- Authority
- KR
- South Korea
- Prior art keywords
- xten
- hgh
- fusion protein
- sequence
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| US201261689390P | 2012-06-05 | 2012-06-05 | |
| US61/689,390 | 2012-06-05 | ||
| US201261663475P | 2012-06-22 | 2012-06-22 | |
| US61/663,475 | 2012-06-22 | ||
| US201361763753P | 2013-02-12 | 2013-02-12 | |
| US61/763,753 | 2013-02-12 | ||
| PCT/US2013/031673 WO2013184216A1 (en) | 2012-06-05 | 2013-03-14 | Hgh-xten fusion protein and its use in the treatment of growth hormone deficiency |
Publications (1)
| Publication Number | Publication Date |
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| KR20150021072A true KR20150021072A (ko) | 2015-02-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| KR20147036167A Withdrawn KR20150021072A (ko) | 2012-06-05 | 2013-03-14 | 성장 호르몬 결핍의 치료에 있어서 hgh-xten 융합 단백질 및 이의 용도 |
Country Status (17)
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| US (2) | US20140162949A1 (https=) |
| EP (1) | EP2858664B1 (https=) |
| JP (2) | JP2015520188A (https=) |
| KR (1) | KR20150021072A (https=) |
| CN (2) | CN104519903A (https=) |
| AU (1) | AU2013272220A1 (https=) |
| BR (1) | BR112014030404A2 (https=) |
| CA (1) | CA2875827A1 (https=) |
| DK (1) | DK2858664T3 (https=) |
| ES (1) | ES2733220T3 (https=) |
| HK (1) | HK1208629A1 (https=) |
| IL (1) | IL236070A0 (https=) |
| MX (1) | MX2014014927A (https=) |
| NZ (1) | NZ702557A (https=) |
| PH (1) | PH12014502738A1 (https=) |
| SG (1) | SG11201408152VA (https=) |
| WO (1) | WO2013184216A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
| ES2610356T3 (es) | 2009-02-03 | 2017-04-27 | Amunix Operating Inc. | Polipéptidos recombinantes extendidos y composiciones que comprenden los mismos |
| US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
| JP2016514132A (ja) * | 2013-03-11 | 2016-05-19 | アムニクス オペレーティング インコーポレイテッド | ヒト成長ホルモン類似体を用いた小児成長ホルモン分泌不全症の治療 |
| IL319047A (en) | 2015-08-28 | 2025-04-01 | Amunix Operating Inc | Chimeric polypeptide composition and methods for its preparation and use |
| WO2017136583A1 (en) | 2016-02-02 | 2017-08-10 | Versartis, Inc. | Growth hormone treatment adherence system |
| CN109152816B (zh) * | 2016-02-17 | 2022-08-16 | 株式会社吉耐森 | 用于治疗生长激素缺乏症的包含重组hgh的药物组合物 |
| WO2017142331A1 (en) * | 2016-02-17 | 2017-08-24 | Genexine, Inc. | Pharmaceutical composition comprising recombinant hgh for the treatment of growth hormone deficiency |
| JP2019525931A (ja) * | 2016-07-27 | 2019-09-12 | アムニクス ファーマシューティカルズ， インコーポレイテッド | ヒト成長ホルモンアナログによる成人成長ホルモン欠乏症の処置 |
| RU2748402C2 (ru) | 2016-08-30 | 2021-05-25 | Дженексин,Инк. | ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ ДЛЯ ТЕРАПИИ ДЕФИЦИТА ГОРМОНА РОСТА, СОДЕРЖАЩАЯ СЛИТЫЙ БЕЛОК hGH |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| AU2018393111B2 (en) | 2017-12-21 | 2025-07-10 | Amunix Pharmaceuticals, Inc. | Release segments and binding compositions comprising same |
| CN119264211A (zh) | 2018-08-27 | 2025-01-07 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| EP4085077A4 (en) | 2019-12-31 | 2024-01-17 | Beijing QL Biopharmaceutical Co., Ltd. | Fusion proteins of glp-1 and gdf15 and conjugates thereof |
| CN113728013B (zh) | 2020-01-11 | 2022-06-14 | 北京质肽生物医药科技有限公司 | Glp-1和fgf21的融合蛋白的缀合物 |
| CN114729060B (zh) | 2020-09-30 | 2022-11-25 | 北京质肽生物医药科技有限公司 | 多肽缀合物和使用方法 |
| CN116554343B (zh) * | 2022-01-30 | 2024-07-12 | 领诺(上海)医药科技有限公司 | 一种长效重组人生长激素及其应用 |
| EP4323413A4 (en) | 2022-03-30 | 2025-10-15 | Beijing Ql Biopharmaceutical Co Ltd | LIQUID PHARMACEUTICAL COMPOSITIONS OF POLYPEPTIDE CONJUGATES AND METHODS OF USE THEREOF |
| CN116003632B (zh) * | 2022-12-07 | 2026-02-24 | 北京大学 | 长效缓释型人重组生长激素融合蛋白及其药物组合物和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4898830A (en) | 1979-07-05 | 1990-02-06 | Genentech, Inc. | Human growth hormone DNA |
| US5206161A (en) | 1991-02-01 | 1993-04-27 | Genentech, Inc. | Human plasma carboxypeptidase B |
| EP0983303B1 (en) | 1997-05-21 | 2006-03-08 | Biovation Limited | Method for the production of non-immunogenic proteins |
| US6406632B1 (en) | 1998-04-03 | 2002-06-18 | Symyx Technologies, Inc. | Rapid characterization of polymers |
| GB9815157D0 (en) | 1998-07-13 | 1998-09-09 | Metron Designs Ltd | High resolution pulse width setting from relatively low frequency clocks |
| US20030228309A1 (en) | 2000-11-08 | 2003-12-11 | Theodora Salcedo | Antibodies that immunospecifically bind to TRAIL receptors |
| WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| US7294513B2 (en) | 2002-07-24 | 2007-11-13 | Wyatt Technology Corporation | Method and apparatus for characterizing solutions of small particles |
| ES2610356T3 (es) * | 2009-02-03 | 2017-04-27 | Amunix Operating Inc. | Polipéptidos recombinantes extendidos y composiciones que comprenden los mismos |
| US8680050B2 (en) * | 2009-02-03 | 2014-03-25 | Amunix Operating Inc. | Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same |
| US8703717B2 (en) * | 2009-02-03 | 2014-04-22 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
| KR101813727B1 (ko) * | 2009-06-08 | 2018-01-02 | 아뮤닉스 오퍼레이팅 인코포레이티드 | 성장 호르몬 폴리펩타이드 및 이를 제조하고 사용하는 방법 |
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2013
- 2013-03-14 CN CN201380041556.9A patent/CN104519903A/zh active Pending
- 2013-03-14 EP EP13712656.1A patent/EP2858664B1/en active Active
- 2013-03-14 ES ES13712656T patent/ES2733220T3/es active Active
- 2013-03-14 SG SG11201408152VA patent/SG11201408152VA/en unknown
- 2013-03-14 WO PCT/US2013/031673 patent/WO2013184216A1/en not_active Ceased
- 2013-03-14 MX MX2014014927A patent/MX2014014927A/es unknown
- 2013-03-14 DK DK13712656.1T patent/DK2858664T3/da active
- 2013-03-14 KR KR20147036167A patent/KR20150021072A/ko not_active Withdrawn
- 2013-03-14 JP JP2015516010A patent/JP2015520188A/ja active Pending
- 2013-03-14 AU AU2013272220A patent/AU2013272220A1/en not_active Abandoned
- 2013-03-14 NZ NZ702557A patent/NZ702557A/en not_active IP Right Cessation
- 2013-03-14 CN CN201710596161.5A patent/CN107320719A/zh not_active Withdrawn
- 2013-03-14 CA CA2875827A patent/CA2875827A1/en not_active Abandoned
- 2013-03-14 BR BR112014030404A patent/BR112014030404A2/pt not_active IP Right Cessation
- 2013-03-14 HK HK15109368.8A patent/HK1208629A1/xx unknown
- 2013-03-14 US US13/829,369 patent/US20140162949A1/en not_active Abandoned
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2014
- 2014-12-04 IL IL236070A patent/IL236070A0/en unknown
- 2014-12-05 PH PH12014502738A patent/PH12014502738A1/en unknown
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2017
- 2017-03-08 JP JP2017043512A patent/JP2017125051A/ja active Pending
- 2017-07-13 US US15/648,967 patent/US20180051063A1/en not_active Abandoned
Also Published As
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| CA2875827A1 (en) | 2013-12-12 |
| CN107320719A (zh) | 2017-11-07 |
| AU2013272220A1 (en) | 2015-01-15 |
| US20140162949A1 (en) | 2014-06-12 |
| JP2017125051A (ja) | 2017-07-20 |
| MX2014014927A (es) | 2015-05-15 |
| DK2858664T3 (da) | 2019-07-08 |
| SG11201408152VA (en) | 2015-01-29 |
| NZ702557A (en) | 2017-06-30 |
| US20180051063A1 (en) | 2018-02-22 |
| PH12014502738A1 (en) | 2015-02-02 |
| EP2858664B1 (en) | 2019-05-08 |
| IL236070A0 (en) | 2015-01-29 |
| WO2013184216A1 (en) | 2013-12-12 |
| EP2858664A1 (en) | 2015-04-15 |
| BR112014030404A2 (pt) | 2017-06-27 |
| HK1208629A1 (en) | 2016-03-11 |
| JP2015520188A (ja) | 2015-07-16 |
| CN104519903A (zh) | 2015-04-15 |
| ES2733220T3 (es) | 2019-11-28 |
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